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Protein

Solute carrier family 22 member 8

Gene

Slc22a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E2, prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDetoxification, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-561048 Organic anion transport

Protein family/group databases

TCDBi2.A.1.19.9 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 8
Alternative name(s):
Organic anion transporter 3
Short name:
mOat3
Reduced in osteosclerosis transporter
Gene namesi
Name:Slc22a8
Synonyms:Oat3, Roct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1336187 Slc22a8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 123ExtracellularSequence analysisAdd BLAST91
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 150CytoplasmicSequence analysis6
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 176ExtracellularSequence analysis5
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 212CytoplasmicSequence analysisAdd BLAST15
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 236ExtracellularSequence analysis3
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 327CytoplasmicSequence analysisAdd BLAST70
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 354ExtracellularSequence analysis6
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 383CytoplasmicSequence analysis8
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 411ExtracellularSequence analysis7
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 471CytoplasmicSequence analysisAdd BLAST39
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 537ExtracellularSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice appear healthy and are fertile. Exhibit a loss of taurocholate, estrone sulfate and para-aminohippurate transport in kidney and of fluorescein (FL) transport in choroid plexus.1 Publication

Chemistry databases

ChEMBLiCHEMBL2073672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734411 – 537Solute carrier family 22 member 8Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO88909
PaxDbiO88909
PRIDEiO88909

PTM databases

iPTMnetiO88909
PhosphoSitePlusiO88909

Expressioni

Tissue specificityi

Highly expressed in kidney. Expressed in developing bone. Weakly expressed in brain and eye.2 Publications

Gene expression databases

BgeeiENSMUSG00000063796 Expressed in 110 organ(s), highest expression level in proximal tubule
GenevisibleiO88909 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010251

Chemistry databases

BindingDBiO88909

Structurei

3D structure databases

ProteinModelPortaliO88909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiO88909
KOiK08205
OMAiAWFSTGF
OrthoDBiEOG091G0738
PhylomeDBiO88909
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

O88909-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFSEILDRV GSMGPFQYLH VTLLALPILG IANHNLLQIF TATTPDHHCR
60 70 80 90 100
PPPNASLEPW VLPLGPNGKP EKCLRFVHLP NASLPNDTQG ATEPCLDGWI
110 120 130 140 150
YNSTRDTIVT EWDLVCGSNK LKEMAQSVFM AGILVGGPVF GELSDRFGRK
160 170 180 190 200
PILTWSYLLL AASGSSAAFS PSLTVYMIFR FLCGCSISGI SLSTIILNVE
210 220 230 240 250
WVPTSTRAIS STTIGYCYTI GQFILPGLAY AVPQWRWLQL SVSAAFFIFS
260 270 280 290 300
LLSWWVPESI RWLVLSGKFS KALKTLQRVA TFNGKKEEGE KLTVEELKFN
310 320 330 340 350
LQKDITSAKV KYGLSDLFRV SILRRVTFCL SLAWFATGFA YYSLAMGVEE
360 370 380 390 400
FGVNIYILQI IFGGVDIPAK FITILSISYL GRRITQGFLL ILAGVAILAL
410 420 430 440 450
IFVSSEMQLL RTALAVFGKG CLSGSFSCLF LYTSELYPTV LRQTGMGISN
460 470 480 490 500
IWARVGSMIA PLVKITGELQ PFIPNVIFGT MTLLGGSAAF FLLETLNRPL
510 520 530
PETIEDIQDW YQQTKKTKQE PEAEKASQTI PLKTGGP
Length:537
Mass (Da):59,246
Last modified:January 23, 2007 - v2
Checksum:iF85FF82002AB26EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271K → R in AAC61265 (PubMed:10087192).Curated1
Sequence conflicti479G → V in BAC27624 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078869 mRNA Translation: AAC61265.1
AK031962 mRNA Translation: BAC27624.1
AK044336 mRNA Translation: BAC31873.1
AK157891 mRNA Translation: BAE34249.1
BC014762 mRNA Translation: AAH14762.1
AB079895 mRNA Translation: BAC53618.1
CCDSiCCDS29537.1
RefSeqiNP_001158106.1, NM_001164634.1
NP_001158107.1, NM_001164635.1
NP_112471.3, NM_031194.5
XP_011245473.1, XM_011247171.1
UniGeneiMm.285294

Genome annotation databases

EnsembliENSMUST00000010251; ENSMUSP00000010251; ENSMUSG00000063796
ENSMUST00000170817; ENSMUSP00000131045; ENSMUSG00000063796
GeneIDi19879
KEGGimmu:19879
UCSCiuc008gmc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078869 mRNA Translation: AAC61265.1
AK031962 mRNA Translation: BAC27624.1
AK044336 mRNA Translation: BAC31873.1
AK157891 mRNA Translation: BAE34249.1
BC014762 mRNA Translation: AAH14762.1
AB079895 mRNA Translation: BAC53618.1
CCDSiCCDS29537.1
RefSeqiNP_001158106.1, NM_001164634.1
NP_001158107.1, NM_001164635.1
NP_112471.3, NM_031194.5
XP_011245473.1, XM_011247171.1
UniGeneiMm.285294

3D structure databases

ProteinModelPortaliO88909
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010251

Chemistry databases

BindingDBiO88909
ChEMBLiCHEMBL2073672

Protein family/group databases

TCDBi2.A.1.19.9 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO88909
PhosphoSitePlusiO88909

Proteomic databases

MaxQBiO88909
PaxDbiO88909
PRIDEiO88909

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010251; ENSMUSP00000010251; ENSMUSG00000063796
ENSMUST00000170817; ENSMUSP00000131045; ENSMUSG00000063796
GeneIDi19879
KEGGimmu:19879
UCSCiuc008gmc.2 mouse

Organism-specific databases

CTDi9376
MGIiMGI:1336187 Slc22a8

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiO88909
KOiK08205
OMAiAWFSTGF
OrthoDBiEOG091G0738
PhylomeDBiO88909
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-MMU-561048 Organic anion transport

Miscellaneous databases

PROiPR:O88909
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063796 Expressed in 110 organ(s), highest expression level in proximal tubule
GenevisibleiO88909 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22A8_MOUSE
AccessioniPrimary (citable) accession number: O88909
Secondary accession number(s): Q3TZF9
, Q8CCX3, Q8CFH5, Q91WJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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