UniProtKB - O88933 (O88933_MOUSE)
Protein
Submitted name:
Extraembryonic, spermatogenesis, homeobox 1
Gene
Esx1
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 186 – 245 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- blood vessel development Source: MGI
- labyrinthine layer blood vessel development Source: MGI
- labyrinthine layer morphogenesis Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Extraembryonic, spermatogenesis, homeobox 1ImportedSubmitted name: Homeobox protein SPX1ImportedSubmitted name: Homeodomain protein EPXImported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096388, Esx1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000023443, Expressed in head and 94 other tissues |
ExpressionAtlasi | O88933, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 184 – 244 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 144 – 187 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 351 – 382 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 351 – 372 | Pro-richSequence analysisAdd BLAST | 22 |
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationImportedARBA annotationPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000163297 |
OrthoDBi | 1351285at2759 |
TreeFami | TF315976 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O88933-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESHKKCPCC YCTDLKTFVG AVKEETLQDP QPSLSSTLLE GADYQENAES
60 70 80 90 100
ETTFYSDFGA SPKEEEVEME NSLFNSMFLE EANYQEPEGF EPSRGEAAAP
110 120 130 140 150
VAEAPQAWNG NENLGGGFLE SNAQLGEADA APVRQSLMRP LMQPVAQSSP
160 170 180 190 200
QPLPANPLQA PQQPEEQEEE EEEQPGEEQP QQEPKPRRYR ICFTPIQLQE
210 220 230 240 250
LEAFFQRVQY PDLFARVELA RRLGLPEPRV QVWFQNRRAK WRRLRRAQAF
260 270 280 290 300
RNMVPVAMSP PVGVYLDDHY GPIPIVEVIW KCYPMVPRPM HPQMMPLPPR
310 320 330 340 350
PPPGFRMPPP FRPPPLPPFP WPPVPPDAHI PNAAREYNPF PFPFPFPFPF
360 370 380
PNPFPNPNPN PNPNPNPNPN PNQNFAGPRY RY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AG22 | A2AG22_MOUSE | Extraembryonic, spermatogenesis, ho... | Esx1 | 314 | Annotation score: | ||
G3UXJ1 | G3UXJ1_MOUSE | Extraembryonic, spermatogenesis, ho... | Esx1 | 99 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672275 Genomic DNA No translation available. AF085715 mRNA Translation: AAC35366.1 AF017735 mRNA Translation: AAD01622.1 |
RefSeqi | NP_031983.2, NM_007957.2 |
Genome annotation databases
Ensembli | ENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443 |
GeneIDi | 13984 |
KEGGi | mmu:13984 |
UCSCi | uc009ujs.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672275 Genomic DNA No translation available. AF085715 mRNA Translation: AAC35366.1 AF017735 mRNA Translation: AAD01622.1 |
RefSeqi | NP_031983.2, NM_007957.2 |
3D structure databases
SMRi | O88933 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074262 |
Proteomic databases
PRIDEi | O88933 |
Protocols and materials databases
Antibodypediai | 15003, 128 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443 |
GeneIDi | 13984 |
KEGGi | mmu:13984 |
UCSCi | uc009ujs.1, mouse |
Organism-specific databases
CTDi | 80712 |
MGIi | MGI:1096388, Esx1 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000163297 |
OrthoDBi | 1351285at2759 |
TreeFami | TF315976 |
Miscellaneous databases
BioGRID-ORCSi | 13984, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023443, Expressed in head and 94 other tissues |
ExpressionAtlasi | O88933, baseline and differential |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O88933_MOUSE | |
Accessioni | O88933Primary (citable) accession number: O88933 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1998 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |