UniProtKB - O88854 (GALR2_MOUSE)
Protein
Galanin receptor type 2
Gene
Galr2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).By similarity1 Publication
GO - Molecular functioni
- galanin receptor activity Source: UniProtKB
- G protein-coupled peptide receptor activity Source: GO_Central
- neuropeptide binding Source: MGI
- peptide hormone binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- galanin-activated signaling pathway Source: MGI
- inositol phosphate metabolic process Source: Ensembl
- negative regulation of adenylate cyclase activity Source: InterPro
- neuron projection development Source: MGI
- neuropeptide signaling pathway Source: GO_Central
- phosphatidylinositol metabolic process Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of large conductance calcium-activated potassium channel activity Source: MGI
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Galanin receptor type 2Short name: GAL2-R Short name: GALR-2 |
Gene namesi | Name:Galr2 Synonyms:Galnr2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1337018, Galr2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cilium Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 59 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 60 – 80 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 98 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 99 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 121 – 140 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 141 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 186 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 187 – 207 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 236 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 237 – 257 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 259 | ExtracellularSequence analysis | 2 | |
Transmembranei | 260 – 280 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 371 | CytoplasmicSequence analysisAdd BLAST | 91 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069467 | 1 – 371 | Galanin receptor type 2Add BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 174 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O88854 |
PRIDEi | O88854 |
PTM databases
GlyGeni | O88854, 1 site |
PhosphoSitePlusi | O88854 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020793, Expressed in adipose tissue and 64 other tissues |
Genevisiblei | O88854, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000054062 |
Miscellaneous databases
RNActi | O88854, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214475 |
HOGENOMi | CLU_009579_6_4_1 |
InParanoidi | O88854 |
OMAi | DICTFVF |
OrthoDBi | 1294084at2759 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR003907, GAL2_rcpt IPR000405, Galanin_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01419, GALANIN2R PR00663, GALANINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O88854-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL
60 70 80 90 100
RGGQAVSTTN LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV
110 120 130 140 150
HFLIFLTMHA SSFTLAAVSL DRYLAIRYPL HSRELRTPRN ALAAIGLIWG
160 170 180 190 200
LALLFSGPYL SYYSQSQLAN LTVCHPAWSA PRRRAMDLCT FVFSYLLPVL
210 220 230 240 250
VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV AVLFCLCWMP
260 270 280 290 300
HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK
310 320 330 340 350
GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP
360 370
LVPAPALPNC TTLSRTLDPA C
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | L → M in AAC36589 (PubMed:9832121).Curated | 1 | |
Sequence conflicti | 184 – 188 | RAMDL → PWNS (PubMed:9832122).Curated | 5 | |
Sequence conflicti | 192 – 193 | VF → CL in AAC95468 (PubMed:9832122).Curated | 2 | |
Sequence conflicti | 221 | A → V in AAC95468 (PubMed:9832122).Curated | 1 | |
Sequence conflicti | 345 – 360 | SEAAG…ALPNC → KRGSRAPRPRTRTSQT (PubMed:9832122).CuratedAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042784 Genomic DNA Translation: AAC36589.1 AF077375 mRNA Translation: AAC95468.1 AL645861 Genomic DNA No translation available. CH466558 Genomic DNA Translation: EDL34569.1 BC116980 mRNA Translation: AAI16981.1 BC116982 mRNA Translation: AAI16983.1 |
CCDSi | CCDS25663.1 |
RefSeqi | NP_034384.3, NM_010254.4 |
Genome annotation databases
Ensembli | ENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793 |
GeneIDi | 14428 |
KEGGi | mmu:14428 |
UCSCi | uc007mkr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042784 Genomic DNA Translation: AAC36589.1 AF077375 mRNA Translation: AAC95468.1 AL645861 Genomic DNA No translation available. CH466558 Genomic DNA Translation: EDL34569.1 BC116980 mRNA Translation: AAI16981.1 BC116982 mRNA Translation: AAI16983.1 |
CCDSi | CCDS25663.1 |
RefSeqi | NP_034384.3, NM_010254.4 |
3D structure databases
SMRi | O88854 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000054062 |
Chemistry databases
GuidetoPHARMACOLOGYi | 244 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O88854, 1 site |
PhosphoSitePlusi | O88854 |
Proteomic databases
PaxDbi | O88854 |
PRIDEi | O88854 |
Protocols and materials databases
Antibodypediai | 19663, 285 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793 |
GeneIDi | 14428 |
KEGGi | mmu:14428 |
UCSCi | uc007mkr.2, mouse |
Organism-specific databases
CTDi | 8811 |
MGIi | MGI:1337018, Galr2 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214475 |
HOGENOMi | CLU_009579_6_4_1 |
InParanoidi | O88854 |
OMAi | DICTFVF |
OrthoDBi | 1294084at2759 |
TreeFami | TF315737 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 14428, 1 hit in 17 CRISPR screens |
PROi | PR:O88854 |
RNActi | O88854, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020793, Expressed in adipose tissue and 64 other tissues |
Genevisiblei | O88854, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003907, GAL2_rcpt IPR000405, Galanin_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01419, GALANIN2R PR00663, GALANINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GALR2_MOUSE | |
Accessioni | O88854Primary (citable) accession number: O88854 Secondary accession number(s): Q14A53, Q9Z2B0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries