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Entry version 147 (12 Aug 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Death domain-containing protein CRADD

Gene

Cradd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
RIP-associated protein with a death domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cradd
Synonyms:Raidd
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1336168, Cradd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi128G → R: Impairs the interaction with PIDD. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793271 – 199Death domain-containing protein CRADDAdd BLAST199

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O88843

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88843

PeptideAtlas

More...
PeptideAtlasi
O88843

PRoteomics IDEntifications database

More...
PRIDEi
O88843

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88843

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045867, Expressed in adult mammalian kidney and 208 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O88843, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex named the PIDDosome with PIDD1 and CASP2 (PubMed:22279524).

Interacts (via Death domain) with RIPK1 (via Death domain); the interaction is direct.

Interacts with TRADD.

Interacts with TNFRSF1A (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
198870, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3963, Caspase-2 PIDDosome

Protein interaction database and analysis system

More...
IntActi
O88843, 1 interactor

Molecular INTeraction database

More...
MINTi
O88843

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000050295

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O88843, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88843

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92
Domaini116 – 188DeathPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Death domain mediates the interaction with PIDD1 and the formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which in turn probably recruit 7 CASP2 to form the PIDDosome. The Death domain mediates a direct interaction with the Death domain of RIPK1.By similarity
The CARD domain mediates a direct interaction with CASP2.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R26C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014448

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_118159_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88843

KEGG Orthology (KO)

More...
KOi
K02832

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRCRSDH

Database of Orthologous Groups

More...
OrthoDBi
1346117at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88843

TreeFam database of animal gene trees

More...
TreeFami
TF333055

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08327, CARD_RAIDD, 1 hit
cd08319, Death_RAIDD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR042148, CARD_RAIDD
IPR037939, CRADD
IPR037926, CRADD_Death
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain

The PANTHER Classification System

More...
PANTHERi
PTHR15034, PTHR15034, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit
PF00531, Death, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00114, CARD, 1 hit
SM00005, DEATH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit
PS50017, DEATH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O88843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEIKAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLEKAR EEVTAELPTG
110 120 130 140 150
DWMAGIPSHI LSSSPSDQQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVHSQV VEAFVRWRQR FGKQATFLSL HKGLQAVEAD PSLLQHMLE
Length:199
Mass (Da):22,656
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C2F987B1ED47229
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185Q → H in AAC35882 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF017992 mRNA Translation: AAC35882.1
AJ224738 mRNA Translation: CAA12107.1
AJ224740 mRNA Translation: CAA12109.1
BC005608 mRNA Translation: AAH05608.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24135.1

NCBI Reference Sequences

More...
RefSeqi
NP_001317067.1, NM_001330138.1
NP_001317070.1, NM_001330141.1
NP_001317104.1, NM_001330175.1
NP_034080.1, NM_009950.3
XP_006513243.1, XM_006513180.2
XP_006513244.1, XM_006513181.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867
ENSMUST00000217809; ENSMUSP00000151735; ENSMUSG00000045867
ENSMUST00000220279; ENSMUSP00000152022; ENSMUSG00000045867

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12905

UCSC genome browser

More...
UCSCi
uc007gwa.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA Translation: AAC35882.1
AJ224738 mRNA Translation: CAA12107.1
AJ224740 mRNA Translation: CAA12109.1
BC005608 mRNA Translation: AAH05608.1
CCDSiCCDS24135.1
RefSeqiNP_001317067.1, NM_001330138.1
NP_001317070.1, NM_001330141.1
NP_001317104.1, NM_001330175.1
NP_034080.1, NM_009950.3
XP_006513243.1, XM_006513180.2
XP_006513244.1, XM_006513181.3

3D structure databases

SMRiO88843
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198870, 3 interactors
ComplexPortaliCPX-3963, Caspase-2 PIDDosome
IntActiO88843, 1 interactor
MINTiO88843
STRINGi10090.ENSMUSP00000050295

PTM databases

PhosphoSitePlusiO88843

Proteomic databases

EPDiO88843
PaxDbiO88843
PeptideAtlasiO88843
PRIDEiO88843

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3943, 523 antibodies

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867
ENSMUST00000217809; ENSMUSP00000151735; ENSMUSG00000045867
ENSMUST00000220279; ENSMUSP00000152022; ENSMUSG00000045867
GeneIDi12905
KEGGimmu:12905
UCSCiuc007gwa.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8738
MGIiMGI:1336168, Cradd

Phylogenomic databases

eggNOGiENOG502R26C, Eukaryota
GeneTreeiENSGT00390000014448
HOGENOMiCLU_118159_0_0_1
InParanoidiO88843
KOiK02832
OMAiFRCRSDH
OrthoDBi1346117at2759
PhylomeDBiO88843
TreeFamiTF333055

Enzyme and pathway databases

ReactomeiR-MMU-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
12905, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cradd, mouse

Protein Ontology

More...
PROi
PR:O88843
RNActiO88843, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045867, Expressed in adult mammalian kidney and 208 other tissues
GenevisibleiO88843, MM

Family and domain databases

CDDicd08327, CARD_RAIDD, 1 hit
cd08319, Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR042148, CARD_RAIDD
IPR037939, CRADD
IPR037926, CRADD_Death
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
PANTHERiPTHR15034, PTHR15034, 2 hits
PfamiView protein in Pfam
PF00619, CARD, 1 hit
PF00531, Death, 1 hit
SMARTiView protein in SMART
SM00114, CARD, 1 hit
SM00005, DEATH, 1 hit
SUPFAMiSSF47986, SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit
PS50017, DEATH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRADD_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88843
Secondary accession number(s): Q9QUN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: August 12, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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