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UniProtKB - O88783 (FA5_MOUSE)

Entry version 143 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Coagulation factor V

Gene

F5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA5.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi138CalciumBy similarity1
Metal bindingi139CalciumBy similarity1
Metal bindingi1802CopperBy similarity1
Metal bindingi1804CopperBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Copper, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-114608, Platelet degranulation
R-MMU-140875, Common Pathway of Fibrin Clot Formation
R-MMU-204005, COPII-mediated vesicle transport
R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530, Cargo concentration in the ER
R-MMU-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor V
Alternative name(s):
Activated protein C cofactor
Cleaved into the following 2 chains:
Coagulation factor V heavy chain
Coagulation factor V light chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:88382, F5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi333R → Q: Does not affect pro-coagulant function. Partially resistant to inactivation by activated protein C. 1 Publication1
Mutagenesisi532R → Q: Does not affect pro-coagulant function. Partially resistant to inactivation by activated protein C. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000035871820 – 2183Coagulation factor VAdd BLAST2164
ChainiPRO_000035871920 – 736Coagulation factor V heavy chainBy similarityAdd BLAST717
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000358720737 – 1533Activation peptide (connecting region)By similarityAdd BLAST797
ChainiPRO_00003587211534 – 2183Coagulation factor V light chainBy similarityAdd BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei638PhosphothreonineBy similarity1
Modified residuei692SulfotyrosineSequence analysis1
Modified residuei725SulfotyrosineSequence analysis1
Glycosylationi841N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei903PhosphoserineCombined sources1
Glycosylationi959N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi972N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1811N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1866 ↔ 2020PROSITE-ProRule annotation
Disulfide bondi2025 ↔ 2180PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).By similarity
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.By similarity
Activated protein C inactivates factor V and factor Va by proteolytic degradation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei333 – 334Cleavage; by activated protein CBy similarity2
Sitei532 – 533Cleavage; by activated protein CBy similarity2
Sitei706 – 707Cleavage; by activated protein CBy similarity2
Sitei736 – 737Cleavage; by thrombinBy similarity2
Sitei1004 – 1005Cleavage; by activated protein CBy similarity2
Sitei1029 – 1030Cleavage; by thrombinBy similarity2
Sitei1533 – 1534Cleavage; by thrombinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O88783

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O88783

PeptideAtlas

More...PeptideAtlasi		O88783

PRoteomics IDEntifications database

More...PRIDEi		O88783

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O88783, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O88783

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O88783

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000026579, Expressed in blood and 145 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O88783, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199574, 3 interactors

Protein interaction database and analysis system

More...IntActi		O88783, 2 interactors

Molecular INTeraction database

More...MINTi		O88783

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000083204

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O88783, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O88783

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 328F5/8 type A 1Add BLAST299
Domaini30 – 192Plastocyanin-like 1Add BLAST163
Domaini202 – 328Plastocyanin-like 2Add BLAST127
Domaini347 – 682F5/8 type A 2Add BLAST336
Domaini347 – 524Plastocyanin-like 3Add BLAST178
Domaini534 – 682Plastocyanin-like 4Add BLAST149
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati892 – 9111-1Add BLAST20
Repeati1175 – 11832-19
Repeati1184 – 11922-29
Repeati1193 – 12012-39
Repeati1202 – 12102-49
Repeati1211 – 12192-59
Repeati1220 – 12282-69
Repeati1229 – 12372-79
Repeati1238 – 12462-89
Repeati1247 – 12552-99
Repeati1256 – 12642-109
Repeati1265 – 12732-119
Repeati1274 – 12822-129
Repeati1283 – 12912-139
Repeati1292 – 12992-148
Repeati1300 – 13082-159
Repeati1309 – 13162-168
Repeati1317 – 13252-179
Repeati1326 – 13342-189
Repeati1335 – 13412-197
Repeati1342 – 13502-209
Repeati1351 – 13592-219
Repeati1360 – 13682-229
Repeati1369 – 13772-239
Repeati1378 – 13862-249
Repeati1387 – 13952-259
Repeati1396 – 14042-269
Repeati1405 – 14132-279
Repeati1414 – 14222-289
Repeati1423 – 14312-299
Repeati1432 – 14402-309
Repeati1441 – 14492-319
Repeati1452 – 14612-3210
Domaini1538 – 1866F5/8 type A 3Add BLAST329
Domaini1538 – 1711Plastocyanin-like 5Add BLAST174
Domaini1721 – 1866Plastocyanin-like 6Add BLAST146
Domaini1866 – 2020F5/8 type C 1PROSITE-ProRule annotationAdd BLAST155
Domaini2025 – 2180F5/8 type C 2PROSITE-ProRule annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni691 – 1533BBy similarityAdd BLAST843
Regioni892 – 9081 X 17 AA tandem repeatsAdd BLAST17
Regioni1175 – 146132 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-TAdd BLAST287

