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Protein

Long-chain fatty acid transport protein 3

Gene

Slc27a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi269 – 280AMPSequence analysisAdd BLAST12

GO - Molecular functioni

  • fatty-acyl-CoA synthase activity Source: MGI
  • long-chain fatty acid-CoA ligase activity Source: MGI
  • nucleotide binding Source: UniProtKB-KW
  • very long-chain fatty acid-CoA ligase activity Source: Reactome

GO - Biological processi

  • acyl-CoA metabolic process Source: MGI
  • long-chain fatty acid metabolic process Source: MGI

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3 3474

Chemistry databases

SwissLipidsiSLP:000001142

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 3 (EC:6.2.1.-)
Short name:
FATP-3
Short name:
Fatty acid transport protein 3
Alternative name(s):
Solute carrier family 27 member 3
Gene namesi
Name:Slc27a3
Synonyms:Acsvl3, Fatp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1347358 Slc27a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932081 – 667Long-chain fatty acid transport protein 3Add BLAST667

Proteomic databases

MaxQBiO88561
PaxDbiO88561
PeptideAtlasiO88561
PRIDEiO88561

PTM databases

iPTMnetiO88561
PhosphoSitePlusiO88561

Expressioni

Tissue specificityi

Expressed at high levels in adrenal gland, testis and ovary. Expressed at lower levels in adult brain. Found in adrenal cortical cells, spermatocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and cerebellar Purkinje cells (at protein level).1 Publication

Developmental stagei

Expressed at higher levels in embryonic brain (embryonic days 12-14) than in newborn or adult.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029541

Structurei

3D structure databases

ProteinModelPortaliO88561
SMRiO88561
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
HOGENOMiHOG000044189
HOVERGENiHBG005642
InParanoidiO88561
KOiK08772
PhylomeDBiO88561

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030307 FATP3
PANTHERiPTHR43107:SF12 PTHR43107:SF12, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88561-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALLLLLPL LLLLPLLLKL DVWPQLRWLP ADLAFTVRAL RCKRALRARA
60 70 80 90 100
LAAAAADPES SESGCSLAWR LAYLAREQPT HTFLIHGAQR FSYAEAERES
110 120 130 140 150
NRIARAFLRA RGWTGGRRGS GRGSTEEGAR VAPPAGDAAA RGTTAPPLAP
160 170 180 190 200
GATVALLLPA GPDFLWIWFG LAKAGLRTAF VPTALRRGPL LHCLRSCGAS
210 220 230 240 250
ALVLATEFLE SLEPDLPALR AMGLHLWATG PETNVAGISN LLSEAADQVD
260 270 280 290 300
EPVPGYLSAP QNIMDTCLYI FTSGTTGLPK AARISHLKVL QCQGFYHLCG
310 320 330 340 350
VHQEDVIYLA LPLYHMSGSL LGIVGCLGIG ATVVLKPKFS ASQFWDDCQK
360 370 380 390 400
HRVTVFQYIG ELCRYLVNQP PSKAECDHKV RLAVGSGLRP DTWERFLRRF
410 420 430 440 450
GPLQILETYG MTEGNVATFN YTGRQGAVGR ASWLYKHIFP FSLIRYDVMT
460 470 480 490 500
GEPIRNAQGH CMTTSPGEPG LLVAPVSQQS PFLGYAGAPE LAKDKLLKDV
510 520 530 540 550
FWSGDVFFNT GDLLVCDEQG FLHFHDRTGD TIRWKGENVA TTEVAEVLET
560 570 580 590 600
LDFLQEVNIY GVTVPGHEGR AGMAALALRP PQALNLVQLY SHVSENLPPY
610 620 630 640 650
ARPRFLRLQE SLATTETFKQ QKVRMANEGF DPSVLSDPLY VLDQDIGAYL
660
PLTPARYSAL LSGDLRI
Length:667
Mass (Da):72,965
Last modified:November 22, 2005 - v2
Checksum:i0F343D14952075E7
GO
Isoform 2 (identifier: O88561-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-528: HIFPFSLIRY...QGFLHFHDRT → VRDRVDRRTP...VGAEPRGSGK
     529-667: Missing.

Show »
Length:528
Mass (Da):57,181
Checksum:i910A0B14CC41CFB3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8Y7G3X8Y7_MOUSE
Long-chain fatty acid transport pro...
Slc27a3 mCG_22222
667Annotation score:
F7CPA3F7CPA3_MOUSE
Long-chain fatty acid transport pro...
Slc27a3
633Annotation score:

Sequence cautioni

The sequence AAH60052 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC36120 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302Missing in AAH60052 (PubMed:15489334).Curated1
Sequence conflicti376C → F in AAC40187 (PubMed:16141072).Curated1
Sequence conflicti532I → F (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016219437 – 528HIFPF…FHDRT → VRDRVDRRTPGAEGGMARAG APGANDAVWLSLPAHLPLLL DSIRCHDRGAYSECPGALHD HISRFVLGGVQSWQTRLNLA PEVGAEPRGSGK in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_016220529 – 667Missing in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060052 mRNA Translation: AAH60052.1 Different initiation.
AK076014 mRNA Translation: BAC36120.1 Different initiation.
AF072758 mRNA Translation: AAC40187.1
CCDSiCCDS17527.1 [O88561-1]
RefSeqiNP_001303617.1, NM_001316688.1
NP_036118.2, NM_011988.3
UniGeneiMm.45519

Genome annotation databases

GeneIDi26568
KEGGimmu:26568

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060052 mRNA Translation: AAH60052.1 Different initiation.
AK076014 mRNA Translation: BAC36120.1 Different initiation.
AF072758 mRNA Translation: AAC40187.1
CCDSiCCDS17527.1 [O88561-1]
RefSeqiNP_001303617.1, NM_001316688.1
NP_036118.2, NM_011988.3
UniGeneiMm.45519

3D structure databases

ProteinModelPortaliO88561
SMRiO88561
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029541

Chemistry databases

SwissLipidsiSLP:000001142

PTM databases

iPTMnetiO88561
PhosphoSitePlusiO88561

Proteomic databases

MaxQBiO88561
PaxDbiO88561
PeptideAtlasiO88561
PRIDEiO88561

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26568
KEGGimmu:26568

Organism-specific databases

CTDi11000
MGIiMGI:1347358 Slc27a3

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
HOGENOMiHOG000044189
HOVERGENiHBG005642
InParanoidiO88561
KOiK08772
PhylomeDBiO88561

Enzyme and pathway databases

BRENDAi6.2.1.3 3474

Miscellaneous databases

PROiPR:O88561
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030307 FATP3
PANTHERiPTHR43107:SF12 PTHR43107:SF12, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS27A3_MOUSE
AccessioniPrimary (citable) accession number: O88561
Secondary accession number(s): Q6PAU1, Q8BK70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: February 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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