Zbtb7a

Functionⁱ

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:15337766, PubMed:15662416, PubMed:17495164, PubMed:26816381, PubMed:29813070). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:15337766, PubMed:15662416, PubMed:26816381, PubMed:29813070). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (PubMed:29813070). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (By similarity). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (By similarity). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (PubMed:15662416). Efficiently abrogates E2F1-dependent CDKN2A transactivation (PubMed:15662416). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (PubMed:15337766). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (By similarity). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (PubMed:17495164). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (PubMed:17495164). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (PubMed:26446488). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (PubMed:26446488). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity).By similarity6 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	376 – 398	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	404 – 426	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	432 – 454	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	460 – 484	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

activating transcription factor binding Source: Ensembl
androgen receptor binding Source: UniProtKB
DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15337766
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15662416
histone acetyltransferase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15337766
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 15337766
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 15337766
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15662416
SMAD binding Source: UniProtKB
transcription corepressor activity Source: UniProtKB
transcription corepressor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17495164
cartilage development
Source: UniProtKB
Non-traceable author statementⁱ
- 15337766
cellular response to DNA damage stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chromatin organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29813070
chromatin remodeling Source: UniProtKB
double-strand break repair via classical nonhomologous end joining
Source: UniProtKB
Inferred from direct assayⁱ
- 26446488
erythrocyte maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26816381
fat cell differentiation Source: UniProtKB
negative regulation of androgen receptor signaling pathway Source: UniProtKB
negative regulation of Notch signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17495164
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15337766
- 17495164
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 15337766
negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
protein localization to nucleus Source: Ensembl
regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
regulation of apoptotic process Source: UniProtKB
regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29813070
regulation of glycolytic process Source: UniProtKB
regulation of osteoclast differentiation Source: MGI
regulation of transcription, DNA-templated Source: MGI
regulation of transcription regulatory region DNA binding Source: UniProtKB
transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29813070

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, DNA damage, DNA repair, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 7ACurated Alternative name(s): Leukemia/lymphoma-related factor1 Publication POZ and Krueppel erythroid myeloid ontogenic factor1 Publication Short name: POK erythroid myeloid ontogenic factor1 Publication Short name: Pokemon1 Publication
Gene namesⁱ	Name:Zbtb7aImported Synonyms:Lrf1 Publication, Zbtb7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1335091 Zbtb7a

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Death around 16.5 dpc because of severe anemia with a profound block in early B-cell development (PubMed:17495164). Conditional knockout in erythroid cells, leads to the expression of fetal globin in peripheral blood of adult mice and inefficient erythroid terminal differentiation (PubMed:26816381).2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047716	1 – 569	Zinc finger and BTB domain-containing protein 7AAdd BLAST		569

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	331	PhosphoserineCombined sources	1
Modified residueⁱ	335	PhosphoserineBy similarity	1
Cross-linkⁱ	430	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	527	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	537	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O88939
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O88939
PaxDbⁱ	O88939
PeptideAtlas More...PeptideAtlasⁱ	O88939
PRIDEⁱ	O88939

PTM databases

iPTMnetⁱ	O88939
PhosphoSitePlusⁱ	O88939

Expressionⁱ

Tissue specificityⁱ

Widely expressed (PubMed:9927193). In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) (PubMed:15662416). In the spleen, mainly expressed in the white pulp germinal centers (at protein level) (PubMed:15662416). Up-regulated in thymic lymphomas (PubMed:15662416).2 Publications

Developmental stageⁱ

Expressed at E9.5-E10.0 day in limb buds, pharyngeal arches, tail bud, placenta and neural tube (PubMed:9927193). Up-regulated during adipocyte differentiation (PubMed:14701838).2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000035011 Expressed in 276 organ(s), highest expression level in ascending aorta
CleanExⁱ	MM_ZBTB7A
ExpressionAtlasⁱ	O88939 baseline and differential
Genevisibleⁱ	O88939 MM

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Interacts with BCL6 (PubMed:9927193). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with HDAC1 (By similarity). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (By similarity). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Hdac1	O09106	3	EBI-595063,EBI-301912

With

Entry

#Exp.

IntAct

Notes

Hdac1

O09106

3

EBI-595063,EBI-301912

GO - Molecular functionⁱ

activating transcription factor binding Source: Ensembl
androgen receptor binding Source: UniProtKB
histone acetyltransferase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15337766
SMAD binding Source: UniProtKB
transcription corepressor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201199, 8 interactors
Database of interacting proteins More...DIPⁱ	DIP-33318N
IntActⁱ	O88939, 10 interactors
Molecular INTeraction database More...MINTⁱ	O88939
STRINGⁱ	10090.ENSMUSP00000047333

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88939
SMRⁱ	O88939
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 101	BTBPROSITE-ProRule annotationAdd BLAST		68

