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Protein

Phosphofurin acidic cluster sorting protein 1

Gene

Pacs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits.1 Publication

GO - Molecular functioni

  • ion channel binding Source: GO_Central

GO - Biological processi

  • cellular protein localization Source: RGD
  • positive regulation of protein binding Source: RGD
  • protein localization to plasma membrane Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphofurin acidic cluster sorting protein 1
Short name:
PACS-1
Gene namesi
Name:Pacs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620579 Pacs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000581732 – 961Phosphofurin acidic cluster sorting protein 1Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei44PhosphothreonineBy similarity1
Modified residuei249PhosphotyrosineBy similarity1
Modified residuei377PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei428PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei502PhosphothreonineBy similarity1
Modified residuei517PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei529PhosphoserineBy similarity1
Modified residuei532PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO88588
PRIDEiO88588

PTM databases

iPTMnetiO88588
PhosphoSitePlusiO88588
SwissPalmiO88588

Interactioni

Subunit structurei

Associates with AP-1 and AP-3 but not with AP-2 complexes (By similarity). Interacts with FURIN (By similarity). Forms a ternary complex with furin and AP-1 (PubMed:9695949). Interacts with PKD2 (via acidic region) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88588, 1 interactor
MINTiO88588
STRINGi10116.ENSRNOP00000027632

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili351 – 375Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 82Ser-richAdd BLAST30
Compositional biasi60 – 63Poly-Ala4
Compositional biasi110 – 113Poly-Ser4
Compositional biasi277 – 281Poly-Glu5

Sequence similaritiesi

Belongs to the PACS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3709 Eukaryota
ENOG410XQNV LUCA
HOGENOMiHOG000047329
HOVERGENiHBG053488
InParanoidiO88588
PhylomeDBiO88588

Family and domain databases

InterProiView protein in InterPro
IPR019381 Phosphofurin_acidic_CS-1
PANTHERiPTHR13280 PTHR13280, 1 hit
PfamiView protein in Pfam
PF10254 Pacs-1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform PACS-1a (identifier: O88588-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERGGAGGG PGGAGGGSSQ RGSGVAQSPQ QQPPQQPSQP QQPTPPKLAQ
60 70 80 90 100
ATSSSSSTSA AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN
110 120 130 140 150
LYATWEVDRS SSSCVPRLFS LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR
160 170 180 190 200
ILRSNEIILP ASGLVETELQ LTFSLQYPHF LKRDANKLQI MLQRRKRYKN
210 220 230 240 250
RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS VPVAEIKIYS
260 270 280 290 300
LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF
310 320 330 340 350
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE
360 370 380 390 400
HVSREQIREV EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF
410 420 430 440 450
FEGMSQSSSQ TEIGSLNSKG SLGKDTTSPM ELAALEKVKS TWIKNQDDSL
460 470 480 490 500
TETDTLEITD QDMFGDASTS LVVPEKVKTP MKSSKADLQG SASPSKVEGT
510 520 530 540 550
HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ IPRKVVYDQL
560 570 580 590 600
NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV
610 620 630 640 650
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD
660 670 680 690 700
WLGHMRFLIV PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE
710 720 730 740 750
PLDVVGRVMQ YVNGATTTHQ LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV
760 770 780 790 800
KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP PSSSGLSRDA TATPPSSPSM
810 820 830 840 850
SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD ASSKNTLKSV
860 870 880 890 900
FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS
910 920 930 940 950
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF
960
PVGLFSGSKP T
Length:961
Mass (Da):104,700
Last modified:November 1, 1998 - v1
Checksum:i9B4A4522DFF9DEAF
GO
Isoform PACS-1b (identifier: O88588-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     541-559: IPRKVVYDQLNQILVSDAA → VILGSSRFRTPFLDFSLFL
     560-961: Missing.

Show »
Length:559
Mass (Da):60,850
Checksum:i6D1D4CDF5EA2AB76
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LPG3F1LPG3_RAT
Phosphofurin acidic cluster sorting...
Pacs1
961Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011558541 – 559IPRKV…VSDAA → VILGSSRFRTPFLDFSLFL in isoform PACS-1b. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_011559560 – 961Missing in isoform PACS-1b. 1 PublicationAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076183 mRNA Translation: AAC31815.1
AF076184 mRNA Translation: AAC31816.1
RefSeqiNP_599233.1, NM_134406.1 [O88588-1]
UniGeneiRn.154425

Genome annotation databases

GeneIDi171444
KEGGirno:171444
UCSCiRGD:620579 rat [O88588-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076183 mRNA Translation: AAC31815.1
AF076184 mRNA Translation: AAC31816.1
RefSeqiNP_599233.1, NM_134406.1 [O88588-1]
UniGeneiRn.154425

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88588, 1 interactor
MINTiO88588
STRINGi10116.ENSRNOP00000027632

PTM databases

iPTMnetiO88588
PhosphoSitePlusiO88588
SwissPalmiO88588

Proteomic databases

PaxDbiO88588
PRIDEiO88588

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171444
KEGGirno:171444
UCSCiRGD:620579 rat [O88588-1]

Organism-specific databases

CTDi55690
RGDi620579 Pacs1

Phylogenomic databases

eggNOGiKOG3709 Eukaryota
ENOG410XQNV LUCA
HOGENOMiHOG000047329
HOVERGENiHBG053488
InParanoidiO88588
PhylomeDBiO88588

Miscellaneous databases

PROiPR:O88588

Family and domain databases

InterProiView protein in InterPro
IPR019381 Phosphofurin_acidic_CS-1
PANTHERiPTHR13280 PTHR13280, 1 hit
PfamiView protein in Pfam
PF10254 Pacs-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPACS1_RAT
AccessioniPrimary (citable) accession number: O88588
Secondary accession number(s): O88589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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