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Protein
Submitted name:

Extraembryonic, spermatogenesis, homeobox 1

Gene

Esx1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 245HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • blood vessel development Source: MGI
  • labyrinthine layer blood vessel development Source: MGI
  • labyrinthine layer morphogenesis Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Extraembryonic, spermatogenesis, homeobox 1Imported
Submitted name:
Homeobox protein SPX1Imported
Submitted name:
Homeodomain protein EPXImported
Gene namesi
Name:Esx1Imported
Synonyms:EpxImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1096388 Esx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000023443 Expressed in 73 organ(s), highest expression level in head

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074262

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 244HomeoboxInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00930000150861
HOVERGENiHBG052987
KOiK18491
OrthoDBiEOG091G10LA
TreeFamiTF315976

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O88933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESHKKCPCC YCTDLKTFVG AVKEETLQDP QPSLSSTLLE GADYQENAES
60 70 80 90 100
ETTFYSDFGA SPKEEEVEME NSLFNSMFLE EANYQEPEGF EPSRGEAAAP
110 120 130 140 150
VAEAPQAWNG NENLGGGFLE SNAQLGEADA APVRQSLMRP LMQPVAQSSP
160 170 180 190 200
QPLPANPLQA PQQPEEQEEE EEEQPGEEQP QQEPKPRRYR ICFTPIQLQE
210 220 230 240 250
LEAFFQRVQY PDLFARVELA RRLGLPEPRV QVWFQNRRAK WRRLRRAQAF
260 270 280 290 300
RNMVPVAMSP PVGVYLDDHY GPIPIVEVIW KCYPMVPRPM HPQMMPLPPR
310 320 330 340 350
PPPGFRMPPP FRPPPLPPFP WPPVPPDAHI PNAAREYNPF PFPFPFPFPF
360 370 380
PNPFPNPNPN PNPNPNPNPN PNQNFAGPRY RY
Length:382
Mass (Da):43,540
Last modified:November 1, 1998 - v1
Checksum:iEC92301A84DA6175
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AG22A2AG22_MOUSE
Extraembryonic, spermatogenesis, ho...
Esx1
314Annotation score:
G3UXJ1G3UXJ1_MOUSE
Extraembryonic, spermatogenesis, ho...
Esx1
99Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672275 Genomic DNA No translation available.
AF085715 mRNA Translation: AAC35366.1
AF017735 mRNA Translation: AAD01622.1
RefSeqiNP_031983.2, NM_007957.2
UniGeneiMm.8017

Genome annotation databases

EnsembliENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443
GeneIDi13984
KEGGimmu:13984
UCSCiuc009ujs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672275 Genomic DNA No translation available.
AF085715 mRNA Translation: AAC35366.1
AF017735 mRNA Translation: AAD01622.1
RefSeqiNP_031983.2, NM_007957.2
UniGeneiMm.8017

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074262

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443
GeneIDi13984
KEGGimmu:13984
UCSCiuc009ujs.1 mouse

Organism-specific databases

CTDi80712
MGIiMGI:1096388 Esx1

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00930000150861
HOVERGENiHBG052987
KOiK18491
OrthoDBiEOG091G10LA
TreeFamiTF315976

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023443 Expressed in 73 organ(s), highest expression level in head

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO88933_MOUSE
AccessioniPrimary (citable) accession number: O88933
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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