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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC2

Gene

Polr2f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed 5'-3' RNA polymerase activity Source: RGD

GO - Biological processi

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-RNO-112382 Formation of RNA Pol II elongation complex
R-RNO-113418 Formation of the Early Elongation Complex
R-RNO-5250924 B-WICH complex positively regulates rRNA expression
R-RNO-5578749 Transcriptional regulation by small RNAs
R-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-6803529 FGFR2 alternative splicing
R-RNO-6807505 RNA polymerase II transcribes snRNA genes
R-RNO-72086 mRNA Capping
R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72165 mRNA Splicing - Minor Pathway
R-RNO-72203 Processing of Capped Intron-Containing Pre-mRNA
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-73772 RNA Polymerase I Promoter Escape
R-RNO-73776 RNA Polymerase II Promoter Escape
R-RNO-73777 RNA Polymerase I Chain Elongation
R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-RNO-73863 RNA Polymerase I Transcription Termination
R-RNO-75953 RNA Polymerase II Transcription Initiation
R-RNO-75955 RNA Polymerase II Transcription Elongation
R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-RNO-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-RNO-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-RNO-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-RNO-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-RNO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Short name:
RNA polymerases I, II, and III subunit ABC2
Alternative name(s):
DNA-directed RNA polymerase II subunit F
RPB6 homolog
Gene namesi
Name:Polr2f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi708567 Polr2f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001338022 – 127DNA-directed RNA polymerases I, II, and III subunit RPABC2Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by CK2Combined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO88828
PRIDEiO88828

PTM databases

iPTMnetiO88828
PhosphoSitePlusiO88828

Expressioni

Gene expression databases

BgeeiENSRNOG00000011214 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiO88828 RN

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi249722, 1 interactor
STRINGi10116.ENSRNOP00000015009

Structurei

3D structure databases

ProteinModelPortaliO88828
SMRiO88828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3405 Eukaryota
COG1758 LUCA
GeneTreeiENSGT00390000010415
HOGENOMiHOG000225272
HOVERGENiHBG002375
InParanoidiO88828
KOiK03014
OMAiCDELIIS
OrthoDBiEOG091G11CG
PhylomeDBiO88828
TreeFamiTF103041

Family and domain databases

Gene3Di3.90.940.10, 1 hit
InterProiView protein in InterPro
IPR020708 DNA-dir_RNA_polK_14-18kDa_CS
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR028363 RPB6
IPR036161 RPB6/omega_like_sf
IPR006111 RpoK/Rpb6
PfamiView protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit
PIRSFiPIRSF500154 RPB6, 1 hit
PIRSF000778 RpoK/RPB6, 1 hit
SMARTiView protein in SMART
SM01409 RNA_pol_Rpb6, 1 hit
SUPFAMiSSF63562 SSF63562, 1 hit
PROSITEiView protein in PROSITE
PS01111 RNA_POL_K_14KD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDNEDNFDG DDFDDVEEDE GLDDLENAEE EGQENVEILP SGERPQANQK
60 70 80 90 100
RITTPYMTKY ERARVLGTRA LQIAMCAPVM VELEGETDPL LIAMKELKAR
110 120
KIPIIIRRYL PDGSYEDWGV DELIISD
Length:127
Mass (Da):14,464
Last modified:November 1, 1998 - v1
Checksum:i6366A0D7EB3F0921
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017711 mRNA Translation: BAA33414.1
BC083552 mRNA Translation: AAH83552.1
RefSeqiNP_112625.1, NM_031335.3
UniGeneiRn.28212

Genome annotation databases

EnsembliENSRNOT00000015009; ENSRNOP00000015009; ENSRNOG00000011214
GeneIDi83503
KEGGirno:83503
UCSCiRGD:708567 rat

Similar proteinsi

Entry informationi

Entry nameiRPAB2_RAT
AccessioniPrimary (citable) accession number: O88828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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