Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (13 Feb 2019)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Zonadhesin

Gene

Zan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI
  • cell adhesion Source: UniProtKB-KW
  • regulation of binding of sperm to zona pellucida Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zonadhesin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zan
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106656 Zan

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 5310ExtracellularSequence analysisAdd BLAST5293
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5311 – 5337HelicalSequence analysisAdd BLAST27
Topological domaini5338 – 5376CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000778418 – 5376ZonadhesinAdd BLAST5359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1814N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1933N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2028N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2533N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2575N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2812N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3052N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3065N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4005N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5252N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi5263 ↔ 5274By similarity
Disulfide bondi5268 ↔ 5283By similarity
Disulfide bondi5285 ↔ 5294By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88799

PRoteomics IDEntifications database

More...
PRIDEi
O88799

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88799

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88799

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In testis, primarily in haploid spermatids.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably forms covalent oligomers.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000114068

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88799

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88799

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 210MAM 1PROSITE-ProRule annotationAdd BLAST166
Domaini215 – 374MAM 2PROSITE-ProRule annotationAdd BLAST160
Domaini377 – 542MAM 3PROSITE-ProRule annotationAdd BLAST166
Domaini1171 – 1220TIL 1Add BLAST50
Domaini1227 – 1275VWFC 1Add BLAST49
Domaini1281 – 1500VWFD 1PROSITE-ProRule annotationAdd BLAST220
Domaini1555 – 1608TIL 2Add BLAST54
Domaini1609 – 1664VWFC 2Add BLAST56
Domaini1670 – 1887VWFD 2PROSITE-ProRule annotationAdd BLAST218
Domaini1941 – 1995TIL 3Add BLAST55
Domaini1996 – 2052VWFC 3Add BLAST57
Domaini2057 – 2273VWFD 3PROSITE-ProRule annotationAdd BLAST217
Domaini2340 – 2398TIL 4Add BLAST59
Domaini2399 – 2454VWFC 4Add BLAST56
Domaini2460 – 2518TIL 5Add BLAST59
Domaini2519 – 2574VWFC 5Add BLAST56
Domaini2580 – 2638TIL 6Add BLAST59
Domaini2639 – 2694VWFC 6Add BLAST56
Domaini2700 – 2758TIL 7Add BLAST59
Domaini2759 – 2814VWFC 7Add BLAST56
Domaini2820 – 2878TIL 8Add BLAST59
Domaini2879 – 2934VWFC 8Add BLAST56
Domaini2940 – 2998TIL 9Add BLAST59
Domaini2999 – 3054VWFC 9Add BLAST56
Domaini3060 – 3118TIL 10Add BLAST59
Domaini3119 – 3174VWFC 10Add BLAST56
Domaini3180 – 3238TIL 11Add BLAST59
Domaini3239 – 3294VWFC 11Add BLAST56
Domaini3300 – 3355TIL 12Add BLAST56
Domaini3356 – 3411VWFC 12Add BLAST56
Domaini3417 – 3475TIL 13Add BLAST59
Domaini3476 – 3531VWFC 13Add BLAST56
Domaini3537 – 3595TIL 14Add BLAST59
Domaini3596 – 3651VWFC 14Add BLAST56
Domaini3657 – 3715TIL 15Add BLAST59
Domaini3716 – 3771VWFC 15Add BLAST56
Domaini3777 – 3835TIL 16Add BLAST59
Domaini3836 – 3891VWFC 16Add BLAST56
Domaini3893 – 3951TIL 17Add BLAST59
Domaini3952 – 4007VWFC 17Add BLAST56
Domaini4029 – 4087TIL 18Add BLAST59
Domaini4088 – 4143VWFC 18Add BLAST56
Domaini4149 – 4207TIL 19Add BLAST59
Domaini4208 – 4262VWFC 19Add BLAST55
Domaini4264 – 4322TIL 20Add BLAST59
Domaini4323 – 4378VWFC 20Add BLAST56
Domaini4384 – 4442TIL 21Add BLAST59
Domaini4443 – 4498VWFC 21Add BLAST56
Domaini4504 – 4562TIL 22Add BLAST59
Domaini4563 – 4618VWFC 22Add BLAST56
Domaini4624 – 4682TIL 23Add BLAST59
Domaini4683 – 4738VWFC 23Add BLAST56
Domaini4744 – 4802TIL 24Add BLAST59
Domaini4803 – 4858VWFC 24Add BLAST56
Domaini4864 – 5065VWFD 4PROSITE-ProRule annotationAdd BLAST202
Domaini5150 – 5203TIL 25Add BLAST54
Domaini5204 – 5258VWFC 25Add BLAST55
Domaini5259 – 5295EGF-likePROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni547 – 117080 X heptapeptide repeats (approximate) (mucin-like domain)Add BLAST624

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MAM domains probably mediates sperm adhesion to the zona pellucida.
During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
The VWFD domain 2 may mediate covalent oligomerization.By similarity

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XNSK LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003977

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88799

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88799

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06263 MAM, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003645 Fol_N
IPR000998 MAM_dom
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00629 MAM, 3 hits
PF01826 TIL, 25 hits
PF12714 TILa, 25 hits
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00181 EGF, 16 hits
SM00274 FOLN, 20 hits
SM00137 MAM, 3 hits
SM00214 VWC, 23 hits
SM00215 VWC_out, 15 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 3 hits
SSF57567 SSF57567, 25 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 18 hits
PS50026 EGF_3, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 3 hits
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O88799-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPVWTLML LVGAAWGQEQ VPAWRPNSPD LGPMVHTSRE DSILSKCDFE
60 70 80 90 100
DNSRPFCDWS QMSADDGDWI RTTGPSLTGT SGPPGGYPNG EGYYLHMDPK
110 120 130 140 150
TFPQGGVARL RSPDIWEQGP LCVHFAFHMF GLSWGAQLRL LLLRGRKHLR
160 170 180 190 200
PYVLWKHVNT QSPSWMPTTV TVPADHDIPS WLMFEGMRGN TAYLDISLDG
210 220 230 240 250
LSIQRGTCNQ VCMSQMCTFD TLNDLCGWSW VPTATGAKWT QKKGPTGKQG
260 270 280 290 300
VGPAEDFSNP GNGYYMLLDS TNARPGQKAV LLSPLSHSRG CMTLSFHYIM
310 320 330 340 350
HGQGHEEGLF VYATFLGNIR KYTLFSGHPG PDWQAVSVNY TGQGQIQFMV
360 370 380 390 400
VGMFGNIPEP AIAVDAISIA PCGESFPQCD FEDRVHPFCD WNQVYGDMGH
410 420 430 440 450
WSWGSKSVPT LIAGSPREFP YGGEHYIFFD SVKLSQEGQS ARLVSPPFCA
460 470 480 490 500
PGGICVEFAY HMYGLGKGTT LKLLLGSPAG SSPIPLWNRV GSQSSGWMNS
510 520 530 540 550
SVTIPKGYQQ PMQLFIEATR GTSTAFVVAL NFILISHGPC RVLLQTEIPS
560 570 580 590 600
SPLLPPTGPS ESTVPTLPME QPTSPTKATT VTIEIPTTPT EEATIPTETT
610 620 630 640 650
TVPTEVINVS PKETSIPPEV TIPTEVITVS PEEIISPTEV TPVPTDVTAA
660 670 680 690 700
YVEATNASPE ETSVPPEVTI LTEVTTVSPE ETTVPTEVPI VLIEATAFPT
710 720 730 740 750
GETTLYTEVP TVPTEVTGVH TEVTNVSPEE TSVPTEETIS TEVTTVSPEE
760 770 780 790 800
TTVPTEVPIV LIEATASPTG EITLYTEVPT VPTEVTGVHT EVTNVSPEET
810 820 830 840 850
SVPTEETIST EVTTVSPEET TLPTEVPTVS TEVTNVSPEE TSVPPEETIL
860 870 880 890 900
TTLYTEVPTV PTEVTGVHTE VTNVSPEETS VPTEETISTE VTTVSPEETT
910 920 930 940 950
LPTEVPTVST EVTNVSPEET SVPPEETILT EITTVSPEET VFPIEGTTLP
960 970 980 990 1000
TEVLTVPIEV TTFPTGETTV PTEVPTVSTE MTGVHTEVTT VFPEETSIPT
1010 1020 1030 1040 1050
EVATVLPASI PPEETTTPTE VTTTPPEETT IPAEVTTVPP ASIPPEETAS
1060 1070 1080 1090 1100
LTEVTTTPPE ETTTPTEVTT VPPEKTTIPT EVTTVPPASI FPEETTVPPE
1110 1120 1130 1140 1150
ETTIASEETT VSTQETTLLT EQSAVTQTSI ACRPPCPSPP LMPIGPLLSK
1160 1170 1180 1190 1200
PPGVSMFSLA PTTGVSTTES CPPNAHIELC ACPASCESPK PSCQPPCIPG
1210 1220 1230 1240 1250
CVCNPGFLFS NNQCINESSC NCPYNNKHYK PGEEWFTPNC TERCRCLPGS
1260 1270 1280 1290 1300
LMECQISQCG THTVCQLKSD QYQCEPYGKA TCLVYGDLHF VTFDERHIGF
1310 1320 1330 1340 1350
TGTCTYILTQ TCSNSTDHFF RITANTEERG VEGVSCLDKV VISLPETTVT
1360 1370 1380 1390 1400
MISGRHTLIG DQEVTLPAIL SDDTYVGLSG RFVELRTTFG LRVRWDGDQQ
1410 1420 1430 1440 1450
LFVTVSSTFS GKLCGFCGNY DGDSSNDNLK SDGMMTHDEE ELRLSWQVEE
1460 1470 1480 1490 1500
DEDKDWVSSR CQKKKNPPSC DAALGSTMSG PKLCGQLVNP SGPFEACLLH
1510 1520 1530 1540 1550
LKASSFLDNC VTDMCSFQGL QQKLCARMSA MTATCQDAGY PVKPWREPQF
1560 1570 1580 1590 1600
CPLVCPKNSR YSLCAKPCPE TCHPISTTQH CSDKCVEGCE CDPGFILSGS
1610 1620 1630 1640 1650
ECVPSSQCGC TSFQGRYFKL QEQWFNPDCK EICTCESHNH ILCKPWKCKA
1660 1670 1680 1690 1700
QEACSYKNGV LGCHAQGAAT CMVSGDPHYL TFDGALHHFM GTCTYVLTQP
1710 1720 1730 1740 1750
CWSKSQENNF VVSATNEIHD GNLEVSYVKA VHVQVFDLKI SMFKGQKVVL
1760 1770 1780 1790 1800
NNQRVVLPVW PSQGRVTIRL SGIFVLLYTN FGLQVRYDGR HLVEVTVPSS
1810 1820 1830 1840 1850
YTGSLCGLCG NYNNNSMDDN LRADMKPAGN SLLLGAAWKI LEASDPGCFL
1860 1870 1880 1890 1900
AGGKPSRCAD SDMDDVWTKK CAILMNPLGP FSNCHEAVPP QASFSSCVYG
1910 1920 1930 1940 1950
QCETNGDNLT FCHSLQAYAS LCAQAGQVTT WRNSTFCPMR CPPRSSYNPC
1960 1970 1980 1990 2000
ANSCPATCLT LSTPRDCPTL PCVEGCECQS GHILSGTTCV PLRQCGCSDQ
2010 2020 2030 2040 2050
DGSYHLLGES WYTEKTCTTL CTCSAHSNIT CSPTACKANH VCLRQEGLLR
2060 2070 2080 2090 2100
CAAEMGECRI SEDSQIVSFD DHSHPIQDTC TYILVKVCHP NTNMPFFMIS
2110 2120 2130 2140 2150
AKTDINTNGK NKTFGVYQLY IDIFNFHITL QKDHLVLISL INDSIVTLPT
2160 2170 2180 2190 2200
TTHIPGVSVM TEDVYTIVTI KDEIQVKFES NNFLDVKIPA SSNGKVCGVC
2210 2220 2230 2240 2250
GNFNGEEEDE LMTPSGELAE DEQEFMNSWK DKSMDPNCQK IEGQNLQVEQ
