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Entry version 149 (16 Oct 2019)
Sequence version 4 (27 Jul 2011)
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Protein

Protein bassoon

Gene

Bsn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12628168, PubMed:12628169, PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity) (PubMed:28231469). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri167 – 190C4-typeSequence analysisAdd BLAST24
Zinc fingeri195 – 217C4-typeSequence analysisAdd BLAST23
Zinc fingeri464 – 487C4-typeSequence analysisAdd BLAST24
Zinc fingeri492 – 514C4-typeSequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein bassoon1 PublicationCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BsnImported
Synonyms:Kiaa0434
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277955 Bsn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show a reduced excitability attributed to inactivation of a fraction of brain glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers, but were unable to fuse. In retina, mutants lacking functional BSN showed normal retinal anatomy, but synapses lacked anchoring of the photoreceptor ribbon to the presynaptic active zone resulting in impaired photoreceptor synaptic transmission (PubMed:12628168). Knockdown of both Bassoon/BSN and Piccolo/PCLO leads to the formation of presynaptic autophagosomes.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000650032 – 3942Protein bassoonAdd BLAST3941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineCombined sources1
Modified residuei145Omega-N-methylarginineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei881Omega-N-methylarginineCombined sources1
Modified residuei980PhosphoserineCombined sources1
Modified residuei1050PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1102PhosphothreonineCombined sources1
Modified residuei1108PhosphoserineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1236PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1354O-linked (GlcNAc) threonineBy similarity1
Glycosylationi1395O-linked (GlcNAc) threonine1 Publication1
Modified residuei1482PhosphoserineCombined sources1
Modified residuei1491PhosphoserineCombined sources1
Modified residuei1493PhosphoserineCombined sources1
Glycosylationi1707O-linked (GlcNAc) serine1 Publication1
Modified residuei1792Omega-N-methylarginineCombined sources1
Modified residuei1796Omega-N-methylarginineCombined sources1
Modified residuei1806Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei1806Omega-N-methylarginine; alternateCombined sources1
Modified residuei1818Omega-N-methylarginineCombined sources1
Glycosylationi1934O-linked (GlcNAc) threonine1 Publication1
Modified residuei1990PhosphoserineCombined sources1
Modified residuei2046PhosphoserineCombined sources1
Modified residuei2051Omega-N-methylarginineCombined sources1
Modified residuei2081Omega-N-methylarginineCombined sources1
Modified residuei2255Asymmetric dimethylarginineCombined sources1
Modified residuei2265Asymmetric dimethylarginineCombined sources1
Modified residuei2270Asymmetric dimethylarginineCombined sources1
Glycosylationi2318O-linked (GlcNAc) threonine1 Publication1
Glycosylationi2524O-linked (GlcNAc) threonine1 Publication1
Modified residuei2578PhosphoserineCombined sources1
Modified residuei2595PhosphothreonineCombined sources1
Modified residuei2622PhosphothreonineCombined sources1
Glycosylationi2700O-linked (GlcNAc) threonine1 Publication1
Modified residuei2811PhosphoserineCombined sources1
Modified residuei2860PhosphoserineCombined sources1
Modified residuei2866PhosphoserineCombined sources1
Glycosylationi2945O-linked (GlcNAc) threonine1 Publication1
Modified residuei3022PhosphoserineCombined sources1
Modified residuei3301PhosphoserineCombined sources1
Modified residuei3382PhosphoserineCombined sources1
Modified residuei3502Omega-N-methylarginineCombined sources1
Modified residuei3823Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88737

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88737

PeptideAtlas

More...
PeptideAtlasi
O88737

PRoteomics IDEntifications database

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PRIDEi
O88737

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88737

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88737

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O88737

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and retina.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032589 Expressed in 146 organ(s), highest expression level in telencephalon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O88737 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O88737 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCLO, ERC2/CAST1, RIMS1 and UNC13A (PubMed:19812333).

Interacts with TPRG1L (PubMed:17869247).

Interacts with DYNLL1 and DYNLL2; these interactions potentially link PTVs to dynein and myosin V motor complexes (By similarity).

Interacts with ATG5; this interaction is important for the regulation of presynaptic autophagy (PubMed:28231469).

Interacts (via C-terminus) with TRIO (via N-terminus) (By similarity).

Interacts with CTBP1 (By similarity).

Interacts with SIAH1; this interaction negatively regulates SIAH1 E3 ligase activity (By similarity).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
198393, 4 interactors

Protein interaction database and analysis system

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IntActi
O88737, 9 interactors

Molecular INTeraction database

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MINTi
O88737

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000035208

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O88737

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati570 – 57617
Repeati577 – 58327
Repeati584 – 59037
Repeati591 – 59747
Repeati598 – 60457

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni62 – 715 X 2 AA tandem repeats of P-G10
Regioni570 – 6045 X 7 AA tandem repeats of K-A-S-P-Q-[AT]-[AT]Add BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2366 – 2422Sequence analysisAdd BLAST57
Coiled coili2453 – 2483Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2608 – 2614Poly-Arg7
Compositional biasi2635 – 2640Poly-Arg6
Compositional biasi3784 – 3798Poly-GlnAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 190C4-typeSequence analysisAdd BLAST24
Zinc fingeri195 – 217C4-typeSequence analysisAdd BLAST23
Zinc fingeri464 – 487C4-typeSequence analysisAdd BLAST24
Zinc fingeri492 – 514C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGEH Eukaryota
ENOG410XX5R LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00620000087961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000095267

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O88737

Database of Orthologous Groups

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OrthoDBi
29707at2759

TreeFam database of animal gene trees

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TreeFami
TF326082

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030627 Bsn
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR14113:SF1 PTHR14113:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05715 zf-piccolo, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O88737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNEASLEGG AGEGPLPPGG SGLGPGPGAG KPPSALAGGG QLPVAGAARA
60 70 80 90 100
AGPPTPGLGP VPGPGPGPGP GSVPRRLDPK EPLGSQRTTS PTPKQASATA
110 120 130 140 150
PGRESPRETR AQGPSGQEAE SPRRTLQVDS RTQRSGRSPS VSPDRGSTPT
160 170 180 190 200
SPYSVPQIAP LPSSTLCPIC KTSDLTSTPS QPNFNTCTQC HNKVCNQCGF
210 220 230 240 250
NPNPHLTQVK EWLCLNCQMQ RALGMDMTTA PRSKSQQQLH SPALSPAHSP
260 270 280 290 300
AKQPLGKPEQ ERSPRGPGAT QSGPRQAEAA RATSVPGPTQ ATAPPEVGRV
310 320 330 340 350
SPQPPLSTKP STAEPRPPAG EAQGKSATTV PSGLGAGEQT QEGLTGKLFG
360 370 380 390 400
LGASLLTQAS TLMSVQPEAD TQGQPSPSKG QPKIVFSDAS KEAGPRPPGS
410 420 430 440 450
GPGPGPTPGA KTEPGARMGP GSGPGALAKT GGTASPKHGR AEHQAASKAA
460 470 480 490 500
AKPKTMPKER ASACPLCQAE LNMGSRGPAN YNTCTACKLQ VCNLCGFNPT
510 520 530 540 550
PHLVEKTEWL CLNCQTKRLL EGSLGEPAPL PLPTPQQPPA GVPHRAAGAA
560 570 580 590 600
PLKQKGPQGL GQPSGSLPAK ASPQATKASP QATKASPQAT KASPQTTKAS
610 620 630 640 650
PQAKPLRATE PSKTSSSAQE KKTVTSAKAE PVPKPPPETT VPPGTPKAKS
660 670 680 690 700
GVKRTDPATP VVKPVPEAPK GGEAEEPVPK PYSQDLSRSP QSLSDTGYSS
710 720 730 740 750
DGVSSSQSEI TGVVQQEVEQ LDSAGVTGPR PPSPSELHKV GSSLRPSLEA
760 770 780 790 800
QAVAPSAEWS KPPRSSSSAV EDQKRRPHSL SITPEAFDSD EELGDILEED
810 820 830 840 850
DSLAWGRQRE QQDTAESSDD FGSQLRHDYV EDSSEGGLSP LPPQPPARAD
860 870 880 890 900
MTDEEFMRRQ ILEMSAEEDN LEEDDTAVSG RGLAKHSAQK ASARPRPESS
910 920 930 940 950
QEPKRRLPHN ATTGYEELLS EAGPAEPTDS SGALQGGLRR FKTIELNSTG
960 970 980 990 1000
SYGHELDLGQ GPDPNLDREP ELEMESLTGS PEDRSRGEHS STLPASTPSY
1010 1020 1030 1040 1050
TSGTSPTSLS SLEEDSDSSP SRRQRLEEAK QQRKARHRSH GPLLPTIEDS
1060 1070 1080 1090 1100
SEEEELREEE ELLREQEKMR EVEQQRIRST ARKTRRDKEE LRAQRRRERS
1110 1120 1130 1140 1150
KTPPSNLSPI EDASPTEELR QAAEMEELHR SSCSEYSPSP SLDSEAETLD
1160 1170 1180 1190 1200
GGPTRLYKSG SEYNLPAFMS LYSPTETPSG SSTTPSSGRP LKSAEEAYED
1210 1220 1230 1240 1250
MMRKAEMLQR QQGQVAGARG PHGGPSQPTG PRSQGSFEYQ DTQDHDYGGR
1260 1270 1280 1290 1300
ASQPVAESTP AGLGAAVYEE ILQTSQSIAR MRQASSRDLG FTEDKKKEKQ
1310 1320 1330 1340 1350
FLNAESAYMD PMKQNGGPLT PGTSPTQLAA PVSFSTSTSS DSSGGRVIPD
1360 1370 1380 1390 1400
VRVTQHFAKE PQDPLKLHSS PVSSTLTSKE VGMTFSQGPG SPATTASPTR
1410 1420 1430 1440 1450
GYMTPTSPAG SERSPSTSST IHSYGQPPTT ANYGSQTEEL PHAPSGPPGS
1460 1470 1480 1490 1500
GRAPREKPLS GGDSEVGAPQ PSRGYSYFTG SSPPLSPSTP SESPTFSPGK
1510 1520 1530 1540 1550
LGPRATAEFS TQTPSLTLSS DIPRSPGPPS PMVAQGTQTP HRPSTPRLVW
1560 1570 1580 1590 1600
QQSSQEAPIM VITLASDASS QTRMVHASAS TSPLCSPTDS QPTSHSYSQT
1610 1620 1630 1640 1650
TPPSASQMPS EPAGPPGFPR APSAGTDGPL ALYGWGALPA ENISLCRISS
1660 1670 1680 1690 1700
VPGTSRVEPG PRPPGTAVVD LRTAVKPTPI ILTDQGMDLT SLAVEARKYG
1710 1720 1730 1740 1750
LALDPVSGRQ STAVQPLVIN LNAQEQTHTF LATATTVSIT MASSVLMAQQ
1760 1770 1780 1790 1800
KQPVVYGDPF QSRLDFGQGS GSPVCLAQVK QVEQAVQTAP YRGGPRGRPR
1810 1820 1830 1840 1850
EAKFARYNLP NQVTPLARRD ILITQMGTAQ GVGLKPGPVP EPGAEPHRAT
1860 1870 1880 1890 1900
PAELRSHAPP GTRKPHTVVV QMGEGTAGTV TTLLPEEPAG ALDLTGMRPE
1910 1920 1930 1940 1950
SQLACCDMVY KFPFGSSCTG TFHPAPSAPD KSVTDTALPG QSSGPFYSPR
1960 1970 1980 1990 2000
DPEPPEPLTF RTQGVVGPGP HEEQRPYPQG LPGRLYSSMS DTNLAEAGLN
2010 2020 2030 2040 2050
YHAQRLGQLF QGPGRDSAVD LSSLKHSYSL GFADGRYLGQ GLQYGSFTDL
2060 2070 2080 2090 2100
RHPTDLLSHP LPLRRYSSVS NIYSDHRYGP RGDAVGFQEA SLAQYSATTA
2110 2120 2130 2140 2150
REISRMCAAL NSMDQYGGRH GSGSGGPDLV QYQPQHGPGL SAPQGLAPLR
2160 2170 2180 2190 2200
SGLLGNPTYP EGQPSPGNLA QYGPAASQAT AVRQLLPSTA TVRAADGMIY
2210 2220 2230 2240 2250
STINTPIAAT LPITTQPASV LRPMVRGGMY RPYVSGGVTA VPLTSLTRVP
2260 2270 2280 2290 2300
MIAPRVPLGP AGLYRYPAPR FPIASSVPPA EGPVYLGKPA AAKASGAGGP
2310 2320 2330 2340 2350
PRPELPAGVA REEPFSTTAP AVIKEAPVAP APGPAPAPPP GQKPAGEAVA
2360 2370 2380 2390 2400
GSGSGVLSRP ASEKEEASQE DRQRKQQEQL LQLERERVEL EKLRQLRLQE
2410 2420 2430 2440 2450
ELERERVELQ RHREEEQLLV QRELQELQTI KQHVLQQQQE ERQAQFALQR
2460 2470 2480 2490 2500
EQLAQQRLQL EQIQQLQQQL QLQLEEQKQR QKAPFPATCE APSRGPPPAA
2510 2520 2530 2540 2550
TELAQNGQYW PPLTHAAFIA VAGTEGPGQP REPVLHRGLP SSASDMSLQT
2560 2570 2580 2590 2600
EEQWEAGRSG IKKRHSMPRL RDACEPESGP DPSTVRRIAD SSVQTDDEEG
2610 2620 2630 2640 2650
EGRYLVTRRR RTRRSADCSV QTDDEDNADW EQPVRRRRSR LSRHSDSGSD
2660 2670 2680 2690 2700
SKHDATASSS TTAAATARAM SSVGIQTISD CSVQTEPEQL PRVSPAIHIT
2710 2720 2730 2740 2750
AATDPKVEIV RYISAPEKTG RGESLACQTE PDGQAQGVAG PQLIGPTAIS
2760 2770 2780 2790 2800
PYLPGIQIVT PGALGRFEKK KPDPLEIGYQ AHLPPESLSQ LVSRQPPKSP
2810 2820 2830 2840 2850
QVLYSPVSPL SPHRLLDTSF ASSERLNKAH VSPQKQFIAD STLRQQTLPR
2860 2870 2880 2890 2900
PMKTLQRSLS DPKPLSPTAE ESAKERFSLY QHQGGLGSQV SALPPNGLVR
2910 2920 2930 2940 2950
KVKRTLPSPP PEEAHLPLAG QVPSQLYAAS LLQRGLAGPT TVPATKASLL
2960 2970 2980 2990 3000
RELDRDLRLV EHESTKLRKK QAELDEEEKE IDAKLKYLEL GITQRKESLA
3010 3020 3030 3040 3050
KDRGGRDYPP LRGLGEHRDY LSDSELNQLR LQGCTTPAGQ YVDYPASAAV
3060 3070 3080 3090 3100
PATPSGPTAF QQPRFPPAAP QYTAGSSGPT QNGFPAHQAP TYTGPSTYPA
3110 3120 3130 3140 3150
PTYPPGTGYP AEPGLPSQPA FHPTGHYAAP TPMPTTQSAP FPVQADSRAA
3160 3170 3180 3190 3200
HQKPRQTSLA DLEQKVPTNY EVIGSPAVTM SSAPPETGYS GPAVSGSYEQ
3210 3220 3230 3240 3250
GKAPEHPRGS DRSSVSQSPA PTYPSDSHYT SLEQNVPRNY VMIDDISELT
3260 3270 3280 3290 3300
KDSTPTASES QRLEPLGPGG VSGRPGKDPG EPAVLEGPTL PCCYGRGEEE
3310 3320 3330 3340 3350
SEEDSYDPRG KSGHHRSMES NGRPSTHYYG DSDYRHGARA DKYGPGPMGP
3360 3370 3380 3390 3400
KHPSKSLAPA AISSKRSKHR KQGMEQKISK FSPIEEAKDV ESDLASYPPP
3410 3420 3430 3440 3450
TVSSSLTSRG RKFQDEITYG LKKNVYEQQR YYGVSSRDAA EEDERMYGSS
3460 3470 3480 3490 3500
SRSRMASAYS GEKLSSHDYS SRGKGYERER DTAERLQKAG SKPSSLSMAH
3510 3520 3530 3540 3550
GRARPPMRSQ ASEEESPVSP LGRPRPAGGA LPPGDTCPQF CSSHSMPDVQ
3560 3570 3580 3590 3600
EHVKDGPRAH AYKREEGYML DDSHCVVSDS EAYHLGQEET DWFDKPRDAR
3610 3620 3630 3640 3650
SDRFRHHGGH TVSSSQKRGP ARHSYHDYDE PPEEGLWPHD EGGPGRHTSA
3660 3670 3680 3690 3700
KEHRHHSDHG RHSGRHAGEE PGRRAAKPHA RDMGRHEARP HPQASPAPAM
3710 3720 3730 3740 3750
QKKGQPGYPS SADYSQSSRA PSAYHHASES KKGSRQAHTG PSALQPKADT
3760 3770 3780 3790 3800
QAQPQMQGRQ AAPGPQQSQP PSSRQTPSGT ASRQPQTQQQ QQQQQQQQGL
3810 3820 3830 3840 3850
GQQAPQQAPS QARLQPQSQP TTRGTAPAAS QPAGKPQPGP TTAPGPQPAG
3860 3870 3880 3890 3900
PPRAEQASSS KPPAAKAPQQ GRAPQAQTTP GPGPAGAKPG ARPGGTPGAP
3910 3920 3930 3940
ASQPGAEGES VFSKILPGGA AEQAGKLTEA VSAFGKKFSS FW
Length:3,942
Mass (Da):418,843
Last modified:July 27, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8BEE60189570857
GO
Isoform 2 (identifier: O88737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2831-2889: Missing.

Note: Incompl.
Show »
Length:3,883
Mass (Da):412,264
Checksum:iD3E73ABF84B9C8D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GX98V9GX98_MOUSE
Protein bassoon
Bsn
1,171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti381Q → P in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti418M → T in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti462S → A in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti473M → V in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti624 – 626VTS → ATP in CAA76598 (PubMed:9679147).Curated3
Sequence conflicti783T → M in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti2292A → T in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti2349V → A in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti2892A → V in CAA76598 (PubMed:9679147).Curated1
Sequence conflicti3902S → G in CAA76598 (PubMed:9679147).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0113752831 – 2889Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y17034
, Y17035, Y17036, Y17037, Y17038 Genomic DNA Translation: CAA76598.1
AC137678 Genomic DNA No translation available.
AC168217 Genomic DNA No translation available.
AK129141 mRNA Translation: BAC97951.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23517.1 [O88737-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42730

NCBI Reference Sequences

More...
RefSeqi
NP_031593.2, NM_007567.2 [O88737-1]
XP_006511697.1, XM_006511634.3 [O88737-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035208; ENSMUSP00000035208; ENSMUSG00000032589 [O88737-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12217

UCSC genome browser

More...
UCSCi
uc009rov.1 mouse [O88737-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17034
, Y17035, Y17036, Y17037, Y17038 Genomic DNA Translation: CAA76598.1
AC137678 Genomic DNA No translation available.
AC168217 Genomic DNA No translation available.
AK129141 mRNA Translation: BAC97951.1
CCDSiCCDS23517.1 [O88737-1]
PIRiT42730
RefSeqiNP_031593.2, NM_007567.2 [O88737-1]
XP_006511697.1, XM_006511634.3 [O88737-1]

3D structure databases

SMRiO88737
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198393, 4 interactors
IntActiO88737, 9 interactors
MINTiO88737
STRINGi10090.ENSMUSP00000035208

PTM databases

iPTMnetiO88737
PhosphoSitePlusiO88737
SwissPalmiO88737

Proteomic databases

MaxQBiO88737
PaxDbiO88737
PeptideAtlasiO88737
PRIDEiO88737

Genome annotation databases

EnsembliENSMUST00000035208; ENSMUSP00000035208; ENSMUSG00000032589 [O88737-1]
GeneIDi12217
KEGGimmu:12217
UCSCiuc009rov.1 mouse [O88737-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8927
MGIiMGI:1277955 Bsn

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IGEH Eukaryota
ENOG410XX5R LUCA
GeneTreeiENSGT00620000087961
HOGENOMiHOG000095267
InParanoidiO88737
OrthoDBi29707at2759
TreeFamiTF326082

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Bsn mouse

Protein Ontology

More...
PROi
PR:O88737

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032589 Expressed in 146 organ(s), highest expression level in telencephalon
ExpressionAtlasiO88737 baseline and differential
GenevisibleiO88737 MM

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR030627 Bsn
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR14113:SF1 PTHR14113:SF1, 1 hit
PfamiView protein in Pfam
PF05715 zf-piccolo, 2 hits
SUPFAMiSSF57903 SSF57903, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBSN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88737
Secondary accession number(s): E9QMZ3, Q6ZQB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 149 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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