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Entry version 146 (07 Apr 2021)
Sequence version 2 (26 Apr 2004)
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Protein

Adhesion G protein-coupled receptor L2

Gene

Adgrl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L2
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgrl2
Synonyms:Cirl2, Cl2, Lphn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620835, Adgrl2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 855ExtracellularCuratedAdd BLAST830
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei856 – 876Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini877 – 884CytoplasmicCurated8
Transmembranei885 – 905Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini906 – 911ExtracellularCurated6
Transmembranei912 – 932Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini933 – 956CytoplasmicCuratedAdd BLAST24
Transmembranei957 – 977Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini978 – 994ExtracellularCuratedAdd BLAST17
Transmembranei995 – 1015Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1016 – 1065CytoplasmicCuratedAdd BLAST50
Transmembranei1066 – 1086Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1087 – 1090ExtracellularCurated4
Transmembranei1091 – 1111Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1112 – 1487CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
207

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291126 – 1487Adhesion G protein-coupled receptor L2Add BLAST1462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi140 ↔ 322PROSITE-ProRule annotation
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi524N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi735N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi791N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1402PhosphoserineBy similarity1
Modified residuei1437PhosphoserineBy similarity1
Modified residuei1458PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei828 – 829CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88923

PRoteomics IDEntifications database

More...
PRIDEi
O88923

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O88923, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88923

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88923

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously with highest concentrations found in placenta, kidney, spleen, ovary, heart and lung.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000042136

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88923

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 130SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini139 – 398Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini789 – 840GPSPROSITE-ProRule annotationAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3545, Eukaryota
KOG4193, Eukaryota
KOG4729, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88923

Database of Orthologous Groups

More...
OrthoDBi
388923at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88923

