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Entry version 104 (13 Feb 2019)
Sequence version 2 (03 Oct 2012)
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Protein

AF4/FMR2 family member 1

Gene

Aff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • double-stranded DNA binding Source: GO_Central

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: MGI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF4/FMR2 family member 1
Alternative name(s):
Proto-oncogene AF4
Short name:
Protein AF-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aff1
Synonyms:Mllt2, Mllt2h
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100819 Aff1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159111 – 1216AF4/FMR2 family member 1Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei183PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei682N6-acetyllysineBy similarity1
Modified residuei755PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88573

MaxQB - The MaxQuant DataBase

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MaxQBi
O88573

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88573

PeptideAtlas

More...
PeptideAtlasi
O88573

PRoteomics IDEntifications database

More...
PRIDEi
O88573

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88573

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88573

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3).By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O88573, 2 interactors

Molecular INTeraction database

More...
MINTi
O88573

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000031256

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88573

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88573

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi261 – 266Poly-Pro6
Compositional biasi467 – 476Poly-Ser10
Compositional biasi477 – 483Poly-Glu7
Compositional biasi840 – 844Poly-Ser5
Compositional biasi870 – 880Poly-SerAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJB Eukaryota
ENOG410XRXU LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246991

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004189

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88573

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797 TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528 PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05110 AF-4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O88573-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAHSSLYNE DRNLLRIREK ERRNQEAHQE KEAFPEKAPL FPEPYKTAKG
60 70 80 90 100
DELSSRIQTM LGDYEEMKEF LSSKSHPHRL DGSEDRPGKP RYPLGHDRGN
110 120 130 140 150
GAASSSLRTH VYHQPIHTSA PGSRPVGNIS HSPKMAQPRM EPSLHTKIYD
160 170 180 190 200
GPRLTQDHLS QGHCSRKCDR RAEGDSAPER KLSPLISSLP SPVPPLSPVH
210 220 230 240 250
SRLQGTSKAH SSGVSSKSCC VAKSSKDLVA KAQDKETPHD GLVAVTSLGS
260 270 280 290 300
APPQPPCQTF PPPPLPSKSA AMQQKPTAYV RPMDGQDQAP SESPELKLPL
310 320 330 340 350
EDYGQQSFEK PDLKVPAKAK LTRLRMPSQS VEQPYSNEVH CVEEILKEMT
360 370 380 390 400
HSWPPPLTAI HTPSTAEPSR FPFPTKDPLH VSPATQSQKQ YDTPSKTHPN
410 420 430 440 450
PQQGTSMLED DLQLSDSEDS DTEQATEKPP SPPAPPSAPQ TLPEPVASAH
460 470 480 490 500
SSSGESESSE SDSSSDSESE SSSSDSEEEE ENEPLETRAP EPEPPTTNKW
510 520 530 540 550
QLDNWLTKVN QPSVPLDGRG STESPQWRQE SKGVAEGSSD QQHPDSKDPL
560 570 580 590 600
PKSSSKTLRG PSEGPSLGRG AVRNPPLNRN PHLGKPWAAN NPGNPPRLRP
610 620 630 640 650
GRAQASSQAE SEVGPLPYGS KEQTSKDRPK VKTKGRPRAV GSREPKPEVP
660 670 680 690 700
APTPQAAVPR PKPPVPTPSE KRKHKSSTAP SKAPSAPQPP KDSAGDRNPE
710 720 730 740 750
HSALVSLTQS QGPSHSSRGS SGSVRTSGCR QAVIAQGDGC KDKLLLPLRD
760 770 780 790 800
TKLLSPLRDS PPPTSLVVKI TLDLLTRIPQ PLGKGSRPRK AEDKQLSAGK
810 820 830 840 850
KQDSETKSCD SSSRVTKKRK VTQKKSTVTR DTNWISRRAS SSSSHTESSR
860 870 880 890 900
TKAPRSSSEN SRKEMLPPAS ASSVSSSSSS QKPSRPAQKR PRPDEDTCSQ
910 920 930 940 950
EPPRSASSTK SSSTDPPAPK HRKVQARGSE HKGSSGDAAN AANPFPVPSL
960 970 980 990 1000
PNGNAKPGKP QVKSDRQQAD FHMKEAKKLK CKAETMVDKA GKAFKYLEAV
1010 1020 1030 1040 1050
LSFIECGMAS ESESSAKSAY AVYSETIDLI RYVMSLKCFS DNTMPAQEKI
1060 1070 1080 1090 1100
FAVLCLRCQS LLNMAMFRCK KDTVMKYSRT LSEHFKSTSK VAQAPSPCTA
1110 1120 1130 1140 1150
RSTGVPSPLS PMPSPASSVG SQSSAGSSMG SVGVTATVST PVSIQNMTSS
1160 1170 1180 1190 1200
YVTITSHVLT AFSLWEQAEA LTRKNKEFFA QLSTKVRVLA LNSSLVDLVH
1210
YTRQGLQRLK QSPKGP
Length:1,216
Mass (Da):131,558
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CCA54DBB4992E8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q921E9Q921_MOUSE
AF4/FMR2 family member 1
Aff1
1,226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KMF4A3KMF4_MOUSE
AF4/FMR2 family member 1
Aff1
1,218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVP1B1AVP1_MOUSE
AF4/FMR2 family member 1
Aff1
870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti378P → L in AAD08668 (PubMed:9880680).Curated1
Sequence conflicti619G → R in AAD08668 (PubMed:9880680).Curated1
Sequence conflicti820K → R in AAD08668 (PubMed:9880680).Curated1
Sequence conflicti838R → KT in AAD08668 (PubMed:9880680).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF074266 mRNA Translation: AAD08668.1
AL713989 Genomic DNA No translation available.
AL731554 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
T42625

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.6949

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074266 mRNA Translation: AAD08668.1
AL713989 Genomic DNA No translation available.
AL731554 Genomic DNA No translation available.
PIRiT42625
UniGeneiMm.6949

3D structure databases

ProteinModelPortaliO88573
SMRiO88573
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88573, 2 interactors
MINTiO88573
STRINGi10090.ENSMUSP00000031256

PTM databases

iPTMnetiO88573
PhosphoSitePlusiO88573

Proteomic databases

jPOSTiO88573
MaxQBiO88573
PaxDbiO88573
PeptideAtlasiO88573
PRIDEiO88573

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1100819 Aff1

Phylogenomic databases

eggNOGiENOG410IGJB Eukaryota
ENOG410XRXU LUCA
HOGENOMiHOG000246991
HOVERGENiHBG004189
InParanoidiO88573

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Aff1 mouse

Protein Ontology

More...
PROi
PR:O88573

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR007797 TF_AF4/FMR2
PANTHERiPTHR10528 PTHR10528, 1 hit
PfamiView protein in Pfam
PF05110 AF-4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAFF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88573
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: February 13, 2019
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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