Cldn1

Functionⁱ

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.3 Publications

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10562289
structural molecule activity Source: InterPro
virus receptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
bicellular tight junction assembly Source: MGI
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Source: UniProtKB
Inferred from direct assayⁱ
- 10508613
cell-cell junction organization Source: MGI
cellular response to butyrate Source: Ensembl
cellular response to interferon-gamma Source: Ensembl
cellular response to lead ion Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
drug transport across blood-nerve barrier Source: MGI
establishment of blood-nerve barrier Source: MGI
establishment of endothelial intestinal barrier Source: MGI
establishment of skin barrier
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11889141
hyperosmotic salinity response Source: Ensembl
liver regeneration Source: Ensembl
positive regulation of bicellular tight junction assembly Source: MGI
protein heterooligomerization Source: MGI
protein homooligomerization Source: MGI
response to dexamethasone Source: Ensembl
response to ethanol Source: Ensembl
response to interleukin-18 Source: MGI
response to lipopolysaccharide Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-1
Gene namesⁱ	Name:Cldn1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:1276109 Cldn1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicBy similarity	7
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 81	ExtracellularSequence analysisAdd BLAST	53
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 115	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	116 – 136	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	137 – 163	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	164 – 184	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	185 – 211	CytoplasmicBy similarityAdd BLAST	27

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Complete perinatal lethality. Mice are born at the expected Mendelian rate, but die within one day after birth, due to severe defects in the skin barrier function, leading to rapid transepidermal water loss and dehydration.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144730	1 – 211	Claudin-1Add BLAST		211

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	54 ↔ 64	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	O88551
PRIDEⁱ	O88551

PTM databases

iPTMnetⁱ	O88551
PhosphoSitePlusⁱ	O88551

Miscellaneous databases

PMAP-CutDBⁱ

O88551

Expressionⁱ

Tissue specificityⁱ

Detected in epidermis and liver (at protein level). Widely expressed, with highest levels in liver and kidney.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000022512 Expressed in 232 organ(s), highest expression level in liver
CleanExⁱ	MM_CLDN1
ExpressionAtlasⁱ	O88551 baseline and differential
Genevisibleⁱ	O88551 MM

Interactionⁱ

Subunit structureⁱ

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and PATJ. Interacts with OCLN, CD81, CLDN4, CLDN6 and CLDN9 (By similarity).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Mpdz	Q8VBX6	2	EBI-7158428,EBI-8026435

With

Entry

#Exp.

IntAct

Notes

Mpdz

Q8VBX6

2

EBI-7158428,EBI-8026435

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10562289

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198743, 2 interactors
IntActⁱ	O88551, 2 interactors
Molecular INTeraction database More...MINTⁱ	O88551
STRINGⁱ	10090.ENSMUSP00000023154

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88551
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	210 – 211	Interactions with TJP1, TJP2, TJP3 and PATJ		2

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IG63 Eukaryota ENOG4111GMP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	O88551
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	WKIYSYA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MX2
PhylomeDBⁱ	O88551
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003548 Claudin1 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF92 PTHR12002:SF92, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01377 CLAUDIN1
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O88551-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANAGLQLLG FILASLGWIG SIVSTALPQW KIYSYAGDNI VTAQAIYEGL 
        60         70         80         90        100
WMSCVSQSTG QIQCKVFDSL LNLNSTLQAT RALMVIGILL GLIAIFVSTI 
       110        120        130        140        150
GMKCMRCLED DEVQKMWMAV IGGIIFLISG LATLVATAWY GNRIVQEFYD 
       160        170        180        190        200
PLTPINARYE FGQALFTGWA AASLCLLGGV LLSCSCPRKT TSYPTPRPYP 
       210 
KPTPSSGKDY V

Length:211

Mass (Da):22,881

Last modified:November 1, 1998 - v1

Checksum:ⁱBEF896FA62DBB6F0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF072127 mRNA Translation: AAC27078.1 AK028428 mRNA Translation: BAC25945.1 AK036762 mRNA Translation: BAC29567.1 AK036780 mRNA Translation: BAC29574.1 AK040604 mRNA Translation: BAC30640.1 AK054207 mRNA Translation: BAC35693.1 AK081601 mRNA Translation: BAC38267.1 BC002003 mRNA Translation: AAH02003.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28087.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057883.1, NM_016674.4
UniGeneⁱ	Mm.289441

Genome annotation databases

Ensemblⁱ	ENSMUST00000023154; ENSMUSP00000023154; ENSMUSG00000022512
GeneIDⁱ	12737
KEGGⁱ	mmu:12737
UCSC genome browser More...UCSCⁱ	uc007yuz.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88551	Claudin		MOUSE		211	UniRef100_O88551
Claudin (Fragment)		NEOLE		74
Claudin (Fragment)		URSMA		48

Protein	Similar proteins		Species	Score	Length	Source
O88551	Claudin-1		HUMAN		211	UniRef90_O95832
Claudin-1		BOVIN		211
Claudin-1		RAT		211
Claudin		PANTR		211
Claudin		PANPA		211
+100

Protein	Similar proteins		Species	Score	Length	Source
O88551	Claudin-1		HUMAN		211	UniRef50_O95832
Claudin-1		RAT		211
Claudin-1		BOVIN		211
Claudin		PANTR		211
Claudin		PANPA		211
+124

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF072127 mRNA Translation: AAC27078.1 AK028428 mRNA Translation: BAC25945.1 AK036762 mRNA Translation: BAC29567.1 AK036780 mRNA Translation: BAC29574.1 AK040604 mRNA Translation: BAC30640.1 AK054207 mRNA Translation: BAC35693.1 AK081601 mRNA Translation: BAC38267.1 BC002003 mRNA Translation: AAH02003.1
CCDSⁱ	CCDS28087.1
RefSeqⁱ	NP_057883.1, NM_016674.4
UniGeneⁱ	Mm.289441

3D structure databases

ProteinModelPortalⁱ	O88551
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198743, 2 interactors
IntActⁱ	O88551, 2 interactors
MINTⁱ	O88551
STRINGⁱ	10090.ENSMUSP00000023154

PTM databases

iPTMnetⁱ	O88551
PhosphoSitePlusⁱ	O88551

Proteomic databases

PaxDbⁱ	O88551
PRIDEⁱ	O88551

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023154; ENSMUSP00000023154; ENSMUSG00000022512
GeneIDⁱ	12737
KEGGⁱ	mmu:12737
UCSCⁱ	uc007yuz.2 mouse

Organism-specific databases

CTDⁱ	9076
MGIⁱ	MGI:1276109 Cldn1

Phylogenomic databases

eggNOGⁱ	ENOG410IG63 Eukaryota ENOG4111GMP LUCA
GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	O88551
KOⁱ	K06087
OMAⁱ	WKIYSYA
OrthoDBⁱ	EOG091G0MX2
PhylomeDBⁱ	O88551
TreeFamⁱ	TF331936

Miscellaneous databases

PMAP-CutDBⁱ	O88551
Protein Ontology More...PROⁱ	PR:O88551
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022512 Expressed in 232 organ(s), highest expression level in liver
CleanExⁱ	MM_CLDN1
ExpressionAtlasⁱ	O88551 baseline and differential
Genevisibleⁱ	O88551 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003548 Claudin1 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF92 PTHR12002:SF92, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01377 CLAUDIN1
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD1_MOUSE
Accessionⁱ	O88551Primary (citable) accession number: O88551
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88551 (CLD1_MOUSE)

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Claudin-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