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Protein

Baculoviral IAP repeat-containing protein 6

Gene

Birc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4691Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor, Transferase
Biological processApoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I32.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 6 (EC:2.3.2.271 Publication)
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name:
BRUCE
RING-type E3 ubiquitin transferase BIRC6Curated
Ubiquitin-conjugating BIR domain enzyme apollon
Short name:
APOLLON
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Birc6
Synonyms:Kiaa1289
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1276108 Birc6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004162471 – 4882Baculoviral IAP repeat-containing protein 6Add BLAST4882

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei476PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei584PhosphoserineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei1724PhosphothreonineBy similarity1
Modified residuei2245PhosphoserineBy similarity1
Modified residuei2978PhosphoserineBy similarity1
Modified residuei3954PhosphothreonineBy similarity1
Modified residuei4047PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O88738

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88738

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88738

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88738

PeptideAtlas

More...
PeptideAtlasi
O88738

PRoteomics IDEntifications database

More...
PRIDEi
O88738

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88738

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88738

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O88738

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in the brain and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024073 Expressed in 296 organ(s), highest expression level in cumulus cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O88738 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O88738 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 (By similarity). Interacts with CASP9, DIABLO/SMAC and HTRA2.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
198389, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O88738

Protein interaction database and analysis system

More...
IntActi
O88738, 11 interactors

Molecular INTeraction database

More...
MINTi
O88738

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000024879

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88738

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88738

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati292 – 362BIRAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4592 – 4720Ubiquitin-conjugatingBy similarityAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1669 – 1697Ala-richAdd BLAST29
Compositional biasi2203 – 2206Poly-Ala4
Compositional biasi2406 – 2410Poly-Leu5
Compositional biasi2694 – 2697Poly-Ser4
Compositional biasi2759 – 2764Poly-Ser6
Compositional biasi4445 – 4450Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0895 Eukaryota
KOG1101 Eukaryota
ENOG410XP8C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168828

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG077728

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O88738

KEGG Orthology (KO)

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KOi
K10586

Identification of Orthologs from Complete Genome Data

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OMAi
CNGGIRP

Database of Orthologous Groups

More...
OrthoDBi
1404665at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105357

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00022 BIR, 1 hit
cd00195 UBCc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001370 BIR_rpt
IPR022103 BIRC6
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00653 BIR, 1 hit
PF12356 BIRC6, 1 hit
PF00179 UQ_con, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238 BIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF54495 SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50143 BIR_REPEAT_2, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88738-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA
60 70 80 90 100
GAAGVSEWLV LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT
110 120 130 140 150
SGATLQASAL SAKPGGQVKC QYISAVDKVI FVDDYAVGCR KDLNGILLLD
160 170 180 190 200
TALQTPVSKQ DDVVQLELPV TEAQQLLSAC IEKIDVSSTE GYDLFITQLK
210 220 230 240 250
DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN ELKKINQNVA
260 270 280 290 300
ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP
310 320 330 340 350
HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE
360 370 380 390 400
HERHSPNCPF VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP
410 420 430 440 450
QFLAAATKRG KICIWDVSKL MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV
460 470 480 490 500
DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL EDSDSEEHSR SDSVTGHTSQ
510 520 530 540 550
KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE LGANPSLTNS
560 570 580 590 600
KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT
610 620 630 640 650
QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS
660 670 680 690 700
QMNNIMSKSL HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS
710 720 730 740 750
LTSPDSEKWN SVFPKPGALV QCLRLPKFAE EETLCIDSIT PCADGIHLLV
760 770 780 790 800
GLRTCSVESL SAINQVEALN NLNKLNSALC NRRKGDLESN LAVVNGANIS
810 820 830 840 850
VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI VTLEEEPVKI
860 870 880 890 900
QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD
910 920 930 940 950
ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC
960 970 980 990 1000
SGTDRLCACT KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR
1010 1020 1030 1040 1050
PLSNPSSPGI SGVELLVDQP FTLEILTSLV ELTRFETLTP RFSATVPPCW
1060 1070 1080 1090 1100
VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT WKLQTDSNSW DEHVFELVLP
1110 1120 1130 1140 1150
KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN ALNIEVEHNG
1160 1170 1180 1190 1200
NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG
1210 1220 1230 1240 1250
HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR
1260 1270 1280 1290 1300
LPSLKQQGHK GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL
1310 1320 1330 1340 1350
LQEVSVTIRR FKKTSICKER VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT
1360 1370 1380 1390 1400
EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE CLLSKTRKCL SDIVRVCFFE
1410 1420 1430 1440 1450
AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN MCFLPAAATG
1460 1470 1480 1490 1500
GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR
1510 1520 1530 1540 1550
YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS
1560 1570 1580 1590 1600
SCTAAEGSFT SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP
1610 1620 1630 1640 1650
PAVGGLSSGT VGEASTALSS AAQVALQSLS HAMASAEQQL QVLQEKQQQL
1660 1670 1680 1690 1700
LKLQQQKAKL EAKLHQTTAA AAAAASAAAA AAAGPVHNAV PSNPVAAPGF
1710 1720 1730 1740 1750
FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ LFPGSVIDPP
1760 1770 1780 1790 1800
AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG
1810 1820 1830 1840 1850
ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD
1860 1870 1880 1890 1900
ISTHSLILHD LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP
1910 1920 1930 1940 1950
WESELKLMHD PLRGEGESAS QPEIDQHLAM MVALQEDIQC RYNLACHRLE
1960 1970 1980 1990 2000
ALLQSIDLPP LNSANNAQYF LRKPDKAVEE DSRVFSAYQD CIQLQLQLNL
2010 2020 2030 2040 2050
AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI VRYLLDTLLS
2060 2070 2080 2090 2100
LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC
2110 2120 2130 2140 2150
GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE
2160 2170 2180 2190 2200
SLLNLLDNLL SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE
2210 2220 2230 2240 2250
DEAAAAKKPL NGKDRERFLT GNQWSFINNN LHTQNLNRSS KGGSSLDRLY
2260 2270 2280 2290 2300
SRKIRKQLVH HKQQLNLLKA KQKALVEQME KEKIQSNKGS SYKLLVEQAK
2310 2320 2330 2340 2350
LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE PLPFTLAHDR
2360 2370 2380 2390 2400
CISVVQKLVL FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE
2410 2420 2430 2440 2450
PQLERLLLLL VGTDFNRGDI SWGGAWAQYS LTCMLQDILA GELLAPVAAE
2460 2470 2480 2490 2500
AMEECTVSED VGATAGDSDD SLQQSPAQLL ETIDEPLTHE IAGTPPLSSL
2510 2520 2530 2540 2550
EKDKEIDLEL LQDLMEVDID PLDIDLEKDP LAAKVFKPIS STWYDYWGAD
2560 2570 2580 2590 2600
YGTYNYNPYI GGLGMPVAKP PSNTEKNGSQ TVSVSVSQAL DARLEVGLEQ
2610 2620 2630 2640 2650
QAELMLKMMS TLEADSILQA LTNTSPTFSQ SPTGTDDSLL GNLQPANQNS
2660 2670 2680 2690 2700
QLMIQLSSVP MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK
2710 2720 2730 2740 2750
ENGADIFLYN ANRIPVISLN QASIASFLTV LAWYPNTLLR TWCLVLHSLT
2760 2770 2780 2790 2800
LMTNMQLNSG SSSSIGIQET TAHLLVSDPN LIHVLVKFLS GTSPHGTNQH
2810 2820 2830 2840 2850
SPQVGPTATQ AMQEFLTRLQ VHLSSTCPQI FSELLLKLIH ILSTERGAFQ
2860 2870 2880 2890 2900
TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS AVIESVTFLV HHYITCSDKV
2910 2920 2930 2940 2950
MSRSGSDSSA GARACFGGLF ANLIRPGDAK AVCGEMTRDQ LMFDLLKLVN
2960 2970 2980 2990 3000
ILVQLPLSSN REYSARVSVT TNTTDSVSDE EKVSGGKDVN GSSASTPGSP
3010 3020 3030 3040 3050
ACVADLVLAN QQIMSQILSA LGLCNSSAMA MIIGASGLHL TKHENFHGGL
3060 3070 3080 3090 3100
DAISVGDGLF TILTTLSKKA STVHMMLQPI LTYMACGYMG RQGSLATCQL
3110 3120 3130 3140 3150
SEPLLWFILR VLDTSDALKA FHDMGGVQLI CNNMVTSTRA IVNTARSMVS
3160 3170 3180 3190 3200
TIMKFLDSGP NKAVDSTLKT RILASEPDNA EGIHNFAPLG TITSSSPTAQ
3210 3220 3230 3240 3250
PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPSA VLLKEIHIQP
3260 3270 3280 3290 3300
HLASLATCPS SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA
3310 3320 3330 3340 3350
VCLRLHRPRD ASTLGLSQIK LLGLTAFGTT SSATVNNPFL PSEDQVSKTS
3360 3370 3380 3390 3400
IGWLRLLHHC LTHISDLEGM MASAAAPTAN LLQTCAALLM SPYCGMHSPN
3410 3420 3430 3440 3450
IEVVLVKIGL QSTRIGLKLI DILLRNCAAS GSDPTDLNSP LLFGRLNGLS
3460 3470 3480 3490 3500
SDSTIDILYQ LGTTQDPGTK DRIQALLKWV SDSAKMAALK RSGRMNYMCP
3510 3520 3530 3540 3550
SSSAVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL DRELFELLFN
3560 3570 3580 3590 3600
WSMSLPCNVV LKKAVDSLLC SMCHIHPNYF SLLMGWMGII PPPVQCHHRL
3610 3620 3630 3640 3650
SMTDDSKKQD LSSSLTDDSK NAQAPLSLTE SHLATLASSS QSPEAIKQLL
3660 3670 3680 3690 3700
DSGLPSLLVR SLASFCFSHI SYSESIAQSV DNSQDKLRRH HVPQHCNKMP
3710 3720 3730 3740 3750
ITADLVAPIL RFLTEVGNSH IMKDWLGGSE VNPLWTALLF LLCHSGSTAG
3760 3770 3780 3790 3800
GHNLGAQQSS TRSASHSSAT TTVLTTQQRT AIENATVAFF LQCISCHPNN
3810 3820 3830 3840 3850
QKLMAQVLCE LFQTAPQRGS LPTSGNISGF VRRLFLQLML EDEKVTMFLQ
3860 3870 3880 3890 3900
SPCPLYKGRI NATSHVIQHP MFGAGHKFRT LHLPVSTTLS DVLDRVSDTP
3910 3920 3930 3940 3950
SITAKLISEQ KDDKEKKNHE EKEKVKAENG FQDNYSVVVA SGLKSQSKRA
3960 3970 3980 3990 4000
MASTPPRPPS RRGRTIPDKI GSASSSADAA SKIITVPVFH LFHRLLAGQP
4010 4020 4030 4040 4050
LPAEMTLAQL LTLLYDRKLP QGYRSIDLTV KLGSKVITDP SLSKTDSFKR
4060 4070 4080 4090 4100
LHPEKDHGDL VGSCPEDEAL TPSDECMDGV LDESLLETCP IQSPLQVFAG
4110 4120 4130 4140 4150
MGGLALIAER LPMLYPEVIQ QVSAPVIAST TQEKPKDSDQ FEWVTIEQSG
4160 4170 4180 4190 4200
ELVYEAPETI AAEPPPVKSA VQATSPIPAH SLAAFGLFLR LPGYAEVLLK
4210 4220 4230 4240 4250
ERKHAQCLLR LVLGVTDDGE GSHILQSPSA NVLPTLPFHV LRSLFSATPL
4260 4270 4280 4290 4300
TTDDGVLLRR MALEIGALHL ILVCLSALSH HAPRVPNSSL SQTEPQVSNS
4310 4320 4330 4340 4350
HNPTSAEEQQ LYWAKGTGFG TGSTASGWDV EQALTKQRLE EEHVTCLLQV
4360 4370 4380 4390 4400
LASYINPMSG AVNGEAQASP ESRAQNSSAL PSVLLELLSQ SCLIPAMSSY
4410 4420 4430 4440 4450
LRNDSVLDMA RHVPLYRALL ELLRAIASCT SMVPLLLPLS TENGEEEEDE
4460 4470 4480 4490 4500
QSECQTSVGT LLAKMKTCVD TYTNRLRSKR ENVKAGVKPD APDQEPEGLA
4510 4520 4530 4540 4550
LLVPDIQRTA EIVHAATANL RQANQEKKLG EYSKKVVMKP KPLSVLKSLE
4560 4570 4580 4590 4600
EKYVAVMKKL QFDTFEMVSE DDDGKLGFKV NYHYMSQVKN ANDANSAARA
4610 4620 4630 4640 4650
RRLAQEAVTL STSLPLSSSS SVFVRCDEER LDIMKVLITG PADTPYANGC
4660 4670 4680 4690 4700
FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF NPNLYNDGKV CLSILNTWHG
4710 4720 4730 4740 4750
RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR GTPSGTQSSR
4760 4770 4780 4790 4800
EYDGNIRQAT VKWAMLEQIR NPSPCFKEVI HKHFYLKRIE LMAQCEEWIA
4810 4820 4830 4840 4850
DIQQYSSDKR VGRTMSHHAA ALKRHTAQLR EELLKLPCPE GLDPDIEDAS
4860 4870 4880
PVCRATAGAE DTLTHDHVNP SSSKDLPSDF QL
Length:4,882
Mass (Da):532,170
Last modified:March 21, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F804ACFA3AFA211
GO
Isoform 2 (identifier: O88738-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2212-2220: Missing.

Show »
Length:4,873
Mass (Da):531,067
Checksum:i58562C9F94576EF2
GO
Isoform 3 (identifier: O88738-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2057-2062: Missing.
     2212-2220: Missing.

Show »
Length:4,867
Mass (Da):530,518
Checksum:iA6386423866153B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2P8S4R2P8_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
4,869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1L5S4R1L5_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
4,853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R268S4R268_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
597Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QP64J3QP64_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
973Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J7S4R2J7_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1R8S4R1R8_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1S3S4R1S3_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2N7S4R2N7_MOUSE
Baculoviral IAP repeat-containing p...
Birc6
437Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32373 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC37801 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA76720 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206T → I in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti552S → R in BAC37801 (PubMed:16141072).Curated1
Sequence conflicti718A → T in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti2107G → R in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti2455C → G in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti2996T → I in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti3214R → K in BAC35061 (PubMed:16141072).Curated1
Sequence conflicti3263S → T in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti3951M → V in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti3966I → V in CAA76720 (PubMed:9628897).Curated1
Sequence conflicti4383V → M in CAA76720 (PubMed:9628897).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0425362057 – 2062Missing in isoform 3. 1 Publication6
Alternative sequenceiVSP_0425372212 – 2220Missing in isoform 2 and isoform 3. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y17267 mRNA Translation: CAA76720.1 Different initiation.
AC098726 Genomic DNA No translation available.
AC154442 Genomic DNA No translation available.
AK041241 mRNA Translation: BAC30874.1
AK045446 mRNA Translation: BAC32373.1 Different initiation.
AK052612 mRNA Translation: BAC35061.1
AK079995 mRNA Translation: BAC37801.1 Different initiation.
AK173143 Transcribed RNA Translation: BAD32421.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37693.2 [O88738-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T31067

NCBI Reference Sequences

More...
RefSeqi
NP_031592.3, NM_007566.3 [O88738-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.442564
Mm.447926

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073 [O88738-2]
ENSMUST00000182133; ENSMUSP00000138693; ENSMUSG00000024073 [O88738-3]
ENSMUST00000182597; ENSMUSP00000138333; ENSMUSG00000024073 [O88738-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12211

UCSC genome browser

More...
UCSCi
uc033hfd.1 mouse [O88738-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17267 mRNA Translation: CAA76720.1 Different initiation.
AC098726 Genomic DNA No translation available.
AC154442 Genomic DNA No translation available.
AK041241 mRNA Translation: BAC30874.1
AK045446 mRNA Translation: BAC32373.1 Different initiation.
AK052612 mRNA Translation: BAC35061.1
AK079995 mRNA Translation: BAC37801.1 Different initiation.
AK173143 Transcribed RNA Translation: BAD32421.1
CCDSiCCDS37693.2 [O88738-2]
PIRiT31067
RefSeqiNP_031592.3, NM_007566.3 [O88738-2]
UniGeneiMm.442564
Mm.447926

3D structure databases

ProteinModelPortaliO88738
SMRiO88738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198389, 4 interactors
CORUMiO88738
IntActiO88738, 11 interactors
MINTiO88738
STRINGi10090.ENSMUSP00000024879

Protein family/group databases

MEROPSiI32.006

PTM databases

iPTMnetiO88738
PhosphoSitePlusiO88738
SwissPalmiO88738

Proteomic databases

EPDiO88738
jPOSTiO88738
MaxQBiO88738
PaxDbiO88738
PeptideAtlasiO88738
PRIDEiO88738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073 [O88738-2]
ENSMUST00000182133; ENSMUSP00000138693; ENSMUSG00000024073 [O88738-3]
ENSMUST00000182597; ENSMUSP00000138333; ENSMUSG00000024073 [O88738-1]
GeneIDi12211
KEGGimmu:12211
UCSCiuc033hfd.1 mouse [O88738-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57448
MGIiMGI:1276108 Birc6

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0895 Eukaryota
KOG1101 Eukaryota
ENOG410XP8C LUCA
GeneTreeiENSGT00940000156126
HOGENOMiHOG000168828
HOVERGENiHBG077728
InParanoidiO88738
KOiK10586
OMAiCNGGIRP
OrthoDBi1404665at2759
TreeFamiTF105357

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Birc6 mouse

Protein Ontology

More...
PROi
PR:O88738

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024073 Expressed in 296 organ(s), highest expression level in cumulus cell
ExpressionAtlasiO88738 baseline and differential
GenevisibleiO88738 MM

Family and domain databases

CDDicd00022 BIR, 1 hit
cd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR022103 BIRC6
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00653 BIR, 1 hit
PF12356 BIRC6, 1 hit
PF00179 UQ_con, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
SSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50143 BIR_REPEAT_2, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIRC6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88738
Secondary accession number(s): E9PYU6
, Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: January 16, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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