UniProtKB - O88746 (TOM1_MOUSE)

BLAST

>sp|O88746|TOM1_MOUSE Target of Myb protein 1 OS=Mus musculus OX=10090 GN=Tom1 PE=1 SV=1
MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIMG
NKNFHEVMLALTVLETCVKNCGHRFHVLVANQDFVENVLVRTILPKNNPPTIVHDKVLNL
IQSWADAFRSSPDLTGVVAVYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETPSRQNS
VSSNTSQRGDLSQHATPLPTPAVLPGDSPITPTPEQIGKLRSELEMVSGNVRVMSEMLTE
LVPTQVEPADLELLQELNRTCRAMQQRILELIPRISNEQLTEELLMINDNLNNVFLRHER
FERFRTGQTAKASSEAELATDLIDMGPDPAATNNLSSQLAGMNLGSRSVRAGLQSLETSG
HLEDDFDMFALTRGSSLADQRKGVKYEAPQTTDGLAGALDARQQSTGAIPATQARIMEDI
EQWLSTDVGNSAEEPSGVTSEEFDKFLEERAKAADRLPNLASPSAEGPPRPSPGTAPRRK
TQEKDDDMLFAL

Align

Format
Add to basket Added to basket
History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Target of Myb protein 1

Gene

Tom1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in intracellular trafficking. Probable association with membranes.

GO - Molecular functionⁱ

clathrin binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular protein transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Target of Myb protein 1
Gene namesⁱ	Name:Tom1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1338026 Tom1

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072629	1 – 492	Target of Myb protein 1Add BLAST		492

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	11	PhosphoserineBy similarity	1
Modified residueⁱ	160	PhosphoserineCombined sources	1
Modified residueⁱ	164	PhosphothreonineCombined sources	1
Modified residueⁱ	176	PhosphoserineCombined sources	1
Modified residueⁱ	180	PhosphoserineCombined sources	1
Modified residueⁱ	208	PhosphoserineCombined sources	1
Modified residueⁱ	355	PhosphoserineBy similarity	1
Modified residueⁱ	376	PhosphoserineBy similarity	1
Cross-linkⁱ	385	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	462	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O88746
PaxDbⁱ	O88746
PeptideAtlas More...PeptideAtlasⁱ	O88746
PRIDEⁱ	O88746

PTM databases

iPTMnetⁱ	O88746
PhosphoSitePlusⁱ	O88746

Miscellaneous databases

PMAP-CutDBⁱ

O88746

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. In adult brain, it is highly expressed at the mesencephalic level, in the hippocampal formation and medial lemniscus. In cerebellum, it is highly expressed in Purkinje cells and granular layers.

Developmental stageⁱ

Ubiquitously expressed in the embryo, with a higher expression in the intestines.

Gene expression databases

Bgeeⁱ	ENSMUSG00000042870 Expressed in 32 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_TOM1
ExpressionAtlasⁱ	O88746 baseline and differential
Genevisibleⁱ	O88746 MM

Interactionⁱ

Subunit structureⁱ

Interacts with ZFYVE16; interaction is required to target it to endosomes.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Tollip	Q9QZ06	2	EBI-74264,EBI-74272

With

Entry

#Exp.

IntAct

Notes

Tollip

Q9QZ06

EBI-74264,EBI-74272

GO - Molecular functionⁱ

clathrin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204274, 2 interactors
IntActⁱ	O88746, 4 interactors
Molecular INTeraction database More...MINTⁱ	O88746
STRINGⁱ	10090.ENSMUSP00000036849

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88746
SMRⁱ	O88746
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – 152	VHSPROSITE-ProRule annotationAdd BLAST		133
Domainⁱ	215 – 303	GATPROSITE-ProRule annotationAdd BLAST		89

Sequence similaritiesⁱ

Belongs to the TOM1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150885
HOGENOMⁱ	HOG000285970
HOVERGENⁱ	HBG025068
InParanoidⁱ	O88746
OMAⁱ	QAHLYRM
PhylomeDBⁱ	O88746
TreeFamⁱ	TF314105

