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Protein

Sterol O-acyltransferase 2

Gene

Soat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Catalytic activityi

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei437Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.1.26 3474
ReactomeiR-MMU-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol O-acyltransferase 2 (EC:2.3.1.26)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 2
Short name:
ACAT-2
Cholesterol acyltransferase 2
Gene namesi
Name:Soat2
Synonyms:Acact-2, Acat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1332226 Soat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
Transmembranei123 – 141HelicalSequence analysisAdd BLAST19
Topological domaini142 – 160LumenalSequence analysisAdd BLAST19
Transmembranei161 – 179HelicalSequence analysisAdd BLAST19
Topological domaini180 – 203CytoplasmicSequence analysisAdd BLAST24
Transmembranei204 – 222HelicalSequence analysisAdd BLAST19
Topological domaini223 – 343LumenalSequence analysisAdd BLAST121
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Topological domaini367 – 478CytoplasmicSequence analysisAdd BLAST112
Transmembranei479 – 497HelicalSequence analysisAdd BLAST19
Topological domaini498 – 525LumenalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2653

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076461 – 525Sterol O-acyltransferase 2Add BLAST525

Proteomic databases

EPDiO88908
MaxQBiO88908
PaxDbiO88908
PRIDEiO88908

PTM databases

iPTMnetiO88908
PhosphoSitePlusiO88908
SwissPalmiO88908

Expressioni

Gene expression databases

BgeeiENSMUSG00000023045 Expressed in 54 organ(s), highest expression level in jejunum
CleanExiMM_ACAT2
MM_SOAT2
ExpressionAtlasiO88908 baseline and differential
GenevisibleiO88908 MM

Interactioni

Subunit structurei

May form homo- or heterodimers.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023806

Structurei

3D structure databases

ProteinModelPortaliO88908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00530000063122
HOGENOMiHOG000020782
HOVERGENiHBG058198
InParanoidiO88908
KOiK00637
OMAiVAHEYIF
OrthoDBiEOG091G0991
TreeFamiTF315226

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPKVPQLRR REGLGEEQEK GARGGEGNAR THGTPDLVQW TRHMEAVKTQ
60 70 80 90 100
FLEQAQRELA ELLDRALWEA MQAYPKQDRP LPSAAPDSTS KTQELHPGKR
110 120 130 140 150
KVFITRKSLI DELMEVQHFR TIYHMFIAGL CVLIISTLAI DFIDEGRLML
160 170 180 190 200
EFDLLLFSFG QLPLALMTWV PMFLSTLLVP YQTLWLWARP RAGGAWMLGA
210 220 230 240 250
SLGCVLLAAH AVVLCVLPVH VSVRHELPPA SRCVLVFEQV RLLMKSYSFL
260 270 280 290 300
RETVPGIFCV RGGKGISPPS FSSYLYFLFC PTLIYRETYP RTPSIRWNYV
310 320 330 340 350
AKNFAQVLGC LLYACFILGR LCVPVFANMS REPFSTRALL LSILHATGPG
360 370 380 390 400
IFMLLLIFFA FLHCWLNAFA EMLRFGDRMF YRDWWNSTSF SNYYRTWNVV
410 420 430 440 450
VHDWLYSYVY QDGLWLLGRR ARGVAMLGVF LVSAVVHEYI FCFVLGFFYP
460 470 480 490 500
VMLMLFLVFG GLLNFTMNDR HTGPAWNILM WTFLFMGQGI QVSLYCQEWY
510 520
ARRHCPLPQT TFWGMVTPRS WSCHP
Length:525
Mass (Da):60,597
Last modified:July 27, 2011 - v2
Checksum:iF1C2DFEB5AB6CCA8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SMH4F6SMH4_MOUSE
Sterol O-acyltransferase 2
Soat2
284Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93Q → P in AAC64057 (PubMed:9756919).Curated1
Sequence conflicti96H → R in AAC64057 (PubMed:9756919).Curated1
Sequence conflicti104 – 105IT → VA in AAC64057 (PubMed:9756919).Curated2
Sequence conflicti131 – 132CV → WF in AAC64057 (PubMed:9756919).Curated2
Sequence conflicti175S → Y in AAC64057 (PubMed:9756919).Curated1
Sequence conflicti262G → R in AAC64057 (PubMed:9756919).Curated1
Sequence conflicti519R → Q in AAC64057 (PubMed:9756919).Curated1
Sequence conflicti525P → T in AAC64057 (PubMed:9756919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078751 mRNA Translation: AAC64057.1
CH466550 Genomic DNA Translation: EDL04004.1
BC025931 mRNA Translation: AAH25931.1
CCDSiCCDS27872.1
RefSeqiNP_666176.1, NM_146064.1
UniGeneiMm.358862

Genome annotation databases

EnsembliENSMUST00000023806; ENSMUSP00000023806; ENSMUSG00000023045
GeneIDi223920
KEGGimmu:223920
UCSCiuc007xut.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078751 mRNA Translation: AAC64057.1
CH466550 Genomic DNA Translation: EDL04004.1
BC025931 mRNA Translation: AAH25931.1
CCDSiCCDS27872.1
RefSeqiNP_666176.1, NM_146064.1
UniGeneiMm.358862

3D structure databases

ProteinModelPortaliO88908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023806

Chemistry databases

ChEMBLiCHEMBL2653

PTM databases

iPTMnetiO88908
PhosphoSitePlusiO88908
SwissPalmiO88908

Proteomic databases

EPDiO88908
MaxQBiO88908
PaxDbiO88908
PRIDEiO88908

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023806; ENSMUSP00000023806; ENSMUSG00000023045
GeneIDi223920
KEGGimmu:223920
UCSCiuc007xut.1 mouse

Organism-specific databases

CTDi8435
MGIiMGI:1332226 Soat2

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00530000063122
HOGENOMiHOG000020782
HOVERGENiHBG058198
InParanoidiO88908
KOiK00637
OMAiVAHEYIF
OrthoDBiEOG091G0991
TreeFamiTF315226

Enzyme and pathway databases

BRENDAi2.3.1.26 3474
ReactomeiR-MMU-8964038 LDL clearance

Miscellaneous databases

PROiPR:O88908
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023045 Expressed in 54 organ(s), highest expression level in jejunum
CleanExiMM_ACAT2
MM_SOAT2
ExpressionAtlasiO88908 baseline and differential
GenevisibleiO88908 MM

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOAT2_MOUSE
AccessioniPrimary (citable) accession number: O88908
Secondary accession number(s): Q8R0Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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