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR003924, GPCR_2_latrophilin
IPR003334, GPCR_2_latrophilin_rcpt_C
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR031240, Latrophilin-2
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
IPR003112, Olfac-like_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12011:SF61, PTHR12011:SF61, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF02354, Latrophilin, 1 hit
PF02191, OLF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249, GPCRSECRETIN
PR01444, LATROPHILIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00284, OLF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51132, OLF, 1 hit
PS50228, SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88923-7) [UniParc]FASTAAdd to basket
Also known as: CL2A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSSGCRMRS LWFIMIISFS PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCVVVTGSD VFPDPCPGTY KYLEVQYECV PYMEQKVFVC PGTLKAIVDS
160 170 180 190 200
PSIYEAEQKA GAWCKDPLQA ADKIYFMPWT PYRTDTLIEY ASLEDFQNSR
210 220 230 240 250
QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKFDLRT RIKSGEAIIN
260 270 280 290 300
YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL
310 320 330 340 350
RFEATWETTY DKRAASNAFM ICGVLYVVRS VYQDNESEAG KNVIDYIYNT
360 370 380 390 400
RLSRGEHVDV PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD
410 420 430 440 450
PAQVPTTAVT ITSSAELFKT TVSTTSSTSQ RGPVSSTVAG PQEGSRGTKP
460 470 480 490 500
PPAVSTTKIP PVTNIFPLPE RFCEALEMKG IKWPQTQRGM MVERPCPKGT
510 520 530 540 550
RGTASYLCMA STGTWNPKGP DLSNCTSHWV NQLAQKIRSG ENAASLANEL
560 570 580 590 600
AKHTKGTVFA GDVSSSVRLM EQLVDILDAQ LQELKPSEKD SAGRSYNKLQ
610 620 630 640 650
KREKTCRAYL KAIVDTVDNL LRAETLDCWK HMNSSEQAHT ATMLLDTLEE
660 670 680 690 700
GAFVLADNLL EPTRVSMPTD NIVLEVAVLS TEGQVQDFTF HLGFKGAFSS
710 720 730 740 750
IQLSANTVKQ NSRNGLAKVV FIIYRSLGPF LSTENATVKL GADLLGRNST
760 770 780 790 800
IAVNSHVLSV SINKESSRVY LTDPVLFSMP HIDSDNYFNA NCSFWNYSER
810 820 830 840 850
TMMGYWSTQG CKLVDTNKTR TTCACSHLTN FAILMAHREI VYKDGVHKLL
860 870 880 890 900
LTVITWVGIV VSLVCLAICI FTFCFFRGLQ SDRNTIHKNL CINLFIAEFI
910 920 930 940 950
FLIGIDKTQY TIACPVFAGL LHFFFLAAFS WMCLEGVQLY LMLVEVFESE
960 970 980 990 1000
YSRKKYYYVA GYLFPATVVG VSAAIDSKSY GTLEACWLHV DNYFIWSFIG
1010 1020 1030 1040 1050
PVTFIILLNI IFLVITLCKM VKHSNTLKPD SSRLENINNY RVCDGYYNTD
1060 1070 1080 1090 1100
LPGYEDNKPF IKSWVLGAFA LLCLLGLTWS FGLLFVNEET VVMAYLFTAF
1110 1120 1130 1140 1150
NAFQGLFIFI FHCALQKKVR KEYAKCFRHW YCCGGLPTES PHSSVKASTS
1160 1170 1180 1190 1200
RTSARYSSGT QSRIRRMWND TVRKQSESSF ISGDINSTST LNQGMTGNYL
1210 1220 1230 1240 1250
LTNPLLRPHG TNNPYNTLLA ETVVCNAPSA PVFNSPGHSL NNTRDTSAMD
1260 1270 1280 1290 1300
TLPLNGNFNN SYSLRKADYH DGVQVVDCGL SLNDTAFEKM IISELVHNNL
1310 1320 1330 1340 1350
RGSNKTHNLE LKLPVKPVIG GSSSEDDAIV ADASSLMHGD NPGLEFRHKE
1360 1370 1380 1390 1400
LEAPLIPQRT HSLLYQPQKK VKPEATDSYV SQLTAEADEH LQSPNRDSLY
1410 1420 1430 1440 1450
TSMPNLRDSP YPESSPDMAE DLSPSRRSEN EDIYYKSMPN LGAGRQLQMC
1460 1470 1480
YQISRGNSDG YIIPINKEGC IPEGDVREGQ MQLVTSL
Length:1,487
Mass (Da):166,729
Last modified:April 26, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56179F1A95471B00
GO
Isoform 2 (identifier: O88923-1) [UniParc]FASTAAdd to basket
Also known as: CL2BC

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1062: Missing.

Show »
Length:1,478
Mass (Da):165,593
Checksum:iCBB1ED1B00F70407
GO
Isoform 3 (identifier: O88923-2) [UniParc]FASTAAdd to basket
Also known as: CL2AA

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: N → K
     1039-1053: Missing.
     1054-1062: Missing.
     1183-1193: Missing.

Show »
Length:1,452
Mass (Da):162,744
Checksum:i3D29320F1A736660
GO
Isoform 4 (identifier: O88923-3) [UniParc]FASTAAdd to basket
Also known as: CL2AB

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: N → K
     1039-1053: Missing.
     1054-1062: Missing.
     1194-1236: Missing.

Show »
Length:1,420
Mass (Da):159,323
Checksum:i30E8DB4FD4717BF2
GO
Isoform 5 (identifier: O88923-4) [UniParc]FASTAAdd to basket
Also known as: CL2AC

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: N → K
     1039-1053: Missing.
     1054-1062: Missing.

Show »
Length:1,463
Mass (Da):163,875
Checksum:iD5DFAC02CC1FC3A1
GO
Isoform 6 (identifier: O88923-5) [UniParc]FASTAAdd to basket
Also known as: CL2BA

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1062: Missing.
     1183-1193: Missing.

Show »
Length:1,467
Mass (Da):164,462
Checksum:i700420D1FD770513
GO
Isoform 7 (identifier: O88923-6) [UniParc]FASTAAdd to basket
Also known as: CL2BB

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1062: Missing.
     1194-1236: Missing.

Show »
Length:1,435
Mass (Da):161,041
Checksum:i593833C7D30AD2D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M7T0F1M7T0_RAT
Adhesion G protein-coupled receptor...
Adgrl2 Lphn2, rCG_29068
1,486Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZNG0D3ZNG0_RAT
Adhesion G protein-coupled receptor...
Adgrl2 Lphn2
1,420Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZBE9D3ZBE9_RAT
Adhesion G protein-coupled receptor...
Adgrl2 Lphn2, rCG_29068
1,477Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti977S → Y in AAC62654 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62655 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62656 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62657 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62658 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62659 (PubMed:9830014).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0504291038N → K in isoform 3, isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0504301039 – 1053Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0101121054 – 1062Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 1 Publication9
Alternative sequenceiVSP_0504281183 – 1193Missing in isoform 6 and isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0504271194 – 1236Missing in isoform 7 and isoform 4. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF063102 mRNA Translation: AAC77815.1
AF081148 mRNA Translation: AAC62654.1
AF081149 mRNA Translation: AAC62655.1
AF081150 mRNA Translation: AAC62656.1
AF081151 mRNA Translation: AAC62657.1
AF081152 mRNA Translation: AAC62658.1
AF081153 mRNA Translation: AAC62659.1

Protein sequence database of the Protein Information Resource

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PIRi
T14324
T17157
T17158
T17159
T17160
T17185
T46611

NCBI Reference Sequences

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RefSeqi
NP_001177404.2, NM_001190475.2
NP_001289137.1, NM_001302208.1
NP_001289138.1, NM_001302209.1
NP_001289139.1, NM_001302210.1
NP_001289140.1, NM_001302211.1
NP_001289141.1, NM_001302212.1
NP_599235.3, NM_134408.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
171447

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:171447

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063102 mRNA Translation: AAC77815.1
AF081148 mRNA Translation: AAC62654.1
AF081149 mRNA Translation: AAC62655.1
AF081150 mRNA Translation: AAC62656.1
AF081151 mRNA Translation: AAC62657.1
AF081152 mRNA Translation: AAC62658.1
AF081153 mRNA Translation: AAC62659.1
PIRiT14324
T17157
T17158
T17159
T17160
T17185
T46611
RefSeqiNP_001177404.2, NM_001190475.2
NP_001289137.1, NM_001302208.1
NP_001289138.1, NM_001302209.1
NP_001289139.1, NM_001302210.1
NP_001289140.1, NM_001302211.1
NP_001289141.1, NM_001302212.1
NP_599235.3, NM_134408.3

3D structure databases

SMRiO88923
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042136

Chemistry databases

GuidetoPHARMACOLOGYi207

Protein family/group databases

MEROPSiP02.009

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

GlyGeniO88923, 9 sites
iPTMnetiO88923
PhosphoSitePlusiO88923

Proteomic databases

PaxDbiO88923
PRIDEiO88923

Genome annotation databases

GeneIDi171447
KEGGirno:171447

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23266
RGDi620835, Adgrl2

Phylogenomic databases

eggNOGiKOG3545, Eukaryota
KOG4193, Eukaryota
KOG4729, Eukaryota
InParanoidiO88923
OrthoDBi388923at2759
PhylomeDBiO88923

Miscellaneous databases

Protein Ontology

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PROi
PR:O88923

Family and domain databases

Gene3Di2.60.120.740, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR003924, GPCR_2_latrophilin
IPR003334, GPCR_2_latrophilin_rcpt_C
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR031240, Latrophilin-2
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
IPR003112, Olfac-like_dom
PANTHERiPTHR12011:SF61, PTHR12011:SF61, 1 hit
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF02354, Latrophilin, 1 hit
PF02191, OLF, 1 hit
PRINTSiPR00249, GPCRSECRETIN
PR01444, LATROPHILIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00284, OLF, 1 hit
PROSITEiView protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51132, OLF, 1 hit
PS50228, SUEL_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRL2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88923
Secondary accession number(s): O88918
, O88919, O88920, O88921, O88922, Q9Z174
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: April 7, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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