2260 2270 2280 2290 2300
QEIMNGKCRP IDFEKAQANC QTALQGPAWA HCSSRVPIKP FLLKCMNSFC
2310 2320 2330 2340 2350
EFRELFRALC DSLQSFEDAC QNQGLKPPIW RNSSFCPLEC PAHSHYTNCL
2360 2370 2380 2390 2400
PSCPPSCLDP DSRCEGSGHK VPATCREGCI CQPDYVLLND KCVLRSHCGC
2410 2420 2430 2440 2450
KDAQGVFIPA GKTWISEDCT QSCTCMKGSM RCWDFQCPPG TYCKNSNDGS
2460 2470 2480 2490 2500
SNCVKISLQC PAHSKFTDCL PPCHPSCSDP DGHCEGISTN AHSNCKEGCV
2510 2520 2530 2540 2550
CQPGYVLRND KCVLRIECGC QHTQGGFIPA GKNWTSRGCS QSCDCMEGVI
2560 2570 2580 2590 2600
RCQNFQCPSG TYCQDIEDGT SNCANITLQC PAHSSFTNCL PPCQPSCSDP
2610 2620 2630 2640 2650
EGHCGGSTTK APSACQEGCV CEPDYVVLNN KCVPRIECGC KDAQGVLIPA
2660 2670 2680 2690 2700
DKIWINKGCT QTCACVTGTI HCRDFQCPSG TYCKDIKDDA SNCTEIILQC
2710 2720 2730 2740 2750
PDHSLYTHCL PSCLLSCSDP DGLCRGTSPE APSTCKEGCV CDPDYVLSND
2760 2770 2780 2790 2800
KCVLRIECGC KDAQGVLIPA GKTWINRGCT QSCSCMGGAI QCQNFKCPSE
2810 2820 2830 2840 2850
AYCQDMEDGN SNCTSIPLQC PAHSHYTNCL PTCQPSCSDP DGHCEGSSTK
2860 2870 2880 2890 2900
APSACKEGCV CEPDYVMLNN KCVPRIECGC KDTQGVLIPA DKTWINRGCT
2910 2920 2930 2940 2950
QSCTCRGGAI QCQKYHCSSG TYCKDMEDDS SSCATITLQC PAHSHFTNCL
2960 2970 2980 2990 3000
PPCQPSCLDS EGHCEGSTTK APSACQEGCV CEPDYVVLNN KCVPRIECGC
3010 3020 3030 3040 3050
KDAQGVLIPA DKTWINRGCT QSCTCKGGAI QCQKFQCPSE TYCKDIEDGN
3060 3070 3080 3090 3100
SNCTRISLQC PANSNFTSCL PSCQPSCSNT DVHCEGSSPN TLSSCREGCV
3110 3120 3130 3140 3150
CQSGYVLHND KCILRNQCGC KDAQGALIPE GKTWITSGCT QSCNCTGGAI
3160 3170 3180 3190 3200
QCQNFQCPLK TYCKDLKDGS SNCTNIPLQC PAHSRYTNCL PSCPPLCLDP
3210 3220 3230 3240 3250
EGLCEGTSPK VPSTCREGCI CQPGYLMHKN KCVLRIFCGC KNTQGAFISA
3260 3270 3280 3290 3300
DKTWISRGCT QSCTCPAGAI HCRNFKCPSG TYCKNGDNGS SNCTEITLQC
3310 3320 3330 3340 3350
PTNSQFTDCL PSCVPSCSNR CEVTSPSVPS SCREGCLCNH GFVFSEDKCV
3360 3370 3380 3390 3400
PRTQCGCKDA RGAIIPAGKT WTSKGCTQSC ACVEGNIQCQ NFQCPPETYC
3410 3420 3430 3440 3450
KDNSEGSSTC TKITLQCPAH TQYTSCLPSC LPSCLDPEGL CKDISPKVPS
3460 3470 3480 3490 3500
TCKEGCVCQS GYVLNSDKCV LRAECDCKDA QGALIPAGKT WTSPGCTQSC
3510 3520 3530 3540 3550
ACMGGAVQCQ SSQCPPGTYC KDNEDGNSNC AKITLQCPAH SLFTNCLPPC
3560 3570 3580 3590 3600
LPSCLDPDGL CKGASPKVPS TCKEGCICQS GYVLSNNKCL LRNRCGCKDA
3610 3620 3630 3640 3650
HGALIPEDKT WVSRGCTQSC VCTGGSIQCL SSQCPPGAYC KDNEDGSSNC
3660 3670 3680 3690 3700
ARIPPQCPAN SHYTDCFPPC PPSCSDPEGH CEASGPRVLS TCREGCLCNP
3710 3720 3730 3740 3750
GFVLDRDKCV PRVECGCKDA QGALIPSGKT WTSPGCTQSC ACMGGVVQCQ
3760 3770 3780 3790 3800
SSQCPPGTYC KDNEDGNSNC AKITLQCPTH SNYTDCLPFC LPSCLDPSAL
3810 3820 3830 3840 3850
CGGTSPKGPS TCKEGCVCQP GYVLDKDKCI LKIECGCRDT QGAVIPAGKT
3860 3870 3880 3890 3900
WLSTGCIQSC ACVEGTIQCQ NFQCPPGTYC NHNNNCAKIP LQCPAHSHFT
3910 3920 3930 3940 3950
SCLPSCPPSC ANLDGSCEQT SPKVPSTCKE GCLCQPGYFL NNGKCVLQTH
3960 3970 3980 3990 4000
CDCKDAEGGL VPAGKTWTSK DCTQSCACTG GAVQCQNFQC PLGTYCKDSG
4010 4020 4030 4040 4050
DGSSNCTKIH KGAMGDGVLM AGGIRALQCP AHSHFTSCLP SCPPSCSNLD
4060 4070 4080 4090 4100
GSCVESNFKA PSVCKKGCIC QPGYLLNNDK CVLRIQCGCK DTQGGLIPAG
4110 4120 4130 4140 4150
RTWISSDCTK SCSCMGGIIQ CRDFQCPPGT YCKESNDSSR TCAKIPLQCP
4160 4170 4180 4190 4200
AHSHYTNCLP ACSRSCTDLD GHCEGTSPKV PSPCKEGCLC QPGYVVHNHK
4210 4220 4230 4240 4250
CVLQIHCGCK DAQGGFVPAG KTWISRGCTQ SCACVGGAVQ CHNFTCPTGT
4260 4270 4280 4290 4300
QCQNSSCSKI TVQCPAHSQY TTCLPSCLPS CFDPEGLCGG ASPRAPSTCR
4310 4320 4330 4340 4350
EGCVCEADYV LREDKCVLRT QCGCKDAQGD LIPANKTWLT RGCAQKCTCK
4360 4370 4380 4390 4400
GGNIHCWNFK CPLGTECKDS VDGGSNCTKI ALQCPAHSHH TYCLPSCIPS
4410 4420 4430 4440 4450
CSNVNDRCES TSLQRPSTCI EGCLCHSGFV FSKDKCVPRT QCGCKDSQGT
4460 4470 4480 4490 4500
LIPAGKNWIT TGCSQRCTCT GGLVQCHDFQ CPSGAECQDI EDGNSNCVEI
4510 4520 4530 4540 4550
TVQCPAHSHY SKCLPPCQPS CSDPDGHCEG TSPEAPSTCE EGCVCEPDYV
4560 4570 4580 4590 4600
LSNDKCVPSS ECGCKDAHGV LIPESKTWVS RGCTKNCTCK GGTVQCHDFS
4610 4620 4630 4640 4650
CPTGSRCLDN NEGNSNCVTY ALKCPAHSLY TNCLPSCLPS CSDPEGLCGG
4660 4670 4680 4690 4700
TSPEVPSTCK EGCICQSGYV LHKNKCMLRI HCDCKDFQGS LIKTGQTWIS
4710 4720 4730 4740 4750
SGCSKICTCK GGFFQCQSYK CPSGTQCEES EDGSSNCVSS TMKCPANSLY
4760 4770 4780 4790 4800
THCLPTCLPS CSNPDGRCEG TSHKAPSTCR EGCVCQPGYL LNKDTCVHKN
4810 4820 4830 4840 4850
QCGCKDIRGN IIPAGNTWIS SDCTQSCACT DGVIQCQNFV CPSGSHCQYN
4860 4870 4880 4890 4900
EDGSSDCAAN KLERCTIFGD PYYLTFDGFT YHFLGRMNYY LIKTVDKLPR
4910 4920 4930 4940 4950
GIEPLIMEGR NKISPKGSST LHEVTTIVYG YKIQLQEELV VLVNDEKVAV
4960 4970 4980 4990 5000
PYNPNEHLRV MLRAQRLLLV TDFEMVLDFD GKHSAVISLP TTYRGLTRGL
5010 5020 5030 5040 5050
CGNYDRDQSN ELMLPSGVLT SNVHVFGNSW EVKAQHAFFR FPRALPEDEE
5060 5070 5080 5090 5100
RDEEPDLLQS ECSQEQTALI SSTQACRVLV DPQGPFAACH QIIAPEPFEQ
5110 5120 5130 5140 5150
RCMLDMCTGW KTKEEEELRC RVLSGYAIIC QEAGANMTGW RDHTHCAMTC
5160 5170 5180 5190 5200
