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Protein

Protein JTB

Gene

Jtb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity (By similarity). Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • mitotic cell cycle Source: UniProtKB
  • mitotic cytokinesis Source: UniProtKB
  • positive regulation of protein kinase activity Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB

Keywordsi

Biological processApoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Gene namesi
Name:Jtb
Synonyms:Gm622
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1346082 Jtb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 105ExtracellularSequence analysisAdd BLAST75
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 146CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13 – 14AG → DD: Abolishes N-terminal proteolytic processing. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002153631 – 146Protein JTBAdd BLAST116

Post-translational modificationi

Undergoes N-terminal proteolytic processing, removing a peptide of about 1 kDa from the N-terminus of the protein.1 Publication

Proteomic databases

PaxDbiO88824
PRIDEiO88824

PTM databases

iPTMnetiO88824
PhosphoSitePlusiO88824

Expressioni

Inductioni

Up-regulated by TGFB1 in mammary epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000027937 Expressed in 286 organ(s), highest expression level in cochlea
CleanExiMM_JTB
ExpressionAtlasiO88824 baseline and differential
GenevisibleiO88824 MM

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO88824
SMRiO88824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4084 Eukaryota
ENOG4111VSR LUCA
GeneTreeiENSGT00390000016136
HOGENOMiHOG000294204
HOVERGENiHBG000952
InParanoidiO88824
OMAiECAPCSN
OrthoDBiEOG091G0PNA
PhylomeDBiO88824
TreeFamiTF316934

Family and domain databases

InterProiView protein in InterPro
IPR008657 JTB
PANTHERiPTHR13041 PTHR13041, 1 hit
PfamiView protein in Pfam
PF05439 JTB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAGAGRRGL PRAGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL
60 70 80 90 100
AEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
LEQHLFWKFE GVVVAVALVF ACLVIVRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,329
Last modified:November 1, 1998 - v1
Checksum:i9E4DAF394B2A2107
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4D1D3Z4D1_MOUSE
Protein JTB
Jtb
95Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016490 mRNA Translation: BAA33733.1
BC008139 mRNA Translation: AAH08139.1
CCDSiCCDS17523.1
RefSeqiNP_996807.1, NM_206924.2
UniGeneiMm.13912

Genome annotation databases

EnsembliENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937
GeneIDi23922
KEGGimmu:23922
UCSCiuc008qbo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016490 mRNA Translation: BAA33733.1
BC008139 mRNA Translation: AAH08139.1
CCDSiCCDS17523.1
RefSeqiNP_996807.1, NM_206924.2
UniGeneiMm.13912

3D structure databases

ProteinModelPortaliO88824
SMRiO88824
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO88824
PhosphoSitePlusiO88824

Proteomic databases

PaxDbiO88824
PRIDEiO88824

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937
GeneIDi23922
KEGGimmu:23922
UCSCiuc008qbo.1 mouse

Organism-specific databases

CTDi10899
MGIiMGI:1346082 Jtb

Phylogenomic databases

eggNOGiKOG4084 Eukaryota
ENOG4111VSR LUCA
GeneTreeiENSGT00390000016136
HOGENOMiHOG000294204
HOVERGENiHBG000952
InParanoidiO88824
OMAiECAPCSN
OrthoDBiEOG091G0PNA
PhylomeDBiO88824
TreeFamiTF316934

Miscellaneous databases

PROiPR:O88824
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027937 Expressed in 286 organ(s), highest expression level in cochlea
CleanExiMM_JTB
ExpressionAtlasiO88824 baseline and differential
GenevisibleiO88824 MM

Family and domain databases

InterProiView protein in InterPro
IPR008657 JTB
PANTHERiPTHR13041 PTHR13041, 1 hit
PfamiView protein in Pfam
PF05439 JTB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJTB_MOUSE
AccessioniPrimary (citable) accession number: O88824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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