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Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

Fut9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: MGI

GO - Biological processi

  • fucosylation Source: GO_Central
  • nervous system development Source: MGI
  • protein glycosylation Source: MGI

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Chemistry databases

SwissLipidsiSLP:000001437

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1330859 Fut9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 359LumenalSequence analysisAdd BLAST327

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211191 – 359Alpha-(1,3)-fucosyltransferase 9Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88819
PRIDEiO88819

PTM databases

PhosphoSitePlusiO88819

Expressioni

Tissue specificityi

Mainly detected in brain and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000055373 Expressed in 152 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_FUT9
ExpressionAtlasiO88819 baseline and differential
GenevisibleiO88819 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081826

Structurei

3D structure databases

ProteinModelPortaliO88819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiO88819
KOiK03663
OMAiKGIFRPF
OrthoDBiEOG091G0846
PhylomeDBiO88819
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequencei

Sequence statusi: Complete.

O88819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWVFSP MESASSVLKM
60 70 80 90 100
KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY
110 120 130 140 150
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH
160 170 180 190 200
LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH
210 220 230 240 250
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK
260 270 280 290 300
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DFNSPSELAK
310 320 330 340 350
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV

GNLEKWFWN
Length:359
Mass (Da):42,041
Last modified:November 1, 1998 - v1
Checksum:i96A2394547F2A44E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015426 mRNA Translation: BAA33522.1
AK032177 mRNA Translation: BAC27746.1
AK036183 mRNA Translation: BAC29338.1
AK043410 mRNA Translation: BAC31540.1
AK047650 mRNA Translation: BAC33112.1
AK049122 mRNA Translation: BAC33555.1
AK163871 mRNA Translation: BAE37522.1
CCDSiCCDS18011.1
RefSeqiNP_034373.1, NM_010243.3
UniGeneiMm.39101

Genome annotation databases

EnsembliENSMUST00000084770; ENSMUSP00000081826; ENSMUSG00000055373
ENSMUST00000108199; ENSMUSP00000103834; ENSMUSG00000055373
GeneIDi14348
KEGGimmu:14348
UCSCiuc008sei.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015426 mRNA Translation: BAA33522.1
AK032177 mRNA Translation: BAC27746.1
AK036183 mRNA Translation: BAC29338.1
AK043410 mRNA Translation: BAC31540.1
AK047650 mRNA Translation: BAC33112.1
AK049122 mRNA Translation: BAC33555.1
AK163871 mRNA Translation: BAE37522.1
CCDSiCCDS18011.1
RefSeqiNP_034373.1, NM_010243.3
UniGeneiMm.39101

3D structure databases

ProteinModelPortaliO88819
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081826

Chemistry databases

SwissLipidsiSLP:000001437

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

PTM databases

PhosphoSitePlusiO88819

Proteomic databases

PaxDbiO88819
PRIDEiO88819

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084770; ENSMUSP00000081826; ENSMUSG00000055373
ENSMUST00000108199; ENSMUSP00000103834; ENSMUSG00000055373
GeneIDi14348
KEGGimmu:14348
UCSCiuc008sei.1 mouse

Organism-specific databases

CTDi10690
MGIiMGI:1330859 Fut9

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiO88819
KOiK03663
OMAiKGIFRPF
OrthoDBiEOG091G0846
PhylomeDBiO88819
TreeFamiTF316348

Enzyme and pathway databases

UniPathwayi
UPA00378

Miscellaneous databases

PROiPR:O88819
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055373 Expressed in 152 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_FUT9
ExpressionAtlasiO88819 baseline and differential
GenevisibleiO88819 MM

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUT9_MOUSE
AccessioniPrimary (citable) accession number: O88819
Secondary accession number(s): Q3TQ63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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