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Protein

AF4/FMR2 family member 1

Gene

Aff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • double-stranded DNA binding Source: GO_Central

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
AF4/FMR2 family member 1
Alternative name(s):
Proto-oncogene AF4
Short name:
Protein AF-4
Gene namesi
Name:Aff1
Synonyms:Mllt2, Mllt2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1100819 Aff1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159111 – 1216AF4/FMR2 family member 1Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei682N6-acetyllysineBy similarity1
Modified residuei755PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO88573
PaxDbiO88573
PeptideAtlasiO88573
PRIDEiO88573

PTM databases

iPTMnetiO88573
PhosphoSitePlusiO88573

Expressioni

Gene expression databases

CleanExiMM_AFF1

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3).By similarity

Protein-protein interaction databases

IntActiO88573, 2 interactors
MINTiO88573
STRINGi10090.ENSMUSP00000031256

Structurei

3D structure databases

ProteinModelPortaliO88573
SMRiO88573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi261 – 266Poly-Pro6
Compositional biasi467 – 476Poly-Ser10
Compositional biasi477 – 483Poly-Glu7
Compositional biasi840 – 844Poly-Ser5
Compositional biasi870 – 880Poly-SerAdd BLAST11

Sequence similaritiesi

Belongs to the AF4 family.Curated

Phylogenomic databases

eggNOGiENOG410IGJB Eukaryota
ENOG410XRXU LUCA
HOGENOMiHOG000246991
HOVERGENiHBG004189
InParanoidiO88573

Family and domain databases

InterProiView protein in InterPro
IPR007797 TF_AF4/FMR2
PANTHERiPTHR10528 PTHR10528, 1 hit
PfamiView protein in Pfam
PF05110 AF-4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O88573-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAHSSLYNE DRNLLRIREK ERRNQEAHQE KEAFPEKAPL FPEPYKTAKG
60 70 80 90 100
DELSSRIQTM LGDYEEMKEF LSSKSHPHRL DGSEDRPGKP RYPLGHDRGN
110 120 130 140 150
GAASSSLRTH VYHQPIHTSA PGSRPVGNIS HSPKMAQPRM EPSLHTKIYD
160 170 180 190 200
GPRLTQDHLS QGHCSRKCDR RAEGDSAPER KLSPLISSLP SPVPPLSPVH
210 220 230 240 250
SRLQGTSKAH SSGVSSKSCC VAKSSKDLVA KAQDKETPHD GLVAVTSLGS
260 270 280 290 300
APPQPPCQTF PPPPLPSKSA AMQQKPTAYV RPMDGQDQAP SESPELKLPL
310 320 330 340 350
EDYGQQSFEK PDLKVPAKAK LTRLRMPSQS VEQPYSNEVH CVEEILKEMT
360 370 380 390 400
HSWPPPLTAI HTPSTAEPSR FPFPTKDPLH VSPATQSQKQ YDTPSKTHPN
410 420 430 440 450
PQQGTSMLED DLQLSDSEDS DTEQATEKPP SPPAPPSAPQ TLPEPVASAH
460 470 480 490 500
SSSGESESSE SDSSSDSESE SSSSDSEEEE ENEPLETRAP EPEPPTTNKW
510 520 530 540 550
QLDNWLTKVN QPSVPLDGRG STESPQWRQE SKGVAEGSSD QQHPDSKDPL
560 570 580 590 600
PKSSSKTLRG PSEGPSLGRG AVRNPPLNRN PHLGKPWAAN NPGNPPRLRP
610 620 630 640 650
GRAQASSQAE SEVGPLPYGS KEQTSKDRPK VKTKGRPRAV GSREPKPEVP
660 670 680 690 700
APTPQAAVPR PKPPVPTPSE KRKHKSSTAP SKAPSAPQPP KDSAGDRNPE
710 720 730 740 750
HSALVSLTQS QGPSHSSRGS SGSVRTSGCR QAVIAQGDGC KDKLLLPLRD
760 770 780 790 800
TKLLSPLRDS PPPTSLVVKI TLDLLTRIPQ PLGKGSRPRK AEDKQLSAGK
810 820 830 840 850
KQDSETKSCD SSSRVTKKRK VTQKKSTVTR DTNWISRRAS SSSSHTESSR
860 870 880 890 900
TKAPRSSSEN SRKEMLPPAS ASSVSSSSSS QKPSRPAQKR PRPDEDTCSQ
910 920 930 940 950
EPPRSASSTK SSSTDPPAPK HRKVQARGSE HKGSSGDAAN AANPFPVPSL
960 970 980 990 1000
PNGNAKPGKP QVKSDRQQAD FHMKEAKKLK CKAETMVDKA GKAFKYLEAV
1010 1020 1030 1040 1050
LSFIECGMAS ESESSAKSAY AVYSETIDLI RYVMSLKCFS DNTMPAQEKI
1060 1070 1080 1090 1100
FAVLCLRCQS LLNMAMFRCK KDTVMKYSRT LSEHFKSTSK VAQAPSPCTA
1110 1120 1130 1140 1150
RSTGVPSPLS PMPSPASSVG SQSSAGSSMG SVGVTATVST PVSIQNMTSS
1160 1170 1180 1190 1200
YVTITSHVLT AFSLWEQAEA LTRKNKEFFA QLSTKVRVLA LNSSLVDLVH
1210
YTRQGLQRLK QSPKGP
Length:1,216
Mass (Da):131,558
Last modified:October 3, 2012 - v2
Checksum:i4CCA54DBB4992E8B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q921E9Q921_MOUSE
AF4/FMR2 family member 1
Aff1
1,226Annotation score:
A3KMF4A3KMF4_MOUSE
AF4/FMR2 family member 1
Aff1
1,218Annotation score:
B1AVP1B1AVP1_MOUSE
AF4/FMR2 family member 1
Aff1
870Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti378P → L in AAD08668 (PubMed:9880680).Curated1
Sequence conflicti619G → R in AAD08668 (PubMed:9880680).Curated1
Sequence conflicti820K → R in AAD08668 (PubMed:9880680).Curated1
Sequence conflicti838R → KT in AAD08668 (PubMed:9880680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074266 mRNA Translation: AAD08668.1
AL713989 Genomic DNA No translation available.
AL731554 Genomic DNA No translation available.
PIRiT42625
UniGeneiMm.6949

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074266 mRNA Translation: AAD08668.1
AL713989 Genomic DNA No translation available.
AL731554 Genomic DNA No translation available.
PIRiT42625
UniGeneiMm.6949

3D structure databases

ProteinModelPortaliO88573
SMRiO88573
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88573, 2 interactors
MINTiO88573
STRINGi10090.ENSMUSP00000031256

PTM databases

iPTMnetiO88573
PhosphoSitePlusiO88573

Proteomic databases

MaxQBiO88573
PaxDbiO88573
PeptideAtlasiO88573
PRIDEiO88573

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1100819 Aff1

Phylogenomic databases

eggNOGiENOG410IGJB Eukaryota
ENOG410XRXU LUCA
HOGENOMiHOG000246991
HOVERGENiHBG004189
InParanoidiO88573

Miscellaneous databases

ChiTaRSiAff1 mouse
PROiPR:O88573
SOURCEiSearch...

Gene expression databases

CleanExiMM_AFF1

Family and domain databases

InterProiView protein in InterPro
IPR007797 TF_AF4/FMR2
PANTHERiPTHR10528 PTHR10528, 1 hit
PfamiView protein in Pfam
PF05110 AF-4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAFF1_MOUSE
AccessioniPrimary (citable) accession number: O88573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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