Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ragulator complex protein LAMTOR3

Gene

Lamtor3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR3
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
MEK-binding partner 1
Short name:
Mp1
Mitogen-activated protein kinase kinase 1-interacting protein 1
Mitogen-activated protein kinase scaffold protein 1
Gene namesi
Name:Lamtor3
Synonyms:Map2k1ip1, Mapbp, Mapksp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929467 Lamtor3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210061 – 124Ragulator complex protein LAMTOR3Add BLAST124

Proteomic databases

EPDiO88653
PaxDbiO88653
PeptideAtlasiO88653
PRIDEiO88653
TopDownProteomicsiO88653

PTM databases

iPTMnetiO88653
PhosphoSitePlusiO88653

Expressioni

Gene expression databases

BgeeiENSMUSG00000091512 Expressed in 48 organ(s), highest expression level in embryo
ExpressionAtlasiO88653 baseline and differential
GenevisibleiO88653 MM

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR2; the interaction is direct (PubMed:11266467, PubMed:15263099, PubMed:19177150). Interacts with MAP2K1/MEK1 and MAPK2 (PubMed:9733512). Interacts with MORG1 (PubMed:15118098).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208123, 1 interactor
CORUMiO88653
IntActiO88653, 11 interactors
MINTiO88653
STRINGi10090.ENSMUSP00000136999

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88653
SMRiO88653
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88653

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 70Required for interaction with LAMTOR21 PublicationAdd BLAST14

Sequence similaritiesi

Belongs to the LAMTOR3 family.Curated

Phylogenomic databases

eggNOGiENOG410IWYZ Eukaryota
ENOG4111KCU LUCA
GeneTreeiENSGT00390000013159
HOVERGENiHBG052480
InParanoidiO88653
KOiK04370
OMAiYQVIQMN
OrthoDBiEOG091G0TYL
PhylomeDBiO88653
TreeFamiTF324889

Family and domain databases

InterProiView protein in InterPro
IPR015019 LAMTOR3
PANTHERiPTHR13378 PTHR13378, 1 hit
PfamiView protein in Pfam
PF08923 MAPKK1_Int, 1 hit
SMARTiView protein in SMART
SM01278 MAPKK1_Int, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL
60 70 80 90 100
STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT
110 120
GLIVSLEKEL APLFEELIKV VEVS
Length:124
Mass (Da):13,553
Last modified:November 1, 1998 - v1
Checksum:i3B9C8A0241D806A9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGQ3A0A0G2JGQ3_MOUSE
Ragulator complex protein LAMTOR3
Lamtor3
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082526 mRNA Translation: AAC34591.1
BC016417 mRNA Translation: AAH16417.1
BC083155 mRNA Translation: AAH83155.1
CCDSiCCDS51078.1
RefSeqiNP_064304.1, NM_019920.2
UniGeneiMm.331392

Genome annotation databases

EnsembliENSMUST00000168345; ENSMUSP00000130811; ENSMUSG00000091512
ENSMUST00000197064; ENSMUSP00000142512; ENSMUSG00000091512
GeneIDi56692
KEGGimmu:56692
UCSCiuc008rms.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082526 mRNA Translation: AAC34591.1
BC016417 mRNA Translation: AAH16417.1
BC083155 mRNA Translation: AAH83155.1
CCDSiCCDS51078.1
RefSeqiNP_064304.1, NM_019920.2
UniGeneiMm.331392

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VETX-ray1.90A1-124[»]
1VEUX-ray2.15A1-124[»]
ProteinModelPortaliO88653
SMRiO88653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208123, 1 interactor
CORUMiO88653
IntActiO88653, 11 interactors
MINTiO88653
STRINGi10090.ENSMUSP00000136999

PTM databases

iPTMnetiO88653
PhosphoSitePlusiO88653

Proteomic databases

EPDiO88653
PaxDbiO88653
PeptideAtlasiO88653
PRIDEiO88653
TopDownProteomicsiO88653

Protocols and materials databases

DNASUi56692
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168345; ENSMUSP00000130811; ENSMUSG00000091512
ENSMUST00000197064; ENSMUSP00000142512; ENSMUSG00000091512
GeneIDi56692
KEGGimmu:56692
UCSCiuc008rms.1 mouse

Organism-specific databases

CTDi8649
MGIiMGI:1929467 Lamtor3

Phylogenomic databases

eggNOGiENOG410IWYZ Eukaryota
ENOG4111KCU LUCA
GeneTreeiENSGT00390000013159
HOVERGENiHBG052480
InParanoidiO88653
KOiK04370
OMAiYQVIQMN
OrthoDBiEOG091G0TYL
PhylomeDBiO88653
TreeFamiTF324889

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

EvolutionaryTraceiO88653
PROiPR:O88653
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091512 Expressed in 48 organ(s), highest expression level in embryo
ExpressionAtlasiO88653 baseline and differential
GenevisibleiO88653 MM

Family and domain databases

InterProiView protein in InterPro
IPR015019 LAMTOR3
PANTHERiPTHR13378 PTHR13378, 1 hit
PfamiView protein in Pfam
PF08923 MAPKK1_Int, 1 hit
SMARTiView protein in SMART
SM01278 MAPKK1_Int, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR3_MOUSE
AccessioniPrimary (citable) accession number: O88653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again