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Protein

Death domain-containing protein CRADD

Gene

Cradd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
RIP-associated protein with a death domain
Gene namesi
Name:Cradd
Synonyms:Raidd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1336168 Cradd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi128G → R: Impairs the interaction with PIDD. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793271 – 199Death domain-containing protein CRADDAdd BLAST199

Proteomic databases

EPDiO88843
PaxDbiO88843
PeptideAtlasiO88843
PRIDEiO88843

PTM databases

PhosphoSitePlusiO88843

Expressioni

Gene expression databases

BgeeiENSMUSG00000045867 Expressed in 184 organ(s), highest expression level in heart
ExpressionAtlasiO88843 baseline and differential
GenevisibleiO88843 MM

Interactioni

Subunit structurei

Forms a complex named the PIDDosome with PIDD1 and CASP2 (PubMed:22279524). Interacts (via Death domain) with RIPK1 (via Death domain); the interaction is direct. Interacts with TRADD. Interacts with TNFRSF1A (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88843, 1 interactor
MINTiO88843
STRINGi10090.ENSMUSP00000050295

Structurei

3D structure databases

ProteinModelPortaliO88843
SMRiO88843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92
Domaini116 – 188DeathPROSITE-ProRule annotationAdd BLAST73

Domaini

The Death domain mediates the interaction with PIDD1 and the formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which in turn probably recruit 7 CASP2 to form the PIDDosome. The Death domain mediates a direct interaction with the Death domain of RIPK1.By similarity
The CARD domain mediates a direct interaction with CASP2.By similarity

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
GeneTreeiENSGT00390000014448
HOGENOMiHOG000111965
HOVERGENiHBG051112
InParanoidiO88843
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P
PhylomeDBiO88843
TreeFamiTF333055

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

O88843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEIKAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLEKAR EEVTAELPTG
110 120 130 140 150
DWMAGIPSHI LSSSPSDQQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVHSQV VEAFVRWRQR FGKQATFLSL HKGLQAVEAD PSLLQHMLE
Length:199
Mass (Da):22,656
Last modified:December 1, 2000 - v2
Checksum:i6C2F987B1ED47229
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185Q → H in AAC35882 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA Translation: AAC35882.1
AJ224738 mRNA Translation: CAA12107.1
AJ224740 mRNA Translation: CAA12109.1
BC005608 mRNA Translation: AAH05608.1
CCDSiCCDS24135.1
RefSeqiNP_001317067.1, NM_001330138.1
NP_001317070.1, NM_001330141.1
NP_001317104.1, NM_001330175.1
NP_034080.1, NM_009950.3
XP_006513243.1, XM_006513180.2
XP_006513244.1, XM_006513181.3
UniGeneiMm.473739

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867
ENSMUST00000217809; ENSMUSP00000151735; ENSMUSG00000045867
ENSMUST00000220279; ENSMUSP00000152022; ENSMUSG00000045867
GeneIDi12905
KEGGimmu:12905
UCSCiuc007gwa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA Translation: AAC35882.1
AJ224738 mRNA Translation: CAA12107.1
AJ224740 mRNA Translation: CAA12109.1
BC005608 mRNA Translation: AAH05608.1
CCDSiCCDS24135.1
RefSeqiNP_001317067.1, NM_001330138.1
NP_001317070.1, NM_001330141.1
NP_001317104.1, NM_001330175.1
NP_034080.1, NM_009950.3
XP_006513243.1, XM_006513180.2
XP_006513244.1, XM_006513181.3
UniGeneiMm.473739

3D structure databases

ProteinModelPortaliO88843
SMRiO88843
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88843, 1 interactor
MINTiO88843
STRINGi10090.ENSMUSP00000050295

PTM databases

PhosphoSitePlusiO88843

Proteomic databases

EPDiO88843
PaxDbiO88843
PeptideAtlasiO88843
PRIDEiO88843

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867
ENSMUST00000217809; ENSMUSP00000151735; ENSMUSG00000045867
ENSMUST00000220279; ENSMUSP00000152022; ENSMUSG00000045867
GeneIDi12905
KEGGimmu:12905
UCSCiuc007gwa.1 mouse

Organism-specific databases

CTDi8738
MGIiMGI:1336168 Cradd

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
GeneTreeiENSGT00390000014448
HOGENOMiHOG000111965
HOVERGENiHBG051112
InParanoidiO88843
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P
PhylomeDBiO88843
TreeFamiTF333055

Enzyme and pathway databases

ReactomeiR-MMU-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases

Miscellaneous databases

PROiPR:O88843
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045867 Expressed in 184 organ(s), highest expression level in heart
ExpressionAtlasiO88843 baseline and differential
GenevisibleiO88843 MM

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRADD_MOUSE
AccessioniPrimary (citable) accession number: O88843
Secondary accession number(s): Q9QUN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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