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UniProtKB - O88839 (ADA15_MOUSE)

Protein

Disintegrin and metalloproteinase domain-containing protein 15

Gene

Adam15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg.By similarity4 Publications

Miscellaneous

Mice targeted for deletion of the first 27 amino acids of the ADAM15 N-terminal sequence are viable and fertile, showing no major developmental defects and displaying normal mortality or morbidity. These mutant mice, however, exhibit significantly reduced ischemia-induced retinal neovascularization, choroidal neovascularization at rupture sites in Bruch's membrane, and VEGF-induced subretinal neovascularization, and develop significantly smaller tumors following implantation of B16F0 melanoma cells. Aging mutant mice exhibit accelerated development of osteoarthritic lesions in knee joints.

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi179Zinc; in inhibited formBy similarity1
Metal bindingi349Zinc; catalyticSequence analysis1
Active sitei350PROSITE-ProRule annotation1
Metal bindingi353Zinc; catalyticSequence analysis1
Metal bindingi359Zinc; catalyticSequence analysis1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processAngiogenesis, Cell adhesion, Collagen degradation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-8941237 Invadopodia formation

Protein family/group databases

MEROPSiM12.215

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 15 (EC:3.4.24.-)
Short name:
ADAM 15
Alternative name(s):
AD56
Metalloprotease RGD disintegrin protein
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Short name:
MDC-15
Metargidin
Gene namesi
Name:Adam15
Synonyms:Mdc15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1333882 Adam15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini208 – 696ExtracellularSequence analysisAdd BLAST489
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 864CytoplasmicSequence analysisAdd BLAST147

Keywords - Cellular componenti

Cell junction, Cell projection, Cilium, Cytoplasmic vesicle, Flagellum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi482R → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication1
Mutagenesisi489D → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication1
Mutagenesisi490L → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication1
Mutagenesisi491P → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication1
Mutagenesisi492E → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication1
Mutagenesisi493F → A: Reduced binding to CHO cells expressing ITAG9-ITGB1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002908418 – 207CuratedAdd BLAST190
ChainiPRO_0000029085208 – 864Disintegrin and metalloproteinase domain-containing protein 15Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 410By similarity
Disulfide bondi366 ↔ 394By similarity
Disulfide bondi368 ↔ 377By similarity
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi481 ↔ 501By similarity
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi658 ↔ 668By similarity
Disulfide bondi662 ↔ 674By similarity
Disulfide bondi676 ↔ 685By similarity
Modified residuei716Phosphotyrosine; by HCK and LCKBy similarity1
Modified residuei736Phosphotyrosine; by HCK and LCKBy similarity1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase. An additional membrane proximal site of cleavage affects a small percentage of the proteins and results in disulfide-linked fragments. The prodomain is apparently cleaved in several positions that are N-terminal of the furin cleavage site.1 Publication
May be partially sialylated.
Phosphorylation increases association with PTKs.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei289 – 290Cleavage; by furinSequence analysis2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

MaxQBiO88839
PaxDbiO88839
PeptideAtlasiO88839
PRIDEiO88839

PTM databases

iPTMnetiO88839
PhosphoSitePlusiO88839
SwissPalmiO88839

Expressioni

Tissue specificityi

Expressed moderately in pericytes of retina. Expressed in testis and in spermatozoa from the caput, corpus, and cauda epididymis, as well as in non-capacitated and acrosome-reacted sperm (at protein level). Highly expressed in heart, brain, lung, and kidney. Expressed at lower levels in spleen, liver, testis and muscle.2 Publications

Developmental stagei

At E13.5, strongly expressed in the developing vasculature of the endocardium. At P17, expressed throughout the retina (at protein level). At E9.5 and thereafter, prominently expressed in the vasculature, including in ventral and dorsal aorta and the caudal artery. In developing heart, detected in endocardium and blood vessels of the ventricle, bulbus arteriosus, and atrium. Also highly expressed in hypertrophic cells of the developing bone. In adult, expressed prominently in brain, including in hippocampus, cerebellum, pons, thalamus, cortex, and olfactory bulb.2 Publications

Inductioni

By hypoxic stimulus in retina (at protein level). Up-regulated by VEGF in retina.2 Publications

Gene expression databases

BgeeiENSMUSG00000028041 Expressed in 240 organ(s), highest expression level in bone marrow macrophage
GenevisibleiO88839 MM

Interactioni

Subunit structurei

Interacts specifically with Src family protein-tyrosine kinases (PTKs) (By similarity). Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1. Interacts with SH3PXD2A (By similarity). Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActiO88839, 3 interactors
MINTiO88839
STRINGi10090.ENSMUSP00000029676

Structurei

3D structure databases

ProteinModelPortaliO88839
SMRiO88839
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 415Peptidase M12BPROSITE-ProRule annotationAdd BLAST202
Domaini422 – 509DisintegrinPROSITE-ProRule annotationAdd BLAST88
Domaini658 – 686EGF-likePROSITE-ProRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi177 – 184Cysteine switchBy similarity8
Motifi816 – 822SH3-bindingSequence analysis7
Motifi851 – 857SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi510 – 657Cys-richAdd BLAST148
Compositional biasi699 – 712Poly-LeuAdd BLAST14

Domaini

The cytoplasmic domain is required for SH3GL2- and SNX9-binding.
Disintegrin domain binds to integrin alphaV-beta3.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Keywords - Domaini

EGF-like domain, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOVERGENiHBG006978
InParanoidiO88839
KOiK06836
OMAiADHQEFL
OrthoDBiEOG091G01NX
PhylomeDBiO88839
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033605 ADAM15
IPR006586 ADAM_Cys-rich
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF130 PTHR11905:SF130, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O88839-1) [UniParc]FASTAAdd to basket
Also known as: ADAM15v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLALLWALG LLGAGSPRPS PPLPNIGGTE EEQQASPERT LSGSMESRVV 
        60         70         80         90        100
QDSPPMSLAD VLQTGLPEAL RISLELDSES HVLELLQNRD LIPGRPTLVW 
       110        120        130        140        150
YQPDGTRMVS EGYSLENCCY RGRVQGHPSS WVSLCACSGI RGLIVLSPER 
       160        170        180        190        200
GYTLELGPGD LQRPVISRIQ DHLLLGHTCA PSWHASVPTR AGPDLLLEQH 
       210        220        230        240        250
HAHRLKRDVV TETKIVELVI VADNSEVRKY PDFQQLLNRT LEAALLLDTF 
       260        270        280        290        300
FQPLNVRVAL VGLEAWTQHN LIEMSSNPAV LLDNFLRWRR TDLLPRLPHD 
       310        320        330        340        350
SAQLVTVTSF SGPMVGMAIQ NSICSPDFSG GVNMDHSTSI LGVASSIAHE 
       360        370        380        390        400
LGHSLGLDHD SPGHSCPCPG PAPAKSCIME ASTDFLPGLN FSNCSRQALE 
       410        420        430        440        450
KALLEGMGSC LFERQPSLAP MSSLCGNMFV DPGEQCDCGF PDECTDPCCD 
       460        470        480        490        500
HFTCQLRPGA QCASDGPCCQ NCKLHPAGWL CRPPTDDCDL PEFCPGDSSQ 
       510        520        530        540        550
CPSDIRLGDG EPCASGEAVC MHGRCASYAR QCQSLWGPGA QPAAPLCLQT 
       560        570        580        590        600
ANTRGNAFGS CGRSPGGSYM PCAPRDVMCG QLQCQWGRSQ PLLGSVQDRL 
       610        620        630        640        650
SEVLEANGTQ LNCSWVDLDL GNDVAQPLLA LPGTACGPGL VCIGHRCQPV 
       660        670        680        690        700
DLLGAQECRR KCHGHGVCDS SGHCRCEEGW APPDCMTQLK ATSSLTTGLL 
       710        720        730        740        750
LSLLLLLVLV LLGASYWHRA RLHQRLCQLK GSSCQYRAPQ SCPPERPGPP 
       760        770        780        790        800
QRAQQMTGTK QASVVSFPVP PSRPLPPNPV PKKLQAALAD RSNPPTRPLP 
       810        820        830        840        850
ADPVVRRPKS QGPTKPPPPR KPLPANPQGQ HPPGDLPGPG DGSLPLVVPS 
       860 
RPAPPPPAAS SLYL
Length:864
Mass (Da):92,664
Last modified:November 14, 2003 - v2
Checksum:iB1CBEB923463BB15
GO
Isoform 2 (identifier: O88839-2) [UniParc]FASTAAdd to basket
Also known as: ADAM15v1

The sequence of this isoform differs from the canonical sequence as follows:
     761-785: Missing.

Show »
Length:839
Mass (Da):90,002
Checksum:i0C61FAA9B79B8123
GO
Isoform 3 (identifier: O88839-3) [UniParc]FASTAAdd to basket
Also known as: ADAM15

The sequence of this isoform differs from the canonical sequence as follows:
     761-809: Missing.

