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Protein

Target of Myb protein 1

Gene

Tom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking. Probable association with membranes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Target of Myb protein 1
Gene namesi
Name:Tom1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338026 Tom1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726291 – 492Target of Myb protein 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei164PhosphothreonineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei355PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Cross-linki385Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei462PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO88746
PaxDbiO88746
PeptideAtlasiO88746
PRIDEiO88746

PTM databases

iPTMnetiO88746
PhosphoSitePlusiO88746

Miscellaneous databases

PMAP-CutDBiO88746

Expressioni

Tissue specificityi

Ubiquitous. In adult brain, it is highly expressed at the mesencephalic level, in the hippocampal formation and medial lemniscus. In cerebellum, it is highly expressed in Purkinje cells and granular layers.

Developmental stagei

Ubiquitously expressed in the embryo, with a higher expression in the intestines.

Gene expression databases

BgeeiENSMUSG00000042870 Expressed in 32 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_TOM1
ExpressionAtlasiO88746 baseline and differential
GenevisibleiO88746 MM

Interactioni

Subunit structurei

Interacts with ZFYVE16; interaction is required to target it to endosomes.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TollipQ9QZ062EBI-74264,EBI-74272

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204274, 2 interactors
IntActiO88746, 4 interactors
MINTiO88746
STRINGi10090.ENSMUSP00000036849

Structurei

3D structure databases

ProteinModelPortaliO88746
SMRiO88746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 152VHSPROSITE-ProRule annotationAdd BLAST133
Domaini215 – 303GATPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the TOM1 family.Curated

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO88746
OMAiQAHLYRM
PhylomeDBiO88746
TreeFamiTF314105

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR002014 VHS_dom
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA
60 70 80 90 100
FRAVKKRIMG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV
110 120 130 140 150
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVAV YEDLRRKGLE
160 170 180 190 200
FPMTDLDMLS PIHTPQRTVF NSETPSRQNS VSSNTSQRGD LSQHATPLPT
210 220 230 240 250
PAVLPGDSPI TPTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQVEPAD
260 270 280 290 300
LELLQELNRT CRAMQQRILE LIPRISNEQL TEELLMINDN LNNVFLRHER
310 320 330 340 350
FERFRTGQTA KASSEAELAT DLIDMGPDPA ATNNLSSQLA GMNLGSRSVR
360 370 380 390 400
AGLQSLETSG HLEDDFDMFA LTRGSSLADQ RKGVKYEAPQ TTDGLAGALD
410 420 430 440 450
ARQQSTGAIP ATQARIMEDI EQWLSTDVGN SAEEPSGVTS EEFDKFLEER
460 470 480 490
AKAADRLPNL ASPSAEGPPR PSPGTAPRRK TQEKDDDMLF AL
Length:492
Mass (Da):54,325
Last modified:November 1, 1998 - v1
Checksum:iA15F24FD9B4D31C3
GO
Isoform 2 (identifier: O88746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.
     325-343: MGPDPAATNNLSSQLAGMN → MGRANGTAGLLPGPSVSAD

Show »
Length:168
Mass (Da):17,788
Checksum:i3AA2CF5B2EBAD575
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UDC3Q3UDC3_MOUSE
Target of Myb protein 1
Tom1
516Annotation score:
A0A1D5RM84A0A1D5RM84_MOUSE
Target of Myb protein 1
Tom1
141Annotation score:
A0A1D5RM12A0A1D5RM12_MOUSE
Target of Myb protein 1
Tom1
68Annotation score:
A0A1D5RL90A0A1D5RL90_MOUSE
Target of Myb protein 1
Tom1
96Annotation score:
A0A1D5RM45A0A1D5RM45_MOUSE
Target of Myb protein 1
Tom1
97Annotation score:
A0A1D5RM51A0A1D5RM51_MOUSE
Target of Myb protein 1
Tom1
25Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039911 – 324Missing in isoform 2. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_003992325 – 343MGPDP…LAGMN → MGRANGTAGLLPGPSVSAD in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006972 mRNA Translation: CAA07361.1
AK004063 mRNA Translation: BAE43160.1
AK028398 mRNA Translation: BAC25932.1
BC021633 mRNA Translation: AAH21633.1
CCDSiCCDS52601.1 [O88746-1]
RefSeqiNP_035752.1, NM_011622.3 [O88746-1]
UniGeneiMm.1967
Mm.290868

Genome annotation databases

EnsembliENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870 [O88746-1]
GeneIDi21968
KEGGimmu:21968
UCSCiuc009mha.2 mouse [O88746-1]
uc009mhb.2 mouse [O88746-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006972 mRNA Translation: CAA07361.1
AK004063 mRNA Translation: BAE43160.1
AK028398 mRNA Translation: BAC25932.1
BC021633 mRNA Translation: AAH21633.1
CCDSiCCDS52601.1 [O88746-1]
RefSeqiNP_035752.1, NM_011622.3 [O88746-1]
UniGeneiMm.1967
Mm.290868

3D structure databases

ProteinModelPortaliO88746
SMRiO88746
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204274, 2 interactors
IntActiO88746, 4 interactors
MINTiO88746
STRINGi10090.ENSMUSP00000036849

PTM databases

iPTMnetiO88746
PhosphoSitePlusiO88746

Proteomic databases

EPDiO88746
PaxDbiO88746
PeptideAtlasiO88746
PRIDEiO88746

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870 [O88746-1]
GeneIDi21968
KEGGimmu:21968
UCSCiuc009mha.2 mouse [O88746-1]
uc009mhb.2 mouse [O88746-2]

Organism-specific databases

CTDi10043
MGIiMGI:1338026 Tom1

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO88746
OMAiQAHLYRM
PhylomeDBiO88746
TreeFamiTF314105

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PMAP-CutDBiO88746
PROiPR:O88746
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042870 Expressed in 32 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_TOM1
ExpressionAtlasiO88746 baseline and differential
GenevisibleiO88746 MM

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR002014 VHS_dom
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOM1_MOUSE
AccessioniPrimary (citable) accession number: O88746
Secondary accession number(s): Q3V4C6, Q9D120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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