Brd7

Functionⁱ

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.By similarity3 Publications

GO - Molecular functionⁱ

histone binding Source: MGI
lysine-acetylated histone binding Source: UniProtKB
p53 binding Source: UniProtKB
transcription coactivator activity Source: UniProtKB
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19909775
transcription factor binding
Source: MGI
Inferred from sequence orthologyⁱ
- 11025449
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
negative regulation of cell proliferation Source: UniProtKB
negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of histone acetylation Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
regulation of transcription by RNA polymerase II Source: MGI
transcription, DNA-templated Source: UniProtKB-KW
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway

Biological process

Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Reactomeⁱ

R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bromodomain-containing protein 7 Alternative name(s): 75 kDa bromodomain protein
Gene namesⁱ	Name:Brd7 Synonyms:Bp75
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1349766 Brd7

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Chemistry databases

ChEMBLⁱ	CHEMBL3822348

ChEMBLⁱ

CHEMBL3822348

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000227665	1 – 651	Bromodomain-containing protein 7Add BLAST		651

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	21	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	127	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	186	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	197	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	201	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	212	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	241	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	279	PhosphoserineCombined sources	1
Modified residueⁱ	289	PhosphoserineBy similarity	1
Cross-linkⁱ	305	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	328	N6-acetyllysineCombined sources	1
Cross-linkⁱ	344	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	380	PhosphoserineBy similarity	1
Cross-linkⁱ	389	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	475	PhosphoserineCombined sources	1
Modified residueⁱ	482	PhosphoserineCombined sources	1
Modified residueⁱ	483	PhosphoserineCombined sources	1
Modified residueⁱ	621	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O88665
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O88665
PaxDbⁱ	O88665
PeptideAtlas More...PeptideAtlasⁱ	O88665
PRIDEⁱ	O88665

PTM databases

iPTMnetⁱ	O88665
PhosphoSitePlusⁱ	O88665

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Developmental stageⁱ

Expressed ubiquitously from 10.5 to 18.5 dpc.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000031660 Expressed in 314 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_BRD7
Genevisibleⁱ	O88665 MM

Interactionⁱ

Subunit structureⁱ

Interacts with IRF2 and HNRPUL1 (By similarity). Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at 'Lys-14' (H3K14ac). Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for histone H3 that is acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8' (H3K8ac) (in vitro) (By similarity). Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Pik3r1	P26450	11	EBI-643930,EBI-641764
Pik3r2	O08908	4	EBI-643930,EBI-643570
Ptpn13	Q64512	3	EBI-643930,EBI-4284057

GO - Molecular functionⁱ

histone binding Source: MGI
lysine-acetylated histone binding Source: UniProtKB
p53 binding Source: UniProtKB
transcription factor binding
Source: MGI
Inferred from sequence orthologyⁱ
- 11025449

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	205094, 5 interactors
ComplexPortalⁱ	CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
IntActⁱ	O88665, 5 interactors
Molecular INTeraction database More...MINTⁱ	O88665
STRINGⁱ	10090.ENSMUSP00000034085

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88665
SMRⁱ	O88665
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	148 – 218	BromoPROSITE-ProRule annotationAdd BLAST		71

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	536 – 567	Sequence analysisAdd BLAST		32

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	65 – 96	Nuclear localization signalBy similarityAdd BLAST		32

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	57 – 91	Lys-richAdd BLAST		35

Keywords - Domainⁱ

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1828 Eukaryota ENOG410XRRI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063939
HOGENOMⁱ	HOG000070022
HOVERGENⁱ	HBG071934
InParanoidⁱ	O88665
KEGG Orthology (KO) More...KOⁱ	K11723
OMAⁱ	GDIVSTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06S4
PhylomeDBⁱ	O88665
TreeFamⁱ	TF106439

Family and domain databases

Gene3Dⁱ	1.20.920.10, 1 hit
InterProⁱ	View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR021900 DUF3512
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00439 Bromodomain, 1 hit PF12024 DUF3512, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 1 hit
SUPFAMⁱ	SSF47370 SSF47370, 1 hit
PROSITEⁱ	View protein in PROSITE PS50014 BROMODOMAIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O88665-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKKHKKHKS DRHFYEEYVE KPLKLVLKVG GSEVTELSTG SSGHDSSLFE 
        60         70         80         90        100
DRSDHDKHKD RKRKKRKKGE KQAPGEEKGR KRRRVKEDKK KRDRDRAENE 
       110        120        130        140        150
VDRDLQCHVP IRLDLPPEKP LTSSLAKQEE VEQTPLQEAL NQLMRQLQRK 
       160        170        180        190        200
DPSAFFSFPV TDFIAPGYSM IIKHPMDFST MKEKIKNNDY QSIEELKDNF 
       210        220        230        240        250
KLMCTNAMIY NKPETIYYKA AKKLLHSGMK ILSQERIQSL KQSIDFMSDL 
       260        270        280        290        300
QKTRKQKERT DACQSGEDSG CWQREREDSG DAETQAFRSP AKDNKRKDKD 
       310        320        330        340        350
VLEDKWRSSN SEREHEQIER VVQESGGKLT RRLANSQCEF ERRKPDGTTT 
       360        370        380        390        400
LGLLHPVDPI VGEPGYCPVR LGMTTGRLQS GVNTLQGFKE DKRNRVTPVL 
       410        420        430        440        450
YLNYGPYSSY APHYDSTFAN ISKDDSDLIY STYGEDSDLP NNFSISEFLA 
       460        470        480        490        500
TCQDYPYVMA DSLLDVLTKG GHSRSLQDLD MSSPEDEGQT RALDTAKEAE 
       510        520        530        540        550
ITQIEPTGRL ESSSQDRLTA LQAVTTFGAP AEVFDSEEAE VFQRKLDETT 
       560        570        580        590        600
RLLRELQEAQ NERLSTRPPP NMICLLGPSY REMYLAEQVT NNLKELTQQV 
       610        620        630        640        650
TPGDVVSIHG VRKAMGISVP SPIVGNSFVD LTGECEEPKE TSTAECGPDA 

S

Length:651

Mass (Da):74,000

Last modified:November 1, 1998 - v1

Checksum:ⁱ5D34B4F14FD51350

GO

Sequence cautionⁱ

The sequence BAE23823 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	102	D → G in BAE23823 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF084259 mRNA Translation: AAC33302.1 AK004429 mRNA Translation: BAB23299.1 AK138934 mRNA Translation: BAE23823.1 Different initiation. AK142758 mRNA Translation: BAE25187.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22510.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036177.1, NM_012047.2 XP_017168329.1, XM_017312840.1
UniGeneⁱ	Mm.5400

Genome annotation databases

Ensemblⁱ	ENSMUST00000034085; ENSMUSP00000034085; ENSMUSG00000031660
GeneIDⁱ	26992
KEGGⁱ	mmu:26992
UCSC genome browser More...UCSCⁱ	uc009mrn.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88665	Bromodomain-containing 7		RAT		652	UniRef90_O88665
bromodomain-containing protein 7 isoform X1		MESAU		651
Brd7 protein		MOUSE		83
UPI00077DEF7E		PERMB		662
UPI00067CAF6B		MICOH		659
+18

Protein	Similar proteins		Species	Score	Length	Source
O88665	Bromodomain-containing 7		RAT		652	UniRef50_O88665
bromodomain-containing protein 7 isoform X1		MESAU		651
Brd7 protein		MOUSE		83
bromodomain-containing protein 7-like		Florida manatee		651
Bromodomain-containing protein 7 isoform B		ALLMI		635
+251

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF084259 mRNA Translation: AAC33302.1 AK004429 mRNA Translation: BAB23299.1 AK138934 mRNA Translation: BAE23823.1 Different initiation. AK142758 mRNA Translation: BAE25187.1
CCDSⁱ	CCDS22510.1
RefSeqⁱ	NP_036177.1, NM_012047.2 XP_017168329.1, XM_017312840.1
UniGeneⁱ	Mm.5400

3D structure databases

ProteinModelPortalⁱ	O88665
SMRⁱ	O88665
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205094, 5 interactors
ComplexPortalⁱ	CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
IntActⁱ	O88665, 5 interactors
MINTⁱ	O88665
STRINGⁱ	10090.ENSMUSP00000034085

Chemistry databases

ChEMBLⁱ	CHEMBL3822348

ChEMBLⁱ

CHEMBL3822348

PTM databases

iPTMnetⁱ	O88665
PhosphoSitePlusⁱ	O88665

Proteomic databases

EPDⁱ	O88665
MaxQBⁱ	O88665
PaxDbⁱ	O88665
PeptideAtlasⁱ	O88665
PRIDEⁱ	O88665

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26992
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034085; ENSMUSP00000034085; ENSMUSG00000031660
GeneIDⁱ	26992
KEGGⁱ	mmu:26992
UCSCⁱ	uc009mrn.2 mouse

Organism-specific databases

CTDⁱ	29117
MGIⁱ	MGI:1349766 Brd7

Phylogenomic databases

eggNOGⁱ	KOG1828 Eukaryota ENOG410XRRI LUCA
GeneTreeⁱ	ENSGT00530000063939
HOGENOMⁱ	HOG000070022
HOVERGENⁱ	HBG071934
InParanoidⁱ	O88665
KOⁱ	K11723
OMAⁱ	GDIVSTY
OrthoDBⁱ	EOG091G06S4
PhylomeDBⁱ	O88665
TreeFamⁱ	TF106439

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Reactomeⁱ

R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88665
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031660 Expressed in 314 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_BRD7
Genevisibleⁱ	O88665 MM

Family and domain databases

Gene3Dⁱ	1.20.920.10, 1 hit
InterProⁱ	View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR021900 DUF3512
Pfamⁱ	View protein in Pfam PF00439 Bromodomain, 1 hit PF12024 DUF3512, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 1 hit
SUPFAMⁱ	SSF47370 SSF47370, 1 hit
PROSITEⁱ	View protein in PROSITE PS50014 BROMODOMAIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BRD7_MOUSE
Accessionⁱ	O88665Primary (citable) accession number: O88665 Secondary accession number(s): Q3UQ56, Q3UU06, Q9CT78
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	November 1, 1998
	Last modified:	September 12, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

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Supporting data

UniProtKB - O88665 (BRD7_MOUSE)

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Bromodomain-containing protein 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