Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM homeobox transcription factor 1-beta

Gene

Lmx1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi219 – 278HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM homeobox transcription factor 1-beta
Alternative name(s):
LIM/homeobox protein 1.2
Short name:
LMX-1.2
LIM/homeobox protein LMX1B
Gene namesi
Name:Lmx1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1100513 Lmx1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758301 – 395LIM homeobox transcription factor 1-betaAdd BLAST395

Proteomic databases

PaxDbiO88609
PRIDEiO88609

PTM databases

PhosphoSitePlusiO88609

Expressioni

Gene expression databases

CleanExiMM_LMX1B

Interactioni

Subunit structurei

Interacts with DHX9.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi201183, 7 interactors
IntActiO88609, 19 interactors
STRINGi10090.ENSMUSP00000043616

Structurei

3D structure databases

ProteinModelPortaliO88609
SMRiO88609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 106LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST51
Domaini115 – 168LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi282 – 288Poly-Gln7

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231629
HOVERGENiHBG052335
InParanoidiO88609
KOiK09371
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O88609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIATGPESL ERCFPRGQTD CAKMLDGIKM EEHALRPGPA TLGVLLGSDC
60 70 80 90 100
PHPAVCEGCQ RPISDRFLMR VNESSWHEEC LQCAACQQAL TTSCYFRDRK
110 120 130 140 150
LYCKQDYQQL FAAKCSGCME KIAPTEFVMR ALECVYHLGC FCCCVCERQL
160 170 180 190 200
RKGDEFVLKE GQLLCKGDYE KEKDLLSSVS PDESDSVKSE DEDGDMKPAK
210 220 230 240 250
GQGSQSKGSG DDGKDPRRPK RPRTILTTQQ RRAFKASFEV SSKPCRKVRE
260 270 280 290 300
TLAAETGLSV RVVQVWFQNQ RAKMKKLARR HQQQQEQQNS QRLGQEVLSS
310 320 330 340 350
RMEGMMASYT PLAPPQQQIV AMEQSPYGSS DPFQQGLTPP QMPGNDSIFH
360 370 380 390
DIDSDTSLTS LSDCFLGSSD VGSLQARVGN PIDRLYSMQS SYFAS
Length:395
Mass (Da):44,102
Last modified:May 1, 2013 - v3
Checksum:i9FFBF8A68E7AC676
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0I7A0A0R4J0I7_MOUSE
LIM homeobox transcription factor 1...
Lmx1b
372Annotation score:
H3BJD7H3BJD7_MOUSE
LIM homeobox transcription factor 1...
Lmx1b
369Annotation score:

Sequence cautioni

The sequence AAC27793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI19170 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25470 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAM26554 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EDL08602 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311P → A in AAC27793 (PubMed:9590288).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929212 Genomic DNA Translation: CAM26554.1 Different initiation.
CH466542 Genomic DNA Translation: EDL08602.1 Different initiation.
BC119169 mRNA Translation: AAI19170.1 Different initiation.
BC125469 mRNA Translation: AAI25470.1 Different initiation.
AF078166 mRNA Translation: AAC27793.1 Different initiation.
RefSeqiNP_034855.2, NM_010725.2
UniGeneiMm.39825

Genome annotation databases

GeneIDi16917
KEGGimmu:16917
UCSCiuc008jhy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929212 Genomic DNA Translation: CAM26554.1 Different initiation.
CH466542 Genomic DNA Translation: EDL08602.1 Different initiation.
BC119169 mRNA Translation: AAI19170.1 Different initiation.
BC125469 mRNA Translation: AAI25470.1 Different initiation.
AF078166 mRNA Translation: AAC27793.1 Different initiation.
RefSeqiNP_034855.2, NM_010725.2
UniGeneiMm.39825

3D structure databases

ProteinModelPortaliO88609
SMRiO88609
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201183, 7 interactors
IntActiO88609, 19 interactors
STRINGi10090.ENSMUSP00000043616

PTM databases

PhosphoSitePlusiO88609

Proteomic databases

PaxDbiO88609
PRIDEiO88609

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16917
KEGGimmu:16917
UCSCiuc008jhy.2 mouse

Organism-specific databases

CTDi4010
MGIiMGI:1100513 Lmx1b

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231629
HOVERGENiHBG052335
InParanoidiO88609
KOiK09371
TreeFamiTF315442

Miscellaneous databases

PROiPR:O88609
SOURCEiSearch...

Gene expression databases

CleanExiMM_LMX1B

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLMX1B_MOUSE
AccessioniPrimary (citable) accession number: O88609
Secondary accession number(s): Q0VEN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2013
Last modified: November 7, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again