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Protein

Ganglioside-induced differentiation-associated protein 1

Gene

Gdap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the mitochondrial network by promoting mitochondrial fission.By similarity1 Publication

Caution

While belonging to the GST superfamily, it lacks glutathione transferase activity.Curated

GO - Biological processi

  • cellular response to vitamin D Source: Ensembl
  • mitochondrial fission Source: UniProtKB
  • mitochondrial fusion Source: MGI
  • mitochondrion organization Source: GO_Central
  • protein targeting to mitochondrion Source: UniProtKB
  • response to retinoic acid Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ganglioside-induced differentiation-associated protein 1
Short name:
GDAP1
Gene namesi
Name:Gdap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1338002 Gdap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860391 – 358Ganglioside-induced differentiation-associated protein 1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei203N6-acetyllysine; alternateBy similarity1
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO88741
PaxDbiO88741
PeptideAtlasiO88741
PRIDEiO88741

PTM databases

iPTMnetiO88741
PhosphoSitePlusiO88741

Expressioni

Tissue specificityi

Expressed in brain, spinal cord, muscles and intestinal villi. In the central nervous system expressed most prominently in the cortex, cerebellum, thalamus, olfactory bulb, and spinal cord. Expressed also in sciatic nerves and in dorsal root ganglia.1 Publication

Developmental stagei

First expressed at embryonic stage E13. Levels then increase gradually to reach maximum levels at adulthood.

Inductioni

Increased expression during neural differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000025777 Expressed in 181 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiO88741 baseline and differential
GenevisibleiO88741 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO88741, 2 interactors
MINTiO88741
STRINGi10090.ENSMUSP00000026879

Structurei

3D structure databases

ProteinModelPortaliO88741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 105GST N-terminalAdd BLAST82
Domaini153 – 309GST C-terminalAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 358Required for mitochondrial localizationBy similarityAdd BLAST39

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4420 Eukaryota
ENOG410YE2J LUCA
GeneTreeiENSGT00510000046788
HOGENOMiHOG000231002
HOVERGENiHBG051717
InParanoidiO88741
KOiK22077
OMAiGHQPWLC
OrthoDBiEOG091G0BAC
PhylomeDBiO88741
TreeFamiTF327072

Family and domain databases

InterProiView protein in InterPro
IPR034336 GDAP1
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR44188 PTHR44188, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O88741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARRQDEARA GVPLRVEGPP DKEVHLILYH WTHSFSSQKV RLVIAEKALK
60 70 80 90 100
CEEHDVSLPL SEHNEPWFMR LNSAGEVPVL VHGENIICEA TQIIDYLEQT
110 120 130 140 150
FLDERTPRLM PDEGSMYYPR VQHYRELLDS LPMDAYTHGC ILHPELTVDS
160 170 180 190 200
MIPAYATTRI RSQIGNTESE LKKLAEENPD LQEAYIAKQK RLKSKLLDHD
210 220 230 240 250
NVKYLKKILD ELEKVLDQVE TELQRRNEET PEEGNQPWLC GESFTLADVS
260 270 280 290 300
LAVTLHRLKF LGFARRNWGH GKRPNLETYY ERVLKRKTFN KVLGHVNNIL
310 320 330 340 350
ISAVLPTAFR VAKKRAPKVL GSTLVVGLLV GMGYFAFMLF RRRLGSMILA

LRPRPNYF
Length:358
Mass (Da):41,311
Last modified:November 1, 1998 - v1
Checksum:i7B533CB34138891F
GO
Isoform 2 (identifier: O88741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: Q → M
     164-358: Missing.

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,839
Checksum:i9EB6A9DF30B75DC3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQZ4A0A087WQZ4_MOUSE
Ganglioside-induced differentiation...
Gdap1
60Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008791163Q → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_008792164 – 358Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17850 mRNA Translation: CAA76893.1
AK020988 mRNA Translation: BAB32270.1
AK045460 mRNA Translation: BAC32380.1
AK049655 mRNA Translation: BAC33861.1
AK083814 mRNA Translation: BAC39027.1
BC048177 mRNA Translation: AAH48177.1
BC051135 mRNA Translation: AAH51135.1
CCDSiCCDS14834.1 [O88741-1]
RefSeqiNP_034397.1, NM_010267.3 [O88741-1]
UniGeneiMm.18218

Genome annotation databases

EnsembliENSMUST00000026879; ENSMUSP00000026879; ENSMUSG00000025777 [O88741-1]
GeneIDi14545
KEGGimmu:14545
UCSCiuc007akb.2 mouse [O88741-2]
uc007akc.2 mouse [O88741-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17850 mRNA Translation: CAA76893.1
AK020988 mRNA Translation: BAB32270.1
AK045460 mRNA Translation: BAC32380.1
AK049655 mRNA Translation: BAC33861.1
AK083814 mRNA Translation: BAC39027.1
BC048177 mRNA Translation: AAH48177.1
BC051135 mRNA Translation: AAH51135.1
CCDSiCCDS14834.1 [O88741-1]
RefSeqiNP_034397.1, NM_010267.3 [O88741-1]
UniGeneiMm.18218

3D structure databases

ProteinModelPortaliO88741
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88741, 2 interactors
MINTiO88741
STRINGi10090.ENSMUSP00000026879

PTM databases

iPTMnetiO88741
PhosphoSitePlusiO88741

Proteomic databases

MaxQBiO88741
PaxDbiO88741
PeptideAtlasiO88741
PRIDEiO88741

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026879; ENSMUSP00000026879; ENSMUSG00000025777 [O88741-1]
GeneIDi14545
KEGGimmu:14545
UCSCiuc007akb.2 mouse [O88741-2]
uc007akc.2 mouse [O88741-1]

Organism-specific databases

CTDi54332
MGIiMGI:1338002 Gdap1

Phylogenomic databases

eggNOGiKOG4420 Eukaryota
ENOG410YE2J LUCA
GeneTreeiENSGT00510000046788
HOGENOMiHOG000231002
HOVERGENiHBG051717
InParanoidiO88741
KOiK22077
OMAiGHQPWLC
OrthoDBiEOG091G0BAC
PhylomeDBiO88741
TreeFamiTF327072

Miscellaneous databases

PROiPR:O88741
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025777 Expressed in 181 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiO88741 baseline and differential
GenevisibleiO88741 MM

Family and domain databases

InterProiView protein in InterPro
IPR034336 GDAP1
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR44188 PTHR44188, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDAP1_MOUSE
AccessioniPrimary (citable) accession number: O88741
Secondary accession number(s): Q8C7Q5, Q9CTN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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