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Protein

Aromatic-L-amino-acid decarboxylase

Gene

Ddc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Pathwayi: dopamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (Th)
  2. Aromatic-L-amino-acid decarboxylase (Ddc)
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei148Pyridoxal phosphate; via amide nitrogenBy similarity1
Binding sitei149Pyridoxal phosphateBy similarity1
Binding sitei192SubstrateBy similarity1
Binding sitei246Pyridoxal phosphate; via carbonyl oxygenBy similarity1
Binding sitei300Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.28 3474
ReactomeiR-MMU-209905 Catecholamine biosynthesis
R-MMU-209931 Serotonin and melatonin biosynthesis
UniPathwayi
UPA00747;UER00734

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:Ddc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94876 Ddc

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4230

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469401 – 480Aromatic-L-amino-acid decarboxylaseAdd BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei303N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO88533
PeptideAtlasiO88533
PRIDEiO88533

PTM databases

iPTMnetiO88533
PhosphoSitePlusiO88533

Expressioni

Gene expression databases

BgeeiENSMUSG00000020182 Expressed in 250 organ(s), highest expression level in pineal body
CleanExiMM_DDC
ExpressionAtlasiO88533 baseline and differential
GenevisibleiO88533 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88533, 2 interactors
MINTiO88533
STRINGi10090.ENSMUSP00000068525

Chemistry databases

BindingDBiO88533

Structurei

3D structure databases

ProteinModelPortaliO88533
SMRiO88533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 1151Add BLAST58
Repeati118 – 1782Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 1782 X approximate tandem repeatsAdd BLAST121

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiO88533
KOiK01593
OMAiSAMWVKK
OrthoDBiEOG091G03KI
PhylomeDBiO88533
TreeFamiTF313863

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP
60 70 80 90 100
ETYEDIIKDI EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC
110 120 130 140 150
IGFSWAASPA CTELETVMMD WLGKMLELPE AFLAGRAGEG GGVIQGSASE
160 170 180 190 200
ATLVALLAAR TKVIRQLQAA SPEFTQAAIM EKLVAYTSDQ AHSSVERAGL
210 220 230 240 250
IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV ATLGTTSCCS
260 270 280 290 300
FDNLLEVGPI CNQEGVWLHI DAAYAGSAFI CPEFRYLLNG VEFADSFNFN
310 320 330 340 350
PHKWLLVNFD CSAMWVKRRT DLTGAFNMDP VYLKHSHQDS GFITDYRHWQ
360 370 380 390 400
IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVELSHEFES LVRQDPRFEI
410 420 430 440 450
CTEVILGLVC FRLKGSNELN ETLLQRINSA KKIHLVPCRL RDKFVLRFAV
460 470 480
CARTVESAHV QLAWEHISDL ASSVLRAEKE
Length:480
Mass (Da):53,874
Last modified:November 1, 1998 - v1
Checksum:iD6C1CA504AC2D10E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SUV9Q5SUV9_MOUSE
Aromatic-L-amino-acid decarboxylase
Ddc
253Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071068 mRNA Translation: AAC25566.1
CCDSiCCDS24439.1
RefSeqiNP_001177377.1, NM_001190448.1
NP_057881.1, NM_016672.4
XP_006514550.1, XM_006514487.3
XP_006514551.1, XM_006514488.3
XP_006514552.1, XM_006514489.2
UniGeneiMm.12906

Genome annotation databases

EnsembliENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182
ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182
ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182
GeneIDi13195
KEGGimmu:13195
UCSCiuc007iaw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071068 mRNA Translation: AAC25566.1
CCDSiCCDS24439.1
RefSeqiNP_001177377.1, NM_001190448.1
NP_057881.1, NM_016672.4
XP_006514550.1, XM_006514487.3
XP_006514551.1, XM_006514488.3
XP_006514552.1, XM_006514489.2
UniGeneiMm.12906

3D structure databases

ProteinModelPortaliO88533
SMRiO88533
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88533, 2 interactors
MINTiO88533
STRINGi10090.ENSMUSP00000068525

Chemistry databases

BindingDBiO88533
ChEMBLiCHEMBL4230

PTM databases

iPTMnetiO88533
PhosphoSitePlusiO88533

Proteomic databases

PaxDbiO88533
PeptideAtlasiO88533
PRIDEiO88533

Protocols and materials databases

DNASUi13195
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066237; ENSMUSP00000068525; ENSMUSG00000020182
ENSMUST00000109659; ENSMUSP00000105286; ENSMUSG00000020182
ENSMUST00000178704; ENSMUSP00000136467; ENSMUSG00000020182
GeneIDi13195
KEGGimmu:13195
UCSCiuc007iaw.2 mouse

Organism-specific databases

CTDi1644
MGIiMGI:94876 Ddc

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiO88533
KOiK01593
OMAiSAMWVKK
OrthoDBiEOG091G03KI
PhylomeDBiO88533
TreeFamiTF313863

Enzyme and pathway databases

UniPathwayi
UPA00747;UER00734

BRENDAi4.1.1.28 3474
ReactomeiR-MMU-209905 Catecholamine biosynthesis
R-MMU-209931 Serotonin and melatonin biosynthesis

Miscellaneous databases

PROiPR:O88533
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020182 Expressed in 250 organ(s), highest expression level in pineal body
CleanExiMM_DDC
ExpressionAtlasiO88533 baseline and differential
GenevisibleiO88533 MM

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDC_MOUSE
AccessioniPrimary (citable) accession number: O88533
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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