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Protein

Sodium/nucleoside cotransporter 2

Gene

Slc28a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • nucleoside transmembrane transport Source: GO_Central
  • protein localization to cell surface Source: MGI
  • purine nucleoside transmembrane transport Source: MGI
  • retina homeostasis Source: MGI

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 2
Alternative name(s):
Concentrative nucleoside transporter 2
Short name:
CNT 2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside cotransporter
Short name:
SPNT
Solute carrier family 28 member 2
Gene namesi
Name:Slc28a2
Synonyms:Cnt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913105 Slc28a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei106 – 125HelicalSequence analysisAdd BLAST20
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Transmembranei338 – 357HelicalSequence analysisAdd BLAST20
Transmembranei364 – 383HelicalSequence analysisAdd BLAST20
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1287613

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704511 – 660Sodium/nucleoside cotransporter 2Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88627
MaxQBiO88627
PaxDbiO88627
PRIDEiO88627

PTM databases

iPTMnetiO88627
PhosphoSitePlusiO88627

Expressioni

Gene expression databases

BgeeiENSMUSG00000027219 Expressed in 24 organ(s), highest expression level in colon
GenevisibleiO88627 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028652

Structurei

3D structure databases

ProteinModelPortaliO88627
SMRiO88627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3747 Eukaryota
COG1972 LUCA
GeneTreeiENSGT00390000016025
HOGENOMiHOG000267658
HOVERGENiHBG054073
InParanoidiO88627
KOiK11536
OMAiEWADCPM
OrthoDBiEOG091G05D5
TreeFamiTF314131

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PTHR10590:SF11 PTHR10590:SF11, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

Sequencei

Sequence statusi: Complete.

O88627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSKGRKSV SQATVENCME NPGLELMEGG NLEQRYTQEE VTQGHSLEDG
60 70 80 90 100
LGHSSLWSRR IFQPFTKARS FFERHAGLFR KILLGLLCLA YAAYFLAACI
110 120 130 140 150
LNFQRALALF VITCLVIFIL ACHFLKKFFP KEQLRCLKPL ENTHLNLWAK
160 170 180 190 200
RVFVGLSVVG LILWLALDTA QRPEQLISFA GICMFILILF ACSKHHSAVC
210 220 230 240 250
WRTVFWGLGL QFIFGILVIR TEPGFNAFQW LGDQIQIFLA YTVEGSSFVF
260 270 280 290 300
GDTLVQNVFA FQSLPIIIFF GCVMSILYYL GLVQWVIQKV AWFLQITMGT
310 320 330 340 350
TAAETLAVAG NIFVGMTEAP LLIRPYLADM TISEIHAVMT GGFATIAGTV
360 370 380 390 400
LGAFISFGID ASSLISASVM AAPCALALSK LVYPEVEESK FKSKEGLKLP
410 420 430 440 450
RGEERNILEA ASNGATDAIS LVANVAANLI AFLAVLAFIN ATLSWLGEMV
460 470 480 490 500
DIHGLSFQVI CSYVLRPMVF MMGVQWADCP LVAEIVGVKF FINEFVAYQQ
510 520 530 540 550
LSQYKNKRLS GVEEWINGEK QWISVKAEII TTFSLCGFAN LSSIGITLGG
560 570 580 590 600
LTSMIPQRKS DLCKIVVRAL FTGACVSFIS ACMAGILYVP RGAETDCVSF
610 620 630 640 650
LNTNFTNRTY ETYVCCRELF QSTSLNGTNM PSFSGPWQDN VSSLRNLASC
660
CDLYTSTVCA
Length:660
Mass (Da):72,916
Last modified:July 27, 2011 - v2
Checksum:i64522D068A2138EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2E → K in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti14T → R in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti18C → G in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti80R → K in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti92A → T in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti154V → I in AAC28858 (PubMed:10721696).Curated1
Sequence conflicti337A → T in AAC28858 (PubMed:10721696).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079853 mRNA Translation: AAC28858.1
AK080957 mRNA Translation: BAC38094.1
AK152776 mRNA Translation: BAE31488.1
AL844566 Genomic DNA No translation available.
CCDSiCCDS16663.1
RefSeqiNP_766568.1, NM_172980.2
XP_006499664.1, XM_006499601.3
XP_011237878.1, XM_011239576.2
UniGeneiMm.29510

Genome annotation databases

EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219
ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219
ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219
GeneIDi269346
KEGGimmu:269346
UCSCiuc008mas.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079853 mRNA Translation: AAC28858.1
AK080957 mRNA Translation: BAC38094.1
AK152776 mRNA Translation: BAE31488.1
AL844566 Genomic DNA No translation available.
CCDSiCCDS16663.1
RefSeqiNP_766568.1, NM_172980.2
XP_006499664.1, XM_006499601.3
XP_011237878.1, XM_011239576.2
UniGeneiMm.29510

3D structure databases

ProteinModelPortaliO88627
SMRiO88627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028652

Chemistry databases

ChEMBLiCHEMBL1287613

PTM databases

iPTMnetiO88627
PhosphoSitePlusiO88627

Proteomic databases

EPDiO88627
MaxQBiO88627
PaxDbiO88627
PRIDEiO88627

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028652; ENSMUSP00000028652; ENSMUSG00000027219
ENSMUST00000110524; ENSMUSP00000106153; ENSMUSG00000027219
ENSMUST00000110525; ENSMUSP00000106154; ENSMUSG00000027219
GeneIDi269346
KEGGimmu:269346
UCSCiuc008mas.1 mouse

Organism-specific databases

CTDi9153
MGIiMGI:1913105 Slc28a2

Phylogenomic databases

eggNOGiKOG3747 Eukaryota
COG1972 LUCA
GeneTreeiENSGT00390000016025
HOGENOMiHOG000267658
HOVERGENiHBG054073
InParanoidiO88627
KOiK11536
OMAiEWADCPM
OrthoDBiEOG091G05D5
TreeFamiTF314131

Enzyme and pathway databases

ReactomeiR-MMU-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Miscellaneous databases

PROiPR:O88627
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027219 Expressed in 24 organ(s), highest expression level in colon
GenevisibleiO88627 MM

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PTHR10590:SF11 PTHR10590:SF11, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS28A2_MOUSE
AccessioniPrimary (citable) accession number: O88627
Secondary accession number(s): Q8BJP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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