Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-13 receptor subunit alpha-2

Gene

Il13ra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds as a monomer with high affinity to interleukin-13 (IL13).1 Publication

GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-2
Short name:
IL-13 receptor subunit alpha-2
Short name:
IL-13R subunit alpha-2
Short name:
IL-13R-alpha-2
Short name:
IL-13RA2
Alternative name(s):
CD_antigen: CD213a2
Gene namesi
Name:Il13ra2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1277954 Il13ra2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 334ExtracellularSequence analysisAdd BLAST313
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 383CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000037845222 – 383Interleukin-13 receptor subunit alpha-2Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 107By similarity
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 149By similarity
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 191By similarity
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 310By similarity
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88786
PaxDbiO88786
PRIDEiO88786

Expressioni

Gene expression databases

BgeeiENSMUSG00000031289 Expressed in 114 organ(s), highest expression level in cumulus cell
GenevisibleiO88786 MM

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88786, 3 interactors
STRINGi10090.ENSMUSP00000033646

Structurei

3D structure databases

ProteinModelPortaliO88786
SMRiO88786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 128Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini131 – 219Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini234 – 332Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi316 – 320WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUDW Eukaryota
ENOG4111JMU LUCA
GeneTreeiENSGT00530000063295
HOGENOMiHOG000004823
InParanoidiO88786
KOiK05077
OMAiSYFIFQL
OrthoDBiEOG091G0FOF
PhylomeDBiO88786
TreeFamiTF331549

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01356 HEMATOPO_REC_S_F2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O88786-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFVHIRCLC FILLCTITGY SLEIKVNPPQ DFEILDPGLL GYLYLQWKPP
60 70 80 90 100
VVIEKFKGCT LEYELKYRNV DSDSWKTIIT RNLIYKDGFD LNKGIEGKIR
110 120 130 140 150
THLSEHCTNG SEVQSPWIEA SYGISDEGSL ETKIQDMKCI YYNWQYLVCS
160 170 180 190 200
WKPGKTVYSD TNYTMFFWYE GLDHALQCAD YLQHDEKNVG CKLSNLDSSD
210 220 230 240 250
YKDFFICVNG SSKLEPIRSS YTVFQLQNIV KPLPPEFLHI SVENSIDIRM
260 270 280 290 300
KWSTPGGPIP PRCYTYEIVI REDDISWESA TDKNDMKLKR RANESEDLCF
310 320 330 340 350
FVRCKVNIYC ADDGIWSEWS EEECWEGYTG PDSKIIFIVP VCLFFIFLLL
360 370 380
LLCLIVEKEE PEPTLSLHVD LNKEVCAYED TLC
Length:383
Mass (Da):44,483
Last modified:November 1, 1998 - v1
Checksum:iC25212325C47E35B
GO
Isoform 2 (identifier: O88786-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-339: GYTGPDSKIIFIV → EPPCGSEQRSVCL
     340-383: Missing.

Show »
Length:339
Mass (Da):39,429
Checksum:i63C0896950A07627
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330G → W in BAE43400 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037588327 – 339GYTGP…IIFIV → EPPCGSEQRSVCL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_037589340 – 383Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65747 mRNA Translation: AAC33240.1
EF219410 mRNA Translation: ABN11267.1
AK089687 mRNA Translation: BAE43400.1
AL662932, AL807780, BX005200 Genomic DNA Translation: CAM15764.1
BX005200, AL662932, AL807780 Genomic DNA Translation: CAM20758.1
AL807780, AL662932, BX005200 Genomic DNA Translation: CAM24879.1
CH466610 Genomic DNA Translation: EDL14709.1
BC003723 mRNA Translation: AAH03723.1
CCDSiCCDS30460.1 [O88786-1]
RefSeqiNP_001292988.1, NM_001306059.1 [O88786-2]
NP_032382.1, NM_008356.4 [O88786-1]
XP_006528770.1, XM_006528707.3 [O88786-1]
XP_006528771.1, XM_006528708.3 [O88786-1]
XP_017173884.1, XM_017318395.1 [O88786-2]
UniGeneiMm.368330

Genome annotation databases

EnsembliENSMUST00000033646; ENSMUSP00000033646; ENSMUSG00000031289 [O88786-1]
ENSMUST00000112827; ENSMUSP00000108446; ENSMUSG00000031289 [O88786-1]
GeneIDi16165
KEGGimmu:16165
UCSCiuc009unf.1 mouse [O88786-1]
uc012hqe.1 mouse [O88786-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65747 mRNA Translation: AAC33240.1
EF219410 mRNA Translation: ABN11267.1
AK089687 mRNA Translation: BAE43400.1
AL662932, AL807780, BX005200 Genomic DNA Translation: CAM15764.1
BX005200, AL662932, AL807780 Genomic DNA Translation: CAM20758.1
AL807780, AL662932, BX005200 Genomic DNA Translation: CAM24879.1
CH466610 Genomic DNA Translation: EDL14709.1
BC003723 mRNA Translation: AAH03723.1
CCDSiCCDS30460.1 [O88786-1]
RefSeqiNP_001292988.1, NM_001306059.1 [O88786-2]
NP_032382.1, NM_008356.4 [O88786-1]
XP_006528770.1, XM_006528707.3 [O88786-1]
XP_006528771.1, XM_006528708.3 [O88786-1]
XP_017173884.1, XM_017318395.1 [O88786-2]
UniGeneiMm.368330

3D structure databases

ProteinModelPortaliO88786
SMRiO88786
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88786, 3 interactors
STRINGi10090.ENSMUSP00000033646

Proteomic databases

MaxQBiO88786
PaxDbiO88786
PRIDEiO88786

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033646; ENSMUSP00000033646; ENSMUSG00000031289 [O88786-1]
ENSMUST00000112827; ENSMUSP00000108446; ENSMUSG00000031289 [O88786-1]
GeneIDi16165
KEGGimmu:16165
UCSCiuc009unf.1 mouse [O88786-1]
uc012hqe.1 mouse [O88786-2]

Organism-specific databases

CTDi3598
MGIiMGI:1277954 Il13ra2

Phylogenomic databases

eggNOGiENOG410IUDW Eukaryota
ENOG4111JMU LUCA
GeneTreeiENSGT00530000063295
HOGENOMiHOG000004823
InParanoidiO88786
KOiK05077
OMAiSYFIFQL
OrthoDBiEOG091G0FOF
PhylomeDBiO88786
TreeFamiTF331549

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

PROiPR:O88786
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031289 Expressed in 114 organ(s), highest expression level in cumulus cell
GenevisibleiO88786 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01356 HEMATOPO_REC_S_F2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI13R2_MOUSE
AccessioniPrimary (citable) accession number: O88786
Secondary accession number(s): A3F812, Q3V2V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again