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008942 ENTH_VHS IPR004152 GAT_dom IPR038425 GAT_sf IPR014645 TOM1 IPR002014 VHS_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03127 GAT, 1 hit PF00790 VHS, 1 hit
PIRSFⁱ	PIRSF036948 TOM1, 1 hit
SMARTⁱ	View protein in SMART SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit
PROSITEⁱ	View protein in PROSITE PS50909 GAT, 1 hit PS50179 VHS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O88746-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA 
        60         70         80         90        100
FRAVKKRIMG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV 
       110        120        130        140        150
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVAV YEDLRRKGLE 
       160        170        180        190        200
FPMTDLDMLS PIHTPQRTVF NSETPSRQNS VSSNTSQRGD LSQHATPLPT 
       210        220        230        240        250
PAVLPGDSPI TPTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQVEPAD 
       260        270        280        290        300
LELLQELNRT CRAMQQRILE LIPRISNEQL TEELLMINDN LNNVFLRHER 
       310        320        330        340        350
FERFRTGQTA KASSEAELAT DLIDMGPDPA ATNNLSSQLA GMNLGSRSVR 
       360        370        380        390        400
AGLQSLETSG HLEDDFDMFA LTRGSSLADQ RKGVKYEAPQ TTDGLAGALD 
       410        420        430        440        450
ARQQSTGAIP ATQARIMEDI EQWLSTDVGN SAEEPSGVTS EEFDKFLEER 
       460        470        480        490 
AKAADRLPNL ASPSAEGPPR PSPGTAPRRK TQEKDDDMLF AL

Length:492

Mass (Da):54,325

Last modified:November 1, 1998 - v1

Checksum:ⁱA15F24FD9B4D31C3

Isoform 2 (identifier: O88746-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-324: Missing.
325-343: MGPDPAATNNLSSQLAGMN → MGRANGTAGLLPGPSVSAD

« Hide

        10         20         30         40         50
MGRANGTAGL LPGPSVSADL GSRSVRAGLQ SLETSGHLED DFDMFALTRG 
        60         70         80         90        100
SSLADQRKGV KYEAPQTTDG LAGALDARQQ STGAIPATQA RIMEDIEQWL 
       110        120        130        140        150
STDVGNSAEE PSGVTSEEFD KFLEERAKAA DRLPNLASPS AEGPPRPSPG 
       160 
TAPRRKTQEK DDDMLFAL

Show »

Length:168

Mass (Da):17,788

Checksum:ⁱ3AA2CF5B2EBAD575

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3UDC3	Q3UDC3_MOUSE	Target of Myb protein 1 Target of Myb protein 1	Tom1	516	Annotation score:
A0A1D5RM84	A0A1D5RM84_MOUSE	Target of Myb protein 1 Target of Myb protein 1	Tom1	141	Annotation score:
A0A1D5RM12	A0A1D5RM12_MOUSE	Target of Myb protein 1 Target of Myb protein 1	Tom1	68	Annotation score:
A0A1D5RL90	A0A1D5RL90_MOUSE	Target of Myb protein 1 Target of Myb protein 1	Tom1	96	Annotation score:
A0A1D5RM45	A0A1D5RM45_MOUSE	Target of Myb protein 1 Target of Myb protein 1	Tom1	97	Annotation score:
A0A1D5RM51	A0A1D5RM51_MOUSE	Target of Myb protein 1 Target of Myb protein 1	Tom1	25	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003991	1 – 324	Missing in isoform 2. 1 PublicationAdd BLAST		324
Alternative sequenceⁱVSP_003992	325 – 343	MGPDP…LAGMN → MGRANGTAGLLPGPSVSAD in isoform 2. 1 PublicationAdd BLAST		19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ006972 mRNA Translation: CAA07361.1 AK004063 mRNA Translation: BAE43160.1 AK028398 mRNA Translation: BAC25932.1 BC021633 mRNA Translation: AAH21633.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52601.1 [O88746-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_035752.1, NM_011622.3 [O88746-1]
UniGeneⁱ	Mm.1967 Mm.290868

Genome annotation databases

Ensemblⁱ	ENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870 [O88746-1]
GeneIDⁱ	21968
KEGGⁱ	mmu:21968
UCSC genome browser More...UCSCⁱ	uc009mha.2 mouse [O88746-1] uc009mhb.2 mouse [O88746-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88746	Target of myb1 homolog (Chicken)		MOUSE		492	UniRef100_O88746
UPI0007ECC06C		MOUSE		459
UPI00001E3F30		MOUSE		340

Protein	Similar proteins		Species	Score	Length	Source
O88746	Target of myb1 homolog (Chicken)		MOUSE		492	UniRef90_O88746
Target of myb1 homolog (Chicken)		RAT		492
Target of Myb protein 1		CRIGR		492
UPI000A317FB8		MUSCR		492
UPI000A306DE1		MUSPA		492
+6

Protein	Similar proteins		Species	Score	Length	Source
O88746	Target of Myb protein 1	)	HUMAN		492	UniRef50_O60784
TOM1-like protein 2		XENLA		507
Uncharacterized protein		CHLSB		510
Uncharacterized protein		RHIRO		510
Target of Myb protein 1		PTEAL		500
+395

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ006972 mRNA Translation: CAA07361.1 AK004063 mRNA Translation: BAE43160.1 AK028398 mRNA Translation: BAC25932.1 BC021633 mRNA Translation: AAH21633.1
CCDSⁱ	CCDS52601.1 [O88746-1]
RefSeqⁱ	NP_035752.1, NM_011622.3 [O88746-1]
UniGeneⁱ	Mm.1967 Mm.290868

3D structure databases

ProteinModelPortalⁱ	O88746
SMRⁱ	O88746
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204274, 2 interactors
IntActⁱ	O88746, 4 interactors
MINTⁱ	O88746
STRINGⁱ	10090.ENSMUSP00000036849

PTM databases

iPTMnetⁱ	O88746
PhosphoSitePlusⁱ	O88746

Proteomic databases

EPDⁱ	O88746
PaxDbⁱ	O88746
PeptideAtlasⁱ	O88746
PRIDEⁱ	O88746

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870 [O88746-1]
GeneIDⁱ	21968
KEGGⁱ	mmu:21968
UCSCⁱ	uc009mha.2 mouse [O88746-1] uc009mhb.2 mouse [O88746-2]

Organism-specific databases

CTDⁱ	10043
MGIⁱ	MGI:1338026 Tom1

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
GeneTreeⁱ	ENSGT00930000150885
HOGENOMⁱ	HOG000285970
HOVERGENⁱ	HBG025068
InParanoidⁱ	O88746
OMAⁱ	QAHLYRM
PhylomeDBⁱ	O88746
TreeFamⁱ	TF314105

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PMAP-CutDBⁱ	O88746
Protein Ontology More...PROⁱ	PR:O88746
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042870 Expressed in 32 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_TOM1
ExpressionAtlasⁱ	O88746 baseline and differential
Genevisibleⁱ	O88746 MM

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008942 ENTH_VHS IPR004152 GAT_dom IPR038425 GAT_sf IPR014645 TOM1 IPR002014 VHS_dom
Pfamⁱ	View protein in Pfam PF03127 GAT, 1 hit PF00790 VHS, 1 hit
PIRSFⁱ	PIRSF036948 TOM1, 1 hit
SMARTⁱ	View protein in SMART SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit
PROSITEⁱ	View protein in PROSITE PS50909 GAT, 1 hit PS50179 VHS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOM1_MOUSE
Accessionⁱ	O88746Primary (citable) accession number: O88746 Secondary accession number(s): Q3V4C6, Q9D120
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88746 (TOM1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Target of Myb protein 1

Tom1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Endosome

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