UniProtKB - O88808 (TUB_RAT)
Protein
Tubby protein homolog
Gene
Tub
Organism
Rattus norvegicus (Rat)
Status
Functioni
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- intraciliary transport particle A binding Source: RGD
- protein-containing complex binding Source: RGD
GO - Biological processi
- intraciliary transport Source: RGD
- phagocytosis, recognition Source: RGD
- photoreceptor cell maintenance Source: RGD
- positive regulation of phagocytosis Source: UniProtKB
- protein localization to cilium Source: RGD
- protein localization to photoreceptor outer segment Source: RGD
- receptor localization to non-motile cilium Source: RGD
- regulation of G protein-coupled receptor signaling pathway Source: RGD
- response to hormone Source: RGD
- retina development in camera-type eye Source: RGD
- sensory perception of sound Source: RGD
Keywordsi
Biological process | Phagocytosis, Sensory transduction |
Names & Taxonomyi
Protein namesi | Recommended name: Tubby protein homolog |
Gene namesi | Name:Tub |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3918, Tub |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Extracellular region or secreted
- Secreted 1 Publication
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm 1 Publication
Note: Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).By similarity
Cytosol
- cytosol Source: RGD
Extracellular region or secreted
- extracellular region Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, Nucleus, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186465 | 1 – 505 | Tubby protein homologAdd BLAST | 505 |
Proteomic databases
jPOSTi | O88808 |
PaxDbi | O88808 |
PRIDEi | O88808 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000046566, Expressed in frontal cortex and 19 other tissues |
Genevisiblei | O88808, RN |
Interactioni
Subunit structurei
Interacts with GNAQ.
Interacts with TULP1.
By similarityGO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247638, 1 interactor |
STRINGi | 10116.ENSRNOP00000064486 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 197 – 204 | Asp/Glu-rich | 8 | |
Compositional biasi | 206 – 210 | Poly-Ser | 5 |
Sequence similaritiesi
Belongs to the TUB family.Curated
Phylogenomic databases
eggNOGi | KOG2502, Eukaryota |
GeneTreei | ENSGT00940000158372 |
HOGENOMi | CLU_028236_1_1_1 |
InParanoidi | O88808 |
OMAi | SMSFDEE |
OrthoDBi | 1445357at2759 |
PhylomeDBi | O88808 |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659, Tubby-like_C IPR000007, Tubby_C IPR018066, Tubby_C_CS IPR005398, Tubby_N |
Pfami | View protein in Pfam PF01167, Tub, 1 hit PF16322, Tub_N, 1 hit |
PRINTSi | PR01573, SUPERTUBBY PR01574, TUBBYPROTEIN |
SUPFAMi | SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200, TUB_1, 1 hit PS01201, TUB_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O88808-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSKPHSDWI PYSVLDDEGS NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA
60 70 80 90 100
NADGRPRSRR ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQPGATR
110 120 130 140 150
PPAPASAKKT KGAAASGGQG GAPRKEKKGK HKGTSGPATL AEDKSEAQGP
160 170 180 190 200
VQILTVGQSD HAKDAGETAA GGGAQPSGQD LRATMQRKGI SSSMSFDEEE
210 220 230 240 250
DEDENSSSSS QLNSNTRPSS ATSRKSTREA ASAPSPAAPE PPVDIEVQDL
260 270 280 290 300
EEFALRPAPQ GITIKCRITR DKKGMDRGMY PTYFLHLDRE DGKKVFLLAG
310 320 330 340 350
RKRKKSKTSN YLISVDPTDL SRGGDSYIGK LRSNLMGTKF TVYDNGVNPQ
360 370 380 390 400
KASSSTLESG TLRQELAAVC YETNVLGFKG PRKMSVIVPG MNMVHERVCI
410 420 430 440 450
RPRNEHETLL ARWQNKNTES IIELQNKTPV WNDDTQSYVL NFHGRVTQAS
460 470 480 490 500
VKNFQIIHGN DPDYIVMQFG RVAEDVFTMD YNYPLCALQA FAIALSSFDS
KLACE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 362 – 379 | LRQEL…VLGFK → CARSWQPCAMRQMSRLQ in AAD09251 (Ref. 2) CuratedAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011544 mRNA Translation: BAA32734.1 U92546 mRNA Translation: AAD09251.1 |
RefSeqi | NP_037209.1, NM_013077.1 |
Genome annotation databases
Ensembli | ENSRNOT00000074636; ENSRNOP00000064486; ENSRNOG00000046566 |
GeneIDi | 25609 |
KEGGi | rno:25609 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011544 mRNA Translation: BAA32734.1 U92546 mRNA Translation: AAD09251.1 |
RefSeqi | NP_037209.1, NM_013077.1 |
3D structure databases
SMRi | O88808 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247638, 1 interactor |
STRINGi | 10116.ENSRNOP00000064486 |
Proteomic databases
jPOSTi | O88808 |
PaxDbi | O88808 |
PRIDEi | O88808 |
Genome annotation databases
Ensembli | ENSRNOT00000074636; ENSRNOP00000064486; ENSRNOG00000046566 |
GeneIDi | 25609 |
KEGGi | rno:25609 |
Organism-specific databases
CTDi | 7275 |
RGDi | 3918, Tub |
Phylogenomic databases
eggNOGi | KOG2502, Eukaryota |
GeneTreei | ENSGT00940000158372 |
HOGENOMi | CLU_028236_1_1_1 |
InParanoidi | O88808 |
OMAi | SMSFDEE |
OrthoDBi | 1445357at2759 |
PhylomeDBi | O88808 |
Miscellaneous databases
PROi | PR:O88808 |
Gene expression databases
Bgeei | ENSRNOG00000046566, Expressed in frontal cortex and 19 other tissues |
Genevisiblei | O88808, RN |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659, Tubby-like_C IPR000007, Tubby_C IPR018066, Tubby_C_CS IPR005398, Tubby_N |
Pfami | View protein in Pfam PF01167, Tub, 1 hit PF16322, Tub_N, 1 hit |
PRINTSi | PR01573, SUPERTUBBY PR01574, TUBBYPROTEIN |
SUPFAMi | SSF54518, SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200, TUB_1, 1 hit PS01201, TUB_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TUB_RAT | |
Accessioni | O88808Primary (citable) accession number: O88808 Secondary accession number(s): Q9Z1A2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | August 12, 2020 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families