Tumor protein 63

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation."
    Laurikkala J., Mikkola M.L., James M., Tummers M., Mills A.A., Thesleff I.
    Development 133:1553-1563(2006) [PubMed] [Europe PMC] [Abstract]
  • "Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice."
    Candi E., Rufini A., Terrinoni A., Dinsdale D., Ranalli M., Paradisi A., De Laurenzi V., Spagnoli L.G., Catani M.V., Ramadan S., Knight R.A., Melino G.
    Cell Death Differ 13:1037-1047(2006) [PubMed] [Europe PMC] [Abstract]
• damaged DNA binding Source: MGIInferred from direct assayⁱ
  • "p63 protects the female germ line during meiotic arrest."
    Suh E.K., Yang A., Kettenbach A., Bamberger C., Michaelis A.H., Zhu Z., Elvin J.A., Bronson R.T., Crum C.P., McKeon F.
    Nature 444:624-628(2006) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles."
    Kulesz-Martin M., Lagowski J., Fei S., Pelz C., Sears R., Powell M.B., Halaban R., Johnson J.
    J Investig Dermatol Symp Proc 10:142-152(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis."
    Fessing M.Y., Mardaryev A.N., Gdula M.R., Sharov A.A., Sharova T.Y., Rapisarda V., Gordon K.B., Smorodchenko A.D., Poterlowicz K., Ferone G., Kohwi Y., Missero C., Kohwi-Shigematsu T., Botchkarev V.A.
    J Cell Biol 194:825-839(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: MGI
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "DNA damage in oocytes induces a switch of the quality control factor TAp63alpha from dimer to tetramer."
    Deutsch G.B., Zielonka E.M., Coutandin D., Weber T.A., Schafer B., Hannewald J., Luh L.M., Durst F.G., Ibrahim M., Hoffmann J., Niesen F.H., Senturk A., Kunkel H., Brutschy B., Schleiff E., Knapp S., Acker-Palmer A., Grez M., McKeon F., Dotsch V.
    Cell 144:566-576(2011) [PubMed] [Europe PMC] [Abstract]
  • "Cell density-dependent acetylation of DeltaNp63alpha is associated with p53-dependent cell cycle arrest."
    Chae Y.S., Kim H., Kim D., Lee H., Lee H.O.
    FEBS Lett 586:1128-1134(2012) [PubMed] [Europe PMC] [Abstract]
• MDM2/MDM4 family protein binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• p53 binding Source: MGI
• protein domain specific binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63."
    Antonini D., Dentice M., Mahtani P., De Rosa L., Della Gatta G., Mandinova A., Salvatore D., Stupka E., Missero C.
    J. Invest. Dermatol. 128:1676-1685(2008) [PubMed] [Europe PMC] [Abstract]
  • "Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation."
    Nguyen B.C., Lefort K., Mandinova A., Antonini D., Devgan V., Della Gatta G., Koster M.I., Zhang Z., Wang J., Tommasi di Vignano A., Kitajewski J., Chiorino G., Roop D.R., Missero C., Dotto G.P.
    Genes Dev 20:1028-1042(2006) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects."
    Lo Iacono N., Mantero S., Chiarelli A., Garcia E., Mills A.A., Morasso M.I., Costanzo A., Levi G., Guerrini L., Merlo G.R.
    Development 135:1377-1388(2008) [PubMed] [Europe PMC] [Abstract]
• WW domain binding Source: MGI

GO - Biological processⁱ

• anatomical structure formation involved in morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4."
    Suzuki K., Haraguchi R., Ogata T., Barbieri O., Alegria O., Vieux-Rochas M., Nakagata N., Ito M., Mills A.A., Kurita T., Levi G., Yamada G.
    Eur J Hum Genet 16:36-44(2008) [PubMed] [Europe PMC] [Abstract]
• animal organ morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.6

    "p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development."
    Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F.
    Nature 398:714-718(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
• apoptotic process Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "p73 and p63 protein stability: the way to regulate function?"
    Maisse C., Guerrieri P., Melino G.
    Biochem Pharmacol 66:1555-1561(2003) [PubMed] [Europe PMC] [Abstract]
• cell aging Source: MGIInferred from mutant phenotypeⁱ
  • "p63 deficiency activates a program of cellular senescence and leads to accelerated aging."
    Keyes W.M., Wu Y., Vogel H., Guo X., Lowe S.W., Mills A.A.
    Genes Dev 19:1986-1999(2005) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Role of p63 and basal cells in the prostate."
    Kurita T., Medina R.T., Mills A.A., Cunha G.R.
    Development 131:4955-4964(2004) [PubMed] [Europe PMC] [Abstract]
• cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• cellular response to DNA damage stimulus Source: MGI
• chromatin remodeling Source: MGIInferred from mutant phenotypeⁱ
  • "p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis."
    Fessing M.Y., Mardaryev A.N., Gdula M.R., Sharov A.A., Sharova T.Y., Rapisarda V., Gordon K.B., Smorodchenko A.D., Poterlowicz K., Ferone G., Kohwi Y., Missero C., Kohwi-Shigematsu T., Botchkarev V.A.
    J Cell Biol 194:825-839(2011) [PubMed] [Europe PMC] [Abstract]
• cloacal septation Source: MGIInferred from mutant phenotypeⁱ
  • "p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract."
    Ince T.A., Cviko A.P., Quade B.J., Yang A., McKeon F.D., Mutter G.L., Crum C.P.
    Am J Pathol 161:1111-1117(2002) [PubMed] [Europe PMC] [Abstract]
• cranial skeletal system development Source: MGIInferred from mutant phenotypeⁱ
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• ectoderm and mesoderm interaction Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "p63 is a p53 homologue required for limb and epidermal morphogenesis."
    Mills A.A., Zheng B., Wang X.-J., Vogel H., Roop D.R., Bradley A.
    Nature 398:708-713(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
  • Ref.6

    "p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development."
    Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F.
    Nature 398:714-718(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
• embryonic forelimb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• embryonic hindlimb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• embryonic limb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "p63 is a p53 homologue required for limb and epidermal morphogenesis."
    Mills A.A., Zheng B., Wang X.-J., Vogel H., Roop D.R., Bradley A.
    Nature 398:708-713(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
• epidermal cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• epidermal cell division Source: MGIInferred from mutant phenotypeⁱ
  • "DeltaNp63 is an ectodermal gatekeeper of epidermal morphogenesis."
    Shalom-Feuerstein R., Lena A.M., Zhou H., De La Forest Divonne S., Van Bokhoven H., Candi E., Melino G., Aberdam D.
    Cell Death Differ 18:887-896(2011) [PubMed] [Europe PMC] [Abstract]
• epidermis development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "p63 is a p53 homologue required for limb and epidermal morphogenesis."
    Mills A.A., Zheng B., Wang X.-J., Vogel H., Roop D.R., Bradley A.
    Nature 398:708-713(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
  • "DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation."
    Romano R.A., Smalley K., Magraw C., Serna V.A., Kurita T., Raghavan S., Sinha S.
    Development 139:772-782(2012) [PubMed] [Europe PMC] [Abstract]
  • "Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice."
    Candi E., Rufini A., Terrinoni A., Dinsdale D., Ranalli M., Paradisi A., De Laurenzi V., Spagnoli L.G., Catani M.V., Ramadan S., Knight R.A., Melino G.
    Cell Death Differ 13:1037-1047(2006) [PubMed] [Europe PMC] [Abstract]
• epithelial cell development Source: MGIInferred from direct assayⁱ
  • "Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice."
    Candi E., Rufini A., Terrinoni A., Dinsdale D., Ranalli M., Paradisi A., De Laurenzi V., Spagnoli L.G., Catani M.V., Ramadan S., Knight R.A., Melino G.
    Cell Death Differ 13:1037-1047(2006) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract."
    Ince T.A., Cviko A.P., Quade B.J., Yang A., McKeon F.D., Mutter G.L., Crum C.P.
    Am J Pathol 161:1111-1117(2002) [PubMed] [Europe PMC] [Abstract]
  • "Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4."
    Suzuki K., Haraguchi R., Ogata T., Barbieri O., Alegria O., Vieux-Rochas M., Nakagata N., Ito M., Mills A.A., Kurita T., Levi G., Yamada G.
    Eur J Hum Genet 16:36-44(2008) [PubMed] [Europe PMC] [Abstract]
• establishment of planar polarity Source: MGIInferred from direct assayⁱ
  • Ref.8

    "p63 is the molecular switch for initiation of an epithelial stratification program."
    Koster M.I., Kim S., Mills A.A., DeMayo F.J., Roop D.R.
    Genes Dev. 18:126-131(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
• establishment of skin barrier Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells."
    Lee S., Kong Y., Weatherbee S.D.
    Dev. Biol. 383:201-213(2013) [PubMed] [Europe PMC] [Abstract]
• female genitalia morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract."
    Ince T.A., Cviko A.P., Quade B.J., Yang A., McKeon F.D., Mutter G.L., Crum C.P.
    Am J Pathol 161:1111-1117(2002) [PubMed] [Europe PMC] [Abstract]
• hair follicle development Source: MGIInferred from mutant phenotypeⁱ
  • "p63 protein is essential for the embryonic development of vibrissae and teeth."
    Rufini A., Weil M., McKeon F., Barlattani A., Melino G., Candi E.
    Biochem Biophys Res Commun 340:737-741(2006) [PubMed] [Europe PMC] [Abstract]
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• hair follicle morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation."
    Laurikkala J., Mikkola M.L., James M., Tummers M., Mills A.A., Thesleff I.
    Development 133:1553-1563(2006) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGIInferred from mutant phenotypeⁱ
  • "p63 protects the female germ line during meiotic arrest."
    Suh E.K., Yang A., Kettenbach A., Bamberger C., Michaelis A.H., Zhu Z., Elvin J.A., Bronson R.T., Crum C.P., McKeon F.
    Nature 444:624-628(2006) [PubMed] [Europe PMC] [Abstract]
• keratinocyte differentiation Source: MGIInferred from direct assayⁱ
  • Ref.8

    "p63 is the molecular switch for initiation of an epithelial stratification program."
    Koster M.I., Kim S., Mills A.A., DeMayo F.J., Roop D.R.
    Genes Dev. 18:126-131(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
• keratinocyte proliferation Source: MGIInferred from direct assayⁱ
  • "Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice."
    Candi E., Rufini A., Terrinoni A., Dinsdale D., Ranalli M., Paradisi A., De Laurenzi V., Spagnoli L.G., Catani M.V., Ramadan S., Knight R.A., Melino G.
    Cell Death Differ 13:1037-1047(2006) [PubMed] [Europe PMC] [Abstract]
• morphogenesis of a polarized epithelium Source: MGIInferred from mutant phenotypeⁱ
  • "Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium."
    Daniely Y., Liao G., Dixon D., Linnoila R.I., Lori A., Randell S.H., Oren M., Jetten A.M.
    Am J Physiol Cell Physiol 287:C171-81(2004) [PubMed] [Europe PMC] [Abstract]
• multicellular organism aging Source: MGIInferred from mutant phenotypeⁱ
  • "p63 deficiency activates a program of cellular senescence and leads to accelerated aging."
    Keyes W.M., Wu Y., Vogel H., Guo X., Lowe S.W., Mills A.A.
    Genes Dev 19:1986-1999(2005) [PubMed] [Europe PMC] [Abstract]
• multicellular organism development Source: MGITraceable author statementⁱ
  • "p73 and p63 protein stability: the way to regulate function?"
    Maisse C., Guerrieri P., Melino G.
    Biochem Pharmacol 66:1555-1561(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cellular senescence Source: MGI
• negative regulation of intracellular estrogen receptor signaling pathway Source: CAFAInferred from mutant phenotypeⁱ
  • "The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage."
    Lindley L.E., Curtis K.M., Sanchez-Mejias A., Rieger M.E., Robbins D.J., Briegel K.J.
    Development 142:893-904(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of keratinocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation."
    Romano R.A., Smalley K., Magraw C., Serna V.A., Kurita T., Raghavan S., Sinha S.
    Development 139:772-782(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mesoderm development Source: MGIInferred from mutant phenotypeⁱ
  • "DeltaNp63 is an ectodermal gatekeeper of epidermal morphogenesis."
    Shalom-Feuerstein R., Lena A.M., Zhou H., De La Forest Divonne S., Van Bokhoven H., Candi E., Melino G., Aberdam D.
    Cell Death Differ 18:887-896(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition."
    Gunschmann C., Stachelscheid H., Akyuz M.D., Schmitz A., Missero C., Bruning J.C., Niessen C.M.
    Dev Cell 26:176-187(2013) [PubMed] [Europe PMC] [Abstract]
• neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "p63 is an essential proapoptotic protein during neural development."
    Jacobs W.B., Govoni G., Ho D., Atwal J.K., Barnabe-Heider F., Keyes W.M., Mills A.A., Miller F.D., Kaplan D.R.
    Neuron 48:743-756(2005) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: UniProtKB-KW
• odontogenesis of dentin-containing tooth Source: MGIInferred from mutant phenotypeⁱ
  • "p63 protein is essential for the embryonic development of vibrissae and teeth."
    Rufini A., Weil M., McKeon F., Barlattani A., Melino G., Candi E.
    Biochem Biophys Res Commun 340:737-741(2006) [PubMed] [Europe PMC] [Abstract]
  • "p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation."
    Laurikkala J., Mikkola M.L., James M., Tummers M., Mills A.A., Thesleff I.
    Development 133:1553-1563(2006) [PubMed] [Europe PMC] [Abstract]
• pattern specification process Source: MGIInferred from mutant phenotypeⁱ
  • Ref.6

    "p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development."
    Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F.
    Nature 398:714-718(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
• polarized epithelial cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium."
    Daniely Y., Liao G., Dixon D., Linnoila R.I., Lori A., Randell S.H., Oren M., Jetten A.M.
    Am J Physiol Cell Physiol 287:C171-81(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic signaling pathway Source: MGIInferred from direct assayⁱ
  • Ref.1

    "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities."
    Yang A., Kaghad M., Wang Y., Gillett E., Fleming M.D., Doetsch V., Andrews N.C., Caput D., McKeon F.
    Mol. Cell 2:305-316(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), TISSUE SPECIFICITY.
• positive regulation of cell cycle G1/S phase transition Source: MGI
• positive regulation of cell population proliferation Source: MGI
• positive regulation of fibroblast apoptotic process Source: MGI
• positive regulation of keratinocyte proliferation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells."
    Lee S., Kong Y., Weatherbee S.D.
    Dev. Biol. 383:201-213(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Notch signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation."
    Romano R.A., Smalley K., Magraw C., Serna V.A., Kurita T., Raghavan S., Sinha S.
    Development 139:772-782(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast differentiation Source: MGI
• positive regulation of somatic stem cell population maintenance Source: CAFAInferred from mutant phenotypeⁱ
  • "The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage."
    Lindley L.E., Curtis K.M., Sanchez-Mejias A., Rieger M.E., Robbins D.J., Briegel K.J.
    Development 142:893-904(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "PERP regulates enamel formation via effects on cell-cell adhesion and gene expression."
    Jheon A.H., Mostowfi P., Snead M.L., Ihrie R.A., Sone E., Pramparo T., Attardi L.D., Klein O.D.
    J Cell Sci 124:745-754(2011) [PubMed] [Europe PMC] [Abstract]
  • "p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis."
    Fessing M.Y., Mardaryev A.N., Gdula M.R., Sharov A.A., Sharova T.Y., Rapisarda V., Gordon K.B., Smorodchenko A.D., Poterlowicz K., Ferone G., Kohwi Y., Missero C., Kohwi-Shigematsu T., Botchkarev V.A.
    J Cell Biol 194:825-839(2011) [PubMed] [Europe PMC] [Abstract]
  • "Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition."
    Gunschmann C., Stachelscheid H., Akyuz M.D., Schmitz A., Missero C., Bruning J.C., Niessen C.M.
    Dev Cell 26:176-187(2013) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities."
    Yang A., Kaghad M., Wang Y., Gillett E., Fleming M.D., Doetsch V., Andrews N.C., Caput D., McKeon F.
    Mol. Cell 2:305-316(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), TISSUE SPECIFICITY.
  • "deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes."
    King K.E., Ponnamperuma R.M., Yamashita T., Tokino T., Lee L.A., Young M.F., Weinberg W.C.
    Oncogene 22:3635-3644(2003) [PubMed] [Europe PMC] [Abstract]
  • "Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice."
    Candi E., Rufini A., Terrinoni A., Dinsdale D., Ranalli M., Paradisi A., De Laurenzi V., Spagnoli L.G., Catani M.V., Ramadan S., Knight R.A., Melino G.
    Cell Death Differ 13:1037-1047(2006) [PubMed] [Europe PMC] [Abstract]
  • "p63 is upstream of IKK alpha in epidermal development."
    Candi E., Terrinoni A., Rufini A., Chikh A., Lena A.M., Suzuki Y., Sayan B.S., Knight R.A., Melino G.
    J Cell Sci 119:4617-4622(2006) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects."
    Lo Iacono N., Mantero S., Chiarelli A., Garcia E., Mills A.A., Morasso M.I., Costanzo A., Levi G., Guerrini L., Merlo G.R.
    Development 135:1377-1388(2008) [PubMed] [Europe PMC] [Abstract]
• post-anal tail morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract."
    Ince T.A., Cviko A.P., Quade B.J., Yang A., McKeon F.D., Mutter G.L., Crum C.P.
    Am J Pathol 161:1111-1117(2002) [PubMed] [Europe PMC] [Abstract]
• prostate gland development Source: MGIInferred from mutant phenotypeⁱ
  • "p63 is a prostate basal cell marker and is required for prostate development."
    Signoretti S., Waltregny D., Dilks J., Isaac B., Lin D., Garraway L., Yang A., Montironi R., McKeon F., Loda M.
    Am J Pathol 157:1769-1775(2000) [PubMed] [Europe PMC] [Abstract]
• prostatic bud formation Source: MGIInferred from mutant phenotypeⁱ
  • "p63 is a prostate basal cell marker and is required for prostate development."
    Signoretti S., Waltregny D., Dilks J., Isaac B., Lin D., Garraway L., Yang A., Montironi R., McKeon F., Loda M.
    Am J Pathol 157:1769-1775(2000) [PubMed] [Europe PMC] [Abstract]
• protein tetramerization Source: InterPro
• proximal/distal pattern formation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "p63 is a p53 homologue required for limb and epidermal morphogenesis."
    Mills A.A., Zheng B., Wang X.-J., Vogel H., Roop D.R., Bradley A.
    Nature 398:708-713(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
• regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "p63 null mutation protects mouse oocytes from radio-induced apoptosis."
    Livera G., Petre-Lazar B., Guerquin M.J., Trautmann E., Coffigny H., Habert R.
    Reproduction 135:3-12(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of epidermal cell division Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells."
    Lee S., Kong Y., Weatherbee S.D.
    Dev. Biol. 383:201-213(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.6

    "p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development."
    Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F.
    Nature 398:714-718(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN EPITHELIAL MORPHOGENESIS.
• skin epidermis development Source: MGIInferred from mutant phenotypeⁱ
  • "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."
    Suzuki D., Sahu R., Leu N.A., Senoo M.
    Development 142:282-290(2015) [PubMed] [Europe PMC] [Abstract]
• skin morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch."
    Richardson R.J., Dixon J., Malhotra S., Hardman M.J., Knowles L., Boot-Handford R.P., Shore P., Whitmarsh A., Dixon M.J.
    Nat. Genet. 38:1329-1334(2006) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: Ensembl
• squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGIInferred from mutant phenotypeⁱ
  • "Role of p63 and basal cells in the prostate."
    Kurita T., Medina R.T., Mills A.A., Cunha G.R.
    Development 131:4955-4964(2004) [PubMed] [Europe PMC] [Abstract]
• sympathetic nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "p63 is an essential proapoptotic protein during neural development."
    Jacobs W.B., Govoni G., Ho D., Atwal J.K., Barnabe-Heider F., Keyes W.M., Mills A.A., Miller F.D., Kaplan D.R.
    Neuron 48:743-756(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "DNA damage in oocytes induces a switch of the quality control factor TAp63alpha from dimer to tetramer."
    Deutsch G.B., Zielonka E.M., Coutandin D., Weber T.A., Schafer B., Hannewald J., Luh L.M., Durst F.G., Ibrahim M., Hoffmann J., Niesen F.H., Senturk A., Kunkel H., Brutschy B., Schleiff E., Knapp S., Acker-Palmer A., Grez M., McKeon F., Dotsch V.
    Cell 144:566-576(2011) [PubMed] [Europe PMC] [Abstract]
  • "Cell density-dependent acetylation of DeltaNp63alpha is associated with p53-dependent cell cycle arrest."
    Chae Y.S., Kim H., Kim D., Lee H., Lee H.O.
    FEBS Lett 586:1128-1134(2012) [PubMed] [Europe PMC] [Abstract]
• MDM2/MDM4 family protein binding Source: MGI
• p53 binding Source: MGI
• protein domain specific binding Source: MGI
• WW domain binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL 
        60         70         80         90        100
SPEVFQHIWD FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD 
       110        120        130        140        150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA 
       160        170        180        190        200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK 
       210        220        230        240        250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS 
       260        270        280        290        300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
       310        320        330        340        350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR 
       360        370        380        390        400
DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL 
       410        420        430        440        450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ 
       460        470        480        490        500
TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG 
       510        520        530        540        550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV 
       560        570        580        590        600
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 
       610        620        630        640        650
ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI 
       660        670        680
SFPPRDEWND FNFDMDSRRN KQQRIKEEGE                       

        10         20         30         40         50
MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT 
        60         70         80         90        100
APSPYAQPSS TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY 
       110        120        130        140        150
STELKKLYCQ IAKTCPIQIK VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC 
       160        170        180        190        200
PNHELSREFN EGQIAPPSHL IRVEGNSHAQ YVEDPITGRQ SVLVPYEPPQ 
       210        220        230        240        250
VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV LGRRCFEARI 
       260        270        280        290        300
CACPGRDRKA DEDSIRKQQV SDSAKNGDGT KRPFRQNTHG IQMTSIKKRR 
       310        320        330        340        350
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ 
       360        370        380        390        400
HLLQKQTSMQ SQSSYGNSSP PLNKMNSMNK LPSVSQLINP QQRNALTPTT 
       410        420        430        440        450
MPEGMGANIP MMGTHMPMAG DMNGLSPTQA LPPPLSMPST SHCTPPPPYP 
       460        470        480        490        500
TDCSIVSFLA RLGCSSCLDY FTTQGLTTIY QIEHYSMDDL ASLKIPEQFR 
       510        520        530        540        550
HAIWKGILDH RQLHDFSSPP HLLRTPSGAS TVSVGSSETR GERVIDAVRF 
       560        570        580 
TLRQTISFPP RDEWNDFNFD MDSRRNKQQR IKEEGE                

        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL 
        60         70         80         90        100
SPEVFQHIWD FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD 
       110        120        130        140        150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA 
       160        170        180        190        200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK 
       210        220        230        240        250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS 
       260        270        280        290        300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
       310        320        330        340        350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR 
       360        370        380        390        400
DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL 
       410        420        430        440        450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ 
       460        470        480        490        500
TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG 
       510        520        530        540        550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV 

RIWQV                                                  

        10         20         30         40         50
MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT 
        60         70         80         90        100
APSPYAQPSS TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY 
       110        120        130        140        150
STELKKLYCQ IAKTCPIQIK VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC 
       160        170        180        190        200
PNHELSREFN EGQIAPPSHL IRVEGNSHAQ YVEDPITGRQ SVLVPYEPPQ 
       210        220        230        240        250
VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV LGRRCFEARI 
       260        270        280        290        300
CACPGRDRKA DEDSIRKQQV SDSAKNGDGT KRPFRQNTHG IQMTSIKKRR 
       310        320        330        340        350
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ 
       360        370        380        390        400
HLLQKQTSMQ SQSSYGNSSP PLNKMNSMNK LPSVSQLINP QQRNALTPTT 
       410        420        430        440        450
MPEGMGANIP MMGTHMPMAG DMNGLSPTQA LPPPLSMPST SHCTPPPPYP 
       460 
TDCSIVRIWQ V                                           

        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL 
        60         70         80         90        100
SPEVFQHIWD FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD 
       110        120        130        140        150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA 
       160        170        180        190        200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK 
       210        220        230        240        250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS 
       260        270        280        290        300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
       310        320        330        340        350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR 
       360        370        380        390        400
DRKADEDSIR KQQVSDSAKN GDAFRQNTHG IQMTSIKKRR SPDDELLYLP 
       410        420        430        440        450
VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ HLLQKHLLSA 
       460        470        480 
CFRNELVEPR GEAPTQSDVF FRHSNPPNHS VYP                   

        10         20         30         40         50
MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT 
        60         70         80         90        100
APSPYAQPSS TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY 
       110        120        130        140        150
STELKKLYCQ IAKTCPIQIK VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC 
       160        170        180        190        200
PNHELSREFN EGQIAPPSHL IRVEGNSHAQ YVEDPITGRQ SVLVPYEPPQ 
       210        220        230        240        250
VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV LGRRCFEARI 
       260        270        280        290        300
CACPGRDRKA DEDSIRKQQV SDSAKNGDAF RQNTHGIQMT SIKKRRSPDD 
       310        320        330        340        350
ELLYLPVRGR ETYEMLLKIK ESLELMQYLP QHTIETYRQQ QQQQHQHLLQ 
       360        370        380 
KHLLSACFRN ELVEPRGEAP TQSDVFFRHS NPPNHSVYP             

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