UniProtKB - O88888 (APBA3_MOUSE)
Protein
Amyloid-beta A4 precursor protein-binding family A member 3
Gene
Apba3
Organism
Mus musculus (Mouse)
Status
Functioni
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).By similarity
GO - Molecular functioni
- amyloid-beta binding Source: MGI
- enzyme binding Source: MGI
- enzyme inhibitor activity Source: MGI
GO - Biological processi
- chemical synaptic transmission Source: MGI
- in utero embryonic development Source: MGI
- negative regulation of catalytic activity Source: MGI
- protein transport Source: UniProtKB-KW
- regulation of gene expression Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid-beta A4 precursor protein-binding family A member 3Alternative name(s): Adapter protein X11gamma Neuron-specific X11L2 protein Neuronal Munc18-1-interacting protein 3 Short name: Mint-3 |
Gene namesi | Name:Apba3 Synonyms:Mint3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888527, Apba3 |
Subcellular locationi
Other locations
- perinuclear region By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- dendritic spine Source: GO_Central
- perinuclear region of cytoplasm Source: MGI
- synapse Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064621 | 1 – 571 | Amyloid-beta A4 precursor protein-binding family A member 3Add BLAST | 571 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 168 | PhosphoserineBy similarity | 1 | |
Modified residuei | 369 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O88888 |
PaxDbi | O88888 |
PeptideAtlasi | O88888 |
PRIDEi | O88888 |
PTM databases
iPTMneti | O88888 |
PhosphoSitePlusi | O88888 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSMUSG00000004931, Expressed in tibialis anterior and 271 other tissues |
Genevisiblei | O88888, MM |
Interactioni
Subunit structurei
Binds to the cytoplasmic domain of amyloid protein (APP).
Interacts with HIF1AN (via N-terminus) (By similarity).
Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity).
By similarityGO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 208237, 1 interactor |
IntActi | O88888, 1 interactor |
STRINGi | 10090.ENSMUSP00000050995 |
Miscellaneous databases
RNActi | O88888, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 214 – 378 | PIDPROSITE-ProRule annotationAdd BLAST | 165 | |
Domaini | 391 – 477 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 482 – 556 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 75 |
Domaini
Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3605, Eukaryota |
GeneTreei | ENSGT00940000160384 |
HOGENOMi | CLU_013563_2_0_1 |
InParanoidi | O88888 |
OMAi | YPAPQEV |
OrthoDBi | 436779at2759 |
PhylomeDBi | O88888 |
TreeFami | TF315245 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR030531, Apba3 IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
PANTHERi | PTHR12345:SF9, PTHR12345:SF9, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits SM00462, PTB, 1 hit |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits PS01179, PID, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O88888-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFLPGPQHP PGPPTMDLEE PKGPEVPSEN HPSNTQSALG PGGPVTLSEM
60 70 80 90 100
ELDTSSVQEL VQQLEALPSD LGGPFPDGAP CPLHIATGQG LATQENPDAG
110 120 130 140 150
GLLSAEAGGD DLLGLLRDEA SSPAQSVPQD PAQTAPRLLQ PPEDPDGDPG
160 170 180 190 200
WMEGASAEPA DSRSSSSSPE PWLETAPLVT QQEPPVGTQS RETLASCPAV
210 220 230 240 250
TEVPGPCGPE ELMDGVIFGA KYLGSTQLLS ERSPAPSTRM GQAQEAMDRV
260 270 280 290 300
KAPEGETQPM VEVDIFISTK RVKVLAADSQ DALMDHALQT ISYIADIGPV
310 320 330 340 350
LVLMARRRLA RRTTPQDRQR RLYKMLCHVF HSEDAQLIAQ AIGQAFSIAY
360 370 380 390 400
SQFLQENRID PSQVGTQPST AASHPHNGDL DHFCNSQNCR EVCIQKRPGE
