Galr2

Functionⁱ

Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).By similarity1 Publication

GO - Molecular functionⁱ

galanin receptor activity Source: UniProtKB
G protein-coupled peptide receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuropeptide binding Source: MGI
peptide hormone binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
galanin-activated signaling pathway Source: MGI
inositol phosphate metabolic process Source: Ensembl
negative regulation of adenylate cyclase activity Source: InterPro
neuron projection development
Source: MGI
Inferred from direct assayⁱ
- 12533601
neuropeptide signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylinositol metabolic process Source: Ensembl
phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of large conductance calcium-activated potassium channel activity Source: MGI
positive regulation of transcription by RNA polymerase II Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375276 Peptide ligand-binding receptors R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Galanin receptor type 2 Short name: GAL2-R Short name: GALR-2
Gene namesⁱ	Name:Galr2 Synonyms:Galnr2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1337018 Galr2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 48	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	49 – 59	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	60 – 80	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	81 – 98	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	99 – 120	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	121 – 140	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	141 – 161	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	162 – 186	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	187 – 207	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	208 – 236	CytoplasmicSequence analysisAdd BLAST	29
Transmembraneⁱ	237 – 257	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	258 – 259	ExtracellularSequence analysis	2
Transmembraneⁱ	260 – 280	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	281 – 371	CytoplasmicSequence analysisAdd BLAST	91

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	244

GuidetoPHARMACOLOGYⁱ

244

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069467	1 – 371	Galanin receptor type 2Add BLAST		371

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	2	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	97 ↔ 174	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O88854
PRIDEⁱ	O88854

PTM databases

PhosphoSitePlusⁱ	O88854

PhosphoSitePlusⁱ

O88854

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020793 Expressed in 37 organ(s), highest expression level in adipose tissue
CleanExⁱ	MM_GALR2
Genevisibleⁱ	O88854 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000054062

STRINGⁱ

10090.ENSMUSP00000054062

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88854
SMRⁱ	O88854
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150908
HOGENOMⁱ	HOG000230487
HOVERGENⁱ	HBG101447
InParanoidⁱ	O88854
KEGG Orthology (KO) More...KOⁱ	K04231
OMAⁱ	FRKICAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZDG
TreeFamⁱ	TF315737

Family and domain databases

InterProⁱ	View protein in InterPro IPR003907 GAL2_rcpt IPR000405 Galanin_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01419 GALANIN2R PR00663 GALANINR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O88854-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL 
        60         70         80         90        100
RGGQAVSTTN LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV 
       110        120        130        140        150
HFLIFLTMHA SSFTLAAVSL DRYLAIRYPL HSRELRTPRN ALAAIGLIWG 
       160        170        180        190        200
LALLFSGPYL SYYSQSQLAN LTVCHPAWSA PRRRAMDLCT FVFSYLLPVL 
       210        220        230        240        250
VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV AVLFCLCWMP 
       260        270        280        290        300
HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK 
       310        320        330        340        350
GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP 
       360        370 
LVPAPALPNC TTLSRTLDPA C

Length:371

Mass (Da):40,516

Last modified:July 27, 2011 - v2

Checksum:ⁱC59F6560AF2EFD34

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	130	L → M in AAC36589 (PubMed:9832121).Curated	1
Sequence conflictⁱ	184 – 188	RAMDL → PWNS (PubMed:9832122).Curated	5
Sequence conflictⁱ	192 – 193	VF → CL in AAC95468 (PubMed:9832122).Curated	2
Sequence conflictⁱ	221	A → V in AAC95468 (PubMed:9832122).Curated	1
Sequence conflictⁱ	345 – 360	SEAAG…ALPNC → KRGSRAPRPRTRTSQT (PubMed:9832122).CuratedAdd BLAST	16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF042784 Genomic DNA Translation: AAC36589.1 AF077375 mRNA Translation: AAC95468.1 AL645861 Genomic DNA Translation: CAM16797.1 CH466558 Genomic DNA Translation: EDL34569.1 BC116980 mRNA Translation: AAI16981.1 BC116982 mRNA Translation: AAI16983.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25663.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034384.3, NM_010254.4
UniGeneⁱ	Mm.57149

Genome annotation databases

Ensemblⁱ	ENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793
GeneIDⁱ	14428
KEGGⁱ	mmu:14428
UCSC genome browser More...UCSCⁱ	uc007mkr.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88854	GALR2 (Fragment)		MOUSE		17	UniRef100_O88854

Protein	Similar proteins		Species	Score	Length	Source
O88854	Galanin receptor type 2		RAT		372	UniRef90_O08726
galanin receptor type 2		MESAU		374
Galanin receptor type 2		CRIGR		373
GALR2 (Fragment)		MOUSE		17
UPI00038BBC75		MICOH		372
+5

Protein	Similar proteins		Species	Score	Length	Source
O88854	Galanin receptor type 3		HUMAN		368	UniRef50_O60755
Galanin receptor type 3		MOUSE		370
Galanin receptor type 2		RAT		372
Uncharacterized protein		OTOGA		380
galanin receptor type 3		TURTR		376
+140

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF042784 Genomic DNA Translation: AAC36589.1 AF077375 mRNA Translation: AAC95468.1 AL645861 Genomic DNA Translation: CAM16797.1 CH466558 Genomic DNA Translation: EDL34569.1 BC116980 mRNA Translation: AAI16981.1 BC116982 mRNA Translation: AAI16983.1
CCDSⁱ	CCDS25663.1
RefSeqⁱ	NP_034384.3, NM_010254.4
UniGeneⁱ	Mm.57149

3D structure databases

ProteinModelPortalⁱ	O88854
SMRⁱ	O88854
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000054062

STRINGⁱ

10090.ENSMUSP00000054062

Chemistry databases

GuidetoPHARMACOLOGYⁱ	244

GuidetoPHARMACOLOGYⁱ

244

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	O88854

PhosphoSitePlusⁱ

O88854

Proteomic databases

PaxDbⁱ	O88854
PRIDEⁱ	O88854

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793
GeneIDⁱ	14428
KEGGⁱ	mmu:14428
UCSCⁱ	uc007mkr.2 mouse

Organism-specific databases

CTDⁱ	8811
MGIⁱ	MGI:1337018 Galr2

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00930000150908
HOGENOMⁱ	HOG000230487
HOVERGENⁱ	HBG101447
InParanoidⁱ	O88854
KOⁱ	K04231
OMAⁱ	FRKICAG
OrthoDBⁱ	EOG091G0ZDG
TreeFamⁱ	TF315737

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375276 Peptide ligand-binding receptors R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88854
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020793 Expressed in 37 organ(s), highest expression level in adipose tissue
CleanExⁱ	MM_GALR2
Genevisibleⁱ	O88854 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003907 GAL2_rcpt IPR000405 Galanin_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01419 GALANIN2R PR00663 GALANINR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GALR2_MOUSE
Accessionⁱ	O88854Primary (citable) accession number: O88854 Secondary accession number(s): Q14A53, Q9Z2B0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88854 (GALR2_MOUSE)

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Galanin receptor type 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