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UniProtKB - O88940 (MUSC_MOUSE)
Protein
Musculin
Gene
Msc
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- branchiomeric skeletal muscle development Source: UniProtKB
- cellular response to leukemia inhibitory factor Source: MGI
- developmental process Source: GO_Central
- diaphragm development Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- roof of mouth development Source: UniProtKB
- skeletal muscle tissue development Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: MusculinAlternative name(s): Myogenic repressor |
Gene namesi | Name:Msc Synonyms:Myor |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333884, Msc |
VEuPathDBi | HostDB:ENSMUSG00000025930 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 110 – 112 | RER → LEG: Loss of DNA-binding. 1 Publication | 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127284 | 1 – 201 | MusculinAdd BLAST | 201 |
Proteomic databases
PaxDbi | O88940 |
PRIDEi | O88940 |
PTM databases
PhosphoSitePlusi | O88940 |
Expressioni
Developmental stagei
Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025930, Expressed in respiratory primordium and 167 other tissues |
Genevisiblei | O88940, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer.
Forms a heterodimer with TCF3.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000027062 |
Miscellaneous databases
RNActi | O88940, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 102 – 154 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 108 | DisorderedSequence analysisAdd BLAST | 108 | |
Regioni | 182 – 201 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 66 – 71 | Nuclear localization signalSequence analysis | 6 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000160438 |
HOGENOMi | CLU_092663_1_0_1 |
InParanoidi | O88940 |
OMAi | GGCKKKR |
OrthoDBi | 1374128at2759 |
PhylomeDBi | O88940 |
TreeFami | TF350742 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O88940-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTGSVSDPE DSEMRGLQRV YPAPASKRPP LLRMERGYGS PSDISSAEEE
60 70 80 90 100
DGEEEPGSLG AAGGCKRKRL RGADAGGAGG RAGGAGKKPL PPKGSAAECK
110 120 130 140 150
QSQRNAANAR ERARMRVLSK AFSRLKTSLP WVPPDTKLSK LDTLRLASSY
160 170 180 190 200
IAHLRQLLQE DRYEDSYVHP VNLTWPFVVS GRPDSDSKDV SAANRLCGTS
A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WRR6 | A0A087WRR6_MOUSE | Musculin | Msc | 52 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087035 mRNA Translation: AAC69869.1 AF108216 mRNA Translation: AAD10053.1 BC103592 mRNA Translation: AAI03593.1 BC103593 mRNA Translation: AAI03594.1 BC103594 mRNA Translation: AAI03595.1 BC103623 mRNA Translation: AAI03624.1 |
CCDSi | CCDS14825.1 |
RefSeqi | NP_034957.1, NM_010827.2 |
Genome annotation databases
Ensembli | ENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930 |
GeneIDi | 17681 |
KEGGi | mmu:17681 |
UCSCi | uc007aja.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087035 mRNA Translation: AAC69869.1 AF108216 mRNA Translation: AAD10053.1 BC103592 mRNA Translation: AAI03593.1 BC103593 mRNA Translation: AAI03594.1 BC103594 mRNA Translation: AAI03595.1 BC103623 mRNA Translation: AAI03624.1 |
CCDSi | CCDS14825.1 |
RefSeqi | NP_034957.1, NM_010827.2 |
3D structure databases
AlphaFoldDBi | O88940 |
SMRi | O88940 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000027062 |
PTM databases
PhosphoSitePlusi | O88940 |
Proteomic databases
PaxDbi | O88940 |
PRIDEi | O88940 |
Protocols and materials databases
Antibodypediai | 25121, 247 antibodies from 30 providers |
DNASUi | 17681 |
Genome annotation databases
Ensembli | ENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930 |
GeneIDi | 17681 |
KEGGi | mmu:17681 |
UCSCi | uc007aja.2, mouse |
Organism-specific databases
CTDi | 9242 |
MGIi | MGI:1333884, Msc |
VEuPathDBi | HostDB:ENSMUSG00000025930 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000160438 |
HOGENOMi | CLU_092663_1_0_1 |
InParanoidi | O88940 |
OMAi | GGCKKKR |
OrthoDBi | 1374128at2759 |
PhylomeDBi | O88940 |
TreeFami | TF350742 |
Miscellaneous databases
BioGRID-ORCSi | 17681, 2 hits in 74 CRISPR screens |
ChiTaRSi | Msc, mouse |
PROi | PR:O88940 |
RNActi | O88940, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025930, Expressed in respiratory primordium and 167 other tissues |
Genevisiblei | O88940, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MUSC_MOUSE | |
Accessioni | O88940Primary (citable) accession number: O88940 Secondary accession number(s): Q3ZAZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot