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Protein

Protein CREG1

Gene

Creg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R (By similarity).By similarity

GO - Molecular functioni

  • cofactor binding Source: InterPro
  • transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CREG1
Alternative name(s):
Cellular repressor of E1A-stimulated genes 1
Gene namesi
Name:Creg1
Synonyms:Creg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1344382 Creg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000620432 – 220Protein CREG1Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO88668
MaxQBiO88668
PaxDbiO88668
PeptideAtlasiO88668
PRIDEiO88668

PTM databases

iPTMnetiO88668
PhosphoSitePlusiO88668

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Found at low level from E7 embryo and increased during embryonic development.1 Publication

Inductioni

Induced during differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000040713 Expressed in 288 organ(s), highest expression level in placenta
CleanExiMM_CREG1
ExpressionAtlasiO88668 baseline and differential
GenevisibleiO88668 MM

Interactioni

Subunit structurei

Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88668, 1 interactor
MINTiO88668

Structurei

3D structure databases

ProteinModelPortaliO88668
SMRiO88668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CREG family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3374 Eukaryota
ENOG4111WS9 LUCA
GeneTreeiENSGT00390000005914
HOGENOMiHOG000239875
HOVERGENiHBG051115
InParanoidiO88668
OMAiGPHKVSA
OrthoDBiEOG091G14BY
PhylomeDBiO88668
TreeFamiTF324680

Family and domain databases

Gene3Di2.30.110.10, 1 hit
InterProiView protein in InterPro
IPR014631 CREG
IPR012349 Split_barrel_FMN-bd
PIRSFiPIRSF036911 CREG, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O88668-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARAPELAR SLLAALLAPA LVALLVSPAS GRGGRDHGDW DVDRRLPPLP
60 70 80 90 100
PREDGPRVAR FVTHVSDWGS LATISTIKEV RGWPFADIIS ISDGPPGEGT
110 120 130 140 150
GEPYMYLSPL QQAVSDLQEN PEATLTMSLA QTVYCRNHGF DPQSPLCVHI
160 170 180 190 200
MMSGTVTKVN KTEEDYARDS LFVRHPEMKH WPSSHNWFFA KLKISRIWVL
210 220
DYFGGPKVVT PEEYFNVTLQ
Length:220
Mass (Da):24,452
Last modified:November 1, 1998 - v1
Checksum:iEF3A8CFD3186163D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QP41J3QP41_MOUSE
Protein CREG1
Creg1
146Annotation score:
K4DI63K4DI63_MOUSE
Cellular repressor of E1A-stimulate...
Creg1 mCG_3602
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62V → M in BAC39549 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084524 mRNA Translation: AAC34862.1
AK005388 mRNA Translation: BAB23994.1
AK010947 mRNA Translation: BAB27285.1
AK085844 mRNA Translation: BAC39549.1
AK144101 mRNA Translation: BAE25699.1
BC027426 mRNA Translation: AAH27426.1
CCDSiCCDS35759.1
RefSeqiNP_035934.1, NM_011804.2
XP_006496993.1, XM_006496930.1
UniGeneiMm.294885
Mm.468745

Genome annotation databases

EnsembliENSMUST00000111432; ENSMUSP00000107060; ENSMUSG00000040713
GeneIDi433375
KEGGimmu:433375
UCSCiuc007djm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084524 mRNA Translation: AAC34862.1
AK005388 mRNA Translation: BAB23994.1
AK010947 mRNA Translation: BAB27285.1
AK085844 mRNA Translation: BAC39549.1
AK144101 mRNA Translation: BAE25699.1
BC027426 mRNA Translation: AAH27426.1
CCDSiCCDS35759.1
RefSeqiNP_035934.1, NM_011804.2
XP_006496993.1, XM_006496930.1
UniGeneiMm.294885
Mm.468745

3D structure databases

ProteinModelPortaliO88668
SMRiO88668
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88668, 1 interactor
MINTiO88668

PTM databases

iPTMnetiO88668
PhosphoSitePlusiO88668

Proteomic databases

EPDiO88668
MaxQBiO88668
PaxDbiO88668
PeptideAtlasiO88668
PRIDEiO88668

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111432; ENSMUSP00000107060; ENSMUSG00000040713
GeneIDi433375
KEGGimmu:433375
UCSCiuc007djm.1 mouse

Organism-specific databases

CTDi8804
MGIiMGI:1344382 Creg1

Phylogenomic databases

eggNOGiKOG3374 Eukaryota
ENOG4111WS9 LUCA
GeneTreeiENSGT00390000005914
HOGENOMiHOG000239875
HOVERGENiHBG051115
InParanoidiO88668
OMAiGPHKVSA
OrthoDBiEOG091G14BY
PhylomeDBiO88668
TreeFamiTF324680

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCreg1 mouse
PROiPR:O88668
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040713 Expressed in 288 organ(s), highest expression level in placenta
CleanExiMM_CREG1
ExpressionAtlasiO88668 baseline and differential
GenevisibleiO88668 MM

Family and domain databases

Gene3Di2.30.110.10, 1 hit
InterProiView protein in InterPro
IPR014631 CREG
IPR012349 Split_barrel_FMN-bd
PIRSFiPIRSF036911 CREG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCREG1_MOUSE
AccessioniPrimary (citable) accession number: O88668
Secondary accession number(s): Q3UNP8, Q8C3I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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