UniProtKB - O88839 (ADA15_MOUSE)
Protein
Disintegrin and metalloproteinase domain-containing protein 15
Gene
Adam15
Organism
Mus musculus (Mouse)
Status
Functioni
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg.By similarity4 Publications
Miscellaneous
Mice targeted for deletion of the first 27 amino acids of the ADAM15 N-terminal sequence are viable and fertile, showing no major developmental defects and displaying normal mortality or morbidity. These mutant mice, however, exhibit significantly reduced ischemia-induced retinal neovascularization, choroidal neovascularization at rupture sites in Bruch's membrane, and VEGF-induced subretinal neovascularization, and develop significantly smaller tumors following implantation of B16F0 melanoma cells. Aging mutant mice exhibit accelerated development of osteoarthritic lesions in knee joints.
Cofactori
Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 179 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 349 | Zinc; catalyticSequence analysis | 1 | |
Active sitei | 350 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 353 | Zinc; catalyticSequence analysis | 1 | |
Metal bindingi | 359 | Zinc; catalyticSequence analysis | 1 |
GO - Molecular functioni
- integrin binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: MGI
- SH3 domain binding Source: MGI
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- cardiac epithelial to mesenchymal transition Source: MGI
- cell adhesion Source: UniProtKB-KW
- cellular response to phorbol 13-acetate 12-myristate Source: MGI
- collagen catabolic process Source: UniProtKB-KW
- immune response to tumor cell Source: MGI
- innate immune response Source: MGI
- integrin-mediated signaling pathway Source: MGI
- male gonad development Source: Ensembl
- negative regulation of cell growth Source: MGI
- negative regulation of cell-matrix adhesion Source: MGI
- negative regulation of cell migration Source: MGI
- negative regulation of receptor binding Source: MGI
- response to hypobaric hypoxia Source: Ensembl
- tissue regeneration Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Biological process | Angiogenesis, Cell adhesion, Collagen degradation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1474228 Degradation of the extracellular matrix R-MMU-8941237 Invadopodia formation |
Protein family/group databases
MEROPSi | M12.215 |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin and metalloproteinase domain-containing protein 15 (EC:3.4.24.-)Short name: ADAM 15 Alternative name(s): AD56 Metalloprotease RGD disintegrin protein Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 Short name: MDC-15 Metargidin |
Gene namesi | Name:Adam15 Synonyms:Mdc15 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333882 Adam15 |
Subcellular locationi
Other locations
- Endomembrane system 1 Publication; Single-pass type I membrane protein 1 Publication
- adherens junction By similarity
- flagellum 1 Publication
- acrosome 1 Publication
Note: The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.
Extracellular region or secreted
- extracellular exosome Source: MGI
- extracellular space Source: BHF-UCL
Other locations
- acrosomal vesicle Source: UniProtKB-SubCell
- adherens junction Source: UniProtKB-SubCell
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
- motile cilium Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 208 – 696 | ExtracellularSequence analysisAdd BLAST | 489 | |
Transmembranei | 697 – 717 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 718 – 864 | CytoplasmicSequence analysisAdd BLAST | 147 |
Keywords - Cellular componenti
Cell junction, Cell projection, Cilium, Cytoplasmic vesicle, Flagellum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 482 | R → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication | 1 | |
Mutagenesisi | 489 | D → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication | 1 | |
Mutagenesisi | 490 | L → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication | 1 | |
Mutagenesisi | 491 | P → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication | 1 | |
Mutagenesisi | 492 | E → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication | 1 | |
Mutagenesisi | 493 | F → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000029084 | 18 – 207 | CuratedAdd BLAST | 190 | |
ChainiPRO_0000029085 | 208 – 864 | Disintegrin and metalloproteinase domain-containing protein 15Add BLAST | 657 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 238 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 324 ↔ 410 | By similarity | ||
Disulfide bondi | 366 ↔ 394 | By similarity | ||
Disulfide bondi | 368 ↔ 377 | By similarity | ||
Glycosylationi | 390 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 393 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 481 ↔ 501 | By similarity | ||
Glycosylationi | 607 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 612 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 658 ↔ 668 | By similarity | ||
Disulfide bondi | 662 ↔ 674 | By similarity | ||
Disulfide bondi | 676 ↔ 685 | By similarity | ||
Modified residuei | 716 | Phosphotyrosine; by HCK and LCKBy similarity | 1 | |
Modified residuei | 736 | Phosphotyrosine; by HCK and LCKBy similarity | 1 |
Post-translational modificationi
The precursor is cleaved by a furin endopeptidase. An additional membrane proximal site of cleavage affects a small percentage of the proteins and results in disulfide-linked fragments. The prodomain is apparently cleaved in several positions that are N-terminal of the furin cleavage site.1 Publication
May be partially sialylated.
Phosphorylation increases association with PTKs.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 289 – 290 | Cleavage; by furinSequence analysis | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
MaxQBi | O88839 |
PaxDbi | O88839 |
PeptideAtlasi | O88839 |
PRIDEi | O88839 |
PTM databases
iPTMneti | O88839 |
PhosphoSitePlusi | O88839 |
SwissPalmi | O88839 |
Expressioni
Tissue specificityi
Expressed moderately in pericytes of retina. Expressed in testis and in spermatozoa from the caput, corpus, and cauda epididymis, as well as in non-capacitated and acrosome-reacted sperm (at protein level). Highly expressed in heart, brain, lung, and kidney. Expressed at lower levels in spleen, liver, testis and muscle.2 Publications
Developmental stagei
At 13.5 dpc, strongly expressed in the developing vasculature of the endocardium. At P17, expressed throughout the retina (at protein level). At 9.5 dpc and thereafter, prominently expressed in the vasculature, including in ventral and dorsal aorta and the caudal artery. In developing heart, detected in endocardium and blood vessels of the ventricle, bulbus arteriosus, and atrium. Also highly expressed in hypertrophic cells of the developing bone. In adult, expressed prominently in brain, including in hippocampus, cerebellum, pons, thalamus, cortex, and olfactory bulb.2 Publications
Inductioni
By hypoxic stimulus in retina (at protein level). Up-regulated by VEGF in retina.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000028041 Expressed in 240 organ(s), highest expression level in bone marrow macrophage |
Genevisiblei | O88839 MM |
Interactioni
Subunit structurei
Interacts specifically with Src family protein-tyrosine kinases (PTKs) (By similarity). Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1. Interacts with SH3PXD2A (By similarity). Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC (By similarity).By similarity
GO - Molecular functioni
- integrin binding Source: MGI
- SH3 domain binding Source: MGI
Protein-protein interaction databases
IntActi | O88839, 3 interactors |
MINTi | O88839 |
STRINGi | 10090.ENSMUSP00000029676 |
Structurei
3D structure databases
ProteinModelPortali | O88839 |
SMRi | O88839 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 214 – 415 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 202 | |
Domaini | 422 – 509 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 658 – 686 | EGF-likePROSITE-ProRule annotationAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 177 – 184 | Cysteine switchBy similarity | 8 | |
Motifi | 816 – 822 | SH3-bindingSequence analysis | 7 | |
Motifi | 851 – 857 | SH3-bindingSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 510 – 657 | Cys-richAdd BLAST | 148 | |
Compositional biasi | 699 – 712 | Poly-LeuAdd BLAST | 14 |
Domaini
The cytoplasmic domain is required for SH3GL2- and SNX9-binding.
