Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COP9 signalosome complex subunit 3

Gene

Cops3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo.1 Publication

GO - Biological processi

  • in utero embryonic development Source: MGI
  • protein deneddylation Source: MGI
  • ubiquitin-dependent protein catabolic process Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 3
Short name:
SGN3
Short name:
Signalosome subunit 3
Alternative name(s):
JAB1-containing signalosome subunit 3
Gene namesi
Name:Cops3
Synonyms:Csn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1349409 Cops3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Disruption phenotypei

Embryos arrest after 5.5 dpc and resorb by 8.5 dpc mainly due to increased cell death.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001209792 – 423COP9 signalosome complex subunit 3Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei407PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei423PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88543
PaxDbiO88543
PeptideAtlasiO88543
PRIDEiO88543

PTM databases

iPTMnetiO88543
PhosphoSitePlusiO88543
SwissPalmiO88543

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000019373 Expressed in 309 organ(s), highest expression level in testis
CleanExiMM_CSN3
ExpressionAtlasiO88543 baseline and differential
GenevisibleiO88543 MM

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi205027, 8 interactors
CORUMiO88543
IntActiO88543, 4 interactors
MINTiO88543
STRINGi10090.ENSMUSP00000019517

Structurei

3D structure databases

ProteinModelPortaliO88543
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 365PCIPROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the CSN3 family.Curated

Phylogenomic databases

eggNOGiKOG2582 Eukaryota
ENOG410XRKY LUCA
GeneTreeiENSGT00490000043408
HOGENOMiHOG000030451
HOVERGENiHBG051135
InParanoidiO88543
KOiK12177
OMAiNHYHDLV
OrthoDBiEOG091G07DK
PhylomeDBiO88543
TreeFamiTF101146

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037753 CSN3
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10758:SF1 PTHR10758:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O88543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD
60 70 80 90 100
VQEHSLGVLA VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF
110 120 130 140 150
AGLCHQLTNA LVERKQPLRG IGILKQAIDK MQMNTNQLTS VHADLCQLCL
160 170 180 190 200
LAKCFKPALP YLDVDMMDIC KENGAYDAKH FLCYYYYGGM IYTGLKNFER
210 220 230 240 250
ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ LPKYTSQIVG
260 270 280 290 300
RFIKPLSNAY HELAQVYSTN NPSELRNLVS KHSETFTRDN NMGLVKQCLS
310 320 330 340 350
SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS
360 370 380 390 400
INQKDGMVSF HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN
410 420
PQFVQKSMGS QEDDSGNKPS SYS
Length:423
Mass (Da):47,832
Last modified:January 23, 2007 - v3
Checksum:i2FDCCDB98A5168FB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YCA7F6YCA7_MOUSE
COP9 signalosome complex subunit 3
Cops3
244Annotation score:
D3Z036D3Z036_MOUSE
COP9 signalosome complex subunit 3
Cops3
106Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071313 mRNA Translation: AAC33900.1
BC068179 mRNA Translation: AAH68179.1
CCDSiCCDS24778.1
RefSeqiNP_036121.1, NM_011991.1
UniGeneiMm.40

Genome annotation databases

EnsembliENSMUST00000019517; ENSMUSP00000019517; ENSMUSG00000019373
GeneIDi26572
KEGGimmu:26572
UCSCiuc007jfa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071313 mRNA Translation: AAC33900.1
BC068179 mRNA Translation: AAH68179.1
CCDSiCCDS24778.1
RefSeqiNP_036121.1, NM_011991.1
UniGeneiMm.40

3D structure databases

ProteinModelPortaliO88543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205027, 8 interactors
CORUMiO88543
IntActiO88543, 4 interactors
MINTiO88543
STRINGi10090.ENSMUSP00000019517

PTM databases

iPTMnetiO88543
PhosphoSitePlusiO88543
SwissPalmiO88543

Proteomic databases

EPDiO88543
PaxDbiO88543
PeptideAtlasiO88543
PRIDEiO88543

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019517; ENSMUSP00000019517; ENSMUSG00000019373
GeneIDi26572
KEGGimmu:26572
UCSCiuc007jfa.1 mouse

Organism-specific databases

CTDi8533
MGIiMGI:1349409 Cops3

Phylogenomic databases

eggNOGiKOG2582 Eukaryota
ENOG410XRKY LUCA
GeneTreeiENSGT00490000043408
HOGENOMiHOG000030451
HOVERGENiHBG051135
InParanoidiO88543
KOiK12177
OMAiNHYHDLV
OrthoDBiEOG091G07DK
PhylomeDBiO88543
TreeFamiTF101146

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Miscellaneous databases

PROiPR:O88543
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019373 Expressed in 309 organ(s), highest expression level in testis
CleanExiMM_CSN3
ExpressionAtlasiO88543 baseline and differential
GenevisibleiO88543 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037753 CSN3
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10758:SF1 PTHR10758:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN3_MOUSE
AccessioniPrimary (citable) accession number: O88543
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again