Msc

Functionⁱ

Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9892671
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9892671

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branchiomeric skeletal muscle development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 12493912
cellular response to leukemia inhibitory factor
Source: MGI
Inferred from expression patternⁱ
- 20439489
diaphragm development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 12493912
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 9892671
roof of mouth development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 12493912
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Musculin Alternative name(s): Myogenic repressor
Gene namesⁱ	Name:Msc Synonyms:Myor
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1333884 Msc

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	110 – 112	RER → LEG: Loss of DNA-binding. 1 Publication		3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127284	1 – 201	MusculinAdd BLAST		201

Proteomic databases

PaxDbⁱ	O88940
PRIDEⁱ	O88940

PTM databases

PhosphoSitePlusⁱ	O88940

PhosphoSitePlusⁱ

O88940

Expressionⁱ

Developmental stageⁱ

Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000025930
CleanExⁱ	MM_MSC
ExpressionAtlasⁱ	O88940 baseline and differential
Genevisibleⁱ	O88940 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027062

STRINGⁱ

10090.ENSMUSP00000027062

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88940
SMRⁱ	O88940
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	102 – 154	bHLHPROSITE-ProRule annotationAdd BLAST		53

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	66 – 71	Nuclear localization signalSequence analysis		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	48 – 55	Glu-rich (acidic)		8
Compositional biasⁱ	76 – 86	Gly-richAdd BLAST		11

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106684
HOGENOMⁱ	HOG000261670
HOVERGENⁱ	HBG105298
InParanoidⁱ	O88940
KEGG Orthology (KO) More...KOⁱ	K09072
OMAⁱ	EERCTLG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N6P
PhylomeDBⁱ	O88940
TreeFamⁱ	TF350742

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O88940-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTGSVSDPE DSEMRGLQRV YPAPASKRPP LLRMERGYGS PSDISSAEEE 
        60         70         80         90        100
DGEEEPGSLG AAGGCKRKRL RGADAGGAGG RAGGAGKKPL PPKGSAAECK 
       110        120        130        140        150
QSQRNAANAR ERARMRVLSK AFSRLKTSLP WVPPDTKLSK LDTLRLASSY 
       160        170        180        190        200
IAHLRQLLQE DRYEDSYVHP VNLTWPFVVS GRPDSDSKDV SAANRLCGTS 

A

Length:201

Mass (Da):21,538

Last modified:November 1, 1998 - v1

Checksum:ⁱ04C757F710C69E32

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087035 mRNA Translation: AAC69869.1 AF108216 mRNA Translation: AAD10053.1 BC103592 mRNA Translation: AAI03593.1 BC103593 mRNA Translation: AAI03594.1 BC103594 mRNA Translation: AAI03595.1 BC103623 mRNA Translation: AAI03624.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14825.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034957.1, NM_010827.2
UniGeneⁱ	Mm.5820

Genome annotation databases

Ensemblⁱ	ENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930
GeneIDⁱ	17681
KEGGⁱ	mmu:17681
UCSC genome browser More...UCSCⁱ	uc007aja.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O88940	UPI00001CF5F8		RAT		220
UPI000A30C660		MUSPA		206
UPI000A3159FD		MUSCR		203
Musculin		RAT		203

Protein	Similar proteins		Species	Score	Length
O88940	UPI00001CF5F8		RAT		220
UPI000A30C660		MUSPA		206
UPI000A3159FD		MUSCR		203
UPI000D6A2FAB		PYTBI		187
musculin isoform X1		DIPOR		208
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087035 mRNA Translation: AAC69869.1 AF108216 mRNA Translation: AAD10053.1 BC103592 mRNA Translation: AAI03593.1 BC103593 mRNA Translation: AAI03594.1 BC103594 mRNA Translation: AAI03595.1 BC103623 mRNA Translation: AAI03624.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14825.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034957.1, NM_010827.2
UniGeneⁱ	Mm.5820

3D structure databases

ProteinModelPortalⁱ	O88940
SMRⁱ	O88940
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027062

STRINGⁱ

10090.ENSMUSP00000027062

PTM databases

PhosphoSitePlusⁱ	O88940

PhosphoSitePlusⁱ

O88940

Proteomic databases

PaxDbⁱ	O88940
PRIDEⁱ	O88940

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930
GeneIDⁱ	17681
KEGGⁱ	mmu:17681
UCSC genome browser More...UCSCⁱ	uc007aja.2 mouse

Organism-specific databases

CTDⁱ	9242
MGIⁱ	MGI:1333884 Msc

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106684
HOGENOMⁱ	HOG000261670
HOVERGENⁱ	HBG105298
InParanoidⁱ	O88940
KEGG Orthology (KO) More...KOⁱ	K09072
OMAⁱ	EERCTLG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N6P
PhylomeDBⁱ	O88940
TreeFamⁱ	TF350742

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88940
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025930
CleanExⁱ	MM_MSC
ExpressionAtlasⁱ	O88940 baseline and differential
Genevisibleⁱ	O88940 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MUSC_MOUSE
Accessionⁱ	O88940Primary (citable) accession number: O88940 Secondary accession number(s): Q3ZAZ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
	Last sequence update:	November 1, 1998
	Last modified:	May 23, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88940 (MUSC_MOUSE)

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Musculin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