Show »
Length:815
Mass (Da):87,425
Checksum:iC064BD3B7347D19B
GO
Isoform 4 (identifier: O88839-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-830: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):48,417
Checksum:i37FEB93BD3704400
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21 – 22PP → RR in BAA88903 (PubMed:13679040).Curated2
Sequence conflicti51Q → H in BAE29090 (PubMed:16141072).Curated1
Sequence conflicti73S → P in BAE41564 (PubMed:16141072).Curated1
Sequence conflicti443E → Q in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti459G → E in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti564 – 565SP → T in BAA88903 (PubMed:13679040).Curated2
Sequence conflicti654G → E in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti660R → S in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti703L → R in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti712L → R in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti729L → R in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti830Q → R in BAE41564 (PubMed:16141072).Curated1
Sequence conflicti846L → S in BAA88903 (PubMed:13679040).Curated1
Sequence conflicti852 – 854PAP → AAS in BAA88903 (PubMed:13679040).Curated3
Sequence conflicti859A → P in BAA88903 (PubMed:13679040).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008879415 – 830Missing in isoform 4. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_008881761 – 809Missing in isoform 3. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_008880761 – 785Missing in isoform 2. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006196 mRNA Translation: AAC61896.1
AB022089 Genomic DNA Translation: BAA88903.1
AK048901 mRNA Translation: BAC33485.1
AK149796 mRNA Translation: BAE29090.1
AK151804 mRNA Translation: BAE30703.1
AK152725 mRNA Translation: BAE31447.1
AK170101 mRNA Translation: BAE41564.1
BC009132 mRNA Translation: AAH09132.1
EF506571 mRNA Translation: ABP73662.1
CCDSiCCDS17502.1 [O88839-1]
CCDS17503.1 [O88839-3]
RefSeqiNP_001032811.2, NM_001037722.3 [O88839-1]
NP_033744.1, NM_009614.3 [O88839-3]
XP_006500981.1, XM_006500918.1 [O88839-2]
UniGeneiMm.274049
Mm.470104

Genome annotation databases

EnsembliENSMUST00000029676; ENSMUSP00000029676; ENSMUSG00000028041 [O88839-1]
ENSMUST00000074582; ENSMUSP00000074167; ENSMUSG00000028041 [O88839-3]
ENSMUST00000107446; ENSMUSP00000103070; ENSMUSG00000028041 [O88839-4]
ENSMUST00000107448; ENSMUSP00000103072; ENSMUSG00000028041 [O88839-2]
ENSMUST00000184651; ENSMUSP00000139147; ENSMUSG00000028041 [O88839-1]
GeneIDi11490
KEGGimmu:11490
UCSCiuc008pyv.1 mouse [O88839-1]
uc008pyw.1 mouse [O88839-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006196 mRNA Translation: AAC61896.1
AB022089 Genomic DNA Translation: BAA88903.1
AK048901 mRNA Translation: BAC33485.1
AK149796 mRNA Translation: BAE29090.1
AK151804 mRNA Translation: BAE30703.1
AK152725 mRNA Translation: BAE31447.1
AK170101 mRNA Translation: BAE41564.1
BC009132 mRNA Translation: AAH09132.1
EF506571 mRNA Translation: ABP73662.1
CCDSiCCDS17502.1 [O88839-1]
CCDS17503.1 [O88839-3]
RefSeqiNP_001032811.2, NM_001037722.3 [O88839-1]
NP_033744.1, NM_009614.3 [O88839-3]
XP_006500981.1, XM_006500918.1 [O88839-2]
UniGeneiMm.274049
Mm.470104

3D structure databases

ProteinModelPortaliO88839
SMRiO88839
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88839, 3 interactors
MINTiO88839
STRINGi10090.ENSMUSP00000029676

Protein family/group databases

MEROPSiM12.215

PTM databases

iPTMnetiO88839
PhosphoSitePlusiO88839
SwissPalmiO88839

Proteomic databases

MaxQBiO88839
PaxDbiO88839
PeptideAtlasiO88839
PRIDEiO88839

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029676; ENSMUSP00000029676; ENSMUSG00000028041 [O88839-1]
ENSMUST00000074582; ENSMUSP00000074167; ENSMUSG00000028041 [O88839-3]
ENSMUST00000107446; ENSMUSP00000103070; ENSMUSG00000028041 [O88839-4]
ENSMUST00000107448; ENSMUSP00000103072; ENSMUSG00000028041 [O88839-2]
ENSMUST00000184651; ENSMUSP00000139147; ENSMUSG00000028041 [O88839-1]
GeneIDi11490
KEGGimmu:11490
UCSCiuc008pyv.1 mouse [O88839-1]
uc008pyw.1 mouse [O88839-3]

Organism-specific databases

CTDi8751
MGIiMGI:1333882 Adam15

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOVERGENiHBG006978
InParanoidiO88839
KOiK06836
OMAiADHQEFL
OrthoDBiEOG091G01NX
PhylomeDBiO88839
TreeFamiTF314733

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-8941237 Invadopodia formation

Miscellaneous databases

PROiPR:O88839
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028041 Expressed in 240 organ(s), highest expression level in bone marrow macrophage
GenevisibleiO88839 MM

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033605 ADAM15
IPR006586 ADAM_Cys-rich
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF130 PTHR11905:SF130, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA15_MOUSE
AccessioniPrimary (citable) accession number: O88839
Secondary accession number(s): A4ZYV2
, Q3TDN7, Q3U7C2, Q3UE21, Q8C7Z0, Q91VS9, Q9QYL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 14, 2003
Last modified: November 7, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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