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Domain B contains 32 X 9 AA tandem repeats, and 1 X 17 AA repeats.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSUG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000948_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O88783

Identification of Orthologs from Complete Genome Data

More...OMAi		GDYWEPS

Database of Orthologous Groups

More...OrthoDBi		454773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O88783

TreeFam database of animal gene trees

More...TreeFami		TF329807

Family and domain databases

Conserved Domains Database

More...CDDi		cd00057, FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.260, 2 hits
2.60.40.420, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR008972, Cupredoxin
IPR000421, FA58C
IPR024715, Factor_5/8-like
IPR008979, Galactose-bd-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07732, Cu-oxidase_3, 3 hits
PF00754, F5_F8_type_C, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000354, Factors_V_VIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00231, FA58C, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49503, SSF49503, 6 hits
SSF49785, SSF49785, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00079, MULTICOPPER_OXIDASE1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O88783-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLVCPCFFL LVVLGTRWAG WGSHQAEAAQ LRQFYVAAQG ILWNYHPEPT 
        60         70         80         90        100
DPSLNSIPSF KKIVYREYEQ YFKKEKPRSS NSGLLGPTLY AEVGDVIKVH 
       110        120        130        140        150
FRNKADKPLS IHPQGIKYSK FSEGASYADH TFPAERKDDA VAPGEEYTYE 
       160        170        180        190        200
WIVSEDSGPT PDDPPCLTHI YYSYENLTQD FNSGLIGPLL ICKKGTLTED 
       210        220        230        240        250
GTQKMFDKQH VLLFAVFDES KSRSQSPSLM YTINGFVNKT MPDITVCAHD 
       260        270        280        290        300
HVSWHLIGMS SGPELFSIHF NGQVLEQNQH KVSTVTLVSA TSTTANMTMS 
       310        320        330        340        350
PEGRWIVSSL IPKHYQAGMQ AYIDIKNCPK KTRSPKTLTR EQRRYMKRWE 
       360        370        380        390        400
YFIAAEEVIW NYAPVIPANM DKIYRSQHLD NFSNQIGKHY KKVIYRQYEE 
       410        420        430        440        450
ETFTKRTDNP SIKQSGILGP VIRAQVRDTL KIVFKNMASR PYSIYPHGVT 
       460        470        480        490        500
FSPYEDGINS SSTSGSHTTI RPVQPGETFT YKWNILEFDE PTENDAQCLT 
       510        520        530        540        550
RPYYSDVDVT RDIASGLIGL LLICKSRSLD QRGVQRVADI EQQAVFAVFD 
       560        570        580        590        600
ENKSWYIEDN INKFCENPDE VKRDDPKFYE SNIMSTINGY VPESISTLGF 
       610        620        630        640        650
CFDDTVQWHF CSVGTHDDIL TIHFTGHSFI YGRRHEDTLT LFPMRGESVT 
       660        670        680        690        700
VTMDNVGTWM LTTMNSNPKR RNLRLRFRDV KCNRDYDNED SYEIYEPPAP 
       710        720        730        740        750
TSMTTRRIHD SLENEFGIDN EDDDYQYLLA SSLGIRSFKN SSLNPEENEF 
       760        770        780        790        800
NLTALALENS SEFISPSTDR VVDSNSSRIL SKIINNNLKD FQRTLPGSGA 
       810        820        830        840        850
TVAGTLLRNL IGLDENFVLN SSTEHRSSSY HENDMENPQS NITMVYLLPL 
       860        870        880        890        900
GPKGSGNREQ DKPKTIKTGR PHMMKHRFSW MKAPAGKTGR HSNPKNSYSG 
       910        920        930        940        950
MKSEEDIPSE LIPLKQKITS KFLNRRWRVA SEKGSYEIIA ANGEDTDVDK 
       960        970        980        990       1000
LTNSPQNQNI TVPRGESTSH TNTTRKPSDL PTFSGVGHKS PHVRQEEENS 
      1010       1020       1030       1040       1050
GFQKRQLFIR TRKKKKNKKL ALHSPLSPRG FDPLRGHNHS PFPDRRLLNH 
      1060       1070       1080       1090       1100
SLLLHKSNET ALSPDLNQTS PSMSTDRSLP DYNQYSKNDT EQMSSSLDLY 
      1110       1120       1130       1140       1150
QSVPAEEHSP TFPAQDPDQT HSTTDPSYRS SPPELSQGLD YDLSHDFYPD 
      1160       1170       1180       1190       1200
DIGLTSFFPD QSQKSSFSSD DDQAIPSSDL SLFTISPELD QTIIYPDLDQ 
      1210       1220       1230       1240       1250
LLLSPEDNQK TSSPDLGQVP LSPDDNQKTS SPDLGQVSLS PDDNQKTSSP 
      1260       1270       1280       1290       1300
DLGQVPLSLD DNQKTTSPDL GQVPLSPDDN QMITSPDLGQ VPLSSDNQKT 
      1310       1320       1330       1340       1350
SSPDLGQVPL FPEDNQNYFL DLSQVPLSSD QNQETSSTDL LTLSPDFGQT 
      1360       1370       1380       1390       1400
VLSPDLDQLP LPSDNSQVTV SPDLSLLTLS PDFNEIILAP DLGQVTLSPD 
      1410       1420       1430       1440       1450
LIQTNPALNH GHKASSADPD QASYPPDSGQ ASSLPELNRT LPHPDLTHIP 
      1460       1470       1480       1490       1500
PPSPSPTLNN TSLSRKFNPL VVVGLSRVDG DDVEIVPSEE PERIDEDYAE 
      1510       1520       1530       1540       1550
DDFVTYNDPY RTDTRTDVNS SRNPDTIAAW YLRGHGGHKK FYYIAAEEIT 
      1560       1570       1580       1590       1600
WNYAEFAQSE MDHEDTGHTP KDTTYKKVVF RKYLDSTFTS RDPRAEYEEH 
      1610       1620       1630       1640       1650
LGILGPVIRA EVDDVIQVRF KNLASRPYSL HAHGLSYEKS SEGKTYEDES 
      1660       1670       1680       1690       1700
PEWFQEDDAV QPNSSYTYVW HATKRSGPEN PGSACRAWAY YSAVNVERDI 
      1710       1720       1730       1740       1750
HSGLIGPLLI CRKGTLHMER NLPMDMREFV LLFMVFDEKK SWYYEKSKGS 
      1760       1770       1780       1790       1800
RRIESPEEKN AHKFYAINGM IYNLPGLRMY EQEWVRLHLL NMGGSRDIHV 
      1810       1820       1830       1840       1850
VHFHGQTLLD NRTKQHQLGV WPLLPGSFKT LEMKASKPGW WLLDTEVGEN 
      1860       1870       1880       1890       1900
QVAGMQTPFL IIDKECKMPM GLSTGVISDS QIKASEYLTY WEPRLARLNN 
      1910       1920       1930       1940       1950
AGSYNAWSIE KTALDFPIKP WIQVDMQKEV VVTGIQTQGA KHYLKSCFTT 
      1960       1970       1980       1990       2000
EFQVAYSSDQ TNWQIFRGKS GKSVMYFTGN SDGSTIKENR LDPPIVARYI 
      2010       2020       2030       2040       2050
RIHPTKSYNR PTLRLELQGC EVNGCSTPLG LEDGRIQDKQ ITASSFKKSW 
      2060       2070       2080       2090       2100
WGDYWEPSLA RLNAQGRVNA WQAKANNNKQ WLQVDLLKIK KVTAIVTQGC 
      2110       2120       2130       2140       2150
KSLSSEMYVK SYSIQYSDQG VAWKPYRQKS SMVDKIFEGN SNTKGHMKNF 
      2160       2170       2180 
FNPPIISRFI RIIPKTWNQS IALRLELFGC DIY
Length:2,183
Mass (Da):247,230
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF0A8AA723F60317
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE23393 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U52925 mRNA Translation: AAC99553.1
AK137521 mRNA Translation: BAE23393.1 Different initiation.
AK139240 mRNA Translation: BAE23928.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35754.1

Protein sequence database of the Protein Information Resource

More...PIRi		T42764

NCBI Reference Sequences

More...RefSeqi		NP_032002.1, NM_007976.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000086040; ENSMUSP00000083204; ENSMUSG00000026579

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14067

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14067

UCSC genome browser

More...UCSCi		uc007dic.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52925 mRNA Translation: AAC99553.1
AK137521 mRNA Translation: BAE23393.1 Different initiation.
AK139240 mRNA Translation: BAE23928.1
CCDSiCCDS35754.1
PIRiT42764
RefSeqiNP_032002.1, NM_007976.3

3D structure databases

SMRiO88783
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199574, 3 interactors
IntActiO88783, 2 interactors
MINTiO88783
STRINGi10090.ENSMUSP00000083204

PTM databases

GlyGeniO88783, 8 sites
iPTMnetiO88783
PhosphoSitePlusiO88783

Proteomic databases

MaxQBiO88783
PaxDbiO88783
PeptideAtlasiO88783
PRIDEiO88783

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		863, 382 antibodies

Genome annotation databases

EnsembliENSMUST00000086040; ENSMUSP00000083204; ENSMUSG00000026579
GeneIDi14067
KEGGimmu:14067
UCSCiuc007dic.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2153
MGIiMGI:88382, F5

Phylogenomic databases

eggNOGiENOG502QSUG, Eukaryota
GeneTreeiENSGT00940000158556
HOGENOMiCLU_000948_0_0_1
InParanoidiO88783
OMAiGDYWEPS
OrthoDBi454773at2759
PhylomeDBiO88783
TreeFamiTF329807

Enzyme and pathway databases

ReactomeiR-MMU-114608, Platelet degranulation
R-MMU-140875, Common Pathway of Fibrin Clot Formation
R-MMU-204005, COPII-mediated vesicle transport
R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530, Cargo concentration in the ER
R-MMU-8957275, Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		14067, 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		F5, mouse

Protein Ontology

More...PROi		PR:O88783
RNActiO88783, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000026579, Expressed in blood and 145 other tissues
GenevisibleiO88783, MM

Family and domain databases

CDDicd00057, FA58C, 2 hits
Gene3Di2.60.120.260, 2 hits
2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR008972, Cupredoxin
IPR000421, FA58C
IPR024715, Factor_5/8-like
IPR008979, Galactose-bd-like_sf
PfamiView protein in Pfam
PF07732, Cu-oxidase_3, 3 hits
PF00754, F5_F8_type_C, 2 hits
PIRSFiPIRSF000354, Factors_V_VIII, 1 hit
SMARTiView protein in SMART
SM00231, FA58C, 2 hits
SUPFAMiSSF49503, SSF49503, 6 hits
SSF49785, SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00079, MULTICOPPER_OXIDASE1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88783
Secondary accession number(s): Q3UTQ2, Q3UV80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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