Syn1

Functionⁱ

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level.

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
ATP binding Source: InterPro
calcium-dependent protein binding Source: MGI
protein dimerization activity
Source: MGI
Traceable author statementⁱ
- 15071120
protein kinase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 21307259

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neuron development Source: Ensembl
neurotransmitter secretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 7777057
regulation of short-term neuronal synaptic plasticity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 15217342
regulation of synaptic vesicle cycle
Source: SynGO
Inferred from direct assayⁱ
- 8794863
synapse organization Source: MGI
synaptic vesicle clustering
Source: SynGO
Inferred from mutant phenotypeⁱ
- 7568108
synaptic vesicle cycle
Source: SynGO
Inferred from mutant phenotypeⁱ
- 7902212

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-181429 Serotonin Neurotransmitter Release Cycle R-MMU-212676 Dopamine Neurotransmitter Release Cycle

Reactomeⁱ

R-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synapsin-1 Alternative name(s): Synapsin I
Gene namesⁱ	Name:Syn1 Synonyms:Syn-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:98460 Syn1

Keywords - Cellular componentⁱ

Cell junction, Golgi apparatus, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183019	1 – 706	Synapsin-1Add BLAST		706

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	9	PhosphoserineCombined sources	1
Modified residueⁱ	39	PhosphoserineCombined sources	1
Glycosylationⁱ	55	O-linked (GlcNAc) serineBy similarity	1
Glycosylationⁱ	56	O-linked (GlcNAc) threonineBy similarity	1
Modified residueⁱ	62	PhosphoserineBy similarity	1
Modified residueⁱ	67	PhosphoserineBy similarity	1
Glycosylationⁱ	87	O-linked (GlcNAc) threonine1 Publication	1
Glycosylationⁱ	96	O-linked (GlcNAc) serineBy similarity	1
Glycosylationⁱ	103	O-linked (GlcNAc) serineBy similarity	1
Glycosylationⁱ	261	O-linked (GlcNAc) serineBy similarity	1
Modified residueⁱ	312	PhosphotyrosineCombined sources	1
Modified residueⁱ	427	PhosphoserineCombined sources	1
Modified residueⁱ	430	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	432	Phosphoserine; alternateCombined sources	1
Glycosylationⁱ	432	O-linked (GlcNAc) serine; alternateBy similarity	1
Modified residueⁱ	434	PhosphoserineCombined sources	1
Modified residueⁱ	437	PhosphoserineCombined sources	1
Modified residueⁱ	438	PhosphoserineCombined sources	1
Modified residueⁱ	476	Omega-N-methylarginineCombined sources	1
Glycosylationⁱ	518	O-linked (GlcNAc) serineBy similarity	1
Glycosylationⁱ	526	O-linked (GlcNAc) threonine1 Publication	1
Modified residueⁱ	534	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	547	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	551	Phosphoserine; by PDPK1By similarity	1
Modified residueⁱ	553	PhosphoserineBy similarity	1
Modified residueⁱ	556	Omega-N-methylarginineCombined sources	1
Glycosylationⁱ	564	O-linked (GlcNAc) threonineBy similarity	1
Modified residueⁱ	568	Phosphoserine; by CaMK2By similarity	1
Glycosylationⁱ	578	O-linked (GlcNAc) serineBy similarity	1
Modified residueⁱ	605	Phosphoserine; by CaMK2By similarity	1
Modified residueⁱ	622	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	664	PhosphoserineCombined sources	1
Modified residueⁱ	666	PhosphoserineCombined sources	1
Modified residueⁱ	680	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	684	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal (By similarity).By similarity

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMⁱ

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	O88935
PeptideAtlas More...PeptideAtlasⁱ	O88935
PRIDEⁱ	O88935

PTM databases

iPTMnetⁱ	O88935
PhosphoSitePlusⁱ	O88935
SwissPalmⁱ	O88935

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037217 Expressed in 119 organ(s), highest expression level in hypothalamus
CleanExⁱ	MM_SYN1
Genevisibleⁱ	O88935 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity). Isoform Ib interacts with PRNP.By similarity1 Publication

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
calcium-dependent protein binding Source: MGI
protein dimerization activity
Source: MGI
Traceable author statementⁱ
- 15071120
protein kinase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 21307259

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203600, 12 interactors
CORUMⁱ	O88935
IntActⁱ	O88935, 15 interactors
Molecular INTeraction database More...MINTⁱ	O88935
STRINGⁱ	10090.ENSMUSP00000080568

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88935
SMRⁱ	O88935
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 28	AAdd BLAST	28
Regionⁱ	29 – 112	B; linkerAdd BLAST	84
Regionⁱ	113 – 420	C; actin-binding and synaptic-vesicle bindingAdd BLAST	308
Regionⁱ	421 – 657	D; Pro-rich linkerAdd BLAST	237
Regionⁱ	658 – 706	EAdd BLAST	49

Domainⁱ

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesⁱ

Belongs to the synapsin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3895 Eukaryota ENOG410XQH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063319
HOGENOMⁱ	HOG000231323
HOVERGENⁱ	HBG016354
InParanoidⁱ	O88935
KEGG Orthology (KO) More...KOⁱ	K19941
OMAⁱ	NGDHRNI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BZ1
PhylomeDBⁱ	O88935
TreeFamⁱ	TF319919

Family and domain databases

Gene3Dⁱ	3.30.1490.20, 1 hit
InterProⁱ	View protein in InterPro IPR013815 ATP_grasp_subdomain_1 IPR016185 PreATP-grasp_dom_sf IPR028713 SYN1 IPR001359 Synapsin IPR020898 Synapsin_ATP-bd_dom IPR019735 Synapsin_CS IPR019736 Synapsin_P_site IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERⁱ	PTHR10841 PTHR10841, 1 hit PTHR10841:SF22 PTHR10841:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02078 Synapsin, 1 hit PF02750 Synapsin_C, 1 hit PF10581 Synapsin_N, 1 hit
PRINTSⁱ	PR01368 SYNAPSIN
SUPFAMⁱ	SSF52440 SSF52440, 1 hit
PROSITEⁱ	View protein in PROSITE PS00415 SYNAPSIN_1, 1 hit PS00416 SYNAPSIN_2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform Ia (identifier: O88935-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPSAASP GATPGSATAS 
        60         70         80         90        100
AERASTAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG 
       110        120        130        140        150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD 
       160        170        180        190        200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS 
       210        220        230        240        250
LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT 
       260        270        280        290        300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 
       310        320        330        340        350
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS 
       360        370        380        390        400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD 
       410        420        430        440        450
EDKQLIVELV VNKMTQALPR QPQRDASPGR GSHSQSSSPG ALTLGRQTSQ 
       460        470        480        490        500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA 
       510        520        530        540        550
GSPLPQRLPS PTAAPQQSAS QATPVTQGQG RQSRPVAGGP GAPPAARPPA 
       560        570        580        590        600
SPSPQRQAGA PQATRQASIS GPAPTKASGA PPGGQQRQGP PQKPPGPAGP 
       610        620        630        640        650
TRQASQAGPG PRTGPPTTQQ PRPSGPGPAG RPAKPQLAQK PSQDVPPPIT 
       660        670        680        690        700
AAAGGPPHPQ LNKSQSLTNA FNLPEPAPPR PSLSQDEVKA ETIRSLRKSF 

ASLFSD

Length:706

Mass (Da):74,097

Last modified:August 30, 2005 - v2

Checksum:ⁱ04C940E68547372B

GO

Isoform Ib (identifier: O88935-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
662-670: NKSQSLTNA → KASPSQAQP
671-706: Missing.

