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Protein

Cytochrome P450 4A10

Gene

Cyp4a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Curated

Catalytic activityi

A long-chain fatty acid + NADPH + O2 = an omega-hydroxy-long-chain fatty acid + NADP+ + H2O.By similarity
A long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei320Heme (covalent; via 1 link)By similarity1
Metal bindingi456Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211979 Eicosanoids
R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Chemistry databases

SwissLipidsiSLP:000000399

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A10
Alternative name(s):
CYPIVA10
Cytochrome P450-LA-omega 1
Cytochrome P452
Lauric acid omega-hydroxylase
Long-chain fatty acid omega-monooxygenase (EC:1.14.14.80By similarity)
Gene namesi
Name:Cyp4a10Imported
Synonyms:Cyp4a-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88611 Cyp4a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518151 – 509Cytochrome P450 4A10Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei439PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88833
PaxDbiO88833
PRIDEiO88833

PTM databases

iPTMnetiO88833
PhosphoSitePlusiO88833

Expressioni

Gene expression databases

BgeeiENSMUSG00000066072 Expressed in 55 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO88833 baseline and differential
GenevisibleiO88833 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061126

Structurei

3D structure databases

ProteinModelPortaliO88833
SMRiO88833
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiO88833
KOiK07425
OMAiYEKPWQS
OrthoDBiEOG091G06KN
TreeFamiTF105088

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSALSPTR FADSLSGFLQ VASVLGLLLL LVKAVQFYLH RQWLLKAFQQ
60 70 80 90 100
FPSPPFHWFF GHEKFKGDQE LQEIVSCIEN FPSAFPRWFW GSKAYLTVYD
110 120 130 140 150
PDYMKVILGR SDPKANGAYR LLAPWIGYGL LLLNGQPWFQ HRRMLTPAFH
160 170 180 190 200
YDILKPYVKN MADSIRLMLD KWERLADQDS SIEIFQHISL MTLDTVMKCA
210 220 230 240 250
FSHKGSVQVD GNYRTYLQAI GDLNNLFHSR VRNIFHQNDT IYKLSSNGRL
260 270 280 290 300
AKQACQLAHD HTDGVIKLRK DQLQDEGELE KIKKKRRLDF LDILLFARME
310 320 330 340 350
NGDSMSDKDL RAEVDTFMFE GHDTTASGVS WIFYALATHP DHQQRCREEV
360 370 380 390 400
QSLLGDGSSI TWDHLDQIPY TTMCIKEALR LYPPVPGIVR ELSTSVTFPD
410 420 430 440 450
GRSLPKGVQV TLSIYGLHHN PKVWPNPEVF DPSRFAPDSP RHSHSFLPFS
460 470 480 490 500
GGARNCIGKQ FAMSELKVIV ALTLLRFELL PDPTRVPMPL ARLVLKSKNG

IYLHLKKLH
Length:509
Mass (Da):58,330
Last modified:July 27, 2011 - v2
Checksum:i94F22CE77BD3EDC0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A977A2A977_MOUSE
Cytochrome P450 4A10
Cyp4a10
499Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62H → L in X69296 (PubMed:8031839).Curated1
Sequence conflicti64K → Q in BAA33804 (Ref. 2) Curated1
Sequence conflicti64K → Q in AAH10747 (PubMed:15489334).Curated1
Sequence conflicti64K → Q in AAH51049 (PubMed:15489334).Curated1
Sequence conflicti69Q → H in BAA33804 (Ref. 2) Curated1
Sequence conflicti69Q → H in AAH10747 (PubMed:15489334).Curated1
Sequence conflicti69Q → H in AAH51049 (PubMed:15489334).Curated1
Sequence conflicti234I → N in X69296 (PubMed:8031839).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69296 mRNA No translation available.
AB018421 mRNA Translation: BAA33804.1
AK002528 mRNA Translation: BAB22165.1
AL627182 Genomic DNA No translation available.
BC010747 mRNA Translation: AAH10747.1
BC051049 mRNA Translation: AAH51049.1
CCDSiCCDS18492.1
PIRiS47553
RefSeqiNP_034141.3, NM_010011.3
UniGeneiMm.10742

Genome annotation databases

EnsembliENSMUST00000058785; ENSMUSP00000061126; ENSMUSG00000066072
GeneIDi13117
KEGGimmu:13117
UCSCiuc008uex.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69296 mRNA No translation available.
AB018421 mRNA Translation: BAA33804.1
AK002528 mRNA Translation: BAB22165.1
AL627182 Genomic DNA No translation available.
BC010747 mRNA Translation: AAH10747.1
BC051049 mRNA Translation: AAH51049.1
CCDSiCCDS18492.1
PIRiS47553
RefSeqiNP_034141.3, NM_010011.3
UniGeneiMm.10742

3D structure databases

ProteinModelPortaliO88833
SMRiO88833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061126

Chemistry databases

SwissLipidsiSLP:000000399

PTM databases

iPTMnetiO88833
PhosphoSitePlusiO88833

Proteomic databases

MaxQBiO88833
PaxDbiO88833
PRIDEiO88833

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058785; ENSMUSP00000061126; ENSMUSG00000066072
GeneIDi13117
KEGGimmu:13117
UCSCiuc008uex.2 mouse

Organism-specific databases

CTDi13117
MGIiMGI:88611 Cyp4a10

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiO88833
KOiK07425
OMAiYEKPWQS
OrthoDBiEOG091G06KN
TreeFamiTF105088

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211979 Eicosanoids
R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Miscellaneous databases

ChiTaRSiCyp4a10 mouse
PROiPR:O88833
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066072 Expressed in 55 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO88833 baseline and differential
GenevisibleiO88833 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP4AA_MOUSE
AccessioniPrimary (citable) accession number: O88833
Secondary accession number(s): A2A976, Q9DCS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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