UniProtKB - O88746 (TOM1_MOUSE)
Protein
Target of Myb protein 1
Gene
Tom1
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in intracellular trafficking. Probable association with membranes.
GO - Molecular functioni
- clathrin binding Source: MGI
GO - Biological processi
- intracellular protein transport Source: InterPro
- signal transduction Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Target of Myb protein 1 |
Gene namesi | Name:Tom1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338026, Tom1 |
Subcellular locationi
Other locations
- Cytoplasm Curated
- Membrane Curated; Peripheral membrane protein Curated
Cytosol
- cytosol Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
- endosome Source: MGI
Other locations
Keywords - Cellular componenti
Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072629 | 1 – 492 | Target of Myb protein 1Add BLAST | 492 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 160 | PhosphoserineCombined sources | 1 | |
Modified residuei | 164 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 176 | PhosphoserineCombined sources | 1 | |
Modified residuei | 180 | PhosphoserineCombined sources | 1 | |
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Modified residuei | 355 | PhosphoserineBy similarity | 1 | |
Modified residuei | 376 | PhosphoserineBy similarity | 1 | |
Cross-linki | 385 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 462 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O88746 |
jPOSTi | O88746 |
PaxDbi | O88746 |
PeptideAtlasi | O88746 |
PRIDEi | O88746 |
PTM databases
iPTMneti | O88746 |
PhosphoSitePlusi | O88746 |
Expressioni
Tissue specificityi
Ubiquitous. In adult brain, it is highly expressed at the mesencephalic level, in the hippocampal formation and medial lemniscus. In cerebellum, it is highly expressed in Purkinje cells and granular layers.
Developmental stagei
Ubiquitously expressed in the embryo, with a higher expression in the intestines.
Gene expression databases
Bgeei | ENSMUSG00000042870, Expressed in lens of camera-type eye and 64 other tissues |
ExpressionAtlasi | O88746, baseline and differential |
Genevisiblei | O88746, MM |
Interactioni
Subunit structurei
Interacts with ZFYVE16; interaction is required to target it to endosomes.
By similarityBinary interactionsi
O88746
With | #Exp. | IntAct |
---|---|---|
Tollip [Q9QZ06] | 2 | EBI-74264,EBI-74272 |
GO - Molecular functioni
- clathrin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204274, 8 interactors |
IntActi | O88746, 4 interactors |
MINTi | O88746 |
STRINGi | 10090.ENSMUSP00000036849 |
Miscellaneous databases
RNActi | O88746, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 152 | VHSPROSITE-ProRule annotationAdd BLAST | 133 | |
Domaini | 215 – 303 | GATPROSITE-ProRule annotationAdd BLAST | 89 |
Sequence similaritiesi
Belongs to the TOM1 family.Curated
Phylogenomic databases
eggNOGi | KOG1087, Eukaryota |
GeneTreei | ENSGT00940000156865 |
HOGENOMi | CLU_043812_3_0_1 |
InParanoidi | O88746 |
OMAi | QGNPFAT |
PhylomeDBi | O88746 |
TreeFami | TF314105 |
Family and domain databases
Gene3Di | 1.20.58.160, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR004152, GAT_dom IPR038425, GAT_sf IPR014645, TOM1 IPR002014, VHS_dom |
Pfami | View protein in Pfam PF03127, GAT, 1 hit PF00790, VHS, 1 hit |
PIRSFi | PIRSF036948, TOM1, 1 hit |
SMARTi | View protein in SMART SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50909, GAT, 1 hit PS50179, VHS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O88746-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA
60 70 80 90 100
FRAVKKRIMG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV
110 120 130 140 150
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVAV YEDLRRKGLE
160 170 180 190 200
FPMTDLDMLS PIHTPQRTVF NSETPSRQNS VSSNTSQRGD LSQHATPLPT
210 220 230 240 250
PAVLPGDSPI TPTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQVEPAD
260 270 280 290 300
LELLQELNRT CRAMQQRILE LIPRISNEQL TEELLMINDN LNNVFLRHER
310 320 330 340 350
FERFRTGQTA KASSEAELAT DLIDMGPDPA ATNNLSSQLA GMNLGSRSVR
360 370 380 390 400
AGLQSLETSG HLEDDFDMFA LTRGSSLADQ RKGVKYEAPQ TTDGLAGALD
410 420 430 440 450
ARQQSTGAIP ATQARIMEDI EQWLSTDVGN SAEEPSGVTS EEFDKFLEER
460 470 480 490
AKAADRLPNL ASPSAEGPPR PSPGTAPRRK TQEKDDDMLF AL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3UDC3 | Q3UDC3_MOUSE | Target of Myb protein 1 | Tom1 | 516 | Annotation score: | ||
A0A1D5RM45 | A0A1D5RM45_MOUSE | Target of Myb protein 1 | Tom1 | 97 | Annotation score: | ||
A0A1D5RM51 | A0A1D5RM51_MOUSE | Target of Myb protein 1 | Tom1 | 25 | Annotation score: | ||
A0A1D5RM84 | A0A1D5RM84_MOUSE | Target of Myb protein 1 | Tom1 | 141 | Annotation score: | ||
A0A1D5RL90 | A0A1D5RL90_MOUSE | Target of Myb protein 1 | Tom1 | 96 | Annotation score: | ||
A0A1D5RM12 | A0A1D5RM12_MOUSE | Target of Myb protein 1 | Tom1 | 68 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003991 | 1 – 324 | Missing in isoform 2. 1 PublicationAdd BLAST | 324 | |
Alternative sequenceiVSP_003992 | 325 – 343 | MGPDP…LAGMN → MGRANGTAGLLPGPSVSAD in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ006972 mRNA Translation: CAA07361.1 AK004063 mRNA Translation: BAE43160.1 AK028398 mRNA Translation: BAC25932.1 BC021633 mRNA Translation: AAH21633.1 |
CCDSi | CCDS52601.1 [O88746-1] |
RefSeqi | NP_035752.1, NM_011622.3 [O88746-1] |
Genome annotation databases
Ensembli | ENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870 [O88746-1] |
GeneIDi | 21968 |
KEGGi | mmu:21968 |
UCSCi | uc009mha.2, mouse [O88746-1] uc009mhb.2, mouse [O88746-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ006972 mRNA Translation: CAA07361.1 AK004063 mRNA Translation: BAE43160.1 AK028398 mRNA Translation: BAC25932.1 BC021633 mRNA Translation: AAH21633.1 |
CCDSi | CCDS52601.1 [O88746-1] |
RefSeqi | NP_035752.1, NM_011622.3 [O88746-1] |
3D structure databases
SMRi | O88746 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204274, 8 interactors |
IntActi | O88746, 4 interactors |
MINTi | O88746 |
STRINGi | 10090.ENSMUSP00000036849 |
PTM databases
iPTMneti | O88746 |
PhosphoSitePlusi | O88746 |
Proteomic databases
EPDi | O88746 |
jPOSTi | O88746 |
PaxDbi | O88746 |
PeptideAtlasi | O88746 |
PRIDEi | O88746 |
Protocols and materials databases
Antibodypediai | 208, 187 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870 [O88746-1] |
GeneIDi | 21968 |
KEGGi | mmu:21968 |
UCSCi | uc009mha.2, mouse [O88746-1] uc009mhb.2, mouse [O88746-2] |
Organism-specific databases
CTDi | 10043 |
MGIi | MGI:1338026, Tom1 |
Phylogenomic databases
eggNOGi | KOG1087, Eukaryota |
GeneTreei | ENSGT00940000156865 |
HOGENOMi | CLU_043812_3_0_1 |
InParanoidi | O88746 |
OMAi | QGNPFAT |
PhylomeDBi | O88746 |
TreeFami | TF314105 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 21968, 0 hits in 17 CRISPR screens |
ChiTaRSi | Tom1, mouse |
PROi | PR:O88746 |
RNActi | O88746, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042870, Expressed in lens of camera-type eye and 64 other tissues |
ExpressionAtlasi | O88746, baseline and differential |
Genevisiblei | O88746, MM |
Family and domain databases
Gene3Di | 1.20.58.160, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR004152, GAT_dom IPR038425, GAT_sf IPR014645, TOM1 IPR002014, VHS_dom |
Pfami | View protein in Pfam PF03127, GAT, 1 hit PF00790, VHS, 1 hit |
PIRSFi | PIRSF036948, TOM1, 1 hit |
SMARTi | View protein in SMART SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50909, GAT, 1 hit PS50179, VHS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TOM1_MOUSE | |
Accessioni | O88746Primary (citable) accession number: O88746 Secondary accession number(s): Q3V4C6, Q9D120 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families