« Hide

        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPSAASP GATPGSATAS 
        60         70         80         90        100
AERASTAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG 
       110        120        130        140        150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD 
       160        170        180        190        200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS 
       210        220        230        240        250
LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT 
       260        270        280        290        300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 
       310        320        330        340        350
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS 
       360        370        380        390        400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD 
       410        420        430        440        450
EDKQLIVELV VNKMTQALPR QPQRDASPGR GSHSQSSSPG ALTLGRQTSQ 
       460        470        480        490        500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA 
       510        520        530        540        550
GSPLPQRLPS PTAAPQQSAS QATPVTQGQG RQSRPVAGGP GAPPAARPPA 
       560        570        580        590        600
SPSPQRQAGA PQATRQASIS GPAPTKASGA PPGGQQRQGP PQKPPGPAGP 
       610        620        630        640        650
TRQASQAGPG PRTGPPTTQQ PRPSGPGPAG RPAKPQLAQK PSQDVPPPIT 
       660        670
AAAGGPPHPQ LKASPSQAQP

Show »

Length:670

Mass (Da):70,035

Checksum:ⁱDE64BF0090A2B58E

GO

Isoform 3 (identifier: O88935-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
573-600: Missing.

« Hide

        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPSAASP GATPGSATAS 
        60         70         80         90        100
AERASTAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG 
       110        120        130        140        150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD 
       160        170        180        190        200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS 
       210        220        230        240        250
LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT 
       260        270        280        290        300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 
       310        320        330        340        350
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS 
       360        370        380        390        400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD 
       410        420        430        440        450
EDKQLIVELV VNKMTQALPR QPQRDASPGR GSHSQSSSPG ALTLGRQTSQ 
       460        470        480        490        500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA 
       510        520        530        540        550
GSPLPQRLPS PTAAPQQSAS QATPVTQGQG RQSRPVAGGP GAPPAARPPA 
       560        570        580        590        600
SPSPQRQAGA PQATRQASIS GPTRQASQAG PGPRTGPPTT QQPRPSGPGP 
       610        620        630        640        650
AGRPAKPQLA QKPSQDVPPP ITAAAGGPPH PQLNKSQSLT NAFNLPEPAP 
       660        670 
PRPSLSQDEV KAETIRSLRK SFASLFSD

Note: No experimental confirmation available.

Show »

Length:678

Mass (Da):71,483

Checksum:ⁱ3B7E5546952C5B8F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	44	P → L in AAA79963 (PubMed:8034599).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_015205	573 – 600	Missing in isoform 3. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_015206	662 – 670	NKSQSLTNA → KASPSQAQP in isoform Ib. 1 Publication	9
Alternative sequenceⁱVSP_015207	671 – 706	Missing in isoform Ib. 1 PublicationAdd BLAST	36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF085809 mRNA Translation: AAD09833.1 BC022954 mRNA Translation: AAH22954.1 L32025 Genomic DNA Translation: AAA79963.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53017.1 [O88935-2] CCDS53018.1 [O88935-1]
PIRⁱ	A53692
NCBI Reference Sequences More...RefSeqⁱ	NP_001104250.1, NM_001110780.1 [O88935-1] NP_038708.3, NM_013680.4 [O88935-2]
UniGeneⁱ	Mm.439844

Genome annotation databases

Ensemblⁱ	ENSMUST00000081893; ENSMUSP00000080568; ENSMUSG00000037217 [O88935-2] ENSMUST00000115345; ENSMUSP00000111002; ENSMUSG00000037217 [O88935-1]
GeneIDⁱ	20964
KEGGⁱ	mmu:20964
UCSC genome browser More...UCSCⁱ	uc009stw.2 mouse [O88935-2] uc009stx.2 mouse [O88935-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88935	Synapsin-1	)	BOVIN		706	UniRef90_O88935
Synapsin-1		HUMAN		705
Synapsin-1	)	RAT		704
Uncharacterized protein		MACMU		728
Synapsin-1-like protein (Fragment)		MUSPF		67
+162
O88935-3	Uncharacterized protein		CAVPO		690	UniRef90_O88935-3
synapsin-1 isoform X2		LIPVE		681
synapsin-1 isoform X2		ERIEU		678
synapsin-1 isoform X2		LEPWE		676
UPI000A30A651		MUSPA		682
+5

