UniProtKB - O88923 (AGRL2_RAT)
Protein
Adhesion G protein-coupled receptor L2
Gene
Adgrl2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.1 Publication
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- G protein-coupled receptor activity Source: GO_Central
- PDZ domain binding Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- brain development Source: RGD
- cell surface receptor signaling pathway Source: InterPro
- positive regulation of synapse assembly Source: RGD
- response to bacterium Source: RGD
- synapse organization Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Ligand | Lectin |
Protein family/group databases
MEROPSi | P02.009 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G protein-coupled receptor L2Alternative name(s): Calcium-independent alpha-latrotoxin receptor 2 Short name: CIRL-2 Latrophilin-2 |
Gene namesi | Name:Adgrl2 Synonyms:Cirl2, Cl2, Lphn2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620835, Adgrl2 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: RGD
Other locations
- glutamatergic synapse Source: RGD
- neuron projection Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 855 | ExtracellularCuratedAdd BLAST | 830 | |
Transmembranei | 856 – 876 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 877 – 884 | CytoplasmicCurated | 8 | |
Transmembranei | 885 – 905 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 906 – 911 | ExtracellularCurated | 6 | |
Transmembranei | 912 – 932 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 933 – 956 | CytoplasmicCuratedAdd BLAST | 24 | |
Transmembranei | 957 – 977 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 978 – 994 | ExtracellularCuratedAdd BLAST | 17 | |
Transmembranei | 995 – 1015 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1016 – 1065 | CytoplasmicCuratedAdd BLAST | 50 | |
Transmembranei | 1066 – 1086 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1087 – 1090 | ExtracellularCurated | 4 | |
Transmembranei | 1091 – 1111 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1112 – 1487 | CytoplasmicCuratedAdd BLAST | 376 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000012911 | 26 – 1487 | Adhesion G protein-coupled receptor L2Add BLAST | 1462 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 140 ↔ 322 | PROSITE-ProRule annotation | ||
Glycosylationi | 335 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 524 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 633 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 735 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 748 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 791 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 796 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 817 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1402 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1437 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1458 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 828 – 829 | CleavageBy similarity | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | O88923 |
PRIDEi | O88923 |
PTM databases
GlyGeni | O88923, 9 sites |
iPTMneti | O88923 |
PhosphoSitePlusi | O88923 |
Expressioni
Tissue specificityi
Expressed ubiquitously with highest concentrations found in placenta, kidney, spleen, ovary, heart and lung.1 Publication
Interactioni
Subunit structurei
Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.
GO - Molecular functioni
- PDZ domain binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000042136 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 130 | SUEL-type lectinPROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 139 – 398 | Olfactomedin-likePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 789 – 840 | GPSPROSITE-ProRule annotationAdd BLAST | 52 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3545, Eukaryota KOG4193, Eukaryota KOG4729, Eukaryota |
