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Protein

Canalicular multispecific organic anion transporter 2

Gene

Abcc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi659 – 666ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1318 – 1325ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • canalicular bile acid transport Source: MGI
  • drug transmembrane transport Source: RGD
  • drug transport Source: RGD
  • response to estradiol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to organonitrogen compound Source: RGD
  • transmembrane transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 2
Alternative name(s):
ATP-binding cassette sub-family C member 3
MRP-like protein 2
Short name:
MLP-2
Multidrug resistance-associated protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc3
Synonyms:Cmoat2, Mlp2, Mrp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
71101 Abcc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32ExtracellularBy similarityAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini54 – 73CytoplasmicBy similarityAdd BLAST20
Transmembranei74 – 94Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini95 – 99ExtracellularBy similarity5
Transmembranei100 – 120Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini121 – 132CytoplasmicBy similarityAdd BLAST12
Transmembranei133 – 153Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini154 – 171ExtracellularBy similarityAdd BLAST18
Transmembranei172 – 192Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini193 – 301CytoplasmicBy similarityAdd BLAST109
Transmembranei302 – 322Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini323 – 347ExtracellularBy similarityAdd BLAST25
Transmembranei348 – 368Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini369 – 424CytoplasmicBy similarityAdd BLAST56
Transmembranei425 – 445Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini446 – 448ExtracellularBy similarity3
Transmembranei449 – 469Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini470 – 531CytoplasmicBy similarityAdd BLAST62
Transmembranei532 – 552Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini553 – 574ExtracellularBy similarityAdd BLAST22
Transmembranei575 – 595Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini596 – 958CytoplasmicBy similarityAdd BLAST363
Transmembranei959 – 979Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini980 – 1016ExtracellularBy similarityAdd BLAST37
Transmembranei1017 – 1037Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1038 – 1080CytoplasmicBy similarityAdd BLAST43
Transmembranei1081 – 1101Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1102ExtracellularBy similarity1
Transmembranei1103 – 1123Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1124 – 1194CytoplasmicBy similarityAdd BLAST71
Transmembranei1195 – 1215Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1216 – 1217ExtracellularBy similarity2
Transmembranei1218 – 1238Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1239 – 1522CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073682

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933611 – 1522Canalicular multispecific organic anion transporter 2Add BLAST1522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei902PhosphoserineCombined sources1
Modified residuei905PhosphoserineCombined sources1
Glycosylationi1001N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O88563

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88563

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88563

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Lung and intestine, low in liver. Higher in liver of Eisai hyperbilirubinemic rats and TR- mutant rats.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
250828, 1 interactor

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O88563

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88563

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88563

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini310 – 592ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST283
Domaini625 – 849ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini966 – 1247ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1286 – 1518ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88563

KEGG Orthology (KO)

More...
KOi
K05667

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88563

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O88563-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRLCGSGEL GSKFWDSNLT VYTNTPDLTP CFQNSLLAWV PCIYLWAALP
60 70 80 90 100
CYLFYLRHHR LGYIVLSCLS RLKTALGVLL WCISWVDLFY SFHGLVHGSS
110 120 130 140 150
PAPVFFITPL LVGITMLLAT LLIQYERLRG VRSSGVLIIF WLLCVICAII
160 170 180 190 200
PFRSKILLAL AEGKILDPFR FTTFYIYFAL VLCAFILSCF QEKPPLFSPE
210 220 230 240 250
NLDTNPCPEA SAGFFSRLSF WWFTKLAILG YRRPLEDSDL WSLSEEDCSH
260 270 280 290 300
KVVQRLLEAW QKQQTQASGP QTAALEPKIA GEDEVLLKAR PKTKKPSFLR
310 320 330 340 350
ALVRTFTSSL LMGACFKLIQ DLSPSSTHSC SASSSGLFRP HGPYWWGFLL
360 370 380 390 400
AGLMFVSSTM QTLILHQHYH CIFVMALRIR TAIIGVIYRK ALTITNSVKR
410 420 430 440 450
EYTVGEMVNL MSVDAQRFMD VSPFINLLWS APLQVILAIY FLWQILGPSA
460 470 480 490 500
LAGVAVIVLL IPLNGAVSMK MKTYQVQQMK FKDSRIKLMS EILNGIKVLK
510 520 530 540 550
LYAWEPTFLE QVEGIRQGEL QLLRKGAYLQ AISTFIWVCT PFMVTLITLG
560 570 580 590 600
VYVCVDKNNV LDAEKAFVSL SLFNILKIPL NLLPQLISGM TQTSVSLKRI
610 620 630 640 650
QDFLNQDELD PQCVERKTIS PGRAITIHNG TFSWSKDLPP TLHSINIQIP
660 670 680 690 700
KGALVAVVGP VGCGKSSLVS ALLGEMEKLE GAVSVKGSVA YVPQQAWIQN
710 720 730 740 750
CTLQENVLFG QPMNPKRYQQ ALETCALLAD LDVLPGGDQT EIGEKGINLS
760 770 780 790 800
GGQRQRVSLA RAVYSDANIF LLDDPLSAVD SHVAKHIFDQ VIGPEGVLAG
810 820 830 840 850
KTRVLVTHGI SFLPQTDFII VLADGQITEM GHYSELLQHD GSFANFLRNY
860 870 880 890 900
APDENQEANE GVLQHANEEV LLLEDTLSTH TDLTDTEPAI YEVRKQFMRE
910 920 930 940 950
MSSLSSEGEG QNRPVLKRYT SSLEKEVPAT QTKETGALIK EEIAETGNVK
960 970 980 990 1000
LSVYWDYAKS VGLCTTLFIC LLYAGQNAVA IGANVWLSAW TNDVEEHGQQ
1010 1020 1030 1040 1050
NNTSVRLGVY ATLGILQGLL VMLSAFTMVV GAIQAARLLH TALLHNQIRA
1060 1070 1080 1090 1100
PQSFFDTTPS GRILNRFSKD IYVIHEVLAP TILMLFNSFY TSISTIVVIV
1110 1120 1130 1140 1150
ASTPLFCVVV LPLAVFYGFV QRFYVATSRQ LKRLESVSRS PIFSHFSETV
1160 1170 1180 1190 1200
TGTSVIRAYG RVQDFKVLSD AKVDSNQKTT YPYIASNRWL GVHVEFVGNC
1210 1220 1230 1240 1250
VVLFSALFAV IGRNSLNPGL VGLSVSYALQ VTLSLNWMIR TLSDLESNII
1260 1270 1280 1290 1300
AVERVKEYSK TETEAPWVLE SNRAPEGWPR SGVVEFRNYS VRYRPGLELV
1310 1320 1330 1340 1350
LKNLTLHVQG GEKVGIVGRT GAGKSSMTLC LFRILEAAEG EIFIDGLNVA
1360 1370 1380 1390 1400
HIGLHDLRSQ LTIIPQDPIL FSGTLRMNLD PFGRYSDEDI WRTLELSHLS
1410 1420 1430 1440 1450
AFVSSQPTGL DFQCSEGGDN LSVGQRQLVC LARALLRKSR VLVLDEATAA
1460 1470 1480 1490 1500
IDLETDDLIQ GTIRTQFEDC TVLTIAHRLN TIMDYNRVLV LDKGVVAEFD
1510 1520
SPVNLIAAGG IFYGMAKDAG LA
Length:1,522
Mass (Da):168,978
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i740E31E0C4C64297
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZF64D3ZF64_RAT
Canalicular multispecific organic a...
Abcc3
1,523Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K4K3A0A0G2K4K3_RAT
Canalicular multispecific organic a...
Abcc3
1,423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LMJ7F1LMJ7_RAT
Canalicular multispecific organic a...
Abcc3
1,520Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JU97A0A0G2JU97_RAT
Canalicular multispecific organic a...
Abcc3
1,486Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA28955 differs from that shown. Reason: Frameshift at positions 323, 339 and 344.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti645I → L in BAA28955 (PubMed:9614210).Curated1
Sequence conflicti1075H → D in BAA28955 (PubMed:9614210).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072816 mRNA Translation: AAC25416.1
AB010467 mRNA Translation: BAA28955.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_542148.1, NM_080581.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.88248

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:140668

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072816 mRNA Translation: AAC25416.1
AB010467 mRNA Translation: BAA28955.1 Frameshift.
RefSeqiNP_542148.1, NM_080581.1
UniGeneiRn.88248

3D structure databases

ProteinModelPortaliO88563
SMRiO88563
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250828, 1 interactor

Chemistry databases

BindingDBiO88563
ChEMBLiCHEMBL2073682

PTM databases

iPTMnetiO88563
PhosphoSitePlusiO88563

Proteomic databases

PRIDEiO88563

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140668
KEGGirno:140668

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8714
RGDi71101 Abcc3

Phylogenomic databases

HOVERGENiHBG108314
InParanoidiO88563
KOiK05667
OrthoDBi138195at2759
PhylomeDBiO88563

Miscellaneous databases

Protein Ontology

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PROi
PR:O88563

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88563
Secondary accession number(s): O88270
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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