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Protein

FYVE, RhoGEF and PH domain-containing protein 3

Gene

Fgd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri528 – 584FYVE-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

  • filopodium assembly Source: UniProtKB
  • regulation of Rho protein signal transduction Source: InterPro

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 3
Gene namesi
Name:Fgd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1353657 Fgd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809451 – 733FYVE, RhoGEF and PH domain-containing protein 3Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1
Modified residuei732PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88842
MaxQBiO88842
PaxDbiO88842
PeptideAtlasiO88842
PRIDEiO88842

PTM databases

iPTMnetiO88842
PhosphoSitePlusiO88842

Expressioni

Tissue specificityi

Detected in adult brain, spleen, lung and skeletal muscle. Detected in embryos from E7 to E17.1 Publication

Gene expression databases

CleanExiMM_FGD3

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048692

Structurei

3D structure databases

ProteinModelPortaliO88842
SMRiO88842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 337DHPROSITE-ProRule annotationAdd BLAST185
Domaini366 – 465PH 1PROSITE-ProRule annotationAdd BLAST100
Domaini612 – 711PH 2PROSITE-ProRule annotationAdd BLAST100

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri528 – 584FYVE-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
HOGENOMiHOG000220866
HOVERGENiHBG007506
InParanoidiO88842
PhylomeDBiO88842

Family and domain databases

CDDicd13236 PH2_FGD1-4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035941 FGD1-4_PH2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88842-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELGRSSSTP QEEAISPLGV LGTGPSSSPL GKLQALPIGP GAHRGAHSSS
60 70 80 90 100
APAGDSSTRE PSGAMKIPNR DSGIDSPSSS VASENFPCEE SSEGSPSPAI
110 120 130 140 150
LGLPSETASD SRVPQDNPQE EEDSGVGEEP DPKVTLFRPQ EDVSLTQCSD
160 170 180 190 200
PQKLLHIAQE LLHTEEAYVK RLHLLDQVFC TKLTEAGIPL EVTTGIFSNI
210 220 230 240 250
SSIYRFHGQF LLPELQKRIT EEWDTNPRLG DILQKLAPFL KMYGEYVKNF
260 270 280 290 300
DRAMGLVSTW TQRSPQFKDV IHTIQKQEVC GNLTLQHHML EPVQRVPRYE
310 320 330 340 350
LLLKDYLKRL PRDAPDRKDA ERSLELISTA ADHSNAAIRK MEKMHKLLEV
360 370 380 390 400
YEQLGGEEDI VNPANELIKE GSIQKLSAKN GTTQDRHLFL FNNVMLYCVP
410 420 430 440 450
KLRLMGQKLS VREKMDISDL QVQDIVKPNA ACTFIITGRK RSLELQTRTE
460 470 480 490 500
EEKKEWIQVI QATVEKHKQK SETFRAFGGA CSQDEEPTLS PDQPVMSTSS
510 520 530 540 550
VEPAGVADSN GGTPGIESRK SSSKTRRDKE KPGCKSCGET FNSITKRRYR
560 570 580 590 600
CKLCGEVICR KCSEFKAENS KQSRVCRECF LEEPLVPPSP SSETPTELKQ
610 620 630 640 650
NAEKPPSVDP RPSLLCGTLN LSDDGTTWNE VWAAIPESDP QVLDLLAGSQ
660 670 680 690 700
AGRLLYSIPL SGCNITMPDP EEGLEAGCAW KLHQGSQTWW LSAPSTKLQQ
710 720 730
CWLKALGTAV HGDTAGDRPG ASQPQAPAGT DTP
Length:733
Mass (Da):80,624
Last modified:November 1, 1998 - v1
Checksum:i86CDFEBB5DC1E8E3
GO
Isoform 2 (identifier: O88842-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-532: IESRKSSSKTRRDKEKP → VSDPHPGISRSERCLGR
     533-733: Missing.

Note: No experimental confirmation available.
Show »
Length:532
Mass (Da):58,758
Checksum:i5BAA48BA0DCA02FE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TNB8Q3TNB8_MOUSE
FYVE, RhoGEF and PH domain containi...
Fgd3 mCG_15640
733Annotation score:
A0A0R4J1D9A0A0R4J1D9_MOUSE
FYVE, RhoGEF and PH domain-containi...
Fgd3
532Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7S → P in BAC34624 (PubMed:16141072).Curated1
Sequence conflicti126V → M in BAC34624 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013076516 – 532IESRK…DKEKP → VSDPHPGISRSERCLGR in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_013077533 – 733Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017369 mRNA Translation: AAC35431.1
AK051395 mRNA Translation: BAC34624.1
BC132340 mRNA Translation: AAI32341.1
BC137954 mRNA Translation: AAI37955.1
CCDSiCCDS26499.1 [O88842-1]
UniGeneiMm.291089

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017369 mRNA Translation: AAC35431.1
AK051395 mRNA Translation: BAC34624.1
BC132340 mRNA Translation: AAI32341.1
BC137954 mRNA Translation: AAI37955.1
CCDSiCCDS26499.1 [O88842-1]
UniGeneiMm.291089

3D structure databases

ProteinModelPortaliO88842
SMRiO88842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048692

PTM databases

iPTMnetiO88842
PhosphoSitePlusiO88842

Proteomic databases

EPDiO88842
MaxQBiO88842
PaxDbiO88842
PeptideAtlasiO88842
PRIDEiO88842

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1353657 Fgd3

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
HOGENOMiHOG000220866
HOVERGENiHBG007506
InParanoidiO88842
PhylomeDBiO88842

Miscellaneous databases

PROiPR:O88842
SOURCEiSearch...

Gene expression databases

CleanExiMM_FGD3

Family and domain databases

CDDicd13236 PH2_FGD1-4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035941 FGD1-4_PH2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGD3_MOUSE
AccessioniPrimary (citable) accession number: O88842
Secondary accession number(s): A2RT26, Q8BQ72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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