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Protein

Musculin

Gene

Msc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.

GO - Molecular functioni

GO - Biological processi

  • branchiomeric skeletal muscle development Source: UniProtKB
  • cellular response to leukemia inhibitory factor Source: MGI
  • diaphragm development Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • roof of mouth development Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Musculin
Alternative name(s):
Myogenic repressor
Gene namesi
Name:Msc
Synonyms:Myor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1333884 Msc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi110 – 112RER → LEG: Loss of DNA-binding. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272841 – 201MusculinAdd BLAST201

Proteomic databases

PaxDbiO88940
PRIDEiO88940

PTM databases

PhosphoSitePlusiO88940

Expressioni

Developmental stagei

Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs.1 Publication

Gene expression databases

BgeeiENSMUSG00000025930 Expressed in 136 organ(s), highest expression level in respiratory primordium
CleanExiMM_MSC
ExpressionAtlasiO88940 baseline and differential
GenevisibleiO88940 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027062

Structurei

3D structure databases

ProteinModelPortaliO88940
SMRiO88940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 154bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 71Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 55Glu-rich (acidic)8
Compositional biasi76 – 86Gly-richAdd BLAST11

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000261670
HOVERGENiHBG105298
InParanoidiO88940
KOiK09072
OMAiEERCTLG
OrthoDBiEOG091G0N6P
PhylomeDBiO88940
TreeFamiTF350742

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTGSVSDPE DSEMRGLQRV YPAPASKRPP LLRMERGYGS PSDISSAEEE
60 70 80 90 100
DGEEEPGSLG AAGGCKRKRL RGADAGGAGG RAGGAGKKPL PPKGSAAECK
110 120 130 140 150
QSQRNAANAR ERARMRVLSK AFSRLKTSLP WVPPDTKLSK LDTLRLASSY
160 170 180 190 200
IAHLRQLLQE DRYEDSYVHP VNLTWPFVVS GRPDSDSKDV SAANRLCGTS

A
Length:201
Mass (Da):21,538
Last modified:November 1, 1998 - v1
Checksum:i04C757F710C69E32
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRR6A0A087WRR6_MOUSE
Musculin
Msc
52Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087035 mRNA Translation: AAC69869.1
AF108216 mRNA Translation: AAD10053.1
BC103592 mRNA Translation: AAI03593.1
BC103593 mRNA Translation: AAI03594.1
BC103594 mRNA Translation: AAI03595.1
BC103623 mRNA Translation: AAI03624.1
CCDSiCCDS14825.1
RefSeqiNP_034957.1, NM_010827.2
UniGeneiMm.5820

Genome annotation databases

EnsembliENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930
GeneIDi17681
KEGGimmu:17681
UCSCiuc007aja.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087035 mRNA Translation: AAC69869.1
AF108216 mRNA Translation: AAD10053.1
BC103592 mRNA Translation: AAI03593.1
BC103593 mRNA Translation: AAI03594.1
BC103594 mRNA Translation: AAI03595.1
BC103623 mRNA Translation: AAI03624.1
CCDSiCCDS14825.1
RefSeqiNP_034957.1, NM_010827.2
UniGeneiMm.5820

3D structure databases

ProteinModelPortaliO88940
SMRiO88940
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027062

PTM databases

PhosphoSitePlusiO88940

Proteomic databases

PaxDbiO88940
PRIDEiO88940

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930
GeneIDi17681
KEGGimmu:17681
UCSCiuc007aja.2 mouse

Organism-specific databases

CTDi9242
MGIiMGI:1333884 Msc

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000261670
HOVERGENiHBG105298
InParanoidiO88940
KOiK09072
OMAiEERCTLG
OrthoDBiEOG091G0N6P
PhylomeDBiO88940
TreeFamiTF350742

Miscellaneous databases

PROiPR:O88940
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025930 Expressed in 136 organ(s), highest expression level in respiratory primordium
CleanExiMM_MSC
ExpressionAtlasiO88940 baseline and differential
GenevisibleiO88940 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMUSC_MOUSE
AccessioniPrimary (citable) accession number: O88940
Secondary accession number(s): Q3ZAZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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