Disintegrin domain binds to integrin alphaV-beta3.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Keywords - Domaini
EGF-like domain, SH3-binding, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3607 Eukaryota ENOG410XX2M LUCA |
GeneTreei | ENSGT00940000159822 |
HOVERGENi | HBG006978 |
InParanoidi | O88839 |
KOi | K06836 |
OMAi | ADHQEFL |
OrthoDBi | 162519at2759 |
PhylomeDBi | O88839 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269 ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR033605 ADAM15 IPR006586 ADAM_Cys-rich IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B IPR002870 Peptidase_M12B_N IPR034027 Reprolysin_adamalysin |
PANTHERi | PTHR11905:SF130 PTHR11905:SF130, 1 hit |
Pfami | View protein in Pfam PF08516 ADAM_CR, 1 hit PF00200 Disintegrin, 1 hit PF01562 Pep_M12B_propep, 1 hit PF01421 Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00608 ACR, 1 hit SM00050 DISIN, 1 hit |
SUPFAMi | SSF57552 SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit PS50214 DISINTEGRIN_2, 1 hit PS01186 EGF_2, 1 hit PS50026 EGF_3, 1 hit PS00142 ZINC_PROTEASE, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O88839-1) [UniParc]FASTAAdd to basket
Also known as: ADAM15v2
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRLALLWALG LLGAGSPRPS PPLPNIGGTE EEQQASPERT LSGSMESRVV
60 70 80 90 100
QDSPPMSLAD VLQTGLPEAL RISLELDSES HVLELLQNRD LIPGRPTLVW
110 120 130 140 150
YQPDGTRMVS EGYSLENCCY RGRVQGHPSS WVSLCACSGI RGLIVLSPER
160 170 180 190 200
GYTLELGPGD LQRPVISRIQ DHLLLGHTCA PSWHASVPTR AGPDLLLEQH
210 220 230 240 250
HAHRLKRDVV TETKIVELVI VADNSEVRKY PDFQQLLNRT LEAALLLDTF
260 270 280 290 300
FQPLNVRVAL VGLEAWTQHN LIEMSSNPAV LLDNFLRWRR TDLLPRLPHD
310 320 330 340 350
SAQLVTVTSF SGPMVGMAIQ NSICSPDFSG GVNMDHSTSI LGVASSIAHE
360 370 380 390 400
LGHSLGLDHD SPGHSCPCPG PAPAKSCIME ASTDFLPGLN FSNCSRQALE
410 420 430 440 450
KALLEGMGSC LFERQPSLAP MSSLCGNMFV DPGEQCDCGF PDECTDPCCD
460 470 480 490 500
HFTCQLRPGA QCASDGPCCQ NCKLHPAGWL CRPPTDDCDL PEFCPGDSSQ
510 520 530 540 550
CPSDIRLGDG EPCASGEAVC MHGRCASYAR QCQSLWGPGA QPAAPLCLQT
560 570 580 590 600
ANTRGNAFGS CGRSPGGSYM PCAPRDVMCG QLQCQWGRSQ PLLGSVQDRL
610 620 630 640 650
SEVLEANGTQ LNCSWVDLDL GNDVAQPLLA LPGTACGPGL VCIGHRCQPV
660 670 680 690 700
DLLGAQECRR KCHGHGVCDS SGHCRCEEGW APPDCMTQLK ATSSLTTGLL
710 720 730 740 750
LSLLLLLVLV LLGASYWHRA RLHQRLCQLK GSSCQYRAPQ SCPPERPGPP
760 770 780 790 800
QRAQQMTGTK QASVVSFPVP PSRPLPPNPV PKKLQAALAD RSNPPTRPLP
810 820 830 840 850
ADPVVRRPKS QGPTKPPPPR KPLPANPQGQ HPPGDLPGPG DGSLPLVVPS
860
RPAPPPPAAS SLYL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 – 22 | PP → RR in BAA88903 (PubMed:13679040).Curated | 2 | |
Sequence conflicti | 51 | Q → H in BAE29090 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 73 | S → P in BAE41564 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 443 | E → Q in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 459 | G → E in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 564 – 565 | SP → T in BAA88903 (PubMed:13679040).Curated | 2 | |
Sequence conflicti | 654 | G → E in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 660 | R → S in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 703 | L → R in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 712 | L → R in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 729 | L → R in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 830 | Q → R in BAE41564 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 846 | L → S in BAA88903 (PubMed:13679040).Curated | 1 | |
Sequence conflicti | 852 – 854 | PAP → AAS in BAA88903 (PubMed:13679040).Curated | 3 | |
Sequence conflicti | 859 | A → P in BAA88903 (PubMed:13679040).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008879 | 415 – 830 | Missing in isoform 4. 1 PublicationAdd BLAST | 416 | |
Alternative sequenceiVSP_008881 | 761 – 809 | Missing in isoform 3. 2 PublicationsAdd BLAST | 49 | |
