UniProtKB - O88875 (BY55_MOUSE)
Protein
CD160 antigen
Gene
Cd160
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (By similarity). Receptor for both classical and non-classical MHC class I molecules (PubMed:16177084). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (PubMed:25711213). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (PubMed:22801499).By similarity3 Publications
The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.By similarity
GO - Molecular functioni
- activating MHC class I receptor activity Source: UniProtKB
- kinase binding Source: MGI
- MHC class Ib receptor activity Source: MGI
- MHC class I protein complex binding Source: UniProtKB
- MHC class I receptor activity Source: MGI
- signaling receptor binding Source: MGI
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- defense response to Gram-negative bacterium Source: MGI
- innate immune response Source: UniProtKB-KW
- mucosal immune response Source: UniProtKB
- negative regulation of adaptive immune memory response Source: MGI
- negative regulation of angiogenesis Source: MGI
- negative regulation of CD4-positive, alpha-beta T cell costimulation Source: MGI
- negative regulation of T cell receptor signaling pathway Source: MGI
- phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of endothelial cell apoptotic process Source: MGI
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of natural killer cell cytokine production Source: UniProtKB
- positive regulation of natural killer cell degranulation Source: MGI
- positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
- positive regulation of natural killer cell mediated immune response to tumor cell Source: UniProtKB
- T cell costimulation Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: CD160 antigenAlternative name(s): Natural killer cell receptor BY55 CD_antigen: CD1601 Publication Cleaved into the following chain: CD160 antigen, soluble form1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1860383, Cd160 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; GPI-anchor By similarity
Extracellular region or secreted
- Secreted By similarity1 Publication
Note: Released from the cell membrane by GPI cleavage.By similarity1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- anchored component of plasma membrane Source: MGI
- plasma membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
No visible phenotype.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000014545 | 28 – 160 | CD160 antigenAdd BLAST | 133 | |
ChainiPRO_0000446050 | 28 – 160 | CD160 antigen, soluble form1 PublicationAdd BLAST | 133 | |
PropeptideiPRO_0000014546 | 161 – 185 | Removed in mature formSequence analysisAdd BLAST | 25 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 47 ↔ 115 | PROSITE-ProRule annotation | ||
Disulfide bondi | 64 ↔ 71 | PROSITE-ProRule annotation | ||
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 156 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 160 | GPI-anchor amidated serineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | O88875 |
PRIDEi | O88875 |
PTM databases
GlyGeni | O88875, 2 sites |
PhosphoSitePlusi | O88875 |
Expressioni
Tissue specificityi
Expressed in resting and activated NK cell subsets (at protein level) (PubMed:25711213, PubMed:16177084). Expressed in resting NKT cells (at protein level) (PubMed:16177084). Expressed in activated CD8+ T cells (at protein level). Highly expressed in intraepithelial lymphocyte (IEL) subsets, particularly in innate-like CD8A-positive IELs (at protein level) (PubMed:22801499).3 Publications
Gene expression databases
Bgeei | ENSMUSG00000038304, Expressed in primary oocyte and 82 other tissues |
Genevisiblei | O88875, MM |
Interactioni
Subunit structurei
Homomultimer; disulfide-linked (By similarity).
Interacts with classical and non-classical MHC class I molecules (PubMed:16177084).
Interacts with TNFRSF14 (via cysteine-rich domain 1); this interaction is direct (PubMed:18193050).
Interacts with LCK and CD247/CD3 zeta chain (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- kinase binding Source: MGI
- signaling receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102689 |
Miscellaneous databases
RNActi | O88875, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 136 | Ig-like V-typeBy similarityAdd BLAST | 109 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
eggNOGi | ENOG502RR8D, Eukaryota |
GeneTreei | ENSGT00390000007258 |
InParanoidi | O88875 |
OMAi | MAPGRGC |
OrthoDBi | 1278184at2759 |
TreeFami | TF338321 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR042385, CD160 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR15425, PTHR15425, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O88875-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRILMAPGQ SCCALAILLA IVNFQHGGCI HVTSSASQKG GRLDLTCTLW
60 70 80 90 100
HKKDEAEGLI LFWCKDNPWN CSPETNLEQL RVKRDPETDG ITEKSSQLVF
110 120 130 140 150
TIEQATPSDS GTYQCCARSQ KPEIYIHGHF LSVLVTGNHT EIRQRQRSHP
160 170 180
DFSHINGTLS SGFLQVKAWG MLVTSLVALQ ALYTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q0X3 | E9Q0X3_MOUSE | CD160 antigen | Cd160 | 141 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | L → P in AAC62227 (PubMed:9743336).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF060982 mRNA Translation: AAC62227.1 AK042093 mRNA Translation: BAC31162.1 AK145332 mRNA Translation: BAE26372.1 AC127297 Genomic DNA No translation available. |
CCDSi | CCDS17648.1 |
RefSeqi | NP_001156968.1, NM_001163496.1 NP_061237.3, NM_018767.3 |
Genome annotation databases
Ensembli | ENSMUST00000047702; ENSMUSP00000037466; ENSMUSG00000038304 ENSMUST00000107074; ENSMUSP00000102689; ENSMUSG00000038304 |
GeneIDi | 54215 |
KEGGi | mmu:54215 |
UCSCi | uc008qof.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF060982 mRNA Translation: AAC62227.1 AK042093 mRNA Translation: BAC31162.1 AK145332 mRNA Translation: BAE26372.1 AC127297 Genomic DNA No translation available. |
CCDSi | CCDS17648.1 |
RefSeqi | NP_001156968.1, NM_001163496.1 NP_061237.3, NM_018767.3 |
3D structure databases
SMRi | O88875 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102689 |
PTM databases
GlyGeni | O88875, 2 sites |
PhosphoSitePlusi | O88875 |
Proteomic databases
PaxDbi | O88875 |
PRIDEi | O88875 |
Protocols and materials databases
Antibodypediai | 33967, 610 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000047702; ENSMUSP00000037466; ENSMUSG00000038304 ENSMUST00000107074; ENSMUSP00000102689; ENSMUSG00000038304 |
GeneIDi | 54215 |
KEGGi | mmu:54215 |
UCSCi | uc008qof.2, mouse |
Organism-specific databases
CTDi | 11126 |
MGIi | MGI:1860383, Cd160 |
Phylogenomic databases
eggNOGi | ENOG502RR8D, Eukaryota |
GeneTreei | ENSGT00390000007258 |
InParanoidi | O88875 |
OMAi | MAPGRGC |
OrthoDBi | 1278184at2759 |
TreeFami | TF338321 |
Miscellaneous databases
BioGRID-ORCSi | 54215, 1 hit in 17 CRISPR screens |
ChiTaRSi | Cd160, mouse |
PROi | PR:O88875 |
RNActi | O88875, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038304, Expressed in primary oocyte and 82 other tissues |
Genevisiblei | O88875, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR042385, CD160 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR15425, PTHR15425, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BY55_MOUSE | |
Accessioni | O88875Primary (citable) accession number: O88875 Secondary accession number(s): Q8C9H4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot