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Protein

Bestrophin-1

Gene

Best1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandCalcium, Chloride

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels

Names & Taxonomyi

Protein namesi
Recommended name:
Bestrophin-1
Alternative name(s):
Vitelliform macular dystrophy protein 2 homolog
Gene namesi
Name:Best1
Synonyms:Bmd1, Vmd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1346332 Best1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 70ExtracellularSequence analysisAdd BLAST24
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 178CytoplasmicSequence analysisAdd BLAST87
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 228ExtracellularSequence analysisAdd BLAST29
Intramembranei229 – 249Sequence analysisAdd BLAST21
Topological domaini250 – 270ExtracellularSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 551CytoplasmicSequence analysisAdd BLAST260

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431161 – 551Bestrophin-1Add BLAST551

Post-translational modificationi

Phosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88870
PaxDbiO88870
PRIDEiO88870

PTM databases

PhosphoSitePlusiO88870

Expressioni

Gene expression databases

BgeeiENSMUSG00000037418 Expressed in 97 organ(s), highest expression level in testis
CleanExiMM_BEST1
GenevisibleiO88870 MM

Interactioni

Subunit structurei

Tetramer or pentamers. May interact with PPP2CB and PPP2R1B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113053

Structurei

3D structure databases

ProteinModelPortaliO88870
SMRiO88870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bestrophin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3547 Eukaryota
ENOG410XS3J LUCA
GeneTreeiENSGT00390000002997
HOGENOMiHOG000115678
HOVERGENiHBG044928
InParanoidiO88870
KOiK13878
OMAiERDMYWN
OrthoDBiEOG091G06XO
TreeFamiTF315803

Family and domain databases

InterProiView protein in InterPro
IPR033041 Best1
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PTHR10736:SF4 PTHR10736:SF4, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit

Sequencei

Sequence statusi: Complete.

O88870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTITYTNKVA NARLGSFSSL LLCWRGSIYK LLYGEFLVFI FLYYSIRGLY
60 70 80 90 100
RMVLSSDQQL LFEKLALYCD SYIQLIPISF VLGFYVTLVV SRWWSQYENL
110 120 130 140 150
PWPDRLMIQV SSFVEGKDEE GRLLRRTLIR YAILGQVLIL RSISTSVYKR
160 170 180 190 200
FPTLHHLVLA GFMTHGEHKQ LQKLGLPHNT FWVPWVWFAN LSMKAYLGGR
210 220 230 240 250
IRDTVLLQSL MNEVCTLRTQ CGQLYAYDWI SIPLVYTQVV TVAVYSFFLA
260 270 280 290 300
CLIGRQFLNP NKDYPGHEMD LVVPVFTILQ FLFYMGWLKV AEQLINPFGE
310 320 330 340 350
DDDDFETNWI IDRNLQVSLL SVDGMHQNLP PMERDMYWNE AAPQPPYTAA
360 370 380 390 400
SARSRRHSFM GSTFNISLKK EDLELWSKEE ADTDKKESGY SSTIGCFLGL
410 420 430 440 450
QPKNYHLPLK DLKTKLLCSK NPLLEGQCKD ANQKNQKDVW KFKGLDFLKC
460 470 480 490 500
VPRFKRRGSH CGPQAPSSHP TEQSAPSSSD TGDGPSTDYQ EICHMKKKTV
510 520 530 540 550
EFNLNIPESP TEHLQQRRLD QMSTNIQALM KEHAESYPYR DEAGTKPVLY

E
Length:551
Mass (Da):63,684
Last modified:July 27, 2011 - v3
Checksum:i0898D6DE08FEEFB9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255R → K in AAS09922 (PubMed:15218265).Curated1
Sequence conflicti255R → K in AAC64345 (PubMed:9662395).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY450427 mRNA Translation: AAS09922.1
BC139060 mRNA Translation: AAI39061.1
BC139061 mRNA Translation: AAI39062.1
AF057171 mRNA Translation: AAC64345.1
CCDSiCCDS29568.1
RefSeqiNP_036043.2, NM_011913.2
UniGeneiMm.31577

Genome annotation databases

EnsembliENSMUST00000117346; ENSMUSP00000113053; ENSMUSG00000037418
GeneIDi24115
KEGGimmu:24115
UCSCiuc008gou.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY450427 mRNA Translation: AAS09922.1
BC139060 mRNA Translation: AAI39061.1
BC139061 mRNA Translation: AAI39062.1
AF057171 mRNA Translation: AAC64345.1
CCDSiCCDS29568.1
RefSeqiNP_036043.2, NM_011913.2
UniGeneiMm.31577

3D structure databases

ProteinModelPortaliO88870
SMRiO88870
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113053

PTM databases

PhosphoSitePlusiO88870

Proteomic databases

EPDiO88870
PaxDbiO88870
PRIDEiO88870

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117346; ENSMUSP00000113053; ENSMUSG00000037418
GeneIDi24115
KEGGimmu:24115
UCSCiuc008gou.2 mouse

Organism-specific databases

CTDi7439
MGIiMGI:1346332 Best1

Phylogenomic databases

eggNOGiKOG3547 Eukaryota
ENOG410XS3J LUCA
GeneTreeiENSGT00390000002997
HOGENOMiHOG000115678
HOVERGENiHBG044928
InParanoidiO88870
KOiK13878
OMAiERDMYWN
OrthoDBiEOG091G06XO
TreeFamiTF315803

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels

Miscellaneous databases

PROiPR:O88870
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037418 Expressed in 97 organ(s), highest expression level in testis
CleanExiMM_BEST1
GenevisibleiO88870 MM

Family and domain databases

InterProiView protein in InterPro
IPR033041 Best1
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PTHR10736:SF4 PTHR10736:SF4, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBEST1_MOUSE
AccessioniPrimary (citable) accession number: O88870
Secondary accession number(s): B2RSY6, Q6H1V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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