Alternative sequenceiVSP_008880 | 761 – 785 | Missing in isoform 2. CuratedAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006196 mRNA Translation: AAC61896.1 AB022089 Genomic DNA Translation: BAA88903.1 AK048901 mRNA Translation: BAC33485.1 AK149796 mRNA Translation: BAE29090.1 AK151804 mRNA Translation: BAE30703.1 AK152725 mRNA Translation: BAE31447.1 AK170101 mRNA Translation: BAE41564.1 BC009132 mRNA Translation: AAH09132.1 EF506571 mRNA Translation: ABP73662.1 |
CCDSi | CCDS17502.1 [O88839-1] CCDS17503.1 [O88839-3] |
RefSeqi | NP_001032811.2, NM_001037722.3 [O88839-1] NP_033744.1, NM_009614.3 [O88839-3] XP_006500981.1, XM_006500918.1 [O88839-2] |
UniGenei | Mm.274049 Mm.470104 |
Genome annotation databases
Ensembli | ENSMUST00000029676; ENSMUSP00000029676; ENSMUSG00000028041 [O88839-1] ENSMUST00000074582; ENSMUSP00000074167; ENSMUSG00000028041 [O88839-3] ENSMUST00000107446; ENSMUSP00000103070; ENSMUSG00000028041 [O88839-4] ENSMUST00000107448; ENSMUSP00000103072; ENSMUSG00000028041 [O88839-2] ENSMUST00000184651; ENSMUSP00000139147; ENSMUSG00000028041 [O88839-1] |
GeneIDi | 11490 |
KEGGi | mmu:11490 |
UCSCi | uc008pyv.1 mouse [O88839-1] uc008pyw.1 mouse [O88839-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006196 mRNA Translation: AAC61896.1 AB022089 Genomic DNA Translation: BAA88903.1 AK048901 mRNA Translation: BAC33485.1 AK149796 mRNA Translation: BAE29090.1 AK151804 mRNA Translation: BAE30703.1 AK152725 mRNA Translation: BAE31447.1 AK170101 mRNA Translation: BAE41564.1 BC009132 mRNA Translation: AAH09132.1 EF506571 mRNA Translation: ABP73662.1 |
CCDSi | CCDS17502.1 [O88839-1] CCDS17503.1 [O88839-3] |
RefSeqi | NP_001032811.2, NM_001037722.3 [O88839-1] NP_033744.1, NM_009614.3 [O88839-3] XP_006500981.1, XM_006500918.1 [O88839-2] |
UniGenei | Mm.274049 Mm.470104 |
3D structure databases
ProteinModelPortali | O88839 |
SMRi | O88839 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | O88839, 3 interactors |
MINTi | O88839 |
STRINGi | 10090.ENSMUSP00000029676 |
Protein family/group databases
MEROPSi | M12.215 |
PTM databases
iPTMneti | O88839 |
PhosphoSitePlusi | O88839 |
SwissPalmi | O88839 |
Proteomic databases
MaxQBi | O88839 |
PaxDbi | O88839 |
PeptideAtlasi | O88839 |
PRIDEi | O88839 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 8751 |
MGIi | MGI:1333882 Adam15 |
Phylogenomic databases
eggNOGi | KOG3607 Eukaryota ENOG410XX2M LUCA |
GeneTreei | ENSGT00940000159822 |
HOVERGENi | HBG006978 |
InParanoidi | O88839 |
KOi | K06836 |
OMAi | ADHQEFL |
OrthoDBi | 162519at2759 |
PhylomeDBi | O88839 |
TreeFami | TF314733 |
Enzyme and pathway databases
Reactomei | R-MMU-1474228 Degradation of the extracellular matrix R-MMU-8941237 Invadopodia formation |
Miscellaneous databases
PROi | PR:O88839 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028041 Expressed in 240 organ(s), highest expression level in bone marrow macrophage |
Genevisiblei | O88839 MM |
Family and domain databases
CDDi | cd04269 ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR033605 ADAM15 IPR006586 ADAM_Cys-rich IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B IPR002870 Peptidase_M12B_N IPR034027 Reprolysin_adamalysin |
PANTHERi | PTHR11905:SF130 PTHR11905:SF130, 1 hit |
Pfami | View protein in Pfam PF08516 ADAM_CR, 1 hit PF00200 Disintegrin, 1 hit PF01562 Pep_M12B_propep, 1 hit PF01421 Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00608 ACR, 1 hit SM00050 DISIN, 1 hit |
SUPFAMi | SSF57552 SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit PS50214 DISINTEGRIN_2, 1 hit PS01186 EGF_2, 1 hit PS50026 EGF_3, 1 hit PS00142 ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ADA15_MOUSE | |
Accessioni | O88839Primary (citable) accession number: O88839 Secondary accession number(s): A4ZYV2 Q9QYL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | November 14, 2003 | |
Last modified: | February 13, 2019 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot