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Protein

Ribonuclease P protein subunit p30

Gene

Rpp30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p30 (EC:3.1.26.5)
Short name:
RNaseP protein p30
Alternative name(s):
RNase P subunit 2
Gene namesi
Name:Rpp30
Synonyms:Rnasep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1859683 Rpp30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001400322 – 268Ribonuclease P protein subunit p30Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88796
MaxQBiO88796
PaxDbiO88796
PeptideAtlasiO88796
PRIDEiO88796

PTM databases

iPTMnetiO88796
PhosphoSitePlusiO88796

Expressioni

Gene expression databases

BgeeiENSMUSG00000024800 Expressed in 291 organ(s), highest expression level in testis
CleanExiMM_RPP30
GenevisibleiO88796 MM

Interactioni

Protein-protein interaction databases

IntActiO88796, 2 interactors
MINTiO88796
STRINGi10090.ENSMUSP00000025714

Structurei

3D structure databases

ProteinModelPortaliO88796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2363 Eukaryota
COG1603 LUCA
GeneTreeiENSGT00390000000883
HOGENOMiHOG000157793
HOVERGENiHBG010226
InParanoidiO88796
KOiK03539
OMAiQVCKGKN
OrthoDBiEOG091G0LMY
PhylomeDBiO88796
TreeFamiTF106113

Family and domain databases

InterProiView protein in InterPro
IPR016195 Pol/histidinol_Pase-like
IPR002738 RNase_P_p30
PANTHERiPTHR13031 PTHR13031, 1 hit
PfamiView protein in Pfam
PF01876 RNase_P_p30, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKREIEK
60 70 80 90 100
PIAVSELFTT LPIVQGKSRP IKILTRLTII VTDPAHCNVL RATSSRVRLY
110 120 130 140 150
DIVAVFPKTE KLFHVACTHL DVDLVCITVT EKLPFYFKRP PVNVAIERGL
160 170 180 190 200
GFELVYGPAI RDATMRRYTI SNALNLMQIC KGKNVILSSA AERPLEIRGP
210 220 230 240 250
YDVANLGLLF GLSENDGKAA VSTNCRAVFL HGETRKTAFG IISTVKKPRP
260
SEADDESLPV CKKAKCEG
Length:268
Mass (Da):29,473
Last modified:November 1, 1998 - v1
Checksum:i068028B3FA99428E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95123 mRNA Translation: AAC24115.1
CCDSiCCDS29770.1
RefSeqiNP_062301.3, NM_019428.3
UniGeneiMm.277891

Genome annotation databases

EnsembliENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800
GeneIDi54364
KEGGimmu:54364
UCSCiuc008hhg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95123 mRNA Translation: AAC24115.1
CCDSiCCDS29770.1
RefSeqiNP_062301.3, NM_019428.3
UniGeneiMm.277891

3D structure databases

ProteinModelPortaliO88796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88796, 2 interactors
MINTiO88796
STRINGi10090.ENSMUSP00000025714

PTM databases

iPTMnetiO88796
PhosphoSitePlusiO88796

Proteomic databases

EPDiO88796
MaxQBiO88796
PaxDbiO88796
PeptideAtlasiO88796
PRIDEiO88796

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800
GeneIDi54364
KEGGimmu:54364
UCSCiuc008hhg.2 mouse

Organism-specific databases

CTDi10556
MGIiMGI:1859683 Rpp30

Phylogenomic databases

eggNOGiKOG2363 Eukaryota
COG1603 LUCA
GeneTreeiENSGT00390000000883
HOGENOMiHOG000157793
HOVERGENiHBG010226
InParanoidiO88796
KOiK03539
OMAiQVCKGKN
OrthoDBiEOG091G0LMY
PhylomeDBiO88796
TreeFamiTF106113

Miscellaneous databases

PROiPR:O88796
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024800 Expressed in 291 organ(s), highest expression level in testis
CleanExiMM_RPP30
GenevisibleiO88796 MM

Family and domain databases

InterProiView protein in InterPro
IPR016195 Pol/histidinol_Pase-like
IPR002738 RNase_P_p30
PANTHERiPTHR13031 PTHR13031, 1 hit
PfamiView protein in Pfam
PF01876 RNase_P_p30, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPP30_MOUSE
AccessioniPrimary (citable) accession number: O88796
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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