UniProtKB - O88667 (RAD_MOUSE)

BLAST

>sp|O88667|RAD_MOUSE GTP-binding protein RAD OS=Mus musculus OX=10090 GN=Rrad PE=1 SV=1
MTLNGGSGASGSRGAGGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALAPGSLATTA
AGTRTQGQRLDWPEGSSDSLSSGGSGSEEGVYKVLLLGAPGVGKSALARIFGGIEDGPEA
EAAGHTYDRSITVDGEEASLLVYDIWEEDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKA
SELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNV
QALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSK
SCHDLSVL

Align
Format
Add to basket Added to basket
History
Entry version 118 (07 Nov 2018)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

GTP-binding protein RAD

Gene

Rrad

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca²⁺ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	98 – 105	GTPBy similarity		8
Nucleotide bindingⁱ	203 – 206	GTPBy similarity		4

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
GTPase activity Source: InterPro
GTP binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell growth Source: MGI
negative regulation of high voltage-gated calcium channel activity Source: InterPro
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding
Ligand	GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GTP-binding protein RAD
Gene namesⁱ	Name:Rrad
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1930943 Rrad

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice show increased susceptibility to thoracic transverse aortic constriction (TAC)-induced cardiac hypertrophy. TAC-induced CAMKII phosphorylation in the heart is also significantly increased.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	105	S → A: Loss of interaction with CACNB2. QT prolongation and ventricular arrhythmias, caused by the augmentation of L-type Ca(2+) channels in the heart. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122479	1 – 308	GTP-binding protein RADAdd BLAST		308

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	24	Omega-N-methylarginineCombined sources		1
Modified residueⁱ	26	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	O88667
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O88667
PaxDbⁱ	O88667
PRIDEⁱ	O88667

PTM databases

iPTMnetⁱ	O88667
PhosphoSitePlusⁱ	O88667

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_RRAD

CleanExⁱ

MM_RRAD

Interactionⁱ

Subunit structureⁱ

Interacts with Calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D (By similarity). Interacts with CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane.By similarity1 Publication

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	O88667, 1 interactor
Molecular INTeraction database More...MINTⁱ	O88667
STRINGⁱ	10090.ENSMUSP00000034351

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88667
SMRⁱ	O88667
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	278 – 297	Calmodulin-bindingBy similarityAdd BLAST		20

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
HOGENOMⁱ	HOG000246961
HOVERGENⁱ	HBG104899
InParanoidⁱ	O88667
PhylomeDBⁱ	O88667

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR028869 RAD IPR017358 RGK IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit PTHR24070:SF74 PTHR24070:SF74, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
PIRSFⁱ	PIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O88667-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLNGGSGAS GSRGAGGRER DRRRGSTPWG PAPPLHRRSM PVDERDLQAA 
        60         70         80         90        100
LAPGSLATTA AGTRTQGQRL DWPEGSSDSL SSGGSGSEEG VYKVLLLGAP 
       110        120        130        140        150
GVGKSALARI FGGIEDGPEA EAAGHTYDRS ITVDGEEASL LVYDIWEEDG 
       160        170        180        190        200
GCWLPGHCMA MGDAYVIVYS ITDKGSFEKA SELRVQLRRA RQTDDVPIIL 
       210        220        230        240        250
VGNKSDLVRS REVSVDEGRA CAVVFDCKFI ETSAALHHNV QALFEGVVRQ 
       260        270        280        290        300
IRLRRDSKED NARRQAGTRR RESLGKKAKR FLGRIVARNS RKMAFRAKSK 

SCHDLSVL

Length:308

Mass (Da):33,279

Last modified:November 1, 1998 - v1

Checksum:ⁱ698F0A3BCE605D53

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q6PGA2	Q6PGA2_MOUSE	GTP-binding protein GTP-binding protein	Rrad mCG_23403	307	Annotation score:
A0A1D5RLT1	A0A1D5RLT1_MOUSE	GTP-binding protein RAD GTP-binding protein RAD	Rrad	100	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF084466 mRNA Translation: AAC33133.1
UniGeneⁱ	Mm.29467

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88667	GTP-binding protein RAD	)	HUMAN		308	UniRef90_P55042
GTP-binding protein RAD isoform X1		TURTR		370
GTP-binding protein RAD isoform X1		Yangtze finless porpoise		352
GTP-binding protein RAD isoform X1		DELLE		352
GTP-binding protein		RABIT		324
+99

Protein	Similar proteins		Species	Score	Length	Source
O88667	GTP-binding protein RAD	)	HUMAN		308	UniRef50_P55042
GTP-binding protein RAD isoform X1		TURTR		370
GTP-binding protein RAD isoform X1		Yangtze finless porpoise		352
GTP-binding protein RAD isoform X1		DELLE		352
GTP-binding protein		RABIT		324
+148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF084466 mRNA Translation: AAC33133.1
UniGeneⁱ	Mm.29467

3D structure databases

ProteinModelPortalⁱ	O88667
SMRⁱ	O88667
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O88667, 1 interactor
MINTⁱ	O88667
STRINGⁱ	10090.ENSMUSP00000034351

PTM databases

iPTMnetⁱ	O88667
PhosphoSitePlusⁱ	O88667

Proteomic databases

EPDⁱ	O88667
MaxQBⁱ	O88667
PaxDbⁱ	O88667
PRIDEⁱ	O88667

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:1930943 Rrad

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
HOGENOMⁱ	HOG000246961
HOVERGENⁱ	HBG104899
InParanoidⁱ	O88667
PhylomeDBⁱ	O88667

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88667
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_RRAD

CleanExⁱ

MM_RRAD

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR028869 RAD IPR017358 RGK IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit PTHR24070:SF74 PTHR24070:SF74, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
PIRSFⁱ	PIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAD_MOUSE
Accessionⁱ	O88667Primary (citable) accession number: O88667
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88667 (RAD_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

GTP-binding protein RAD

Rrad

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