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Protein

COP9 signalosome complex subunit 4

Gene

Cops4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 4
Short name:
SGN4
Short name:
Signalosome subunit 4
Alternative name(s):
JAB1-containing signalosome subunit 4
Gene namesi
Name:Cops4
Synonyms:Csn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1349414 Cops4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Nucleus, Signalosome, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001209882 – 406COP9 signalosome complex subunit 4Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei25N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO88544
PaxDbiO88544
PeptideAtlasiO88544
PRIDEiO88544

2D gel databases

REPRODUCTION-2DPAGEiO88544

PTM databases

iPTMnetiO88544
PhosphoSitePlusiO88544
SwissPalmiO88544

Expressioni

Gene expression databases

BgeeiENSMUSG00000035297 Expressed in 307 organ(s), highest expression level in midbrain
ExpressionAtlasiO88544 baseline and differential
GenevisibleiO88544 MM

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex. Interacts with STON2; controls STON2 neddylation levels (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat2Q9QXJ26EBI-646659,EBI-646643

Protein-protein interaction databases

BioGridi205043, 10 interactors
CORUMiO88544
IntActiO88544, 4 interactors
MINTiO88544
STRINGi10090.ENSMUSP00000048416

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88544
SMRiO88544
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88544

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 366PCIPROSITE-ProRule annotationAdd BLAST170

Sequence similaritiesi

Belongs to the CSN4 family.Curated

Phylogenomic databases

eggNOGiKOG1497 Eukaryota
ENOG410XPDE LUCA
GeneTreeiENSGT00730000111161
HOGENOMiHOG000158382
HOVERGENiHBG051136
InParanoidiO88544
KOiK12178
OMAiYNNITFR
OrthoDBiEOG091G08VK
PhylomeDBiO88544
TreeFamiTF101147

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037754 CSN4
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10855:SF2 PTHR10855:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O88544-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVRQDLA QLMNSSGSHK DLAGKYRQIL EKAIQLSGTE QLEALKAFVE
60 70 80 90 100
AMVNENVSLV ISRQLLTDFC THLPNLPDST AKEVYHFTLE KIQPRVISFE
110 120 130 140 150
EQVASIRQHL ASIYEKEEDW RNAAQVLVGI PLETGQKQYN VDYKLETYLK
160 170 180 190 200
IARLYLEDDD PVQAEAYINR ASLLQNESTN EQLQIHYKVC YARVLDYRRK
210 220 230 240 250
FIEAAQRYNE LSYKTIVHES ERLEALKHAL HCTILASAGQ QRSRMLATLF
260 270 280 290 300
KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
310 320 330 340 350
DRAVIEHNLL SASKLYNNIT FEELGALLEI PAAKAEKIAS QMITEGRMNG
360 370 380 390 400
FIDQIDGIVH FETREALPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAM

EAQMAQ
Length:406
Mass (Da):46,285
Last modified:November 1, 1998 - v1
Checksum:i9584559823F99EB4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1R9D3Z1R9_MOUSE
COP9 signalosome complex subunit 4
Cops4
206Annotation score:
F6QTS1F6QTS1_MOUSE
COP9 signalosome complex subunit 4
Cops4
253Annotation score:
D3YV99D3YV99_MOUSE
COP9 signalosome complex subunit 4
Cops4
244Annotation score:
D6RG47D6RG47_MOUSE
COP9 signalosome complex subunit 4
Cops4
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071314 mRNA Translation: AAC33901.1
AK009955 mRNA Translation: BAB26607.1
CCDSiCCDS19463.1
RefSeqiNP_036131.1, NM_012001.2
UniGeneiMm.957

Genome annotation databases

EnsembliENSMUST00000045993; ENSMUSP00000048416; ENSMUSG00000035297
GeneIDi26891
KEGGimmu:26891
UCSCiuc008yhs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071314 mRNA Translation: AAC33901.1
AK009955 mRNA Translation: BAB26607.1
CCDSiCCDS19463.1
RefSeqiNP_036131.1, NM_012001.2
UniGeneiMm.957

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFMNMR-A296-366[»]
ProteinModelPortaliO88544
SMRiO88544
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205043, 10 interactors
CORUMiO88544
IntActiO88544, 4 interactors
MINTiO88544
STRINGi10090.ENSMUSP00000048416

PTM databases

iPTMnetiO88544
PhosphoSitePlusiO88544
SwissPalmiO88544

2D gel databases

REPRODUCTION-2DPAGEiO88544

Proteomic databases

EPDiO88544
PaxDbiO88544
PeptideAtlasiO88544
PRIDEiO88544

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045993; ENSMUSP00000048416; ENSMUSG00000035297
GeneIDi26891
KEGGimmu:26891
UCSCiuc008yhs.2 mouse

Organism-specific databases

CTDi51138
MGIiMGI:1349414 Cops4

Phylogenomic databases

eggNOGiKOG1497 Eukaryota
ENOG410XPDE LUCA
GeneTreeiENSGT00730000111161
HOGENOMiHOG000158382
HOVERGENiHBG051136
InParanoidiO88544
KOiK12178
OMAiYNNITFR
OrthoDBiEOG091G08VK
PhylomeDBiO88544
TreeFamiTF101147

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Miscellaneous databases

EvolutionaryTraceiO88544
PROiPR:O88544
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035297 Expressed in 307 organ(s), highest expression level in midbrain
ExpressionAtlasiO88544 baseline and differential
GenevisibleiO88544 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037754 CSN4
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10855:SF2 PTHR10855:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN4_MOUSE
AccessioniPrimary (citable) accession number: O88544
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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