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	275 – 569	Mediates interaction with KHDRBS1By similarityAdd BLAST	295
Regionⁱ	343 – 569	Mediates interaction with RELA1 PublicationAdd BLAST	227
Regionⁱ	371 – 569	Mediates interaction with SMAD4By similarityAdd BLAST	199

Domainⁱ

The BTB domain mediates the interaction with the androgen receptor/AR and HDAC1. Also mediates the interaction with SP1.By similarity

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	376 – 398	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	404 – 426	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	432 – 454	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	460 – 484	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150939
HOGENOMⁱ	HOG000082521
HOVERGENⁱ	HBG106747
InParanoidⁱ	O88939
KEGG Orthology (KO) More...KOⁱ	K10494
OMAⁱ	IDQRNHL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G057O
PhylomeDBⁱ	O88939
TreeFamⁱ	TF331824

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O88939-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS 
        60         70         80         90        100
VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS 
       110        120        130        140        150
TANVGDILSA ARLLEIPAVS HVCADLLERQ ILAADDVGDA SQPDGAGPTD 
       160        170        180        190        200
QRNLLRAKEY LEFFRSNPMN SLPPTAFPWS GFGAPDDDLD ATKEAVAAAV 
       210        220        230        240        250
AAVAAGDCNG LDFYGPGPPA DRPPAGDGDE GDSTPGLWPE RDEDAPPGGL 
       260        270        280        290        300
FPPPTAPPAT TQNGHYGRAG AGTGEEEAAA LSEAAPEPGD SPGFLSGAAE 
       310        320        330        340        350
GEDGDAADVD GLAASTLLQQ MMSSVGRAGD SDEESRTDDK GVMDYYLKYF 
       360        370        380        390        400
SGAHEGDVYP AWSQKGEKKI RAKAFQKCPI CEKVIQGAGK LPRHIRTHTG 
       410        420        430        440        450
EKPYECNICK VRFTRQDKLK VHMRKHTGEK PYLCQQCGAA FAHNYDLKNH 
       460        470        480        490        500
MRVHTGLRPY QCDSCCKTFV RSDHLHRHLK KDGCNGVPSR RGRKPRVRGV 
       510        520        530        540        550
PPDVPAGAGA PPGLPDAPRN GQEKHFKDEE EDEEEASPDG SGRLNVAGSG 
       560 
GDDGAGGPAV ATAEGNFAT

Length:569

Mass (Da):60,281

Last modified:September 2, 2008 - v2

Checksum:ⁱB4F79FF89A88CBD5

GO

Isoform 2 (identifier: O88939-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
532-535: Missing.

« Hide

        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS 
        60         70         80         90        100
VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS 
       110        120        130        140        150
TANVGDILSA ARLLEIPAVS HVCADLLERQ ILAADDVGDA SQPDGAGPTD 
       160        170        180        190        200
QRNLLRAKEY LEFFRSNPMN SLPPTAFPWS GFGAPDDDLD ATKEAVAAAV 
       210        220        230        240        250
AAVAAGDCNG LDFYGPGPPA DRPPAGDGDE GDSTPGLWPE RDEDAPPGGL 
       260        270        280        290        300
FPPPTAPPAT TQNGHYGRAG AGTGEEEAAA LSEAAPEPGD SPGFLSGAAE 
       310        320        330        340        350
GEDGDAADVD GLAASTLLQQ MMSSVGRAGD SDEESRTDDK GVMDYYLKYF 
       360        370        380        390        400
SGAHEGDVYP AWSQKGEKKI RAKAFQKCPI CEKVIQGAGK LPRHIRTHTG 
       410        420        430        440        450
EKPYECNICK VRFTRQDKLK VHMRKHTGEK PYLCQQCGAA FAHNYDLKNH 
       460        470        480        490        500
MRVHTGLRPY QCDSCCKTFV RSDHLHRHLK KDGCNGVPSR RGRKPRVRGV 
       510        520        530        540        550
PPDVPAGAGA PPGLPDAPRN GQEKHFKDEE EASPDGSGRL NVAGSGGDDG 
       560 
AGGPAVATAE GNFAT

Show »

Length:565

Mass (Da):59,778

Checksum:ⁱB59CCA89D740DC70

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z4C3	D3Z4C3_MOUSE	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 7A	Zbtb7a	415	Annotation score:
D3YVF8	D3YVF8_MOUSE	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 7A	Zbtb7a	174	Annotation score:
D3YZI8	D3YZI8_MOUSE	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 7A	Zbtb7a	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	433	L → M in BAB26897 (PubMed:16141072).Curated		1
Sequence conflictⁱ	548	G → D in BAE32917 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035026	532 – 535	Missing in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF086830 mRNA Translation: AAC35367.1 AK010379 mRNA Translation: BAB26897.1 AK154907 mRNA Translation: BAE32917.1 CH466553 Genomic DNA Translation: EDL31455.1 BC057204 mRNA Translation: AAH57204.1 BC138524 mRNA Translation: AAI38525.1 BC145311 mRNA Translation: AAI45312.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35991.1 [O88939-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_034861.3, NM_010731.3 [O88939-1] XP_006513342.2, XM_006513279.2 [O88939-1] XP_006513343.2, XM_006513280.3 [O88939-1] XP_006513345.1, XM_006513282.2 [O88939-1]
UniGeneⁱ	Mm.20920 Mm.486315

Genome annotation databases

Ensemblⁱ	ENSMUST00000048128; ENSMUSP00000047333; ENSMUSG00000035011 [O88939-1] ENSMUST00000117956; ENSMUSP00000113428; ENSMUSG00000035011 [O88939-1] ENSMUST00000119606; ENSMUSP00000113612; ENSMUSG00000035011 [O88939-1]
GeneIDⁱ	16969
KEGGⁱ	mmu:16969
UCSC genome browser More...UCSCⁱ	uc007gfz.1 mouse [O88939-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88939	Zinc finger and BTB domain-containing protein 7A		MOUSE		415	UniRef100_O88939
Zinc finger and BTB domain-containing protein 7A (Fragment)		MOUSE		174
UPI0003D733BA		MOUSE		648

Protein	Similar proteins		Species	Score	Length	Source
O88939	Zinc finger and BTB domain-containing protein 7A		RAT		569	UniRef90_O88939
Zinc finger and BTB domain-containing protein 7A		MOUSE		415
zinc finger and BTB domain-containing protein 7A isoform X1		MESAU		647
UPI000B4EAAF7		MERUN		645
UPI0004ED49E6		NANGA		570
+11

Protein	Similar proteins		Species	Score	Length	Source
O88939	Zinc finger and BTB domain-containing protein 7A	)	HUMAN		584	UniRef50_O95365
Zinc finger and BTB domain-containing protein 7A		RAT		569
ZBTB7A isoform 1		PANTR		584
Uncharacterized protein		PONAB		421
Zinc finger and BTB domain-containing protein 7A		HETGA		611
+104

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF086830 mRNA Translation: AAC35367.1 AK010379 mRNA Translation: BAB26897.1 AK154907 mRNA Translation: BAE32917.1 CH466553 Genomic DNA Translation: EDL31455.1 BC057204 mRNA Translation: AAH57204.1 BC138524 mRNA Translation: AAI38525.1 BC145311 mRNA Translation: AAI45312.1
CCDSⁱ	CCDS35991.1 [O88939-1]
RefSeqⁱ	NP_034861.3, NM_010731.3 [O88939-1] XP_006513342.2, XM_006513279.2 [O88939-1] XP_006513343.2, XM_006513280.3 [O88939-1] XP_006513345.1, XM_006513282.2 [O88939-1]
UniGeneⁱ	Mm.20920 Mm.486315

3D structure databases

ProteinModelPortalⁱ	O88939
SMRⁱ	O88939
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201199, 8 interactors
DIPⁱ	DIP-33318N
IntActⁱ	O88939, 10 interactors
MINTⁱ	O88939
STRINGⁱ	10090.ENSMUSP00000047333

PTM databases

iPTMnetⁱ	O88939
PhosphoSitePlusⁱ	O88939

Proteomic databases

EPDⁱ	O88939
MaxQBⁱ	O88939
PaxDbⁱ	O88939
PeptideAtlasⁱ	O88939
PRIDEⁱ	O88939

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000048128; ENSMUSP00000047333; ENSMUSG00000035011 [O88939-1] ENSMUST00000117956; ENSMUSP00000113428; ENSMUSG00000035011 [O88939-1] ENSMUST00000119606; ENSMUSP00000113612; ENSMUSG00000035011 [O88939-1]
GeneIDⁱ	16969
KEGGⁱ	mmu:16969
UCSCⁱ	uc007gfz.1 mouse [O88939-1]

Organism-specific databases

CTDⁱ	51341
MGIⁱ	MGI:1335091 Zbtb7a

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150939
HOGENOMⁱ	HOG000082521
HOVERGENⁱ	HBG106747
InParanoidⁱ	O88939
KOⁱ	K10494
OMAⁱ	IDQRNHL
OrthoDBⁱ	EOG091G057O
PhylomeDBⁱ	O88939
TreeFamⁱ	TF331824

Miscellaneous databases

ChiTaRSⁱ	Zbtb7a mouse
Protein Ontology More...PROⁱ	PR:O88939
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035011 Expressed in 276 organ(s), highest expression level in ascending aorta
CleanExⁱ	MM_ZBTB7A
ExpressionAtlasⁱ	O88939 baseline and differential
Genevisibleⁱ	O88939 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT7A_MOUSE
Accessionⁱ	O88939Primary (citable) accession number: O88939 Secondary accession number(s): B2RRP7 , B7ZNL6, Q3U372, Q9CRJ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	September 2, 2008
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88939 (ZBT7A_MOUSE)

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Zinc finger and BTB domain-containing protein 7A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