PANTVYQRCM TPCPASCAKF VTPKVCEGPC VEGCASLPGY IYSDTQSLPV
5210 5220 5230 5240 5250
THCGCTADGI YYKLGDSFVT NDCSQHCTCA SQGILLCEPY GCRAGESCMV
5260 5270 5280 5290 5300
ANFTRGCFQD SPCLQNPCHN DGRCEEQGAT FICHCDFGYG GEFCTEPQDI
5310 5320 5330 5340 5350
TTRKKIEASS LVAILPGVLV MVLVPVLLPR VYVYMATRTT MGRRRMKRKE
5360 5370
KKLLRQSRLR LEDADVPEPT FKATEF
Length:5,376
Mass (Da):579,913
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E44DB77DF2A2620
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWQ7E9PWQ7_MOUSE
Zonadhesin
Zan
5,420Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ACV3F7ACV3_MOUSE
Zonadhesin
Zan
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U97068 mRNA Translation: AAC26680.1
U83190 mRNA Translation: AAC53125.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42215

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.7984

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97068 mRNA Translation: AAC26680.1
U83190 mRNA Translation: AAC53125.1
PIRiT42215
UniGeneiMm.7984

3D structure databases

ProteinModelPortaliO88799
SMRiO88799
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114068

PTM databases

iPTMnetiO88799
PhosphoSitePlusiO88799

Proteomic databases

PaxDbiO88799
PRIDEiO88799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106656 Zan

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
HOVERGENiHBG003977
InParanoidiO88799
PhylomeDBiO88799

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O88799

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd06263 MAM, 3 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003645 Fol_N
IPR000998 MAM_dom
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF00629 MAM, 3 hits
PF01826 TIL, 25 hits
PF12714 TILa, 25 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00181 EGF, 16 hits
SM00274 FOLN, 20 hits
SM00137 MAM, 3 hits
SM00214 VWC, 23 hits
SM00215 VWC_out, 15 hits
SM00216 VWD, 4 hits
SUPFAMiSSF49899 SSF49899, 3 hits
SSF57567 SSF57567, 25 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 18 hits
PS50026 EGF_3, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 3 hits
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZAN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88799
Secondary accession number(s): O08647
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: February 13, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again