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Protein

Killer cell lectin-like receptor subfamily G member 1

Gene

Klrg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • innate immune response Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processImmunity, Innate immunity
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily G member 1
Alternative name(s):
Mast cell function-associated antigen 2F1
Gene namesi
Name:Klrg1
Synonyms:Mafa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1355294 Klrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini57 – 188ExtracellularSequence analysisAdd BLAST132

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5S → A: Decreases association with PTPN11. 1 Publication1
Mutagenesisi7Y → F: Abolishes the formation of KLRG1/PTPN11 and KLRG1/INPP5D. 1 Publication1
Mutagenesisi8S → A: Enhances association with PTPN11. 1 Publication1
Mutagenesisi10L → A: Abrogates completely INPP5D recruitment. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312571 – 188Killer cell lectin-like receptor subfamily G member 1Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 86PROSITE-ProRule annotation1 Publication
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation1 Publication
Disulfide bondi162 ↔ 175PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO88713
PRIDEiO88713

PTM databases

iPTMnetiO88713
PhosphoSitePlusiO88713

Expressioni

Tissue specificityi

Expressed specifically on natural killer (NK) cells and activated CD8 T-cells. Not detected in spleen, thymus, lymph node, testis, brain or kidney. Not detected on mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells.2 Publications

Inductioni

By pathogens and viruses infections.2 Publications

Gene expression databases

BgeeiENSMUSG00000030114 Expressed in 68 organ(s), highest expression level in decidua
GenevisibleiO88713 MM

Interactioni

Subunit structurei

Forms a monomer and homodimer; disulfide-linked (By similarity). Interacts (via ITIM motif) with PTPN11 and INPP5D.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032207

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88713
SMRiO88713
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88713

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 184C-type lectinPROSITE-ProRule annotationAdd BLAST103

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITIM motif6

Domaini

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00930000151009
HOGENOMiHOG000082429
HOVERGENiHBG103557
InParanoidiO88713
KOiK10076
OMAiEKKDWNS
OrthoDBiEOG091G0MK5
PhylomeDBiO88713
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSSIYSTL ELPEAPQVQD ESRWKLKAVL HRPHLSRFAM VALGLLTVIL
60 70 80 90 100
MSLLMYQRIL CCGSKDSTCS HCPSCPILWT RNGSHCYYFS MEKKDWNSSL
110 120 130 140 150
KFCADKGSHL LTFPDNQGVK LFGEYLGQDF YWIGLRNIDG WRWEGGPALS
160 170 180
LRILTNSLIQ RCGAIHRNGL QASSCEVALQ WICKKVLY
Length:188
Mass (Da):21,396
Last modified:August 1, 1999 - v2
Checksum:i876336802EA134F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120Missing in AAI01954 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097357 mRNA Translation: AAD03718.1
AJ010751 mRNA Translation: CAA09342.1
AF317727 Genomic DNA Translation: AAK40082.1
BC101953 mRNA Translation: AAI01954.1
BC103546 mRNA Translation: AAI03547.1
BC103547 mRNA Translation: AAI03548.1
BC103548 mRNA Translation: AAI03549.1
CCDSiCCDS20492.1
RefSeqiNP_058666.1, NM_016970.1
UniGeneiMm.20434

Genome annotation databases

EnsembliENSMUST00000032207; ENSMUSP00000032207; ENSMUSG00000030114
GeneIDi50928
KEGGimmu:50928
UCSCiuc009dov.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

MCFA

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097357 mRNA Translation: AAD03718.1
AJ010751 mRNA Translation: CAA09342.1
AF317727 Genomic DNA Translation: AAK40082.1
BC101953 mRNA Translation: AAI01954.1
BC103546 mRNA Translation: AAI03547.1
BC103547 mRNA Translation: AAI03548.1
BC103548 mRNA Translation: AAI03549.1
CCDSiCCDS20492.1
RefSeqiNP_058666.1, NM_016970.1
UniGeneiMm.20434

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FF8X-ray2.00C/D75-188[»]
3FF9X-ray1.80A/B75-188[»]
ProteinModelPortaliO88713
SMRiO88713
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032207

PTM databases

iPTMnetiO88713
PhosphoSitePlusiO88713

Proteomic databases

PaxDbiO88713
PRIDEiO88713

Protocols and materials databases

DNASUi50928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032207; ENSMUSP00000032207; ENSMUSG00000030114
GeneIDi50928
KEGGimmu:50928
UCSCiuc009dov.2 mouse

Organism-specific databases

CTDi10219
MGIiMGI:1355294 Klrg1

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00930000151009
HOGENOMiHOG000082429
HOVERGENiHBG103557
InParanoidiO88713
KOiK10076
OMAiEKKDWNS
OrthoDBiEOG091G0MK5
PhylomeDBiO88713
TreeFamiTF336674

Miscellaneous databases

EvolutionaryTraceiO88713
PROiPR:O88713
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030114 Expressed in 68 organ(s), highest expression level in decidua
GenevisibleiO88713 MM

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLRG1_MOUSE
AccessioniPrimary (citable) accession number: O88713
Secondary accession number(s): Q3T1F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 1, 1999
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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