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Protein

Peptidoglycan recognition protein 1

Gene

Pglyrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Cytokine
Biological processApoptosis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Cytokine tag7
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:Pglyrp1
Synonyms:Pglyrp, Pgrp, Pgrps, Tag7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1345092 Pglyrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002390219 – 182Peptidoglycan recognition protein 1Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi17 ↔ 141By similarity
Disulfide bondi33 ↔ 78By similarity
Disulfide bondi54 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88593
PeptideAtlasiO88593
PRIDEiO88593

PTM databases

PhosphoSitePlusiO88593

Expressioni

Tissue specificityi

Strongly expressed in spleen and lung. Also detected in brain and thymus. In the lung, expressed in the intraalveolar space, in the brain, expressed in the Purkinje cells of the cerebellum and in certain layers of neurons in the hippocampus. Also detected in cells filling the space within the intestinal villus.1 Publication

Gene expression databases

BgeeiENSMUSG00000030413 Expressed in 137 organ(s), highest expression level in cochlea
CleanExiMM_PGLYRP1
ExpressionAtlasiO88593 baseline and differential
GenevisibleiO88593 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032573

Structurei

3D structure databases

ProteinModelPortaliO88593
SMRiO88593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 167N-acetylmuramoyl-L-alanine amidaseSequence analysisAdd BLAST129

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD Eukaryota
ENOG4111PQD LUCA
GeneTreeiENSGT00390000016833
HOGENOMiHOG000267017
HOVERGENiHBG007406
InParanoidiO88593
KOiK01446
OMAiTECPGES
OrthoDBiEOG091G0O6Z
PhylomeDBiO88593
TreeFamiTF323898

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR017331 Peptidoglycan_recognition
IPR015510 PGRP
IPR006619 PGRP_domain_met/bac
PANTHERiPTHR11022 PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
PIRSFiPIRSF037945 PGRPs, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SM00701 PGRP, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFACALLAL LGLATSCSFI VPRSEWRALP SECSSRLGHP VRYVVISHTA
60 70 80 90 100
GSFCNSPDSC EQQARNVQHY HKNELGWCDV AYNFLIGEDG HVYEGRGWNI
110 120 130 140 150
KGDHTGPIWN PMSIGITFMG NFMDRVPAKR ALRAALNLLE CGVSRGFLRS
160 170 180
NYEVKGHRDV QSTLSPGDQL YQVIQSWEHY RE
Length:182
Mass (Da):20,489
Last modified:November 1, 1998 - v1
Checksum:i9844E2137F047F14
GO

Sequence cautioni

The sequence CAA60133 differs from that shown. Reason: Frameshift at position 127.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141C → S in CAA60133 (PubMed:9660837).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076482 mRNA Translation: AAC31821.1
X86374 mRNA Translation: CAA60133.1 Frameshift.
Y12088 Genomic DNA Translation: CAA72803.1
AF193843 mRNA Translation: AAF06335.1
AY144361, AY144360 Genomic DNA Translation: AAN52146.1
AK008335 mRNA Translation: BAB25611.1
BC005582 mRNA Translation: AAH05582.1
CCDSiCCDS20881.1
RefSeqiNP_033428.1, NM_009402.2
UniGeneiMm.21855

Genome annotation databases

EnsembliENSMUST00000032573; ENSMUSP00000032573; ENSMUSG00000030413
GeneIDi21946
KEGGimmu:21946
UCSCiuc009fjv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076482 mRNA Translation: AAC31821.1
X86374 mRNA Translation: CAA60133.1 Frameshift.
Y12088 Genomic DNA Translation: CAA72803.1
AF193843 mRNA Translation: AAF06335.1
AY144361, AY144360 Genomic DNA Translation: AAN52146.1
AK008335 mRNA Translation: BAB25611.1
BC005582 mRNA Translation: AAH05582.1
CCDSiCCDS20881.1
RefSeqiNP_033428.1, NM_009402.2
UniGeneiMm.21855

3D structure databases

ProteinModelPortaliO88593
SMRiO88593
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032573

PTM databases

PhosphoSitePlusiO88593

Proteomic databases

PaxDbiO88593
PeptideAtlasiO88593
PRIDEiO88593

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032573; ENSMUSP00000032573; ENSMUSG00000030413
GeneIDi21946
KEGGimmu:21946
UCSCiuc009fjv.1 mouse

Organism-specific databases

CTDi8993
MGIiMGI:1345092 Pglyrp1

Phylogenomic databases

eggNOGiENOG410IYTD Eukaryota
ENOG4111PQD LUCA
GeneTreeiENSGT00390000016833
HOGENOMiHOG000267017
HOVERGENiHBG007406
InParanoidiO88593
KOiK01446
OMAiTECPGES
OrthoDBiEOG091G0O6Z
PhylomeDBiO88593
TreeFamiTF323898

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

PROiPR:O88593
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030413 Expressed in 137 organ(s), highest expression level in cochlea
CleanExiMM_PGLYRP1
ExpressionAtlasiO88593 baseline and differential
GenevisibleiO88593 MM

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR017331 Peptidoglycan_recognition
IPR015510 PGRP
IPR006619 PGRP_domain_met/bac
PANTHERiPTHR11022 PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
PIRSFiPIRSF037945 PGRPs, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SM00701 PGRP, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP1_MOUSE
AccessioniPrimary (citable) accession number: O88593
Secondary accession number(s): Q62185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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