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Protein

Interferon-induced transmembrane protein 5

Gene

Ifitm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal bone mineralization.4 Publications

Miscellaneous

Membrane topology is controversial. The N-terminus is cytoplasmic and the C-terminus extracellular according to PubMed:24715519, while both the N-terminus and the C-terminus are extracellular according to PubMed:18442316.

GO - Biological processi

  • bone mineralization Source: UniProtKB
  • bone morphogenesis Source: UniProtKB
  • in utero embryonic development Source: UniProtKB
  • multicellular organism development Source: MGI
  • regulation of bone mineralization Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processMineral balance

Protein family/group databases

TCDBi8.A.58.1.4 the dispanin (dispanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 5
Alternative name(s):
Bone-restricted interferon-induced transmembrane protein-like protein
Short name:
Bril
Dispanin subfamily A member 1
Short name:
DSPA1
Fragilis family member 4
Gene namesi
Name:Ifitm5
Synonyms:Bril, Fragilis4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1934923 Ifitm5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88CytoplasmicSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 134ExtracellularSequence analysis2 PublicationsAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality, leading to the birth of only 7% homozygous mutant pups, instead of the expected 25%. Only two out of eight pups were female. Crossing homozygous mice gave rise to about one sixth of the normal litter size, and many newborns died within 48 hours after birth. Homozygous newborns display no striking phenotype other than smaller bones and especially shorter long bones, and this pehnotype persists into adulthood. The radius, ulna and tibia are frequently bent in newborns, but this is no longer the case in young adults.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42S → L: Abolishes expression at the cell membrane. 1 Publication1
Mutagenesisi52C → A: Strongly reduces expression at the cell membrane. Reduces palmitoylation; when associated with A-53. Abolishes palmitoylation; when associated with A-53 and A-86. 2 Publications1
Mutagenesisi53C → A: Strongly reduces expression at the cell membrane. Reduces palmitoylation; when associated with A-52. Abolishes palmitoylation; when associated with A-52 and A-86. 2 Publications1
Mutagenesisi86C → A: No effect on location at the cell membrane. Abolishes palmitoylation; when associated with A-52 and A-53. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003976761 – 134Interferon-induced transmembrane protein 5Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi52S-palmitoyl cysteine2 Publications1
Lipidationi53S-palmitoyl cysteine2 Publications1
Lipidationi86S-palmitoyl cysteine2 Publications1

Post-translational modificationi

Palmitoylated.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88728
PRIDEiO88728

PTM databases

PhosphoSitePlusiO88728
SwissPalmiO88728

Expressioni

Tissue specificityi

Detected in embryonic bone (at protein level) (PubMed:18442316). Highly expressed in osteoblasts of adults and embryos. Expressed in primitive hemopoietic cells.2 Publications

Developmental stagei

In embryos at 16.5 dpf, detected in lumbar and thoracic vertebra, the basisphenoid bone, the mandible, the coronal suture between the frontal and parietal bones, the maxilla, the nasal bone and the palate, as well as in the bone collars of long bones and digital bones in hind limbs, and in the primary ossification center.1 Publication

Inductioni

By interferons.1 Publication

Gene expression databases

BgeeiENSMUSG00000025489 Expressed in 60 organ(s), highest expression level in cochlea
GenevisibleiO88728 MM

Interactioni

Subunit structurei

Interacts with FKBP11.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026562

Structurei

3D structure databases

ProteinModelPortaliO88728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ40 Eukaryota
ENOG410YP9N LUCA
GeneTreeiENSGT00390000003476
HOGENOMiHOG000115781
HOVERGENiHBG053217
InParanoidiO88728
KOiK06566
OMAiTKFDDAD
OrthoDBiEOG091G1143
PhylomeDBiO88728
TreeFamiTF334894

Family and domain databases

InterProiView protein in InterPro
IPR007593 CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505 CD225, 1 hit

Sequencei

Sequence statusi: Complete.

O88728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSYPREDP RAPSSRKADA AAHTALSMGT PGPTPRDHML WSVFSTMYLN
60 70 80 90 100
LCCLGFLALV HSVKARDQKM AGNLEAARQY GSKAKCYNIL AAMWTLVPPL
110 120 130
LLLGLVVTGA LHLSKLAKDS AAFFSTKFDE EDYN
Length:134
Mass (Da):14,667
Last modified:November 1, 1998 - v1
Checksum:iEED20D259EEDD712
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009781 mRNA Translation: CAA08829.1
EU380257 mRNA Translation: ABZ85873.1
FJ200451 mRNA Translation: ACI26732.1
CH466531 Genomic DNA Translation: EDL17974.1
BC103790 mRNA Translation: AAI03791.1
BK001124 mRNA Translation: DAA01239.1
CCDSiCCDS21993.1
RefSeqiNP_444318.1, NM_053088.2
UniGeneiMm.389989

Genome annotation databases

EnsembliENSMUST00000026562; ENSMUSP00000026562; ENSMUSG00000025489
GeneIDi73835
KEGGimmu:73835
UCSCiuc009kiy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009781 mRNA Translation: CAA08829.1
EU380257 mRNA Translation: ABZ85873.1
FJ200451 mRNA Translation: ACI26732.1
CH466531 Genomic DNA Translation: EDL17974.1
BC103790 mRNA Translation: AAI03791.1
BK001124 mRNA Translation: DAA01239.1
CCDSiCCDS21993.1
RefSeqiNP_444318.1, NM_053088.2
UniGeneiMm.389989

3D structure databases

ProteinModelPortaliO88728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026562

Protein family/group databases

TCDBi8.A.58.1.4 the dispanin (dispanin) family

PTM databases

PhosphoSitePlusiO88728
SwissPalmiO88728

Proteomic databases

PaxDbiO88728
PRIDEiO88728

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026562; ENSMUSP00000026562; ENSMUSG00000025489
GeneIDi73835
KEGGimmu:73835
UCSCiuc009kiy.1 mouse

Organism-specific databases

CTDi387733
MGIiMGI:1934923 Ifitm5

Phylogenomic databases

eggNOGiENOG410IZ40 Eukaryota
ENOG410YP9N LUCA
GeneTreeiENSGT00390000003476
HOGENOMiHOG000115781
HOVERGENiHBG053217
InParanoidiO88728
KOiK06566
OMAiTKFDDAD
OrthoDBiEOG091G1143
PhylomeDBiO88728
TreeFamiTF334894

Miscellaneous databases

PROiPR:O88728
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025489 Expressed in 60 organ(s), highest expression level in cochlea
GenevisibleiO88728 MM

Family and domain databases

InterProiView protein in InterPro
IPR007593 CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505 CD225, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFM5_MOUSE
AccessioniPrimary (citable) accession number: O88728
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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