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Protein

Tubby protein homolog

Gene

Tub

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPhagocytosis, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby protein homolog
Gene namesi
Name:Tub
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3918 Tub

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864651 – 505Tubby protein homologAdd BLAST505

Proteomic databases

PaxDbiO88808
PRIDEiO88808

Expressioni

Gene expression databases

BgeeiENSRNOG00000046566
GenevisibleiO88808 RN

Interactioni

Subunit structurei

Interacts with GNAQ. Interacts with TULP1.By similarity

Protein-protein interaction databases

BioGridi247638, 1 interactor
STRINGi10116.ENSRNOP00000064486

Structurei

3D structure databases

ProteinModelPortaliO88808
SMRiO88808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi197 – 204Asp/Glu-rich8
Compositional biasi206 – 210Poly-Ser5

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiKOG2502 Eukaryota
ENOG410XQFT LUCA
GeneTreeiENSGT00610000085970
HOVERGENiHBG018010
InParanoidiO88808
OMAiFQIIHGN
OrthoDBiEOG091G04TF
PhylomeDBiO88808

Family and domain databases

Gene3Di3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR018066 Tubby_C_CS
IPR005398 Tubby_N
PfamiView protein in Pfam
PF01167 Tub, 1 hit
PF16322 Tub_N, 1 hit
PRINTSiPR01573 SUPERTUBBY
PR01574 TUBBYPROTEIN
SUPFAMiSSF54518 SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS01200 TUB_1, 1 hit
PS01201 TUB_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKPHSDWI PYSVLDDEGS NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA
60 70 80 90 100
NADGRPRSRR ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQPGATR
110 120 130 140 150
PPAPASAKKT KGAAASGGQG GAPRKEKKGK HKGTSGPATL AEDKSEAQGP
160 170 180 190 200
VQILTVGQSD HAKDAGETAA GGGAQPSGQD LRATMQRKGI SSSMSFDEEE
210 220 230 240 250
DEDENSSSSS QLNSNTRPSS ATSRKSTREA ASAPSPAAPE PPVDIEVQDL
260 270 280 290 300
EEFALRPAPQ GITIKCRITR DKKGMDRGMY PTYFLHLDRE DGKKVFLLAG
310 320 330 340 350
RKRKKSKTSN YLISVDPTDL SRGGDSYIGK LRSNLMGTKF TVYDNGVNPQ
360 370 380 390 400
KASSSTLESG TLRQELAAVC YETNVLGFKG PRKMSVIVPG MNMVHERVCI
410 420 430 440 450
RPRNEHETLL ARWQNKNTES IIELQNKTPV WNDDTQSYVL NFHGRVTQAS
460 470 480 490 500
VKNFQIIHGN DPDYIVMQFG RVAEDVFTMD YNYPLCALQA FAIALSSFDS

KLACE
Length:505
Mass (Da):55,318
Last modified:November 1, 1998 - v1
Checksum:i8ECAAB751B06469F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362 – 379LRQEL…VLGFK → CARSWQPCAMRQMSRLQ in AAD09251 (Ref. 2) CuratedAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011544 mRNA Translation: BAA32734.1
U92546 mRNA Translation: AAD09251.1
RefSeqiNP_037209.1, NM_013077.1
UniGeneiRn.30017

Genome annotation databases

EnsembliENSRNOT00000074636; ENSRNOP00000064486; ENSRNOG00000046566
GeneIDi25609
KEGGirno:25609

Similar proteinsi

Entry informationi

Entry nameiTUB_RAT
AccessioniPrimary (citable) accession number: O88808
Secondary accession number(s): Q9Z1A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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