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Protein

Amyloid-beta A4 precursor protein-binding family A member 3

Gene

Apba3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family A member 3
Alternative name(s):
Adapter protein X11gamma
Neuron-specific X11L2 protein
Neuronal Munc18-1-interacting protein 3
Short name:
Mint-3
Gene namesi
Name:Apba3
Synonyms:Mint3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1888527 Apba3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646211 – 571Amyloid-beta A4 precursor protein-binding family A member 3Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei369PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO88888
PeptideAtlasiO88888
PRIDEiO88888

PTM databases

iPTMnetiO88888
PhosphoSitePlusiO88888

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000004931 Expressed in 253 organ(s), highest expression level in tibialis anterior
ExpressionAtlasiO88888 baseline and differential
GenevisibleiO88888 MM

Interactioni

Subunit structurei

Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050995

Structurei

3D structure databases

ProteinModelPortaliO88888
SMRiO88888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 378PIDPROSITE-ProRule annotationAdd BLAST165
Domaini391 – 477PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini482 – 556PDZ 2PROSITE-ProRule annotationAdd BLAST75

Domaini

Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00390000013578
HOGENOMiHOG000033981
HOVERGENiHBG050523
InParanoidiO88888
OMAiLYKMICH
OrthoDBiEOG091G0PDJ
PhylomeDBiO88888
TreeFamiTF315245

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030531 Apba3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF9 PTHR12345:SF9, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O88888-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFLPGPQHP PGPPTMDLEE PKGPEVPSEN HPSNTQSALG PGGPVTLSEM
60 70 80 90 100
ELDTSSVQEL VQQLEALPSD LGGPFPDGAP CPLHIATGQG LATQENPDAG
110 120 130 140 150
GLLSAEAGGD DLLGLLRDEA SSPAQSVPQD PAQTAPRLLQ PPEDPDGDPG
160 170 180 190 200
WMEGASAEPA DSRSSSSSPE PWLETAPLVT QQEPPVGTQS RETLASCPAV
210 220 230 240 250
TEVPGPCGPE ELMDGVIFGA KYLGSTQLLS ERSPAPSTRM GQAQEAMDRV
260 270 280 290 300
KAPEGETQPM VEVDIFISTK RVKVLAADSQ DALMDHALQT ISYIADIGPV
310 320 330 340 350
LVLMARRRLA RRTTPQDRQR RLYKMLCHVF HSEDAQLIAQ AIGQAFSIAY
360 370 380 390 400
SQFLQENRID PSQVGTQPST AASHPHNGDL DHFCNSQNCR EVCIQKRPGE
410 420 430 440 450
GLGVALVESG WGSLLPTAVI ANLLHGGPAE RCGALSIGDR VTAINGTSLV
460 470 480 490 500
GLSLAACQAA VREVRRLSSV TLSIIHCPPV TTAVIRRPHV REQLGFCVED
510 520 530 540 550
GIICSLLRGG AAERGGVRVG HRIIEVNGQS VVAMPHARII QLLTETREIH
560 570
IKTMPAATYR LLTGQEQPVY L
Length:571
Mass (Da):60,718
Last modified:November 1, 1998 - v1
Checksum:i1BBAC7BD1CCF3BCA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6Z9A0A1W2P6Z9_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba3
239Annotation score:
A0A1W2P6S0A0A1W2P6S0_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba3
164Annotation score:
A0A1W2P7G9A0A1W2P7G9_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba3
131Annotation score:
A0A1W2P837A0A1W2P837_MOUSE
Amyloid-beta A4 precursor protein-b...
Apba3
108Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238T → A in BAC32549 (PubMed:16141072).Curated1
Sequence conflicti381D → G in BAC32549 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070975 mRNA Translation: AAC78837.1
AK045965 mRNA Translation: BAC32549.1
AK170182 mRNA Translation: BAE41620.1
CH466553 Genomic DNA Translation: EDL31434.1
BC005423 mRNA Translation: AAH05423.1
BC009666 mRNA Translation: AAH09666.1
CCDSiCCDS24050.1
RefSeqiNP_061228.1, NM_018758.2
XP_006513968.1, XM_006513905.1
XP_006513969.1, XM_006513906.3
UniGeneiMm.293931

Genome annotation databases

EnsembliENSMUST00000057798; ENSMUSP00000050995; ENSMUSG00000004931
ENSMUST00000220297; ENSMUSP00000151985; ENSMUSG00000004931
GeneIDi57267
KEGGimmu:57267
UCSCiuc007ggz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070975 mRNA Translation: AAC78837.1
AK045965 mRNA Translation: BAC32549.1
AK170182 mRNA Translation: BAE41620.1
CH466553 Genomic DNA Translation: EDL31434.1
BC005423 mRNA Translation: AAH05423.1
BC009666 mRNA Translation: AAH09666.1
CCDSiCCDS24050.1
RefSeqiNP_061228.1, NM_018758.2
XP_006513968.1, XM_006513905.1
XP_006513969.1, XM_006513906.3
UniGeneiMm.293931

3D structure databases

ProteinModelPortaliO88888
SMRiO88888
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050995

PTM databases

iPTMnetiO88888
PhosphoSitePlusiO88888

Proteomic databases

PaxDbiO88888
PeptideAtlasiO88888
PRIDEiO88888

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057798; ENSMUSP00000050995; ENSMUSG00000004931
ENSMUST00000220297; ENSMUSP00000151985; ENSMUSG00000004931
GeneIDi57267
KEGGimmu:57267
UCSCiuc007ggz.2 mouse

Organism-specific databases

CTDi9546
MGIiMGI:1888527 Apba3

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00390000013578
HOGENOMiHOG000033981
HOVERGENiHBG050523
InParanoidiO88888
OMAiLYKMICH
OrthoDBiEOG091G0PDJ
PhylomeDBiO88888
TreeFamiTF315245

Miscellaneous databases

ChiTaRSiApba3 mouse
PROiPR:O88888
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004931 Expressed in 253 organ(s), highest expression level in tibialis anterior
ExpressionAtlasiO88888 baseline and differential
GenevisibleiO88888 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030531 Apba3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF9 PTHR12345:SF9, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPBA3_MOUSE
AccessioniPrimary (citable) accession number: O88888
Secondary accession number(s): Q3TDI1, Q8BR09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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