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Protein

Putative hydrolase RBBP9

Gene

Rbbp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemSequence analysis1
Active sitei138Charge relay systemSequence analysis1
Active sitei165Charge relay systemSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERimouse-rbbp9 Hydrolase_RBBP9_YdeN

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydrolase RBBP9 (EC:3.-.-.-)
Alternative name(s):
B5T-overexpressed gene protein
Short name:
Protein BOG
Retinoblastoma-binding protein 9
Short name:
RBBP-9
Gene namesi
Name:Rbbp9
Synonyms:Bog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1347074 Rbbp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971811 – 186Putative hydrolase RBBP9Add BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Phosphothreonine; by CK2Sequence analysis1
Modified residuei135Phosphoserine; by CK2Sequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88851
MaxQBiO88851
PaxDbiO88851
PRIDEiO88851

2D gel databases

REPRODUCTION-2DPAGEiO88851

PTM databases

iPTMnetiO88851
PhosphoSitePlusiO88851
SwissPalmiO88851

Expressioni

Gene expression databases

BgeeiENSMUSG00000027428 Expressed in 286 organ(s), highest expression level in cortex of kidney
CleanExiMM_RBBP9
ExpressionAtlasiO88851 baseline and differential
GenevisibleiO88851 MM

Interactioni

Protein-protein interaction databases

IntActiO88851, 4 interactors
MINTiO88851
STRINGi10090.ENSMUSP00000028915

Structurei

3D structure databases

ProteinModelPortaliO88851
SMRiO88851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 70Retinoblastoma protein bindingSequence analysisAdd BLAST15

Sequence similaritiesi

Belongs to the RBBP9 family.Curated

Phylogenomic databases

eggNOGiENOG410IK06 Eukaryota
ENOG411109T LUCA
GeneTreeiENSGT00390000014861
HOGENOMiHOG000231689
HOVERGENiHBG056175
InParanoidiO88851
KOiK07002
OMAiANWYGWL
OrthoDBiEOG091G0MJ3
PhylomeDBiO88851
TreeFamiTF106470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR010662 Hydrolase_RBBP9/YdeN
PfamiView protein in Pfam
PF06821 Ser_hydrolase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

O88851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPNKAVIV PGNGGGDVAT HGWYGWVKKG LEQIPGFQCL AKNMPDPITA
60 70 80 90 100
RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHQV YALVLVSAYT
110 120 130 140 150
SDLGDENERA SGYFSRPWQW EKIKANCPHI VQFGSTDDPF LPWKEQQEVA
160 170 180
DRLDAKLYKF TDRGHFQNTE FHELISVVKS MLKGPE
Length:186
Mass (Da):20,912
Last modified:September 26, 2001 - v2
Checksum:iA2351381F228FCCC
GO

Sequence cautioni

The sequence AAC63497 differs from that shown. Reason: Frameshift at position 152.Curated
The sequence AK017606 differs from that shown. Reason: Frameshift at position 20.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131V → I in AAC63497 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039563 mRNA Translation: AAC63497.1 Frameshift.
AK017606 mRNA No translation available.
BC011107 mRNA Translation: AAH11107.1
CCDSiCCDS16821.1
RefSeqiNP_056569.2, NM_015754.2
UniGeneiMm.440564

Genome annotation databases

EnsembliENSMUST00000028915; ENSMUSP00000028915; ENSMUSG00000027428
GeneIDi26450
KEGGimmu:26450
UCSCiuc008mri.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039563 mRNA Translation: AAC63497.1 Frameshift.
AK017606 mRNA No translation available.
BC011107 mRNA Translation: AAH11107.1
CCDSiCCDS16821.1
RefSeqiNP_056569.2, NM_015754.2
UniGeneiMm.440564

3D structure databases

ProteinModelPortaliO88851
SMRiO88851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88851, 4 interactors
MINTiO88851
STRINGi10090.ENSMUSP00000028915

Chemistry databases

ChEMBLiCHEMBL3259487

Protein family/group databases

ESTHERimouse-rbbp9 Hydrolase_RBBP9_YdeN

PTM databases

iPTMnetiO88851
PhosphoSitePlusiO88851
SwissPalmiO88851

2D gel databases

REPRODUCTION-2DPAGEiO88851

Proteomic databases

EPDiO88851
MaxQBiO88851
PaxDbiO88851
PRIDEiO88851

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028915; ENSMUSP00000028915; ENSMUSG00000027428
GeneIDi26450
KEGGimmu:26450
UCSCiuc008mri.1 mouse

Organism-specific databases

CTDi10741
MGIiMGI:1347074 Rbbp9

Phylogenomic databases

eggNOGiENOG410IK06 Eukaryota
ENOG411109T LUCA
GeneTreeiENSGT00390000014861
HOGENOMiHOG000231689
HOVERGENiHBG056175
InParanoidiO88851
KOiK07002
OMAiANWYGWL
OrthoDBiEOG091G0MJ3
PhylomeDBiO88851
TreeFamiTF106470

Miscellaneous databases

PROiPR:O88851
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027428 Expressed in 286 organ(s), highest expression level in cortex of kidney
CleanExiMM_RBBP9
ExpressionAtlasiO88851 baseline and differential
GenevisibleiO88851 MM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR010662 Hydrolase_RBBP9/YdeN
PfamiView protein in Pfam
PF06821 Ser_hydrolase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBBP9_MOUSE
AccessioniPrimary (citable) accession number: O88851
Secondary accession number(s): Q9CYJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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