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Protein

Menin

Gene

Men1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Menin
Gene namesi
Name:Men1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1316736 Men1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Homozygous mice die in utero at 11.5-12.5 dpc. At 9 months of age, heterozygous mice develop pancreatic islet lesions, from hyperplasia to insulin-producing islet cell tumors, and frequently parathyroid adenomas. Larger, more numerous tumors involving pancreatic islets, parathyroids, thyroid, adrenal cortex and pituitary are seen by 16 months. All tumors show loss of the wild-type allele.1 Publication

Chemistry databases

ChEMBLiCHEMBL3124739

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964121 – 611MeninAdd BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei487PhosphoserineBy similarity1
Modified residuei544PhosphoserineBy similarity1
Modified residuei595PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88559
MaxQBiO88559
PaxDbiO88559
PeptideAtlasiO88559
PRIDEiO88559

PTM databases

iPTMnetiO88559
PhosphoSitePlusiO88559

Expressioni

Tissue specificityi

Widely expressed, with high levels in hippocampus, cerebral cortex, testis and thymus (at protein level). Also expressed at high levels in pancreatic islets, ovary and bone marrow. In the brain, highest expression in hippocampus pyramidal nerve cells (at protein level). In the testis, may be expressed in spermatogonia (at protein level). Low expression, if any, in skeletal muscle.3 Publications

Developmental stagei

First detected at 7 dpc. At 13.5 dpc, expressed throughout the embryo, including forelimb, gut, head, heart and lung. At 17 dpc, expression becomes more restricted, with high levels mainly in the thymus, skeletal muscle, brain and spinal cord.2 Publications

Gene expression databases

BgeeiENSMUSG00000024947 Expressed in 270 organ(s), highest expression level in neocortex
CleanExiMM_MEN1
ExpressionAtlasiO88559 baseline and differential
GenevisibleiO88559 MM

Interactioni

Subunit structurei

Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 (By similarity). Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 (By similarity). Interacts with POLR2B (By similarity). Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms (By similarity). Interacts with FANCD2 and DBF4 (By similarity). Interacts with SMAD3, but not with SMAD2, nor SMAD4 (By similarity). Directly interacts with NFKB1, NFKB2 and RELA (By similarity). Interacts with JUND.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201393, 10 interactors
ComplexPortaliCPX-628 Menin-JUND transcription inhibition complex
IntActiO88559, 6 interactors
MINTiO88559
STRINGi10090.ENSMUSP00000109130

Structurei

3D structure databases

ProteinModelPortaliO88559
SMRiO88559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 390Interaction with FANCD2By similarityAdd BLAST177

Phylogenomic databases

eggNOGiENOG410IF2R Eukaryota
ENOG410ZNZF LUCA
GeneTreeiENSGT00390000014237
HOGENOMiHOG000007225
HOVERGENiHBG000208
InParanoidiO88559
KOiK14970
TreeFamiTF323888

Family and domain databases

CDDicd14456 Menin, 1 hit
InterProiView protein in InterPro
IPR007747 Menin
PANTHERiPTHR12693 PTHR12693, 1 hit
PfamiView protein in Pfam
PF05053 Menin, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV
60 70 80 90 100
NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA
110 120 130 140 150
VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGT
160 170 180 190 200
KLDSSGVAFA VVGACQALGL RDVHLALSED HAWVVFGPNG EQTAEVTWHG
210 220 230 240 250
KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV CAINPSIDLH
260 270 280 290 300
TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT
310 320 330 340 350
LYHKGIASAK TYYQDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD
360 370 380 390 400
YNYCREDEEI YKEFFEVAND VIPNLLKEAA SLLETGEERT GEQAQGTQGQ
410 420 430 440 450
GSALQDPECF AHLLRFYDGI CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ
460 470 480 490 500
VRQKVHIVSR EAEAAEAEEP WGDEAREGRR RGPRRESKPE EPPPPKKPAL
510 520 530 540 550
DKGPGSGQSA GSGPPRKTSG TVPGTTRGGQ EVGNAAQAPA PAASPPPEGP
560 570 580 590 600
VLTFQSEKMK GMKELLVATK INSSAIKLQL TAQSQVQMKK QKVSTPSDYT
610
LSFLKRQRKG L
Length:611
Mass (Da):67,501
Last modified:May 31, 2011 - v2
Checksum:iEF45DE5B5EB1B8D1
GO
Isoform 2 (identifier: O88559-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-450: Missing.

Note: No experimental confirmation available.
Show »
Length:556
Mass (Da):61,453
Checksum:iBE74BD285110C63E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1I3A0A0R4J1I3_MOUSE
Menin
Men1
617Annotation score:
F8WHD9F8WHD9_MOUSE
Menin
Men1
616Annotation score:
D3YZC2D3YZC2_MOUSE
Menin
Men1
576Annotation score:
E9PV51E9PV51_MOUSE
Menin
Men1
64Annotation score:
F7CJP6F7CJP6_MOUSE
Menin
Men1
108Annotation score:
F6ZTV9F6ZTV9_MOUSE
Menin
Men1
135Annotation score:

Sequence cautioni

The sequence BAE32542 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti457I → M in AAC26001 (PubMed:10524203).Curated1
Sequence conflicti457I → M in AAC78843 (PubMed:10524203).Curated1
Sequence conflicti466E → G in AAC26001 (PubMed:10524203).Curated1
Sequence conflicti466E → G in AAC78843 (PubMed:10524203).Curated1
Sequence conflicti512S → L in AAC26001 (PubMed:10524203).Curated1
Sequence conflicti512S → L in AAC78843 (PubMed:10524203).Curated1
Sequence conflicti512S → L in AAH36287 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041100396 – 450Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016398 mRNA Translation: AAC79938.1
AF024513 Genomic DNA Translation: AAC79939.1
AF130368 mRNA Translation: AAF01352.1
AF072755 mRNA Translation: AAC26001.1
AF093756 Genomic DNA Translation: AAC78843.1
AF109389 mRNA Translation: AAD37498.1
AF109390 Genomic DNA Translation: AAD38333.1
AB023401 mRNA Translation: BAA74964.1
AK154371 mRNA Translation: BAE32542.1 Different initiation.
AK170713 mRNA Translation: BAE41971.1
CH466612 Genomic DNA Translation: EDL33234.1
CH466612 Genomic DNA Translation: EDL33236.1
BC036287 mRNA Translation: AAH36287.1
CCDSiCCDS29502.1 [O88559-1]
CCDS50367.1 [O88559-2]
RefSeqiNP_001161960.1, NM_001168488.1
NP_001161961.1, NM_001168489.1 [O88559-1]
NP_001161962.1, NM_001168490.1 [O88559-2]
NP_032609.1, NM_008583.2 [O88559-1]
UniGeneiMm.12917

Genome annotation databases

EnsembliENSMUST00000056391; ENSMUSP00000058149; ENSMUSG00000024947 [O88559-1]
ENSMUST00000078137; ENSMUSP00000077272; ENSMUSG00000024947 [O88559-2]
ENSMUST00000079327; ENSMUSP00000078306; ENSMUSG00000024947 [O88559-1]
ENSMUST00000113500; ENSMUSP00000109128; ENSMUSG00000024947 [O88559-1]
ENSMUST00000113504; ENSMUSP00000109132; ENSMUSG00000024947 [O88559-1]
ENSMUST00000201284; ENSMUSP00000144549; ENSMUSG00000106695 [O88559-1]
ENSMUST00000202062; ENSMUSP00000143849; ENSMUSG00000106695 [O88559-2]
ENSMUST00000202424; ENSMUSP00000144028; ENSMUSG00000106695 [O88559-1]
ENSMUST00000202550; ENSMUSP00000144083; ENSMUSG00000106695 [O88559-1]
ENSMUST00000202978; ENSMUSP00000143830; ENSMUSG00000106695 [O88559-1]
GeneIDi17283
KEGGimmu:17283
UCSCiuc008gib.2 mouse [O88559-1]
uc012bhl.1 mouse [O88559-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016398 mRNA Translation: AAC79938.1
AF024513 Genomic DNA Translation: AAC79939.1
AF130368 mRNA Translation: AAF01352.1
AF072755 mRNA Translation: AAC26001.1
AF093756 Genomic DNA Translation: AAC78843.1
AF109389 mRNA Translation: AAD37498.1
AF109390 Genomic DNA Translation: AAD38333.1
AB023401 mRNA Translation: BAA74964.1
AK154371 mRNA Translation: BAE32542.1 Different initiation.
AK170713 mRNA Translation: BAE41971.1
CH466612 Genomic DNA Translation: EDL33234.1
CH466612 Genomic DNA Translation: EDL33236.1
BC036287 mRNA Translation: AAH36287.1
CCDSiCCDS29502.1 [O88559-1]
CCDS50367.1 [O88559-2]
RefSeqiNP_001161960.1, NM_001168488.1
NP_001161961.1, NM_001168489.1 [O88559-1]
NP_001161962.1, NM_001168490.1 [O88559-2]
NP_032609.1, NM_008583.2 [O88559-1]
UniGeneiMm.12917

3D structure databases

ProteinModelPortaliO88559
SMRiO88559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201393, 10 interactors
ComplexPortaliCPX-628 Menin-JUND transcription inhibition complex
IntActiO88559, 6 interactors
MINTiO88559
STRINGi10090.ENSMUSP00000109130

Chemistry databases

ChEMBLiCHEMBL3124739

PTM databases

iPTMnetiO88559
PhosphoSitePlusiO88559

Proteomic databases

EPDiO88559
MaxQBiO88559
PaxDbiO88559
PeptideAtlasiO88559
PRIDEiO88559

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056391; ENSMUSP00000058149; ENSMUSG00000024947 [O88559-1]
ENSMUST00000078137; ENSMUSP00000077272; ENSMUSG00000024947 [O88559-2]
ENSMUST00000079327; ENSMUSP00000078306; ENSMUSG00000024947 [O88559-1]
ENSMUST00000113500; ENSMUSP00000109128; ENSMUSG00000024947 [O88559-1]
ENSMUST00000113504; ENSMUSP00000109132; ENSMUSG00000024947 [O88559-1]
ENSMUST00000201284; ENSMUSP00000144549; ENSMUSG00000106695 [O88559-1]
ENSMUST00000202062; ENSMUSP00000143849; ENSMUSG00000106695 [O88559-2]
ENSMUST00000202424; ENSMUSP00000144028; ENSMUSG00000106695 [O88559-1]
ENSMUST00000202550; ENSMUSP00000144083; ENSMUSG00000106695 [O88559-1]
ENSMUST00000202978; ENSMUSP00000143830; ENSMUSG00000106695 [O88559-1]
GeneIDi17283
KEGGimmu:17283
UCSCiuc008gib.2 mouse [O88559-1]
uc012bhl.1 mouse [O88559-2]

Organism-specific databases

CTDi4221
MGIiMGI:1316736 Men1

Phylogenomic databases

eggNOGiENOG410IF2R Eukaryota
ENOG410ZNZF LUCA
GeneTreeiENSGT00390000014237
HOGENOMiHOG000007225
HOVERGENiHBG000208
InParanoidiO88559
KOiK14970
TreeFamiTF323888

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiMen1 mouse
PROiPR:O88559
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024947 Expressed in 270 organ(s), highest expression level in neocortex
CleanExiMM_MEN1
ExpressionAtlasiO88559 baseline and differential
GenevisibleiO88559 MM

Family and domain databases

CDDicd14456 Menin, 1 hit
InterProiView protein in InterPro
IPR007747 Menin
PANTHERiPTHR12693 PTHR12693, 1 hit
PfamiView protein in Pfam
PF05053 Menin, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMEN1_MOUSE
AccessioniPrimary (citable) accession number: O88559
Secondary accession number(s): Q3U491, Q8CI72, Q91UZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 31, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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