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Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).By similarity

GO - Molecular functioni

  • vasopressin receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:Avpr2
Synonyms:V2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:88123 Avpr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 271CytoplasmicSequence analysisAdd BLAST51
Transmembranei272 – 293Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 328Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini329 – 371CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702091 – 371Vasopressin V2 receptorAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi341S-palmitoyl cysteineBy similarity1
Lipidationi342S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88721
PRIDEiO88721

PTM databases

PhosphoSitePlusiO88721

Expressioni

Gene expression databases

BgeeiENSMUSG00000031390 Expressed in 62 organ(s), highest expression level in cortex of kidney
CleanExiMM_AVPR2
ExpressionAtlasiO88721 baseline and differential
GenevisibleiO88721 MM

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033765

Structurei

3D structure databases

ProteinModelPortaliO88721
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiO88721
KOiK04228
OMAiHIFIGHL
OrthoDBiEOG091G0DB6
PhylomeDBiO88721
TreeFamiTF106499

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O88721-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILVSTTSAV PGALSSPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA
60 70 80 90 100
VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW
210 220 230 240 250
GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG
260 270 280 290 300
HRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS
360 370
LGPQDESCAT ASSSLMKDTP S
Length:371
Mass (Da):40,645
Last modified:November 1, 1998 - v1
Checksum:iF2E7CBEA1113FD5E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3SWS4Q3SWS4_MOUSE
Vasopressin V2 receptor
Avpr2
334Annotation score:
Q3KNZ4Q3KNZ4_MOUSE
Vasopressin V2 receptor
Avpr2
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006691 Genomic DNA Translation: CAA07187.1
AF133093 Genomic DNA No translation available.
AJ310753 mRNA Translation: CAC34589.1
CCDSiCCDS30216.1
RefSeqiNP_062277.1, NM_019404.2
XP_006527819.1, XM_006527756.3
UniGeneiMm.383171

Genome annotation databases

EnsembliENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390
GeneIDi12000
KEGGimmu:12000
UCSCiuc009tmx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006691 Genomic DNA Translation: CAA07187.1
AF133093 Genomic DNA No translation available.
AJ310753 mRNA Translation: CAC34589.1
CCDSiCCDS30216.1
RefSeqiNP_062277.1, NM_019404.2
XP_006527819.1, XM_006527756.3
UniGeneiMm.383171

3D structure databases

ProteinModelPortaliO88721
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033765

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO88721

Proteomic databases

PaxDbiO88721
PRIDEiO88721

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390
GeneIDi12000
KEGGimmu:12000
UCSCiuc009tmx.1 mouse

Organism-specific databases

CTDi554
MGIiMGI:88123 Avpr2

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiO88721
KOiK04228
OMAiHIFIGHL
OrthoDBiEOG091G0DB6
PhylomeDBiO88721
TreeFamiTF106499

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

PROiPR:O88721
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031390 Expressed in 62 organ(s), highest expression level in cortex of kidney
CleanExiMM_AVPR2
ExpressionAtlasiO88721 baseline and differential
GenevisibleiO88721 MM

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_MOUSE
AccessioniPrimary (citable) accession number: O88721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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