InParanoidi | O88923 |
OrthoDBi | 388923at2759 |
PhylomeDBi | O88923 |
Family and domain databases
Gene3Di | 2.60.120.740, 1 hit 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR003924, GPCR_2_latrophilin IPR003334, GPCR_2_latrophilin_rcpt_C IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR031240, Latrophilin-2 IPR000922, Lectin_gal-bd_dom IPR043159, Lectin_gal-bd_sf IPR003112, Olfac-like_dom |
PANTHERi | PTHR12011:SF61, PTHR12011:SF61, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF16489, GAIN, 1 hit PF02140, Gal_Lectin, 1 hit PF01825, GPS, 1 hit PF02793, HRM, 1 hit PF02354, Latrophilin, 1 hit PF02191, OLF, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR01444, LATROPHILIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00284, OLF, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51132, OLF, 1 hit PS50228, SUEL_LECTIN, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O88923-7) [UniParc]FASTAAdd to basket
Also known as: CL2A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSSGCRMRS LWFIMIISFS PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCVVVTGSD VFPDPCPGTY KYLEVQYECV PYMEQKVFVC PGTLKAIVDS
160 170 180 190 200
PSIYEAEQKA GAWCKDPLQA ADKIYFMPWT PYRTDTLIEY ASLEDFQNSR
210 220 230 240 250
QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKFDLRT RIKSGEAIIN
260 270 280 290 300
YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL
310 320 330 340 350
RFEATWETTY DKRAASNAFM ICGVLYVVRS VYQDNESEAG KNVIDYIYNT
360 370 380 390 400
RLSRGEHVDV PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD
410 420 430 440 450
PAQVPTTAVT ITSSAELFKT TVSTTSSTSQ RGPVSSTVAG PQEGSRGTKP
460 470 480 490 500
PPAVSTTKIP PVTNIFPLPE RFCEALEMKG IKWPQTQRGM MVERPCPKGT
510 520 530 540 550
RGTASYLCMA STGTWNPKGP DLSNCTSHWV NQLAQKIRSG ENAASLANEL
560 570 580 590 600
AKHTKGTVFA GDVSSSVRLM EQLVDILDAQ LQELKPSEKD SAGRSYNKLQ
610 620 630 640 650
KREKTCRAYL KAIVDTVDNL LRAETLDCWK HMNSSEQAHT ATMLLDTLEE
660 670 680 690 700
GAFVLADNLL EPTRVSMPTD NIVLEVAVLS TEGQVQDFTF HLGFKGAFSS
710 720 730 740 750
IQLSANTVKQ NSRNGLAKVV FIIYRSLGPF LSTENATVKL GADLLGRNST
760 770 780 790 800
IAVNSHVLSV SINKESSRVY LTDPVLFSMP HIDSDNYFNA NCSFWNYSER
810 820 830 840 850
TMMGYWSTQG CKLVDTNKTR TTCACSHLTN FAILMAHREI VYKDGVHKLL
860 870 880 890 900
LTVITWVGIV VSLVCLAICI FTFCFFRGLQ SDRNTIHKNL CINLFIAEFI
910 920 930 940 950
FLIGIDKTQY TIACPVFAGL LHFFFLAAFS WMCLEGVQLY LMLVEVFESE
960 970 980 990 1000
YSRKKYYYVA GYLFPATVVG VSAAIDSKSY GTLEACWLHV DNYFIWSFIG
1010 1020 1030 1040 1050
PVTFIILLNI IFLVITLCKM VKHSNTLKPD SSRLENINNY RVCDGYYNTD
1060 1070 1080 1090 1100
LPGYEDNKPF IKSWVLGAFA LLCLLGLTWS FGLLFVNEET VVMAYLFTAF
1110 1120 1130 1140 1150
NAFQGLFIFI FHCALQKKVR KEYAKCFRHW YCCGGLPTES PHSSVKASTS
1160 1170 1180 1190 1200
RTSARYSSGT QSRIRRMWND TVRKQSESSF ISGDINSTST LNQGMTGNYL
1210 1220 1230 1240 1250
LTNPLLRPHG TNNPYNTLLA ETVVCNAPSA PVFNSPGHSL NNTRDTSAMD
1260 1270 1280 1290 1300
TLPLNGNFNN SYSLRKADYH DGVQVVDCGL SLNDTAFEKM IISELVHNNL
1310 1320 1330 1340 1350
RGSNKTHNLE LKLPVKPVIG GSSSEDDAIV ADASSLMHGD NPGLEFRHKE
1360 1370 1380 1390 1400
LEAPLIPQRT HSLLYQPQKK VKPEATDSYV SQLTAEADEH LQSPNRDSLY
1410 1420 1430 1440 1450
TSMPNLRDSP YPESSPDMAE DLSPSRRSEN EDIYYKSMPN LGAGRQLQMC
1460 1470 1480
YQISRGNSDG YIIPINKEGC IPEGDVREGQ MQLVTSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1M7T0 | F1M7T0_RAT | Adhesion G protein-coupled receptor... | Adgrl2 Lphn2, rCG_29068 | 1,486 | Annotation score: | ||
D3ZNG0 | D3ZNG0_RAT | Adhesion G protein-coupled receptor... | Adgrl2 Lphn2 | 1,420 | Annotation score: | ||
D3ZBE9 | D3ZBE9_RAT | Adhesion G protein-coupled receptor... | Adgrl2 Lphn2, rCG_29068 | 1,477 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 977 | S → Y in AAC62654 (PubMed:9830014).Curated | 1 | |
Sequence conflicti | 977 | S → Y in AAC62655 (PubMed:9830014).Curated | 1 | |