410 420 430 440 450
GLGVALVESG WGSLLPTAVI ANLLHGGPAE RCGALSIGDR VTAINGTSLV
460 470 480 490 500
GLSLAACQAA VREVRRLSSV TLSIIHCPPV TTAVIRRPHV REQLGFCVED
510 520 530 540 550
GIICSLLRGG AAERGGVRVG HRIIEVNGQS VVAMPHARII QLLTETREIH
560 570
IKTMPAATYR LLTGQEQPVY L
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P6S0 | A0A1W2P6S0_MOUSE | Amyloid-beta A4 precursor protein-b... | Apba3 | 164 | Annotation score: | ||
A0A1W2P7G9 | A0A1W2P7G9_MOUSE | Amyloid-beta A4 precursor protein-b... | Apba3 | 131 | Annotation score: | ||
A0A1W2P837 | A0A1W2P837_MOUSE | Amyloid-beta A4 precursor protein-b... | Apba3 | 108 | Annotation score: | ||
A0A1W2P6Z9 | A0A1W2P6Z9_MOUSE | Amyloid-beta A4 precursor protein-b... | Apba3 | 239 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 238 | T → A in BAC32549 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 381 | D → G in BAC32549 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070975 mRNA Translation: AAC78837.1 AK045965 mRNA Translation: BAC32549.1 AK170182 mRNA Translation: BAE41620.1 CH466553 Genomic DNA Translation: EDL31434.1 BC005423 mRNA Translation: AAH05423.1 BC009666 mRNA Translation: AAH09666.1 |
CCDSi | CCDS24050.1 |
RefSeqi | NP_061228.1, NM_018758.2 XP_006513968.1, XM_006513905.1 XP_006513969.1, XM_006513906.3 |
Genome annotation databases
Ensembli | ENSMUST00000057798; ENSMUSP00000050995; ENSMUSG00000004931 ENSMUST00000220297; ENSMUSP00000151985; ENSMUSG00000004931 |
GeneIDi | 57267 |
KEGGi | mmu:57267 |
UCSCi | uc007ggz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070975 mRNA Translation: AAC78837.1 AK045965 mRNA Translation: BAC32549.1 AK170182 mRNA Translation: BAE41620.1 CH466553 Genomic DNA Translation: EDL31434.1 BC005423 mRNA Translation: AAH05423.1 BC009666 mRNA Translation: AAH09666.1 |
CCDSi | CCDS24050.1 |
RefSeqi | NP_061228.1, NM_018758.2 XP_006513968.1, XM_006513905.1 XP_006513969.1, XM_006513906.3 |
3D structure databases
SMRi | O88888 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208237, 1 interactor |
IntActi | O88888, 1 interactor |
STRINGi | 10090.ENSMUSP00000050995 |
PTM databases
iPTMneti | O88888 |
PhosphoSitePlusi | O88888 |
Proteomic databases
EPDi | O88888 |
PaxDbi | O88888 |
PeptideAtlasi | O88888 |
PRIDEi | O88888 |
Protocols and materials databases
Antibodypediai | 23338, 159 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000057798; ENSMUSP00000050995; ENSMUSG00000004931 ENSMUST00000220297; ENSMUSP00000151985; ENSMUSG00000004931 |
GeneIDi | 57267 |
KEGGi | mmu:57267 |
UCSCi | uc007ggz.2, mouse |
Organism-specific databases
CTDi | 9546 |
MGIi | MGI:1888527, Apba3 |
Phylogenomic databases
eggNOGi | KOG3605, Eukaryota |
GeneTreei | ENSGT00940000160384 |
HOGENOMi | CLU_013563_2_0_1 |
InParanoidi | O88888 |
OMAi | YPAPQEV |
OrthoDBi | 436779at2759 |
PhylomeDBi | O88888 |
TreeFami | TF315245 |
Miscellaneous databases
BioGRID-ORCSi | 57267, 0 hits in 17 CRISPR screens |
ChiTaRSi | Apba3, mouse |
PROi | PR:O88888 |
RNActi | O88888, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004931, Expressed in tibialis anterior and 271 other tissues |
Genevisiblei | O88888, MM |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR030531, Apba3 IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
PANTHERi | PTHR12345:SF9, PTHR12345:SF9, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits SM00462, PTB, 1 hit |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits PS01179, PID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APBA3_MOUSE | |
Accessioni | O88888Primary (citable) accession number: O88888 Secondary accession number(s): Q3TDI1, Q8BR09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot