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Protein

Golgi SNAP receptor complex member 1

Gene

Gosr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 1
Alternative name(s):
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Short name:
GOS-28
Gene namesi
Name:Gosr1
Synonyms:Gs28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858260 Gosr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 229CytoplasmicSequence analysisAdd BLAST228
Transmembranei230 – 250Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002125432 – 250Golgi SNAP receptor complex member 1Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei141PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88630
PaxDbiO88630
PeptideAtlasiO88630
PRIDEiO88630

PTM databases

iPTMnetiO88630
PhosphoSitePlusiO88630
SwissPalmiO88630

Expressioni

Inductioni

Decreased levels in 25-hydroxycholesterol treated melanocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000010392 Expressed in 267 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_GOSR1
GenevisibleiO88630 MM

Interactioni

Subunit structurei

Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207294, 1 interactor
IntActiO88630, 2 interactors
MINTiO88630
STRINGi10090.ENSMUSP00000010536

Structurei

3D structure databases

ProteinModelPortaliO88630
SMRiO88630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 27Sequence analysisAdd BLAST19
Coiled coili72 – 93Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the GOSR1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3208 Eukaryota
ENOG410YI1X LUCA
GeneTreeiENSGT00390000008688
HOGENOMiHOG000207760
HOVERGENiHBG051764
InParanoidiO88630
KOiK08495
OMAiRIDNSHN
OrthoDBiEOG091G0W5M
TreeFamiTF105782

Family and domain databases

InterProiView protein in InterPro
IPR023601 Golgi_SNAP_su1
PANTHERiPTHR21094 PTHR21094, 1 hit
PIRSFiPIRSF027109 Golgi_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88630-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGTSNYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS GSRDGGRDRY
60 70 80 90 100
SSDTTPLLNG SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTHSAGVPSL
110 120 130 140 150
NAALMHTLQR HRDILQDYTH EFHKTKANFT AIRERENLMG SVRKDIESYK
160 170 180 190 200
SGSGVNNRRT ELFLKEHDHL RNSDRLIEET ISIAMATKEN MTSQRGMLKS
210 220 230 240 250
IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH
Length:250
Mass (Da):28,489
Last modified:October 3, 2012 - v2
Checksum:iACF7FF5CCA0C2D52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30F → S in AAC32189 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079901 mRNA Translation: AAC32189.1
AK133836 mRNA Translation: BAE21873.1
AK134515 mRNA Translation: BAE22167.1
AK147799 mRNA Translation: BAE28147.1
AK154972 mRNA Translation: BAE32964.1
AK161386 mRNA Translation: BAE36365.1
BX000359 Genomic DNA Translation: CAI25288.1
CH466596 Genomic DNA Translation: EDL12868.1
BC008542 mRNA Translation: AAH08542.1
CCDSiCCDS25070.1
RefSeqiNP_058090.2, NM_016810.3
UniGeneiMm.20931

Genome annotation databases

EnsembliENSMUST00000010536; ENSMUSP00000010536; ENSMUSG00000010392
GeneIDi53334
KEGGimmu:53334
UCSCiuc007kfz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079901 mRNA Translation: AAC32189.1
AK133836 mRNA Translation: BAE21873.1
AK134515 mRNA Translation: BAE22167.1
AK147799 mRNA Translation: BAE28147.1
AK154972 mRNA Translation: BAE32964.1
AK161386 mRNA Translation: BAE36365.1
BX000359 Genomic DNA Translation: CAI25288.1
CH466596 Genomic DNA Translation: EDL12868.1
BC008542 mRNA Translation: AAH08542.1
CCDSiCCDS25070.1
RefSeqiNP_058090.2, NM_016810.3
UniGeneiMm.20931

3D structure databases

ProteinModelPortaliO88630
SMRiO88630
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207294, 1 interactor
IntActiO88630, 2 interactors
MINTiO88630
STRINGi10090.ENSMUSP00000010536

PTM databases

iPTMnetiO88630
PhosphoSitePlusiO88630
SwissPalmiO88630

Proteomic databases

EPDiO88630
PaxDbiO88630
PeptideAtlasiO88630
PRIDEiO88630

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010536; ENSMUSP00000010536; ENSMUSG00000010392
GeneIDi53334
KEGGimmu:53334
UCSCiuc007kfz.1 mouse

Organism-specific databases

CTDi9527
MGIiMGI:1858260 Gosr1

Phylogenomic databases

eggNOGiKOG3208 Eukaryota
ENOG410YI1X LUCA
GeneTreeiENSGT00390000008688
HOGENOMiHOG000207760
HOVERGENiHBG051764
InParanoidiO88630
KOiK08495
OMAiRIDNSHN
OrthoDBiEOG091G0W5M
TreeFamiTF105782

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Miscellaneous databases

PROiPR:O88630
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010392 Expressed in 267 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_GOSR1
GenevisibleiO88630 MM

Family and domain databases

InterProiView protein in InterPro
IPR023601 Golgi_SNAP_su1
PANTHERiPTHR21094 PTHR21094, 1 hit
PIRSFiPIRSF027109 Golgi_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOSR1_MOUSE
AccessioniPrimary (citable) accession number: O88630
Secondary accession number(s): Q91VU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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