Sequence conflicti | 977 | S → Y in AAC62656 (PubMed:9830014).Curated | 1 | |
Sequence conflicti | 977 | S → Y in AAC62657 (PubMed:9830014).Curated | 1 | |
Sequence conflicti | 977 | S → Y in AAC62658 (PubMed:9830014).Curated | 1 | |
Sequence conflicti | 977 | S → Y in AAC62659 (PubMed:9830014).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050429 | 1038 | N → K in isoform 3, isoform 4 and isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_050430 | 1039 – 1053 | Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_010112 | 1054 – 1062 | Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 1 Publication | 9 | |
Alternative sequenceiVSP_050428 | 1183 – 1193 | Missing in isoform 6 and isoform 3. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_050427 | 1194 – 1236 | Missing in isoform 7 and isoform 4. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063102 mRNA Translation: AAC77815.1 AF081148 mRNA Translation: AAC62654.1 AF081149 mRNA Translation: AAC62655.1 AF081150 mRNA Translation: AAC62656.1 AF081151 mRNA Translation: AAC62657.1 AF081152 mRNA Translation: AAC62658.1 AF081153 mRNA Translation: AAC62659.1 |
PIRi | T14324 T17157 T17158 T17159 T17160 T17185 T46611 |
RefSeqi | NP_001177404.2, NM_001190475.2 NP_001289137.1, NM_001302208.1 NP_001289138.1, NM_001302209.1 NP_001289139.1, NM_001302210.1 NP_001289140.1, NM_001302211.1 NP_001289141.1, NM_001302212.1 NP_599235.3, NM_134408.3 |
Genome annotation databases
GeneIDi | 171447 |
KEGGi | rno:171447 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063102 mRNA Translation: AAC77815.1 AF081148 mRNA Translation: AAC62654.1 AF081149 mRNA Translation: AAC62655.1 AF081150 mRNA Translation: AAC62656.1 AF081151 mRNA Translation: AAC62657.1 AF081152 mRNA Translation: AAC62658.1 AF081153 mRNA Translation: AAC62659.1 |
PIRi | T14324 T17157 T17158 T17159 T17160 T17185 T46611 |
RefSeqi | NP_001177404.2, NM_001190475.2 NP_001289137.1, NM_001302208.1 NP_001289138.1, NM_001302209.1 NP_001289139.1, NM_001302210.1 NP_001289140.1, NM_001302211.1 NP_001289141.1, NM_001302212.1 NP_599235.3, NM_134408.3 |
3D structure databases
SMRi | O88923 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000042136 |
Chemistry databases
GuidetoPHARMACOLOGYi | 207 |
Protein family/group databases
MEROPSi | P02.009 |
GPCRDBi | Search... |
PTM databases
GlyGeni | O88923, 9 sites |
iPTMneti | O88923 |
PhosphoSitePlusi | O88923 |
Proteomic databases
PaxDbi | O88923 |
PRIDEi | O88923 |
Genome annotation databases
GeneIDi | 171447 |
KEGGi | rno:171447 |
Organism-specific databases
CTDi | 23266 |
RGDi | 620835, Adgrl2 |
Phylogenomic databases
eggNOGi | KOG3545, Eukaryota KOG4193, Eukaryota KOG4729, Eukaryota |
InParanoidi | O88923 |
OrthoDBi | 388923at2759 |
PhylomeDBi | O88923 |
Miscellaneous databases
PROi | PR:O88923 |
Family and domain databases
Gene3Di | 2.60.120.740, 1 hit 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR003924, GPCR_2_latrophilin IPR003334, GPCR_2_latrophilin_rcpt_C IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR031240, Latrophilin-2 IPR000922, Lectin_gal-bd_dom IPR043159, Lectin_gal-bd_sf IPR003112, Olfac-like_dom |
PANTHERi | PTHR12011:SF61, PTHR12011:SF61, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF16489, GAIN, 1 hit PF02140, Gal_Lectin, 1 hit PF01825, GPS, 1 hit PF02793, HRM, 1 hit PF02354, Latrophilin, 1 hit PF02191, OLF, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR01444, LATROPHILIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00284, OLF, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51132, OLF, 1 hit PS50228, SUEL_LECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRL2_RAT | |
Accessioni | O88923Primary (citable) accession number: O88923 Secondary accession number(s): O88918 Q9Z174 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families