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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

Kcnj15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: MGI
  • potassium channel activity Source: MGI

GO - Biological processi

  • potassium ion import Source: GO_Central
  • potassium ion transport Source: MGI
  • regulation of ion transmembrane transport Source: UniProtKB-KW

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:Kcnj15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1310000 Kcnj15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicBy similarityAdd BLAST63
Transmembranei64 – 88Helical; Name=M1By similarityAdd BLAST25
Topological domaini89 – 113ExtracellularBy similarityAdd BLAST25
Intramembranei114 – 125Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei126 – 132Pore-formingBy similarity7
Topological domaini133 – 141ExtracellularBy similarity9
Transmembranei142 – 163Helical; Name=M2By similarityAdd BLAST22
Topological domaini164 – 375CytoplasmicBy similarityAdd BLAST212

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi439

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549731 – 375ATP-sensitive inward rectifier potassium channel 15Add BLAST375

Proteomic databases

PaxDbiO88932
PRIDEiO88932

PTM databases

iPTMnetiO88932
PhosphoSitePlusiO88932

Expressioni

Gene expression databases

BgeeiENSMUSG00000062609 Expressed in 153 organ(s), highest expression level in proximal tubule
ExpressionAtlasiO88932 baseline and differential
GenevisibleiO88932 MM

Interactioni

Subunit structurei

Interacts with PATJ.By similarity

Protein-protein interaction databases

BioGridi200898, 2 interactors
IntActiO88932, 1 interactor
MINTiO88932
STRINGi10090.ENSMUSP00000045218

Structurei

3D structure databases

ProteinModelPortaliO88932
SMRiO88932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 132Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiO88932
KOiK05008
PhylomeDBiO88932

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003270 K_chnl_inward-rec_Kir1.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF20 PTHR11767:SF20, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01323 KIR13CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O88932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES
110 120 130 140 150
NSNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVISKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK
360 370
LEEQYRQEDQ RERELRSLLL QQSNV
Length:375
Mass (Da):42,605
Last modified:November 1, 1998 - v1
Checksum:i163277597D4B2C8E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TNE6Q3TNE6_MOUSE
ATP-sensitive inward rectifier pota...
Kcnj15
402Annotation score:
D3YXQ3D3YXQ3_MOUSE
ATP-sensitive inward rectifier pota...
Kcnj15
173Annotation score:
D3YV68D3YV68_MOUSE
ATP-sensitive inward rectifier pota...
Kcnj15
34Annotation score:
D3YVH1D3YVH1_MOUSE
ATP-sensitive inward rectifier pota...
Kcnj15
53Annotation score:
D3Z370D3Z370_MOUSE
ATP-sensitive inward rectifier pota...
Kcnj15
23Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14V → W in CAB89666 (PubMed:10906485).Curated1
Sequence conflicti99E → G in CAB89666 (PubMed:10906485).Curated1
Sequence conflicti262S → K in CAB89666 (PubMed:10906485).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085696 mRNA Translation: AAC68685.1
AJ012368 mRNA Translation: CAB89666.1
AK085689 mRNA Translation: BAC39507.1
BC010794 mRNA Translation: AAH10794.1
BC057915 mRNA Translation: AAH57915.1
CCDSiCCDS37410.1
RefSeqiNP_001034145.1, NM_001039056.2
NP_001258618.1, NM_001271689.1
NP_001258620.1, NM_001271691.1
NP_001258622.1, NM_001271693.1
NP_001258624.1, NM_001271695.1
NP_062638.1, NM_019664.5
XP_006523014.1, XM_006522951.3
XP_006523015.1, XM_006522952.3
XP_017172374.1, XM_017316885.1
UniGeneiMm.272239
Mm.491313

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609
ENSMUST00000113858; ENSMUSP00000109489; ENSMUSG00000062609
GeneIDi16516
KEGGimmu:16516
UCSCiuc008abs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085696 mRNA Translation: AAC68685.1
AJ012368 mRNA Translation: CAB89666.1
AK085689 mRNA Translation: BAC39507.1
BC010794 mRNA Translation: AAH10794.1
BC057915 mRNA Translation: AAH57915.1
CCDSiCCDS37410.1
RefSeqiNP_001034145.1, NM_001039056.2
NP_001258618.1, NM_001271689.1
NP_001258620.1, NM_001271691.1
NP_001258622.1, NM_001271693.1
NP_001258624.1, NM_001271695.1
NP_062638.1, NM_019664.5
XP_006523014.1, XM_006522951.3
XP_006523015.1, XM_006522952.3
XP_017172374.1, XM_017316885.1
UniGeneiMm.272239
Mm.491313

3D structure databases

ProteinModelPortaliO88932
SMRiO88932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200898, 2 interactors
IntActiO88932, 1 interactor
MINTiO88932
STRINGi10090.ENSMUSP00000045218

Chemistry databases

GuidetoPHARMACOLOGYi439

PTM databases

iPTMnetiO88932
PhosphoSitePlusiO88932

Proteomic databases

PaxDbiO88932
PRIDEiO88932

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609
ENSMUST00000113858; ENSMUSP00000109489; ENSMUSG00000062609
GeneIDi16516
KEGGimmu:16516
UCSCiuc008abs.2 mouse

Organism-specific databases

CTDi3772
MGIiMGI:1310000 Kcnj15

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiO88932
KOiK05008
PhylomeDBiO88932

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

ChiTaRSiKcnj15 mouse
PROiPR:O88932
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062609 Expressed in 153 organ(s), highest expression level in proximal tubule
ExpressionAtlasiO88932 baseline and differential
GenevisibleiO88932 MM

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003270 K_chnl_inward-rec_Kir1.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF20 PTHR11767:SF20, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01323 KIR13CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCJ15_MOUSE
AccessioniPrimary (citable) accession number: O88932
Secondary accession number(s): Q9JK34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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