Protein	Similar proteins		Species	Score	Length	Source
O88935	Synapsin-1	)	BOVIN		706	UniRef50_O88935
Synapsin-1		HUMAN		705
Synapsin-1	)	RAT		704
Uncharacterized protein		MACMU		728
Synapsin-1-like protein (Fragment)		MUSPF		67
+203

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF085809 mRNA Translation: AAD09833.1 BC022954 mRNA Translation: AAH22954.1 L32025 Genomic DNA Translation: AAA79963.1
CCDSⁱ	CCDS53017.1 [O88935-2] CCDS53018.1 [O88935-1]
PIRⁱ	A53692
RefSeqⁱ	NP_001104250.1, NM_001110780.1 [O88935-1] NP_038708.3, NM_013680.4 [O88935-2]
UniGeneⁱ	Mm.439844

3D structure databases

ProteinModelPortalⁱ	O88935
SMRⁱ	O88935
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203600, 12 interactors
CORUMⁱ	O88935
IntActⁱ	O88935, 15 interactors
MINTⁱ	O88935
STRINGⁱ	10090.ENSMUSP00000080568

PTM databases

iPTMnetⁱ	O88935
PhosphoSitePlusⁱ	O88935
SwissPalmⁱ	O88935

Proteomic databases

PaxDbⁱ	O88935
PeptideAtlasⁱ	O88935
PRIDEⁱ	O88935

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000081893; ENSMUSP00000080568; ENSMUSG00000037217 [O88935-2] ENSMUST00000115345; ENSMUSP00000111002; ENSMUSG00000037217 [O88935-1]
GeneIDⁱ	20964
KEGGⁱ	mmu:20964
UCSCⁱ	uc009stw.2 mouse [O88935-2] uc009stx.2 mouse [O88935-1]

Organism-specific databases

CTDⁱ	6853
MGIⁱ	MGI:98460 Syn1

Phylogenomic databases

eggNOGⁱ	KOG3895 Eukaryota ENOG410XQH5 LUCA
GeneTreeⁱ	ENSGT00530000063319
HOGENOMⁱ	HOG000231323
HOVERGENⁱ	HBG016354
InParanoidⁱ	O88935
KOⁱ	K19941
OMAⁱ	NGDHRNI
OrthoDBⁱ	EOG091G0BZ1
PhylomeDBⁱ	O88935
TreeFamⁱ	TF319919

Enzyme and pathway databases

Reactomeⁱ	R-MMU-181429 Serotonin Neurotransmitter Release Cycle R-MMU-212676 Dopamine Neurotransmitter Release Cycle

Reactomeⁱ

R-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle

Miscellaneous databases

ChiTaRSⁱ	Sdc1 mouse
Protein Ontology More...PROⁱ	PR:O88935
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037217 Expressed in 119 organ(s), highest expression level in hypothalamus
CleanExⁱ	MM_SYN1
Genevisibleⁱ	O88935 MM

Family and domain databases

Gene3Dⁱ	3.30.1490.20, 1 hit
InterProⁱ	View protein in InterPro IPR013815 ATP_grasp_subdomain_1 IPR016185 PreATP-grasp_dom_sf IPR028713 SYN1 IPR001359 Synapsin IPR020898 Synapsin_ATP-bd_dom IPR019735 Synapsin_CS IPR019736 Synapsin_P_site IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERⁱ	PTHR10841 PTHR10841, 1 hit PTHR10841:SF22 PTHR10841:SF22, 1 hit
Pfamⁱ	View protein in Pfam PF02078 Synapsin, 1 hit PF02750 Synapsin_C, 1 hit PF10581 Synapsin_N, 1 hit
PRINTSⁱ	PR01368 SYNAPSIN
SUPFAMⁱ	SSF52440 SSF52440, 1 hit
PROSITEⁱ	View protein in PROSITE PS00415 SYNAPSIN_1, 1 hit PS00416 SYNAPSIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYN1_MOUSE
Accessionⁱ	O88935Primary (citable) accession number: O88935 Secondary accession number(s): Q62279, Q8QZT8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	August 30, 2005
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88935 (SYN1_MOUSE)

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Synapsin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Cytoskeleton

Cytosol

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